Saudi Journal of Medicine & Medical Sciences最新文献

{"title":"Association of Clinical Characteristics, Hematological Indices, and Acute Inflammatory Markers in Hospitalized COVID-19 Patients with Disease Severity and Mortality: A Single-center Retrospective Study.","authors":"Abeer Mohammed Al-Subaie","doi":"10.4103/sjmms.sjmms_1118_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_1118_25","url":null,"abstract":"<p><strong>Objective: </strong>To determine clinical and laboratory predictors of disease severity and mortality among patients with COVID-19 admitted to a tertiary care center in Saudi Arabia.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with laboratory-confirmed SARS-CoV-2 infection admitted to King Fahd Hospital of the University, Al Khobar, Saudi Arabia, between May and August 2020. Disease severity was defined based on intensive care unit (ICU) admission. Demographic, clinical, and laboratory data were extracted from the patients' electronic medical records and the laboratory information system.</p><p><strong>Results: </strong>The study included 207 patients (mean age: 51 ± 16 years; male: 72%), of which 56 were severe cases. Compared to non-severe patients, severe patients had significantly higher white blood cell count (9.3 K/μl vs. 7.1 K/μl; <i>P</i> < 0.001), median absolute neutrophil count (6.2 vs. 4.4 K/μl; <i>P</i> = 0.003), absolute lymphocyte count (1.4 K/μl vs. 1.0 K/μl; <i>P</i> = 0.002); neutrophil-to-lymphocyte ratio (5.6 vs. 3.2; <i>P</i> < 0.001), median D-dimer (1.0 vs. 0.6 μg/ml; <i>P</i> < 0.001), median C-reactive protein (8.7 vs. 2.9 mg/dl; <i>P</i> < 0.001), and prothrombin time (14.1 vs. 13.6 seconds; <i>P</i> = 0.003). Similarly, compared to survivors, non-survivors had significantly higher median absolute neutrophil count (6.9 K/μl vs. 4.8 K/μl; <i>P</i> = 0.016), neutrophil-to-lymphocyte ratio (6.9 vs. 3.5; <i>P</i> < 0.001), median D-dimer (1.6 vs. 0.6 μg/ml; <i>P</i> = 0.005), and median C-reactive protein (11.7 vs. 3.1 mg/dl; <i>P</i> < 0.001). However, in the multivariable analysis, none of the laboratory parameters remained independently associated with disease severity or mortality.</p><p><strong>Conclusion: </strong>This study found that among hospitalized COVID-19 patients in Saudi Arabia, several clinical and laboratory markers were associated with disease severity and mortality in univariable analyses; however, no independent predictors were identified after adjustment. These findings highlight the complexity of COVID-19 progression and the need for cautious interpretation of laboratory markers in clinical decision-making.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"269-278"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spirometry Patterns in Adult Sickle Cell Disease: A Retrospective Observational Study.","authors":"Rayyan M Almusally, Raghad Alghamdi, Mahdi Almubarak, Mahmoud Ibrahim, Hussain Alyousif, Zainab Alelq, Abrar Alwaheed, Osamah Alsultan, Abir Alsaeed, Hatem Qutub, Yijin Wert, Jafar Aljazeeri","doi":"10.4103/sjmms.sjmms_490_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_490_25","url":null,"abstract":"<p><strong>Background: </strong>Patients with sickle cell disease (SCD) are at an increased risk of pulmonary complications, including acute chest syndrome, which can lead to significant morbidity and mortality.</p><p><strong>Objective: </strong>To determine the impact of SCD on pulmonary functions using spirometry and to identify an association between the level of hemoglobin S (Hgb S) and spirometry values.</p><p><strong>Methods: </strong>This retrospective study enrolled adult patients with SCD who had undergone spirometry testing at a university hospital in Saudi Arabia between February 2020 to January 2023. Spirometry parameters included forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and their ratio. Abnormal spirometry was subcategorized into obstructive and restrictive patterns. Spirometry was performed according to the American Thoracic Society/European Respiratory Society guidelines.