Scandinavian Journal of Immunology最新文献_第2页

Inflammasomes and Cardiovascular Disease: Linking Inflammation to Cardiovascular Pathophysiology. 炎症小体与心血管疾病：将炎症与心血管病理生理学联系起来。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70020

Mohamed J Saadh, Faris Anad Muhammad, Rafid Jihad Albadr, Gaurav Sanghvi, S Renuka Jyothi, Mayank Kundlas, Kamal Kant Joshi, Akmal Rakhmatullaev, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Ali M Ali Al-Nuaimi

{"title":"Inflammasomes and Cardiovascular Disease: Linking Inflammation to Cardiovascular Pathophysiology.","authors":"Mohamed J Saadh, Faris Anad Muhammad, Rafid Jihad Albadr, Gaurav Sanghvi, S Renuka Jyothi, Mayank Kundlas, Kamal Kant Joshi, Akmal Rakhmatullaev, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Ali M Ali Al-Nuaimi","doi":"10.1111/sji.70020","DOIUrl":"10.1111/sji.70020","url":null,"abstract":"Cardiovascular diseases (CVDs) remain a leading cause of global mortality, driven by risk factors such as dyslipidemia, hypertension and diabetes. Recent research has highlighted the critical role of inflammasomes, particularly the NLRP3 inflammasome, in the pathogenesis of various CVDs, including hypertension, atherosclerosis, myocardial infarction and heart failure. Inflammasomes are intracellular protein complexes that activate inflammatory responses through the production of pro-inflammatory cytokines such as IL-1β and IL-18, contributing to endothelial dysfunction, plaque formation and myocardial injury. This review provides a comprehensive overview of the structure, activation mechanisms and pathways of inflammasomes, with a focus on their involvement in cardiovascular pathology. Key activation pathways include ion fluxes (K+ efflux and Ca2+ signalling), endoplasmic reticulum (ER) stress, mitochondrial dysfunction and lysosomal destabilisation. The review also explores the therapeutic potential of targeting inflammasomes to mitigate inflammation and improve outcomes in CVDs. Emerging strategies include small-molecule inhibitors, biologics and RNA-based therapeutics, with a particular emphasis on NLRP3 inhibition. Additionally, the integration of artificial intelligence (AI) in cardiovascular research offers promising avenues for identifying novel biomarkers, predicting disease risk and developing personalised treatment strategies. Future research directions should focus on understanding the interactions between inflammasomes and other immune components, as well as genetic regulators, to uncover new therapeutic targets. By elucidating the complex role of inflammasomes in CVDs, this review underscores the potential for innovative therapies to address inflammation-driven cardiovascular pathology, ultimately improving patient outcomes.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70020"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD1d-iNKT Axis in Infectious Diseases: Lessons Learned From the Past. 传染病中的cd1 - inkt轴：从过去的经验教训。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70024

Priyajit Chatterjee, Shubhranil Brahma, Peter Cresswell, Syamdas Bandyopadhyay

{"title":"CD1d-iNKT Axis in Infectious Diseases: Lessons Learned From the Past.","authors":"Priyajit Chatterjee, Shubhranil Brahma, Peter Cresswell, Syamdas Bandyopadhyay","doi":"10.1111/sji.70024","DOIUrl":"https://doi.org/10.1111/sji.70024","url":null,"abstract":"CD1d is an antigen-presenting molecule that presents lipid or glycolipid antigens to iNKT cells, a distinct subset of T lymphocytes characterised by their innate-like properties and restricted use of Vα, Jα and Vβ segments. The CD1d-iNKT axis represents an interesting aspect of the immune system with significant potential for therapeutic interventions against infectious diseases. Upon recognition of lipid antigens, iNKT cells initiate rapid and potent immune responses, releasing a diverse array of cytokines such as IL-4, IL-13, IFN-γ etc. that profoundly influence immune reactions against various pathogens, including bacteria and parasites, bridging innate and adaptive immunity. We identify and describe the key features of lipidic antigens and their derivatives that determine the nature of their antigenicity. Furthermore, modulating CD1d-driven iNKT cell responses by an array of lipid and glycolipid antigens holds promise as adjunctive therapy to existing antimicrobial treatments. Understanding the complexities of the CD1d-iNKT axis and exploiting its therapeutic potential in the case of infectious diseases could lead to innovative immunotherapeutic strategies, ushering in a new era of immunotherapy against pathogenic insults.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70024"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Epstein-Barr Virus Molecular Mimicry in Various Autoimmune Diseases. eb病毒分子拟态在多种自身免疫性疾病中的作用

