Physiopathology of Allergic Asthma: A Comprehensive Review.

Abstract

Allergic asthma is a chronic inflammatory airway disease characterised by airway hyperresponsiveness, reversible airflow obstruction and chronic inflammation. Environmental allergens trigger a series of immune responses driven by a Th2-dominated immune system, along with innate cells like innate lymphoid cells type 2 (ILC2) and effector cells such as mast cells, basophils and eosinophils. In addition to these immune pathways, genetic predisposition plays a crucial role in asthma onset. This review highlights the genetic basis of allergic asthma, the key immune responses, the mechanisms behind airway remodelling and advances in therapeutic strategies.