</p><p><strong>Results: </strong>The study included 68 patients with SCD (female: 67.7%). A total of 28 (41.2%) patients had abnormal spirometry, of whom 85.7% had restrictive patterns. No statistically significant correlation was found between Hgb S levels and FVC or FEV1. Baseline characteristics including age, sex, previous medical history of pneumonia or ACS, use of HU, white blood cells, hemoglobin levels and hemoglobin electrophoresis, were not statistically different between those with normal and abnormal spirometry. However, SCD patients with abnormal spirometry had higher platelet counts (<i>P</i> = 0.03).</p><p><strong>Conclusion: </strong>This study found that higher Hgb S levels were not associated with abnormal spirometry in patients with sickle cell disease. The predominant abnormal spirometry pattern was restrictive, and higher platelet counts is a potential predictor of an abnormal spirometry in patients with sickle cell disease.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"279-285"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBUS-guided Cryobiopsy-Proven Anthracotic Mediastinal Lymph Node Mimicking Malignancy on FDG PET-CT: A Case Report.","authors":"Trilok Chand, Hussa M A Alshehhi","doi":"10.4103/sjmms.sjmms_198_26","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_198_26","url":null,"abstract":"<p><p>Anthracotic mediastinal lymph nodes are an uncommon cause of intense fluorodeoxyglucose (FDG) uptake on positron-emission tomography-computed tomography (PET-CT), often mimicking malignancy and leading to diagnostic uncertainty. Here, we report the case of a 67-year-old Asian male with FDG-avid mediastinal lymphadenopathy that was highly suspicious for metastatic disease. Subsequent endobronchial ultrasound-guided lymph node sampling demonstrated anthracosis without evidence of malignancy or infection. Recognition of this rare benign entity prevented cancer upstaging and unnecessary treatment. This case highlights the importance of histopathological confirmation of PET-positive mediastinal lymph nodes, particularly in patients with suspected or known malignancy, to ensure accurate diagnosis and appropriate clinical management.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"286-290"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs as Key Regulators of Degeneration and Inflammation in Osteoarthritis: A Narrative Review.","authors":"Mujitapha Umar Safiyyu, Nazmul Huda Syed, Maryam Azlan, Muhammad Rajaei Ahmad Mohd Zain, Asma Abdullah Nurul","doi":"10.4103/sjmms.sjmms_1064_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_1064_25","url":null,"abstract":"<p><p>Osteoarthritis (OA) is the most prevalent degenerative joint disease and a leading cause of chronic pain and disability worldwide, particularly among aging populations. It is characterized by progressive degeneration of articular cartilage, synovial inflammation, subchondral bone remodeling, and metabolic alterations in the infrapatellar fat pad, reflecting pathology across the entire joint microenvironment. The onset and progression of OA are driven by complex interactions among mechanical stress, aging, obesity, and metabolic dysregulation, which collectively disrupt joint homeostasis. Mechanical injury and cartilage damage induce the release of damage-associated molecular patterns, activating innate immune receptors on chondrocytes and synovial cells. This promotes the production of pro-inflammatory mediators, including interleukin-1β, tumor necrosis factor-α (TNF-α), interleukin-6, and interleukin-17, which contribute to extracellular matrix degradation and cartilage deterioration. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, have emerged as key modulators in OA pathogenesis. They regulate chondrocyte proliferation, apoptosis, extracellular matrix turnover, inflammation, and osteochondral remodeling. Notably, certain miRNAs exhibit mechanosensitive properties, responding to altered biomechanical loading and translating mechanical stimuli into gene regulatory responses. This review synthesizes current evidence on the roles of miRNAs in OA, focusing on their regulatory functions across joint tissues, including cartilage, synovium, subchondral bone, and the infrapatellar fat pad. Key miRNAs such as miR-140, miR-146a, miR-27b, miR-34a, miR-155, and mechanosensitive miR-365 are discussed, along with their interactions with major inflammatory and degenerative signaling pathways. Their potential as diagnostic biomarkers and therapeutic targets is also highlighted.