Reumatologia最新文献

{"title":"Life satisfaction, generalized sense of self-efficacy and acceptance of illness in rheumatoid arthritis patients depending on age and severity of the disease.","authors":"Magdalena Staszkiewicz,&nbsp;Małgorzata Kulesa-Mrowiecka,&nbsp;Joanna Szklarczyk,&nbsp;Jolanta Jaworek","doi":"10.5114/reum/168294","DOIUrl":"https://doi.org/10.5114/reum/168294","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by periods of exacerbation (physical limitations, depressed mood, depressive states and decreased life satisfaction) and remission (hope of health improvement). Our objective was to present social functioning of RA patients taking into consideration their age and employing selected determinants: satisfaction with life, generalized sense of self-efficacy and acceptance of illness.</p><p><strong>Material and methods: </strong>Standardized tools were employed: the Satisfaction with Life Scale, Generalized Self Efficacy Scale and Acceptance of Illness Scale. The study group included 46 RA patients aged 18-45 years and 54 RA patients aged over 60 years. The control group consisted of 24 non-RA subjects in every group.</p><p><strong>Results: </strong>Rheumatoid arthritis patients in the period of disease exacerbation reported low and moderate levels of satisfaction with life, in the patients in remission period the score was moderate, while the control group subjects described their level of satisfaction with life as high and moderate. The level of acceptance of illness was described by the RA patients in the period of disease exacerbation as 20.4/40 points; the patients in remission defined their level of acceptance of illness as 29.38/40 points. The patients with RA exacerbation showed a low sense of self-efficacy, yet a large group of such patients also presented high self-efficacy levels and the majority of the RA subjects in remission reported a high sense of self-efficacy.</p><p><strong>Conclusions: </strong>In the RA patients, satisfaction with life, generalized sense of self-efficacy and acceptance of illness were closely related and affected their general psychosocial functioning.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 3","pages":"175-185"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/85/RU-61-168294.PMC10373164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and correlation of depression and anxiety with disease activity in rheumatoid arthritis.","authors":"Sousan Moudi,&nbsp;Behzad Heidari,&nbsp;Behnaz Yousefghahari,&nbsp;Reza Gholami,&nbsp;Hemmat Gholinia,&nbsp;Mansour Babaei","doi":"10.5114/reum/154905","DOIUrl":"https://doi.org/10.5114/reum/154905","url":null,"abstract":"<p><strong>Introduction: </strong>Depression and anxiety share similar symptoms with rheumatoid arthritis (RA) and these conditions are often not diagnosed or overlooked in RA. This study aimed to determine the prevalence of depression/anxiety in RA and their correlation with RA activity.</p><p><strong>Material and methods: </strong>Rheumatoid arthritis patients who presented at a rheumatology clinic were selected consecutively. The diagnosis of RA was confirmed by the ACR/EULAR criteria, disease activity was assessed by Disease Activity Score based on the 28-joint count (DAS28) and patients with DAS28 > 2.6 were considered to have active RA. The diagnosis of depression and anxiety was made by the Hospital Anxiety and Depression Scale (HADS). The Pearson test was used to determine the correlation between DAS28 and HADS scores.</p><p><strong>Results: </strong>Two-hundred patients (female, 82%) with a mean age of 53.5 ±10.1 years and mean disease duration of 6.6 ±6.8 years were studied. Depression was diagnosed in 27 (13.5%) patients and anxiety in 38 (19%) patients. The DAS28 score correlated positively with depression (<i>r</i> = 0.173, <i>p</i> = 0.014) and anxiety score (<i>r</i> = 0.229, <i>p</i> = 0.001). In multiple logistic regression analysis after adjustment for all covariates, age < 40 years and female sex were independently associated with RA activity in patients with depression, with OR = 4.21 (<i>p</i> = 0.002) and OR = 3.56 (<i>p</i> = 0.028) respectively.</p><p><strong>Conclusions: </strong>These findings indicate that depression and anxiety are prevalent in RA and correlate positively with active disease in particular in depressive female patients aged < 40 years.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 2","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/6d/RU-61-154905.PMC10201383.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9510011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of antiresorptive agents on body composition: a case-control retrospective study.","authors":"Suhel Gabriele Al Khayyat,&nbsp;Giuseppe Fogliame,&nbsp;Edoardo Conticini,&nbsp;Virginia Berlengiero,&nbsp;Paolo Falsetti,&nbsp;Stefano Gentileschi,&nbsp;Caterina Baldi,&nbsp;Marco Bardelli,&nbsp;Luca Cantarini,&nbsp;Bruno Frediani","doi":"10.5114/reum.2023.124335","DOIUrl":"https://doi.org/10.5114/reum.2023.124335","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis is the most represented metabolic bone disease and is characterized by the reduction of bone mineral density (BMD), exposing patients to high fracture risk and disability. Bisphosphonates (BPs) are the main compounds exploited in treatment of osteoporosis and significantly reduce fracture risk. Sarcopenia is the pathological reduction of muscle masses and strength, and many studies highlighted its co-existence in patients with impaired bone mass. Indeed, the pathological reduction of lean tissue has been linked to a higher risk of falls and, consequently, fractures and disability. Moreover, the pathological reduction of lean tissue seems to share many pathological mechanisms with impaired bone strength and structure; thus, in this context, we decided to conduct a retrospective case-control study aimed at evaluating the effects of BPs on lean mass and body composition.