Scandinavian Journal of Immunology最新文献_第3页

Role of AKR1B10 in inflammatory diseases. AKR1B10 在炎症性疾病中的作用

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1111/sji.13390

Min Guo, Tao Wang, Wenjun Ge, Chenran Ren, Ben Chi-Bun Ko, Xi Zeng, Deliang Cao

{"title":"Role of AKR1B10 in inflammatory diseases.","authors":"Min Guo, Tao Wang, Wenjun Ge, Chenran Ren, Ben Chi-Bun Ko, Xi Zeng, Deliang Cao","doi":"10.1111/sji.13390","DOIUrl":"10.1111/sji.13390","url":null,"abstract":"Inflammation is an important pathophysiological process in many diseases; it has beneficial and harmful effects. When exposed to various stimuli, the body triggers an inflammatory response to eliminate invaded pathogens and damaged tissues to maintain homeostasis. However, uncontrollable persistent or excessive inflammatory responses may damage tissues and induce various diseases, such as metabolic diseases (e.g. diabetes), autoimmune diseases, nervous system-related diseases, digestive system-related diseases, and even tumours. Aldo-keto reductase 1B10 (AKR1B10) is an important player in the development and progression of multiple diseases, such as tumours and inflammatory diseases. AKR1B10 is upregulated in solid tumours, such as hepatocellular carcinoma (HCC), non-small cell lung carcinoma, and breast cancer, and is a reliable serum marker. However, information on the role of AKR1B10 in inflammation is limited. In this study, we summarized the role of AKR1B10 in inflammatory diseases, including its expression, functional contribution to inflammatory responses, and regulation of signalling pathways related to inflammation. We also discussed the role of AKR1B10 in glucose and lipid metabolism and oxidative stress. This study provides novel information and increases the understanding of clinical inflammatory diseases.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early graft-infiltrating lymphocytes are not associated with graft rejection in a mouse model of skin transplantation. 在小鼠皮肤移植模型中，早期移植物浸润淋巴细胞与移植物排斥反应无关。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-07-30 DOI: 10.1111/sji.13397

Ryo Kanazawa, Ryoichi Goto, Takuya Harada, Takuji Ota, Nozomi Kobayashi, Kazuaki Shibuya, Yoshikazu Ganchiku, Masaaki Watanabe, Masaaki Zaitsu, Norio Kawamura, Tsuyoshi Shimamura, Akinobu Taketomi

{"title":"Early graft-infiltrating lymphocytes are not associated with graft rejection in a mouse model of skin transplantation.","authors":"Ryo Kanazawa, Ryoichi Goto, Takuya Harada, Takuji Ota, Nozomi Kobayashi, Kazuaki Shibuya, Yoshikazu Ganchiku, Masaaki Watanabe, Masaaki Zaitsu, Norio Kawamura, Tsuyoshi Shimamura, Akinobu Taketomi","doi":"10.1111/sji.13397","DOIUrl":"https://doi.org/10.1111/sji.13397","url":null,"abstract":"Graft-infiltrating lymphocytes (GILs) play an important role in promoting rejection after organ transplantation. We recently reported that GILs that accumulated up to 3 days post-transplantation did not promote rejection, whereas GILs present 3-5 days post-transplantation promoted rejection in a mouse heart transplantation model. However, the immunological behaviour of GILs in murine skin transplantation remains unclear. GILs were isolated on days 3, 5 or 7 post-transplantation from C57BL/6 (B6) allogeneic skin grafts transplanted onto BALB/c mice. BALB/c Rag2-/- γc-/- mice (BRGs) underwent B6 skin graft transplantation 10 weeks after adoptive transfer of day 3, 5, or 7 GILs. BRGs reconstituted with day 5 or 7 GILs completely rejected B6 grafts. However, when B6 grafts harvested from recipient BALB/c mice on day 5 or 7 were re-transplanted into BRGs, half of the re-transplanted day 5 grafts established long-term survival, although all re-transplanted day 7 grafts were rejected. BRGs reconstituted with day 3 GILs did not reject B6 grafts. Consistently, re-transplantation using day 3 skin grafts resulted in no rejection. Administration of anti-CD25 antibodies did not prevent the phenomenon observed for the day 3 skin grafts. Furthermore, BRGs reconstituted with splenocytes from naïve BALB/c mice immediately rejected the naïve B6 skin grafts and the re-transplanted day 3 B6 grafts, suggesting that day 3 GILs were unable to induce allograft rejection during the rejection process. In conclusion, the immunological role of GILs depends on the time since transplantation. Day 3 GILs had neither protective nor alloreactive effects in the skin transplant model.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidermal growth factor receptor and programmed cell death-1 expression levels in peripheral T cell subsets of patients with non-small cell lung cancer. 非小细胞肺癌患者外周 T 细胞亚群中表皮生长因子受体和程序性细胞死亡-1 的表达水平。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-07-29 DOI: 10.1111/sji.13398