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"197-208"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Outcome of Early Acute Kidney Injuries in Patients with Acute Intracerebral Hemorrhage Admitted to the Apex Neurosciences Center in Dubai.","authors":"Bhushan S Wankhade, Zeyad F Alrais, Maged M K Beniamein, Ammar M A Hadi, Madhavi M Telang, Nayeem G Mohammed, Sachin K Bhosale, Ammar A Salman, Iram Mir, Meeruna Narainen, Shaikha B Alfalasi, Mohamed H Elkhouly","doi":"10.4103/sjmms.sjmms_156_26","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_156_26","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the incidence, etiological factors, predictors, and clinical outcomes of acute kidney injury (AKI) in patients with acute intracerebral hemorrhage (ICH).</p><p><strong>Methods: </strong>This retrospective cohort study included patients with ICH who were admitted to the ICU of Rashid Hospital, Dubai, between 2019 and 2024. Patients were grouped into AKI and non-AKI groups depending on the occurrence of AKI according to KDIGO clinical practice guidelines. Demographic characteristics, comorbidities, potential risk factors, and clinical outcomes were compared between both groups.</p><p><strong>Results: </strong>A total of 418 patients were included (median age: 44 years; males: 79.2%). Of these, 138 patients developed AKI (33%). AKI was more common in patients with spontaneous ICH (<i>P</i> = 0.016), males with hypertensive crisis, lower Glasgow Coma Scale (GCS) scores, and higher APACHE II scores (for all, <i>P</i> < 0.001). Significant etiological factors included hypertensive crisis (<i>P</i> = 0.005), hypotension (<i>P</i> = 0.024), high intracranial pressure (<i>P</i> = 0.004), blood transfusion (<i>P</i> = 0.002), diabetes insipidus (<i>P</i> < 0.001), and rhabdomyolysis (<i>P</i> = 0.017). Lower GCS scores on admission was associated with AKI (<i>r_pb</i> : -0.23; <i>P</i> < 0.001). Factors that were independently associated with the development of early AKI were history of chronic kidney disease (OR: 4.79, 95% CI: 2.29-10.04; <i>P</i> < 0.001), diabetes insipidus (OR: 3.97, 95% CI: 1.95-8.10; <i>P</i> < 0.001), and hypertensive crisis (OR: 2.09, 95% CI: 1.21-3.61; <i>P</i> < 0.008). AKI was associated with lower GCS score at ICU discharge (<i>P</i> < 0.001) and increased length of ICU stay (<i>P</i> = 0.017), requirement for and duration of mechanical ventilation, incidence of brain death, 28-day mortality (for all, <i>P</i> < 0.001), and >28-day mortality (<i>P</i> = 0.004).</p><p><strong>Conclusions: </strong>Acute kidney injury (AKI) develops in about one third of patients with acute intracerebral hemorrhage (ICH). Lower GCS score, chronic kidney disease history, diabetes insipidus and hypertensive crisis are independently associated with increased odds of AKI. AKI is associated with an increase in morbidity and mortality in ICH patients.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"261-268"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-alcoholic Wernicke-Korsakoff Syndrome: A Narrative Review.","authors":"Munirah Abdulqade Batarfi","doi":"10.4103/sjmms.sjmms_447_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_447_25","url":null,"abstract":"<p><p>Non-alcoholic Wernicke-Korsakoff Syndrome (NA-WKS) is an under-recognised, thiamine-deficiency-mediated neurological disorder. While classically linked to chronic alcoholism, NA-WKS occurs in non-alcoholic patients. NA-WKS usually presents with episodes of anterograde amnesia accompanied by oculomotor signs, which occur more frequently than in alcoholic WKS. NA-WKS typically follows bariatric surgery, hyperemesis gravidarum, cancer cachexia, eating disorders, chronic kidney disease, or the use of certain oncologic or antidiabetic agents and chronic infectious diseases (e.g., immunodeficiency syndrome, tuberculosis, severe infections). Late diagnosis remains one of the leading factors for irreversible cognitive impairment. High-dose intravenous thiamine can reverse acute Wernicke encephalopathy when given early and prevent long-term damage. This review aims to provide clinicians with evidence based guidance regarding NA WKS to facilitate early recognition, timely treatment, and improved patient outcomes.