</p><p><strong>Material and methods: </strong>We enrolled postmenopausal women from our metabolic bone diseases outpatient clinic who underwent at least two consecutive dual-energy X-ray absorptiometry (DXA) examinations concomitantly to the beginning of an antiresorptive agent. The body composition of patients and controls was compared by fat masses, lean masses and android-to-gynoid ratio (A/G ratio).</p><p><strong>Results: </strong>A total of 64 female subjects were considered for the study: 41 starting a BPs and 23 without treatment were used as control. The fat masses and lean masses appeared to be unaffected by BPs. Conversely, A/G ratio was lower in BPs group after 18 months of therapy compared to baseline (<i>p</i> < 0.05). From the stratification based on the single BP we failed to highlight any significant difference between the tested variables.</p><p><strong>Conclusions: </strong>Bisphosphonates treatment did not modify lean tissues, however a significant reduction of A/G ratio in BP group was documented. Thus the BPs seems to act on patients body composition and extra-skeletal tissues but larger prospective studies are needed to evaluate whether these modifications have clinical relevance.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 2","pages":"92-96"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/2c/RU-61-156907.PMC10201384.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9521982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis and diabetes - possible links and diagnostic difficulties.","authors":"Joanna Magdalena Tomasiuk,&nbsp;Anna Nowakowska-Płaza,&nbsp;Małgorzata Wisłowska,&nbsp;Piotr Głuszko","doi":"10.5114/reum/170048","DOIUrl":"https://doi.org/10.5114/reum/170048","url":null,"abstract":"<p><strong>Objectives: </strong>In this review, the authors aimed to clarify the relationship between the occurrence of osteoporosis and diabetes, analyze the differences between the pathogenesis of osteoporosis in different types of diabetes and propose the most effective diagnostic strategy and fracture risk assessment in diabetic patients.</p><p><strong>Material and methods: </strong>A analysis of publications in MEDLINE, COCHRANE and SCOPUS databases was performed, searching for reports on the diagnostics, fracture risk assessment, prevention, and treatment of osteoporosis in patients with diabetes mellitus (DM) published in the years 2016-2022. The key words for the search were: diabetes, osteoporosis, and low-energy fracture.</p><p><strong>Results: </strong>Bone complications of T1DM are more severe than T2DM, because of the lack of anabolic effect of insulin on bones. In T2DM the risk of fractures is elevated; however, identifying the mechanisms underlying the increased risk of fractures in T2DM is not clear. The FRAX tool is not appropriate for assessing the fracture risk in young patients with T1DM. It is quite useful in older patients with T2DM, but in these patients the calculated fracture risk may be underestimated. In T2DM the fracture risk often does not correspond to BMD value as measured by dual-energy X-ray absorptiometry (DXA). Diagnostic tools such as the trabecular bone score may play a significant role in this group of patients. Conclusions: Optimal strategies to identify and treat high risk individuals require further research and proper definition. The diagnostic criteria for osteoporosis should be clearly defined as well as fracture risk assessment and choice of anti-osteoporotic medication. In all cases of secondary osteoporosis, treatment of the underlying disease is the most important. The relationship between high risk of fractures and diabetes is inseparable, and its full understanding seems to be the key to effective management.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 4","pages":"294-304"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/ba/RU-61-170048.PMC10515121.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41134723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymyalgia rheumatica and polymyalgia-like syndromes as adverse events following immunisation with COVID-19 vaccines: a 15 months update.","authors":"Ciro Manzo, Alberto Castagna, Arvind Nune, Marco Isetta","doi":"10.5114/reum/172508","DOIUrl":"https://doi.org/10.5114/reum/172508","url":null,"abstract":"","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 5","pages":"408-409"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134649591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review.","authors":"Łukasz Pulik,&nbsp;Paweł Łęgosz,&nbsp;Gabriela Motyl","doi":"10.5114/reum/168503","DOIUrl":"https://doi.org/10.5114/reum/168503","url":null,"abstract":"<p><p>Although the pathological mechanisms involved in osteoarthritis (OA) and rheumatoid arthritis (RA) are different, the onset and progression of both diseases are associated with several analogous clinical manifestations, inflammation, and immune mechanisms. In both diseases, cartilage destruction is mediated by matrix metalloproteinases (MMPs) synthesized by chondrocytes and synovium fibroblasts. This review aims to summarize recent articles regarding the role of MMPs in OA and RA, as well as the possible methods of targeting MMPs to alleviate the degradation processes taking part in OA and RA. The novel experimental MMP-targeted treatments in OA and RA are MMP inhibitors eg. 3-B2, taraxasterol, and naringin, while other treatments aim to silence miRNAs, lncRNAs, or transcription factors. Additionally, other recent MMP-related developments include gene polymorphism of MMPs, which have been linked to OA susceptibility, and the MMP-generated neoepitope of CRP, which could serve as a biomarker of OA progression.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 3","pages":"191-201"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/66/RU-61-168503.PMC10373173.