过敏性哮喘的生理病理：综述。

IF 4.1 4区医学 Q2 IMMUNOLOGY

Scandinavian Journal of Immunology Pub Date : 2025-05-01 DOI:10.1111/sji.70032

Najla Ghrairi, Youssef Zied Elhechmi

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引用次数: 0

摘要

过敏性哮喘是一种以气道高反应性、可逆性气流阻塞和慢性炎症为特征的慢性炎症性气道疾病。环境过敏原触发一系列由th2主导的免疫系统驱动的免疫反应，以及先天细胞如先天淋巴样细胞2型（ILC2）和效应细胞如肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞。除了这些免疫途径外，遗传易感性在哮喘发病中起着至关重要的作用。本文综述了过敏性哮喘的遗传基础、关键的免疫反应、气道重塑的机制以及治疗策略的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Physiopathology of Allergic Asthma: A Comprehensive Review.

Allergic asthma is a chronic inflammatory airway disease characterised by airway hyperresponsiveness, reversible airflow obstruction and chronic inflammation. Environmental allergens trigger a series of immune responses driven by a Th2-dominated immune system, along with innate cells like innate lymphoid cells type 2 (ILC2) and effector cells such as mast cells, basophils and eosinophils. In addition to these immune pathways, genetic predisposition plays a crucial role in asthma onset. This review highlights the genetic basis of allergic asthma, the key immune responses, the mechanisms behind airway remodelling and advances in therapeutic strategies.

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来源期刊

Scandinavian Journal of Immunology 医学-免疫学

CiteScore

7.70

自引率

5.40%

发文量

109

审稿时长

1 months

期刊介绍： This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.