Risk Analysis最新文献

{"title":"Benchmark dose modeling for epidemiological dose-response assessment using case-control studies.","authors":"Francesco De Pretis, Yun Zhou, Kan Shao","doi":"10.1111/risa.17671","DOIUrl":"https://doi.org/10.1111/risa.17671","url":null,"abstract":"<p><p>Following a previous article that focused on integrating epidemiological data from prospective cohort studies into toxicological risk assessment, this paper shifts the focus to case-control studies. Specifically, it utilizes the odds ratio (OR) as the main epidemiological measure, aligning it with the benchmark dose (BMD) methodology as the standard dose-response modeling approach to determine chemical toxicity values for regulatory risk assessment. A standardized BMD analysis framework has been established for toxicological data, including input data requirements, dose-response models, definitions of benchmark response, and consideration of model uncertainty. This framework has been enhanced by recent methods capable of handling both cohort and case-control studies using summary data that have been adjusted for confounders. The present study aims to investigate and compare the \"effective count\" based BMD modeling approach, merged with an algorithm used for converting odds ratio to relative risk in cohort studies with partial data information (i.e., the Wang algorithm), with the adjusted OR-based BMD analysis approach. The goal is to develop an adequate BMD modeling framework that can be generalized for analyzing published case-control study data. As in the previous study, these methods were applied to a database examining the association between bladder and lung cancer and inorganic arsenic exposure. The results indicate that estimated BMDs and BMDLs are relatively consistent across both methods. However, modeling adjusted OR values as continuous data for BMD estimation aligns better with established practices in toxicological BMD analysis, making it a more generalizable approach.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lasting effect of the Romantic view of nature: How it influences perceptions of risk and the support of symbolic actions against climate change.","authors":"Michael Siegrist, Anne Berthold","doi":"10.1111/risa.17672","DOIUrl":"https://doi.org/10.1111/risa.17672","url":null,"abstract":"<p><p>Culture can have a major impact on how we perceive different hazards. In the Romantic period, nature was described and portrayed as mysterious and benevolent. A deep connection to nature was perceived as important. We proposed that this romantic view would be positively related to people's risk perceptions of man-made hazards and, more specifically, to concerns about climate change. Further, we hypothesized that the Romantic perception of nature leads to a biased perception of natural hazards and that the moral component of action is of particular importance above and beyond the mere efficacy of the action. We conducted an online survey in Germany (N = 531), a country where Romanticism had a very widespread influence. The study shows that individuals with a Romantic view of nature perceived greater risks associated with climate change than those without such a view. In addition, those with a Romantic view of nature were more likely to support measures to reduce the risks of climate change, even when it is said that such measures are not effective. Finally, the study found a significantly higher positive correlation between Romantic views of nature and risk perceptions of man-made versus natural hazards. The results suggest that ideas developed during the Romantic era continue to influence hazard perception in Germany.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence and uncertainty: An info-gap analysis of uncertainty-augmenting evidence.","authors":"Yakov Ben-Haim","doi":"10.1111/risa.14346","DOIUrl":"10.1111/risa.14346","url":null,"abstract":"<p><p>Decisions in many disciplines are based on understanding and evidence. More evidence is better than less when it enhances the decision-maker's understanding. This is achieved by reducing uncertainty confronting the decision-maker and reducing the potential for misunderstanding and failure. However, some evidence may actually augment uncertainty by revealing prior error or ignorance. True evidence that augments uncertainty is important because it identifies inadequacies of current understanding and may suggest directions for rectifying this. True evidence that reduces uncertainty may simply reconfirm or strengthen prior understanding. Uncertainty-augmenting evidence, when it is true, can support the expansion of one's previously incomplete understanding. A dilemma arises because both reduction and enhancement of uncertainty can be beneficial, and both are not simultaneously possible on the same issue. That is, uncertainty can be either pernicious or propitious. Info-gap theory provides a response. The info-gap robustness function enables protection against pernicious uncertainty by inhibiting failure. The info-gap opportuneness function enables exploitation of propitious uncertainty by facilitating wonderful windfall outcomes. The dilemma of uncertainty-augmenting evidence is that robustness and opportuneness are in conflict; a decision that enhances one, worsens the other. This antagonism between robustness and opportuneness-between protecting against pernicious uncertainty and exploiting propitious uncertainty-is characterized in a generic proposition and corollary. These results are illustrated in an example of allocation of limited resources.