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70016

Ayesha Munir, Sanaullah Khan, Aisha Saleem, Hira Nusrat, Salman Ali Khan, Humaira Sayyed, Ayesha Khalid, Bushra Javed, Fatima Hidayat

引用次数: 0

Autoantibodies as Potential Liquid Biopsy Biomarker in Detection of Pancreatic Cancer: A Diagnostic Test Accuracy Review and Meta-Analysis. 自身抗体作为检测胰腺癌的潜在液体活检生物标志物：一项诊断测试的准确性回顾和荟萃分析。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70012

Yuqi Liu, Yuyi Gao, Yangxue Wu, Wanyang Wu, Jinyao Yu, Siyao Ma, Jianxiang Shi, Keyan Wang, Hua Ye

{"title":"Autoantibodies as Potential Liquid Biopsy Biomarker in Detection of Pancreatic Cancer: A Diagnostic Test Accuracy Review and Meta-Analysis.","authors":"Yuqi Liu, Yuyi Gao, Yangxue Wu, Wanyang Wu, Jinyao Yu, Siyao Ma, Jianxiang Shi, Keyan Wang, Hua Ye","doi":"10.1111/sji.70012","DOIUrl":"10.1111/sji.70012","url":null,"abstract":"Autoantibodies against tumour-associated antigens (TAA) are promising biomarkers for cancer diagnosis. This systematic review aims to evaluate the diagnostic values of tumour-associated autoantibodies (TAAbs) in patients with pancreatic cancer. A search was conducted in the PubMed, Web of Science, and Embase databases to collect eligible studies. The primary outcomes included sensitivity, specificity, and accuracy of the test. We used QUADAS-2 to evaluate the risk of bias in the included studies. Meta-analysis was performed using MetaDisc 1.4 and STATA 14.0 software to calculate the combined sensitivity and specificity. A total of 49 articles were included in the final analysis that reported over 100 different TAAbs that were studied for the detection of pancreatic cancer. p53, Ezrin, CLDN17, KCNN3, SLAMF7, SLC22A11 and OR51F2 were the most frequently investigated autoantibodies in these studies. Ezrin exhibited better diagnostic performance with the pooled sensitivity, specificity and summary area under the receiver operating characteristic (SROC) curves being 56%, 88% and 0.90, respectively. Moreover, certain autoantibody combinations achieved substantially higher sensitivity at reasonably high levels of specificity. For example, the combination of Ezrin and ENOA1.2 autoantibodies with CA19.9 yielded sensitivity, specificity and area under the SROC curve of 100%, 92% and 0.96, respectively. TAAb is a promising diagnostic biomarker for early detection of PC, especially when combining TAAb with other markers. The promising candidate markers identified in this review deserve further validation in a broad screening population.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70012"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine Expression and Cytolytic Effect of Natural Killer Cells are Suppressed in Septic Shock. 感染性休克中细胞因子表达和自然杀伤细胞的杀伤作用受到抑制。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70023

Fengying Jie, Fang Dong, Lingwen Xu, Shuping Deng, Qian Wang, Qun Wu

{"title":"Cytokine Expression and Cytolytic Effect of Natural Killer Cells are Suppressed in Septic Shock.","authors":"Fengying Jie, Fang Dong, Lingwen Xu, Shuping Deng, Qian Wang, Qun Wu","doi":"10.1111/sji.70023","DOIUrl":"https://doi.org/10.1111/sji.70023","url":null,"abstract":"Septic shock is the most severe stage of sepsis. How immune dysregulation contributes to the pathogenesis of septic shock has not been thoroughly understood. In the current research, the phenotype and function of circulating natural killer (NK) cells of septic patients were characterised. The absolute number of NK cells was comparably reduced in septic shock survivors and non-survivors, probably owing to elevated NK cell apoptosis. Activating receptors including signalling lymphocytic activation molecule 4 (SLAMF4), natural killer cell p30-related protein (NKp30), natural killer group 2, member D (NKG2D), and DNAX accessory molecule 1 (DNAM-1) were significantly downregulated on NK cell surface in septic shock patients, especially non-survivors. Furthermore, the patients' NK cells exhibited lower expression of granzyme B and perforin, weaker target cell-induced degranulation and cytokine expression, as well as incompetent cytolytic effect. These alterations were more profound in septic shock non-survivors. Importantly, serum interleukin-35 (IL-35), which is an immunosuppressive cytokine, was remarkably elevated in septic shock patients. Besides, serum interleukin-35 concentration was positively correlated with disease scores but negatively correlated with NK cell activating receptor expression. In vitro assays indicated IL-35-induced strong suppression of NK cell activity, as evidenced by concomitant downregulation of cytokines and activating receptors along with inhibition of cytolytic capacity. Therefore, we uncovered for the first time the contributing role of IL-35 in septic shock-related human NK cell dysfunction.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70023"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Advances on Molecular Mechanisms of Complement Regulatory Factor Vitronectin-Mediated Immune Escape of Pathogens. 补体调节因子玻璃体连接蛋白介导病原体免疫逃逸的分子机制研究进展。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70019

