传染病中的cd1 - inkt轴:从过去的经验教训。

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Priyajit Chatterjee, Shubhranil Brahma, Peter Cresswell, Syamdas Bandyopadhyay
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引用次数: 0

摘要

CD1d是一种抗原呈递分子,可向iNKT细胞呈递脂质或糖脂质抗原,iNKT细胞是T淋巴细胞的一个独特亚群,其特征是其固有的类似性质和限制使用Vα, Jα和Vβ段。cd1 - inkt轴代表了免疫系统的一个有趣的方面,对传染性疾病的治疗干预具有重要的潜力。在识别脂质抗原后,iNKT细胞启动快速有效的免疫反应,释放多种细胞因子,如IL-4、IL-13、IFN-γ等,深刻影响针对各种病原体(包括细菌和寄生虫)的免疫反应,架起先天免疫和适应性免疫的桥梁。我们确定和描述脂质抗原及其衍生物的关键特征,决定其抗原性的性质。此外,通过一系列脂质和糖脂抗原调节cd1驱动的iNKT细胞反应有望作为现有抗菌治疗的辅助治疗。了解cd1 - inkt轴的复杂性并利用其在感染性疾病中的治疗潜力可能导致创新的免疫治疗策略,开创针对致病性损伤的免疫治疗的新时代。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CD1d-iNKT Axis in Infectious Diseases: Lessons Learned From the Past.

CD1d is an antigen-presenting molecule that presents lipid or glycolipid antigens to iNKT cells, a distinct subset of T lymphocytes characterised by their innate-like properties and restricted use of Vα, Jα and Vβ segments. The CD1d-iNKT axis represents an interesting aspect of the immune system with significant potential for therapeutic interventions against infectious diseases. Upon recognition of lipid antigens, iNKT cells initiate rapid and potent immune responses, releasing a diverse array of cytokines such as IL-4, IL-13, IFN-γ etc. that profoundly influence immune reactions against various pathogens, including bacteria and parasites, bridging innate and adaptive immunity. We identify and describe the key features of lipidic antigens and their derivatives that determine the nature of their antigenicity. Furthermore, modulating CD1d-driven iNKT cell responses by an array of lipid and glycolipid antigens holds promise as adjunctive therapy to existing antimicrobial treatments. Understanding the complexities of the CD1d-iNKT axis and exploiting its therapeutic potential in the case of infectious diseases could lead to innovative immunotherapeutic strategies, ushering in a new era of immunotherapy against pathogenic insults.

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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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