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"209-216"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Travel Consultation for the Prevention of Infectious Diseases among International Travelers from GCC Countries: Travel Medicine Recommendations for Clinicians.","authors":"Mazin Barry, Jaffar A Al-Tawfiq, Fayssal Farahat, Mohammed Alzunitan, Sultan Almaziad, Majid Alshamrani, Ziad A Memish","doi":"10.4103/sjmms.sjmms_998_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_998_25","url":null,"abstract":"<p><p>Travel has been increasing globally since the COVID-19 pandemic ended, including travel from the Gulf Cooperation Council (GCC) countries to international destinations. This creates unique risks for travelers, who may return with various infectious diseases. Travel medicine is a well-established medical specialty worldwide; however, it has only recently been introduced within the GCC, with limited healthcare and public awareness of the importance of these services in preventing infectious diseases among international travelers. This document presents travel medicine recommendations for practicing clinicians in the GCC to help prevent these diseases through pre-travel consultation.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"183-196"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastectomy Patients' Perspectives on Breast Reconstruction at a Tertiary Care Center in Eastern Saudi Arabia.","authors":"Raseel B Almutairi, Batool Y Altayeb, Zahra N Alqarrashi, Lyan M Alghamdi, Zahra H Alghazwi, Seba Samer Abduljabbar, Laila H Alshawaf, Reem K Aljehani, Mariam M AlQurashi, Eiman Mohammed AlShammari","doi":"10.4103/sjmms.sjmms_919_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_919_25","url":null,"abstract":"<p><strong>Background: </strong>Breast reconstruction surgery (BRS) following mastectomy offers psychological and physical benefits; however, its acceptance remains limited among patients. Cultural perceptions, lack of awareness, and limited communication with healthcare providers may contribute to this gap.</p><p><strong>Objectives: </strong>To assess knowledge, misconceptions, attitudes, barriers, and motivators related to BRS among mastectomy patients in Eastern Saudi Arabia, and to explore associations with demographic and clinical factors.</p><p><strong>Methods: </strong>This cross-sectional survey was conducted from February to June 2025 at King Fahd Hospital of the University, Al Khobar, Saudi Arabia, and included all women who underwent mastectomy for breast cancer between 2016 and 2025. Data were elicited using a self-administered questionnaire assessing demographics, breast cancer history, knowledge and misconceptions about BRS, attitudes, and perceived barriers and motivators.</p><p><strong>Results: </strong>Of 144 eligible patients, 100 completed the questionnaire (response rate: 69.4%). Only 15% of patients had undergone BRS. Most patients had moderate misconceptions (85%), while 22% had excellent knowledge about BRS. Nonetheless, 65% had a positive attitude and 52% expressed willingness to undergo BRS. Key barriers included fear of additional surgery (42.4%) and lack of knowledge (38.8%), while key motivators were restoring body image (93.3%) and improving self-esteem (80%). In the univariate analysis, significant associations were observed between knowledge levels and factors such as age (<i>P</i> = 0.010), education (<i>P</i> < 0.001), income (<i>P</i> = 0.008), and current/past employment in healthcare (<i>P</i> = 0.008). However, in the multivariate logistic regression analysis, no variable was found to be an independent predictor of high knowledge of BRS.</p><p><strong>Conclusion: </strong>In breast cancer patients who underwent mastectomy in Eastern Saudi Arabia, there is positive attitude and willingness toward breast reconstruction surgery, yet the proportion of patients who underwent the surgery is low. The primary barriers identified are modifiable, and thus enhanced patient education and counseling may improve decision-making about breast reconstruction surgery.