Tong Wei, Yujie Yan, Yuelin Li, Wenman Li, Yunzhi Fa

{"title":"Research Advances on Molecular Mechanisms of Complement Regulatory Factor Vitronectin-Mediated Immune Escape of Pathogens.","authors":"Tong Wei, Yujie Yan, Yuelin Li, Wenman Li, Yunzhi Fa","doi":"10.1111/sji.70019","DOIUrl":"https://doi.org/10.1111/sji.70019","url":null,"abstract":"Vitronectin (Vn) is a complement regulatory component found in humans and a variety of animals. It can inhibit the formation of membrane attack complexes in the complement system. Studies have shown that a variety of pathogenic microorganisms, including Yersinia pestis, dengue viruses, Plasmodium and Candida albicans, may recruit Vn on the surface of pathogens and inhibit the killing effect of the complement system in the host. After entering the body, pathogenic microorganisms may attach to and infect target cells through multiple pathogenic mechanisms. Meanwhile, the body will attack the invading pathogenic microorganisms through its own immune system. However, the immune escape of pathogens will make the host's immune system difficult to respond effectively, thus causing the aggravation of the disease. Therefore, the study of immune escape is of great significance for the treatment, prevention and control of infectious diseases and tumours. In this paper, the mechanism of vitronectin (one of the complement regulatory factors)-mediated immune escape of pathogens is reviewed from multiple aspects.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70019"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-HBc Positivity After Intravenous Immunoglobulin in Bone Marrow Transplant Patients. 骨髓移植患者静脉注射免疫球蛋白后抗hbc阳性。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70022

Fahir Ozturk, Mehmet Sezgin Pepeler

引用次数: 0

Longitudinal Immune Profiling in Autoimmune Polyendocrine Syndrome Type 1. 自身免疫性多内分泌综合征1型的纵向免疫谱分析

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70021

Isil Kucuka, Dorsa Iraji, Sarah Braun, Lars Breivik, Anette S B Wolff, Eystein S Husebye, Bergithe E Oftedal

{"title":"Longitudinal Immune Profiling in Autoimmune Polyendocrine Syndrome Type 1.","authors":"Isil Kucuka, Dorsa Iraji, Sarah Braun, Lars Breivik, Anette S B Wolff, Eystein S Husebye, Bergithe E Oftedal","doi":"10.1111/sji.70021","DOIUrl":"10.1111/sji.70021","url":null,"abstract":"Autoimmune polyendocrine syndrome Type-1 (APS-1) is a rare, but severe organ-specific autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. Lack of AIRE causes autoreactive T cells to escape negative selection and alters the T regulatory cell subset. However, little is known about how the immune cell subsets vary across the lifespan in APS-1. Here we analysed the peripheral distribution of 13 immune cell subsets along the lifespan using epigenetic quantification. We found the largest discrepancy in immune cells to appear early in APS-1 patients' lives, coinciding with the time point they obtained most of their clinical symptoms. We further revealed longitudinal changes in cell compositions both within the adaptive and the innate arms of the immune system. We found that cell frequencies of B cells, T-cell subgroups, nonclassical monocytes, and Natural Killer cells to be reduced in young APS-1 patients. We also found B-cell frequencies to decrease with ageing in both patients and healthy controls. Our results suggest that Tregs, follicular helper T, and natural killer cells have opposing trends of cell frequencies during life, indicating the importance of considering the age profiles of cohorts which could otherwise lead to conflicting conclusions.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70021"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salvianolic Acid A From Salvia miltiorrhiza Suppresses Endometrial Carcinoma Progression via CD40-AKT-NF-κB Pathway. 丹参丹酚酸A通过CD40-AKT-NF-κB途径抑制子宫内膜癌进展。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70017