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between freight train length and the risk of derailment.","authors":"Peter M Madsen, Robin L Dillon, Konstantinos P Triantis, Joseph A Bradley","doi":"10.1111/risa.14312","DOIUrl":"10.1111/risa.14312","url":null,"abstract":"<p><p>In recent years, longer and heavier trains have become more common, primarily driven by efficiency and cost-saving measures in the railroad industry. Regulation of train length is currently under consideration in the United States at both the federal and state levels, because of concerns that longer trains may have a higher risk of derailment, but the relationship between train length and risk of derailment is not yet well understood. In this study, we use data on freight train accidents during the 2013-2022 period from the Federal Railroad Administration (FRA) Rail Equipment Accident and Highway-Rail Grade Crossing Accident databases to estimate the relationship between freight train length and the risk of derailment. We determine that longer trains do have a greater risk of derailment. Based on our analysis, running 100-car trains is associated with 1.11 (95% confidence interval: 1.10-1.12) times the derailment odds of running 50-car trains (or a 11% increase), even accounting for the fact that only half as many 100-car trains would need to run. For 200-car trains, the odds increase by 24% (odds ratio 1.24, 95% confidence interval: 1.20-1.28), again accounting for the need for fewer trains. Understanding derailment risk is an important component for evaluating the overall safety of the rail system and for the future development and regulation of freight rail transportation. Given the limitations of the current data on freight train length, this study provides an important step toward such an understanding.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The exposure of nonhuman living organisms to mobile communication emissions: A survey to establish European stakeholders' policy option preferences.","authors":"Laura Recuero Virto, Arno Thielens, Marek Czerwiński, Jérémy Froidevaux","doi":"10.1111/risa.14322","DOIUrl":"10.1111/risa.14322","url":null,"abstract":"<p><p>There is an unprecedented exposure of living organisms to mobile communications radiofrequency electromagnetic field (RF-EMF) emissions. Guidelines on exposure thresholds to limit thermal effects from these emissions are restricted to humans. However, tissue heating can occur in all living organisms that are exposed. In addition, exposure at millimetric frequencies used by 5G may impact surface tissues and organs of plants and small-size species. It is also expected that the addition of 5G to existing networks will intensify radiofrequency absorption by living organisms. A European Parliament report proposed policy options on the effects of RF-EMF exposure of plants, animals, and other living organisms in the context of 5G: funding more research, implementing monitoring networks, accessing more information from operators on antennas and EMF emissions, and developing compliance studies when antennas are installed. However, there is no evidence on the preferences of relevant stakeholders regarding these policy options. This paper reports the findings of a survey of key European stakeholders' policy option preferences based on the European Parliament's report. It reveals a broad consensus on funding more research on the effects of exposure of plants, animals, and other living organisms to EMFs. It also highlights the need for deliberation concerning the other policy options that could provide solutions for regulatory authorities, central administrations, the private sector, nongovernmental associations and advocates, and academics. Such deliberation would pave the way for effective solutions, focusing on long-term output from funding research, and enabling short-term socially and economically acceptable actions for all parties concerned.