Ayca Ceylan, Mehmet Artac, Mehmet Zahid Kocak, Hasibe Artac

{"title":"Epidermal growth factor receptor and programmed cell death-1 expression levels in peripheral T cell subsets of patients with non-small cell lung cancer.","authors":"Ayca Ceylan, Mehmet Artac, Mehmet Zahid Kocak, Hasibe Artac","doi":"10.1111/sji.13398","DOIUrl":"https://doi.org/10.1111/sji.13398","url":null,"abstract":"Lung cancer is the leading cause of cancer-related deaths, in part due to its late diagnosis. Increased epidermal growth factor receptor (EGFR) expression in cancer cells is associated with a poor prognosis, and EGFR tyrosine kinase inhibitors are widely used in cancer treatment. This study aimed to clarify the relationship between EGFR expression on T cells and cancer prognosis in patients with non-small cell lung cancer (NSCLC). Forty patients with NSCLC and 40 healthy volunteers were included in this study. Peripheral CD4+T helper (Th1, Th2, Th9, Th17, Th1Th17, follicular and peripheral Th) and cytotoxic T lymphocyte (CD8+follicular and peripheral T) subsets were identified with flow cytometry according to their chemokine receptors. EGFR expression on T lymphocytes in relation to overall survival (OS) was investigated in patients with NSCLC. The patients [mean age (min-max) = 64.03 (45-83); 20 stage I-III and 20 stage IV] had increased EGFR expression on CD3+T, CD4+Th, Th1, Th2, and Th17 cells compared to the controls (p < 0.05). High EGFR expression on CD3+T, CD4+Th, Th1, and Th2 cells was associated with poor OS. Also, PD-1 expression on lymphocytes, CD3+T, and Th cells was increased in patients with NSCLC compared to controls. The high expression of EGFR and PD-1 on Th cells and the reduced percentage of lymphocytes and Th cells, especially in stage IV patients with NSCLC, revealed that increased EGFR activity may trigger apoptosis of Th cells and promote the development of metastases, while high EGFR expression on CD3+T, CD4+Th, Th1, and Th2 cells may be an independent poor prognostic marker in NSCLC.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA hsa-let-7e-5p in hUC-MSC-EVs alleviates oral mucositis by targeting TAB2. hUC-MSC-EVs 中的 microRNA hsa-let-7e-5p 通过靶向 TAB2 缓解口腔黏膜炎。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-07-28 DOI: 10.1111/sji.13399

Shuting Lin, Dong Lai, Yan Tian, Fei Lai, Min Long, Changfu Ji, Gengxin Hao

{"title":"MicroRNA hsa-let-7e-5p in hUC-MSC-EVs alleviates oral mucositis by targeting TAB2.","authors":"Shuting Lin, Dong Lai, Yan Tian, Fei Lai, Min Long, Changfu Ji, Gengxin Hao","doi":"10.1111/sji.13399","DOIUrl":"https://doi.org/10.1111/sji.13399","url":null,"abstract":"Oral mucositis (OM) is a severe side effect of anti-cancer therapy, with limited available treatments. Mesenchymal stem cells (MSCs) and their secreted extracellular vesicles (EVs) have demonstrated effective protection against OM. However, the underlying mechanism remains elusive. In the current study, we purified EVs secreted by human umbilical cord MSCs (hUC-MSC-EVs) and investigated their role in lipopolysaccharide (LPS)-induced human oral keratinocytes (HOKs). We observed that treatment with hUC-MSC-EVs significantly reduced the inflammatory response of HOKs to LPS induction. Through small RNA-seq using miRNAs extracted from hUC-MSC-EVs, we identified hsa-let-7e-5p as one of the most highly expressed miRNAs. Bioinformatic analysis data indicated that hsa-let-7e-5p may inhibit the NF-κB signalling pathway by targeting TAB2. Overexpression of the hsa-let-7e-5p inhibitor significantly attenuated the anti-inflammatory effect of hUC-MSC-EVs in LPS-induced HOKs, which could be reversed by the knockdown of TAB2. In addition, we administered hUC-MSC-EVs in a hamster model for OM and observed that these EVs alleviated OM phenotypes. Taken together, our observations suggest that hsa-let-7e-5p in hUC-MSC-EVs could protect the oral mucosa from OM by repressing TAB2 expression.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of autoantibodies associated with intravenous immunoglobulin replacement therapy in children with primary immunodeficiency. 评估与原发性免疫缺陷儿童静脉注射免疫球蛋白替代疗法相关的自身抗体。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-07-07 DOI: 10.1111/sji.13396