Chunhua Zhang, Qing Liu, Lei Bi, Weiping Chen, Li Zeng

{"title":"Salvianolic Acid A From Salvia miltiorrhiza Suppresses Endometrial Carcinoma Progression via CD40-AKT-NF-κB Pathway.","authors":"Chunhua Zhang, Qing Liu, Lei Bi, Weiping Chen, Li Zeng","doi":"10.1111/sji.70017","DOIUrl":"10.1111/sji.70017","url":null,"abstract":"We aimed to investigate the effects of Salvianolic acid A (SA), an active ingredient of Salvia miltiorrhiza Bunge, on the proliferation, metastasis and CD40-AKT-NF-κB signalling pathway in endometrial carcinoma (EC). Human EC cell lines (Ishikawa and HEC-1A) were treated with varying concentrations of SA, CD40 soluble ligand (sCD40L) or a combination of both. Cell viability, proliferation, invasion and migration were assessed using MTT, colony formation and transwell assays. Flow cytometry was used to analyse apoptosis and cell cycle progression. qRT-PCR evaluated the mRNA level of CD40. The protein expression of CD40, p-AKT, p-mTOR, p-p65, and p52 was evaluated via Western blot and immunofluorescence. A subcutaneous tumour model was used to examine the impact of SA on tumour growth, followed by immunohistochemical analysis of Ki-67, CD40, p-AKT and p-mTOR. SA treatment reduced EC cell viability, proliferation, invasion and migration, while also triggering apoptosis and inducing cell cycle arrest in the G0/G1 phase in a dose-dependent way. These effects correlated with marked downregulation of CD40, p-AKT, p-mTOR, p-p65 and p52 expression. Conversely, activation of CD40 signalling with sCD40L promoted EC cell malignancy and overturned the anti-tumour effects of SA on EC cells. Additionally, SA treatment suppressed tumour growth in xenograft mouse models, along with reduced levels of Ki67, CD40, p-AKT, p-mTOR, p-p65 and p52 in mouse tumour tissues, which were counteracted by sCD40L co-treatment. SA effectively suppresses endometrial carcinoma progression by targeting the CD40-AKT-NF-κB pathway.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70017"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant Lower CD6 Expression on Peripheral B Cells Associated With Liver/Kidney Injury and Autoantibody Production of Systemic Lupus Erythematosus Patients. 与系统性红斑狼疮患者肝/肾损伤和自身抗体产生相关的外周B细胞CD6异常低表达

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-04-01 DOI: 10.1111/sji.70018

Yongjian Chen, Yang Mei, Chun Zou, Fen Tan, Haoran Hu, Miao Yang, Yaxiong Deng, Qianwen Li, Gangcai Zhu, Ping Yi, Ming Yang

{"title":"Aberrant Lower CD6 Expression on Peripheral B Cells Associated With Liver/Kidney Injury and Autoantibody Production of Systemic Lupus Erythematosus Patients.","authors":"Yongjian Chen, Yang Mei, Chun Zou, Fen Tan, Haoran Hu, Miao Yang, Yaxiong Deng, Qianwen Li, Gangcai Zhu, Ping Yi, Ming Yang","doi":"10.1111/sji.70018","DOIUrl":"10.1111/sji.70018","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease characterised by aberrant activation and differentiation of autoreactive T and B cells, as well as the overproduction of autoantibodies. CD6, a cell-surface glycoprotein, regulates lymphocyte activation, differentiation and survival, and is implicated in the pathogenesis of various autoimmune disorders. In SLE, the CD6/activated leukocyte cell adhesion molecule (ALCAM) pathway promotes renal T-cell immune responses. However, the distribution, expression, and function of CD6 in lupus B cells remain poorly understood. In this work, we employed flow cytometry and multi-colour immunohistochemical staining to analyse the expression and distribution of CD6 on peripheral B cells. Correlation analysis was performed to assess the associations of CD6 and clinical indicators of disease severity. We found that SLE patients exhibited significantly reduced CD6 expression on peripheral CD19+ B, CD19+CD27- B, CD19+CD27+ B, naïve B, CD19+CD27-IgD- double-negative B (DNB) and CD19+CD27+IgD+ B cells. Moreover, CD6 expression was negatively correlated with serum levels of alanine transaminase (ALT), lactate dehydrogenase (LDH) and the degree of white blood cell (WBC) depletion. Notably, SLE patients positive for antinuclear antibody (ANA) or anti-SSA antibody displayed lower CD6 expression on circulating B cells. Additionally, CD6 expression in B cells was predominantly localised in the extrafollicular (EF) region of human tonsils, suggesting a potential regulatory role of CD6 in EF B-cell responses. In conclusion, dysregulated CD6 expression on peripheral B cells might be related to liver/kidney injury and ANA/anti-SSA antibody production in SLE patients.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"101 4","pages":"e70018"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0