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"244-253"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Successful Pectus Carinatum Bracing: A Narrative Review.","authors":"Zeead M AlGhamdi","doi":"10.4103/sjmms.sjmms_306_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_306_25","url":null,"abstract":"<p><p>Pectus carinatum (PC) is a chest wall deformity characterized by the anterior projection of the sternum that typically manifests in adolescence and may result in notable psychosocial morbidity despite insubstantial physiological signs. Historically considered less common than pectus excavatum, recent trends suggest that PC may be underdiagnosed, with increasing recognition and referrals to specialized pectus clinics. The main objective of this review is to provide a comprehensive understanding of the role of bracing, particularly the dynamic compression system, in the non-surgical management of PC. Traditionally, a surgical condition, PC is currently being treated more often with dynamic compression bracing, especially in younger, more flexible chest wall patients. This evidence-based review aims to analyze the optimal time to start bracing, using current literature on anatomical correction, compliance, and psychosocial outcomes. It is known that early treatment, ideally at the pre-pubertal or early pubertal stage, can result in better-bracing success, shorter treatment time, and more favorable cosmetic and emotional outcomes. The key determinants of treatment effectiveness are age, severity of deformity at the start of treatment, pressure limits, brace type, and patient cooperation. Further, physiotherapy and psychosocial support have been found to have a positive impact on adherence and quality of life. However, there is no standard protocol for bracing. As outlined in this review, the proposed solution is a patient-centered, multidisciplinary approach that combines clinical timing and personalized care to develop feasible guidelines for effective and timely bracing in adolescents with pectus carinatum.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"217-222"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Its Determinants among Jordanian Patients with Multiple Sclerosis: A Cross-sectional Analytical Study.","authors":"Najah Essam Mahadin, Abdullah Sulaiman Odeh Alshobaki, Mahmoud Mohammed Mahmoud Hamdan, Amro Osama Khalil Salem, Obieda Husam Hussein, Nour Amin Tarawneh, Aya Amin Tarawneh, Rashed Omar Alqaisi, Ahmad Samer Abu Khashab, Waqar Abdul-Qahar Al-Kubaisy","doi":"10.4103/sjmms.sjmms_740_25","DOIUrl":"https://doi.org/10.4103/sjmms.sjmms_740_25","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a non-traumatic disability that affects the central nervous system and reduces quality of life (QoL). No study from Jordan has specifically assessed the QoL in patients with MS.</p><p><strong>Objectives: </strong>To evaluate QoL among Jordanian MS patients and examine its association with sociodemographic and medical characteristics.</p><p><strong>Methods: </strong>This cross-sectional analytical study included adult Jordanian MS patients (aged ≥18 years) who attended the MS Unit at Albasheer Governmental Teaching Hospital, Amman, between December 2023 and July 2025. Data was collected through face-to-face interviews using the validated 26-item WHOQOL-BREF questionnaire.</p><p><strong>Results: </strong>A total of 300 patients with MS were included (mean age: 35.3 ± 11.1 years; female: 68.7%). The overall mean QoL score was 57.2 ± 15.2, indicating generally low QoL. Physical and psychological domains had lower mean scores (49.7 ± 18 and 57.8 ± 18.4, respectively). In the univariate analysis, significant risk factors for poor QoL were parental consanguinity (OR: 1.88, 95% CI = 1.01-3.45) and smoking (OR: 1.74, 95% CI = 1.08-2.77). In the multivariable logistic regression analysis, factors independently associated with lower odds of higher QoL were smoking (OR = 0.454, 95% CI: 0.236-0.871; <i>P</i> = 0.018), having one comorbidity (OR = 0.278, 95% CI: 0.108-0.714; <i>P</i> = 0.008), and secondary progressive MS (OR = 0.260, 95% CI: 0.084-0.798; <i>P</i> = 0.019).</p><p><strong>Conclusions: </strong>The overall QoL of Jordanian multiple sclerosis patients is poor, particularly in the physical and psychological domains. Factors independently associated with lower odds of higher QoL were smoking, having one comorbidity, and secondary progressive multiple sclerosis, and thus interventions targeting these risk factors may improve the QoL.</p>","PeriodicalId":21442,"journal":{"name":"Saudi Journal of Medicine & Medical Sciences","volume":"14 3","pages":"235-243"},"PeriodicalIF":2.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}