Murat Özer, Seher Tekeli, Selçuk Doğan, Sema Çetin, Rıdvan Selen, Caner Aytekin

{"title":"Assessment of autoantibodies associated with intravenous immunoglobulin replacement therapy in children with primary immunodeficiency.","authors":"Murat Özer, Seher Tekeli, Selçuk Doğan, Sema Çetin, Rıdvan Selen, Caner Aytekin","doi":"10.1111/sji.13396","DOIUrl":"https://doi.org/10.1111/sji.13396","url":null,"abstract":"While it is known that immunoglobulin replacement therapy (IgRT) used in the treatment of primary immunodeficiency disorders (PIDs) can lead to the passive transfer of autoantibodies, there is no data indicating that these antibodies can cause clinical symptoms in patients. This study aimed to investigate the presence of autoantibodies and their clinical correlation in patients diagnosed with PIDs receiving IgRT. Paediatric patients who were diagnosed with PIDs, and administered IgRT at our immunology clinic between 1 January 2012 and 31 December 2021, were included in the study. The medical records of these patients were retrospectively analysed, and autoantibodies were screened. Autoantibody screening was conducted at least once in 48 cases. Among these cases, 29 cases (60.4%) demonstrated positivity for at least one of the autoantibodies screened in the study. Among these cases, 23 tested positive for anti-TPO, 9 for anti-TG and 2 for both anti-TPO and anti-TG. Only two of these patients were confirmed to have Hashimoto's thyroiditis. In 30 cases, autoantibodies related to Celiac disease (CD) were screened, with at least one being positive in five different cases; CD was not confirmed. The results of our study suggest that passive transfer of autoantibodies to patients with IgRT does not cause any significant clinical findings. In addition, in cases of PID, autoantibodies detected in the blood passed to patients with IgRT can lead to misdiagnosis. Screening for autoantibodies in patients with PID undergoing IgRT may not yield accurate results in terms of detecting autoimmune diseases.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mite-negative allergic rhinitis: A model of the regulation mechanism of atopy onset. 螨阴性过敏性鼻炎：过敏性鼻炎发病调节机制模型。

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-31 DOI: 10.1111/sji.13367

Yasuhiro Horiuchi

引用次数: 0

Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study. 重大低能量创伤会导致非特异性免疫球蛋白生成，但无证据表明会产生特异性自身抗体：一项前瞻性队列研究。

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1111/sji.13368

Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova

{"title":"Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study.","authors":"Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova","doi":"10.1111/sji.13368","DOIUrl":"10.1111/sji.13368","url":null,"abstract":"Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control. Blood leukocyte differential and lymphocyte subpopulations were determined at baseline and in the first two postoperative samples. The mean age of the patients reached 80.1 years, and 23 (46%) completed all visits. Serum concentrations of total IgG, IgM and IgA increased at all follow-up time points. The ANA fluorescence light intensity units increased at 12 weeks and 12 months postoperatively (p < 0.0001), but the proportion of ANA-positive patients did not change (35%). The values of anti-C1q mildly increased at all follow-up visits, but not the ratio to total IgG. Anti-dsDNA remained negative in all patients, and anti-cardiolipin IgG/IgM antibodies did not change. Anti-CMV IgG antibodies increased significantly at all follow-up visits, without change in the ratio to total IgG. Flow cytometry showed an increased proportion of B-cells 3-4 days postoperatively. In conclusion, major musculoskeletal trauma in elderly patients induces a generalized non-specific increase in immunoglobulin production without laboratory signs for enhanced systemic autoimmunity.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease Isoliquiritigenin 通过与 Syk 对接限制巨噬细胞炎性体的激活，从而缓解小鼠非酒精性脂肪肝的病情