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9913640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EULAR. European Congress of Rheumatology: Milan, 31 May-3 June 2023.","authors":"","doi":"10.5114/reum/169417","DOIUrl":"10.5114/reum/169417","url":null,"abstract":"","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 3","pages":"221-222"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6a/35/RU-61-169417.PMC10373171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibromyalgia - etiology, diagnosis and treatment including perioperative management in patients with fibromyalgia.","authors":"Anna Dizner-Golab, Barbara Lisowska, Dariusz Kosson","doi":"10.5114/reum/163094","DOIUrl":"10.5114/reum/163094","url":null,"abstract":"<p><p>Fibromyalgia (FM) is considered a multifactorial disorder/syndrome with not fully understood etiology. Chronic generalized pain is the main symptom. A broad spectrum of factors is proposed to explain the etiology. Its multifactorial nature is inherently associated with challenges in diagnosis and therapy. Various evidence of etiology has been evaluated with the aim of establishing a novel therapeutic approach. The main issue in the diagnosis and management is to focus on the evaluation of strict diagnostic criteria to minimize under- and overdiagnosis. Fibromyalgia is a challenge for perioperative management because of the increased risk of possible complications and poorer outcomes, including postoperative pain chronification. The authors have proposed an up-to-date evaluation of perioperative management considering the current guidelines. Multimodal analgesia combined with tailored perioperative care is the most appropriate assessment. Interdisciplinary research with special interest in pain management, including perioperative medicine, seems to be the main theme for the future.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 2","pages":"137-148"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/6e/RU-61-163094.PMC10201378.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9517172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overlapping clinical features of systemic juvenile idiopathic arthritis and SARS-CoV-2-related multisystem inflammatory syndrome in children.","authors":"Oksana Boyarchuk,&nbsp;Tetiana Kovalchuk","doi":"10.5114/reum/161185","DOIUrl":"https://doi.org/10.5114/reum/161185","url":null,"abstract":"<p><strong>Introduction: </strong>Differential diagnosis of the systemic juvenile idiopathic arthritis (sJIA) is often complicated, because of the variability in clinical presentation and the absence of specific signs.</p><p><strong>Material and methods: </strong>The PubMed/Medline and Scopus databases from the years 2013-2022 were analysed for full articles in English and the following key words were used: \"juvenile idiopathic arthritis\" and \"MIS-C\"; \"juvenile idiopathic arthritis\" and \"Kawasaki disease\". As an example of the problem the case description of a 3-year-old patient is presented.</p><p><strong>Results: </strong>In the first step 167 publications were identified; however, after exclusion of duplicated articles and those not relevant to the topic, only 13 were included in the analysis. We analysed studies that describe overlapping clinical features of sJIA and Kawasaki disease (KD) or multisystem inflammatory syndrome in children (MIS-C). The main issues we discussed were the search for the specific features that would distinguish one disease from another. Fever refractory to intravenous immunoglobulin treatment was the most frequent indicator among the features of clinical courses. Among other clinical signs prolonged, recurrent fever, rash, an incomplete KD phenotype, Caucasian race, splenomegaly, and complicated macrophage activation syndrome also supported sJIA diagnosis. Among laboratory tests, high ferritin and serum interleukin-18 levels were found to be the most useful in differentiation. The present case demonstrates that prolonged, unexplained, recurrent fever with a specific pattern should be the reason to suspect sJIA.</p><p><strong>Conclusions: </strong>Overlapping features of sJIA and SARS-CoV-2-related MIS-C complicates diagnosis in the era of the COVID-19 pandemic. Our case presentation adds symptoms of prolonged, spiking, unexplained, recurrent fever with a specific pattern for supporting systemic juvenile idiopathic arthritis diagnosis.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 1","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/30/RU-61-161185.PMC10044031.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity in rheumatological practice.","authors":"Jarosław Kozakowski,&nbsp;Piotr Dudek,&nbsp;Wojciech Zgliczyński","doi":"10.5114/reum/170401","DOIUrl":"https://doi.org/10.5114/reum/170401","url":null,"abstract":"<p><p>Obesity is a chronic disease that leads to the development of secondary metabolic disturbances and diseases and strongly contributes to increased morbidity and mortality. On the other hand, musculoskeletal disorders are currently the main cause of disability and the second most frequent reason for visits to the doctor. Many studies clearly show that excessive body weight adversely affects the course of almost all musculoskeletal system diseases, from osteoarthritis, through metabolic, systemic connective tissue, to rarely diagnosed diseases. The impact of increased fat mass on the musculoskeletal system is presumably complex in nature and involves the influence of biomechanical, dietary, genetic, inflammatory and metabolic factors. Due to the epidemic nature of obesity and its serious health consequences, this disease requires energetic treatment. It is always based on lifestyle modification enriched, if necessary, by pharmacological and, in justified cases, surgical treatment.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"61 4","pages":"318-325"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/e3/RU-61-170401.PMC10515124.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}