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pairwise summation as a method for the additive combination of probabilities in qualitative risk assessments.","authors":"Matteo Crotta, Eleonora Chinchio, Vito Tranquillo, Nicola Ferrari, Javier Guitian","doi":"10.1111/risa.14323","DOIUrl":"10.1111/risa.14323","url":null,"abstract":"<p><p>Qualitative frameworks are widely employed to tackle urgent animal or public health issues when data are scarce and/or urgent decisions need to be made. In qualitative models, the degree of belief regarding the probabilities of the events occurring along the risk pathway(s) and the outcomes is described in nonnumerical terms, typically using words such as Low, Medium, or High. The main methodological challenge, intrinsic in qualitative models, relates to performing mathematical operations and adherence to the rule of probabilities when probabilities are nonnumerical. Although methods to obtain the qualitative probability from the conditional realization of n events are well-established and consistent with the multiplication rule of probabilities, there is a lack of accepted methods for addressing situations where the probability of an event occurring can increase, and the rule of probability P(AUB) = P(A) + P(B) - P(A∩B) should apply. In this work, we propose a method based on the pairwise summation to fill this methodological gap. Our method was tested on two qualitative models and compared by means of scenario analysis to other approaches found in literature. The qualitative nature of the models prevented formal validation; however, when using the pairwise summation, results consistently appeared more coherent with probability rules. Even if the final qualitative estimate can only represent an approximation of the actual probability of the event occurring, qualitative models have proven to be effective in providing scientific-based evidence to support decision-making. The method proposed in this study contributes to reducing the subjectivity that characterizes qualitative models, improving transparency and reproducibility.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research gaps and priorities for quantitative microbial risk assessment (QMRA).","authors":"Kerry A Hamilton, Joanna Ciol Harrison, Jade Mitchell, Mark Weir, Marc Verhougstraete, Charles N Haas, A Pouyan Nejadhashemi, Julie Libarkin, Tiong Gim Aw, Kyle Bibby, Aaron Bivins, Joe Brown, Kara Dean, Gwyneth Dunbar, Joseph N S Eisenberg, Monica Emelko, Daniel Gerrity, Patrick L Gurian, Emma Hartnett, Michael Jahne, Rachael M Jones, Timothy R Julian, Hongwan Li, Yanbin Li, Jacqueline MacDonald Gibson, Gertjan Medema, J Scott Meschke, Alexis Mraz, Heather Murphy, David Oryang, Emmanuel de-Graft Johnson Owusu-Ansah, Emily Pasek, Abani K Pradhan, Maria Tereza Pepe Razzolini, Michael O Ryan, Mary Schoen, Patrick W M H Smeets, Jeffrey Soller, Helena Solo-Gabriele, Clinton Williams, Amanda M Wilson, Amy Zimmer-Faust, Jumana Alja'fari, Joan B Rose","doi":"10.1111/risa.14318","DOIUrl":"10.1111/risa.14318","url":null,"abstract":"<p><p>The coronavirus disease 2019 pandemic highlighted the need for more rapid and routine application of modeling approaches such as quantitative microbial risk assessment (QMRA) for protecting public health. QMRA is a transdisciplinary science dedicated to understanding, predicting, and mitigating infectious disease risks. To better equip QMRA researchers to inform policy and public health management, an Advances in Research for QMRA workshop was held to synthesize a path forward for QMRA research. We summarize insights from 41 QMRA researchers and experts to clarify the role of QMRA in risk analysis by (1) identifying key research needs, (2) highlighting emerging applications of QMRA; and (3) describing data needs and key scientific efforts to improve the science of QMRA. Key identified research priorities included using molecular tools in QMRA, advancing dose-response methodology, addressing needed exposure assessments, harmonizing environmental monitoring for QMRA, unifying a divide between disease transmission and QMRA models, calibrating and/or validating QMRA models, modeling co-exposures and mixtures, and standardizing practices for incorporating variability and uncertainty throughout the source-to-outcome continuum. Cross-cutting needs identified were to: develop a community of research and practice, integrate QMRA with other scientific approaches, increase QMRA translation and impacts, build communication strategies, and encourage sustainable funding mechanisms. Ultimately, a vision for advancing the science of QMRA is outlined for informing national to global health assessments, controls, and policies.