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-27 DOI: 10.1111/sji.13371

Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong

{"title":"Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease","authors":"Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong","doi":"10.1111/sji.13371","DOIUrl":"https://doi.org/10.1111/sji.13371","url":null,"abstract":"Isoliquiritigenin (ISL) is a chalcone‐type flavonoid derived from the root of licorice with antioxidant, anti‐inflammatory, anti‐tumour and neuroprotective properties. ISL has been proven to downregulate the productions of IL‐1β, TNF‐α and IL‐6 by macrophages. However, detailed molecular mechanisms of this modulation remain elusive. Here, ISL suppressed Syk phosphorylation and CD80, CD86, IL‐1β, TNF‐α and IL‐6 expressions in lipopolysaccharide‐stimulated macrophages ex vivo. ApoC3‐transgenic (ApoC3TG) mice had more activated macrophages. ISL was also able to downregulate the inflammatory activities of macrophages from ApoC3TG mice. Administration of ISL inhibited Syk activation and inflammatory activities of macrophages in ApoC3TG mice in vivo. The treatment of ISL further alleviated MCD‐induced non‐alcoholic fatty liver disease (NAFLD) in wild‐type and ApoC3TG mice, accompanied by less recruitment and activation of liver macrophages. Due to the inhibition of Syk phosphorylation, ISL‐treated macrophages displayed less production of cytoplasmic ROS, NLRP3, cleaved‐GSDMD and cleaved‐IL‐1β, suggesting less inflammasome activation. Finally, the molecular docking study demonstrated that ISL bound to Syk directly with the Kd of 1.273 × 10−8 M. When the Syk expression was knocked down by its shRNA, the inhibitory effects of ISL on activated macrophages disappeared, indicating that Syk was at least one of key docking‐molecules of ISL. Collectively, ISL could alleviate MCD‐induced NAFLD in mice involved with the inhibition of macrophage inflammatory activity by the blockade of Syk‐induced inflammasome activation.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic SARS‐CoV‐2 infection: A possible role of platelet HLA class I expression level 无症状 SARS-CoV-2 感染：血小板 HLA I 类表达水平的可能作用

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-08 DOI: 10.1111/sji.13370

Rocco Cantisani, Adriano Spreafico, Giuseppe Marotta

引用次数: 0

Elevated levels of anti‐Golgi antibodies: An early sign of seronegative rheumatoid arthritis 抗高尔基体抗体水平升高：血清阴性类风湿性关节炎的早期征兆

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-03 DOI: 10.1111/sji.13369

Emrah Salman, Bedia Dinç

{"title":"Elevated levels of anti‐Golgi antibodies: An early sign of seronegative rheumatoid arthritis","authors":"Emrah Salman, Bedia Dinç","doi":"10.1111/sji.13369","DOIUrl":"https://doi.org/10.1111/sji.13369","url":null,"abstract":"Anti‐Golgi antibodies are uncommon antibodies that exhibit specific, polarized cytoplasmic staining on the Hep‐2 substrate. The objective of our study was to identify the clinical and laboratory features associated with anti‐Golgi antibodies. We examined 4.5 years of data from a Turkish tertiary hospital in this retrospective cohort analysis. The indirect immunofluorescence staining patterns, antinuclear antibody (ANA) titres and clinical data of all patients were obtained from the hospital record system. A total of 146,055 ANAs were detected, of which 224 patients (0.15%) exhibited anti‐Golgi antibody staining. In total, 39.4% of diagnosed patients had autoimmune diseases (AIDs). Of the AIDs, 26 (46.4%) were rheumatoid arthritis (RA). This is a very high rate and another remarkable point is that 17 (65.3%) of these patients had seronegative RA. High‐titre results (1 ≥ 1/320) were more common in patients with AID. Anti‐Ro52 was prevalent in 50% of extractable nuclear antigen (ENA)‐positive patients, making it a remarkable finding. The majority of individuals with high‐titre anti‐Golgi antibodies had AID, particularly RA. The majority of these patients also tested negative for anti‐cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor (RF). Finally, high‐titre anti‐Golgi antibodies may be an important serologic marker for seronegative RA in the Turkish population.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140574511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0