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origin of the H1N1 (Russian influenza) pandemic of 1977-A risk assessment using the modified Grunow-Finke tool (mGFT).","authors":"Fatema Kalyar, Xin Chen, Abrar Ahmad Chughtai, Chandini Raina MacIntyre","doi":"10.1111/risa.14343","DOIUrl":"10.1111/risa.14343","url":null,"abstract":"<p><p>In 1977, the Soviet Union (Union of Soviet Socialist Republics [USSR]) notified the World Health Organization (WHO) about an outbreak of H1N1 influenza, which later spread to many countries. The H1N1 strain of 1977 reappeared after being absent from the world for over 20 years. This pandemic simultaneously spread to several cities in the USSR and China. Many theories have been postulated to account for the emergence of this pandemic, including natural and unnatural origins. The purpose of this study was to use the modified Grunow-Finke risk assessment tool (modified Grunow-Finke tool [mGFT]) to investigate the origin of the 1977 H1N1 pandemic. Data was collected from WHO archives and published documents. The assessment of the pandemic's origin involved the utilization of a modified version of the original Grunow-Finke risk assessment tool (GFT). Using the mGFT, the final score was 37 out of 60 points (probability: 62%), indicating a high likelihood that the Russian influenza pandemic of 1977 was of unnatural origin. Several variables supported this finding, including the sudden re-emergence of a previously extinct strain, a genetic signature of laboratory modification for vaccine development, and unusual epidemiology. Inter-rater reliability was moderate to high. By applying the mGFT to the 1977 Russian influenza pandemic, we established a high probability that this pandemic was of unnatural origin. Although this is not definitive, it is consistent with the possibility that it originated from an incompletely attenuated live influenza vaccine. The mGFT is a useful risk analysis tool to evaluate the origin of epidemics.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive sampling method to monitor low-risk pathways with limited surveillance resources.","authors":"Thao P Le, Thomas K Waring, Howard Bondell, Andrew P Robinson, Christopher M Baker","doi":"10.1111/risa.14344","DOIUrl":"10.1111/risa.14344","url":null,"abstract":"<p><p>The rise of globalization has led to a sharp increase in international trade with high volumes of containers, goods, and items moving across the world. Unfortunately, these trade pathways also facilitate the movement of unwanted pests, weeds, diseases, and pathogens. Each item could contain biosecurity risk material, but it is impractical to inspect every item. Instead, inspection efforts typically focus on high-risk items. However, low risk does not imply no risk. It is crucial to monitor the low-risk pathways to ensure that they are and remain low risk. To do so, many approaches would seek to estimate the risk to some precision, but increasingly lower risks require more samples. On a low-risk pathway that can be afforded only limited inspection resources, it makes more sense to assign fewer samples to the lower risk activities. We approach the problem by introducing two thresholds. Our method focuses on letting us know whether the risk is below certain thresholds, rather than estimating the risk precisely. This method also allows us to detect a significant change in risk. Our approach typically requires less sampling than previous methods, while still providing evidence to regulators to help them efficiently and effectively allocate inspection effort.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining social vulnerability to multi-hazards in North-Western Himalayas, India.","authors":"Lucky Sharma, Narendra Kumar Rana, Shiva Kant Dube","doi":"10.1111/risa.14340","DOIUrl":"10.1111/risa.14340","url":null,"abstract":"<p><p>The enhancing risk from human action and multi-hazard interaction has substantially complicated the hazard-society relationship. The underlying vulnerabilities are crucial in predicting the probable impact to be caused by multi-hazards. Thus, the evaluation of social vulnerability is decisive in inferring the driving factor and preparing for mitigation strategies. The Himalayan landscape is prone to multiple hazards as well as possesses a multitude of vulnerabilities owing to changing human landscape. Thus, an attempt has been made to inquire into the underlying socioeconomic factors enhancing the susceptibility of the region to multi-hazards. The social vulnerability index (SVI_ent) has been introduced, consisting of 13 indicators and 33 variables. The variables have been standardized using the maximum and minimum normalization method and the relative importance for each indicator has been determined using Shannon entropy methods to compute SVI_ent. The findings revealed that female population, population above 60 years old, net irrigated area, migrant population, dilapidated house, nonworkers, bank, and nonworkers seeking jobs were found to be relatively significant contributors to the vulnerability. The western part of the study area was classified as the highly vulnerable category (SVI > 0.40628), attributed to high dependence, and higher share of unemployed workers and high poverty. The SVI_ent was shown to have positive correlation between unemployment, socioeconomic status, migration, dependency, and household structure significant at two-tailed test. The study's impact can be found in influencing the decision of policymakers and stakeholders in framing the mitigation strategies and policy documents.</p>","PeriodicalId":21472,"journal":{"name":"Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}