Reumatologia最新文献

{"title":"Assessment of quality of life in patients with Lyme arthritis and rheumatoid arthritis.","authors":"Valentyna Vasylivna Yuskevych, Igor Valentynovych Zhulkevych, Oleksandra Stepanivna Makhovska, Svitlana Ivanivna Smiyan","doi":"10.5114/reum.2022.114352","DOIUrl":"10.5114/reum.2022.114352","url":null,"abstract":"<p><strong>Objectives: </strong>Patients' quality of life is one of the key concepts of modern medicine, which characterizes the role of physical and mental functioning in the course of the disease. This article presents a stratification of factors influencing the quality of life in patients with rheumatoid arthritis (RA) and Lyme arthritis (LA).</p><p><strong>Material and methods: </strong>Ninety patients with RA were included in this study among them <i>n</i> = 44 (48.89%) also with LA diagnosis and <i>n</i> = 46 (51.11%) with RA. All studied patients were examined and questioned according to the Health Assessment Questionnaire-Disability Index and the 36-Item Short Form Survey (SF-36) to assess their quality of life. The disease activity score with examination of 28 joints was used to assess the activity of the disease. Multiple regression analysis was used to determine the most significant factors influencing patients' quality of life.</p><p><strong>Results: </strong>Patients who agreed to participate in the study had high and moderate disease activity; however, patients with LA showed significantly higher baseline data on the intensity of the inflammatory process. According to the analysis of the questionnaire responses, a significantly reduced physical activity of both groups was revealed, but patients with LA had significantly worse BP (<i>p</i> = 0.002), GH (<i>p</i> = 0.006), and Mental Component Summary scales (<i>p</i> = 0.001). The greatest relationship between disease activity and quality of life by Physical Component Summary according to SF-36 (<i>r</i> = -0.80) was found in patients with LA and (<i>r</i> = -0.72) - with RA.</p><p><strong>Conclusions: </strong>The presence of <i>Borrelia burgdorferi</i> in patients with arthritis not only significantly reduced the motor activity of patients, but also complicated the mental adaptation to their own disease. Factors that affect the quality of life - the activity and duration of the disease in patients of both cohorts, and age and total number of affected joints - for patients with RA.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86001618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic arthritides: an up-to-date case-based systematic review.","authors":"Suhel Gabriele Al Khayyat,&nbsp;Edoardo Conticini,&nbsp;Paolo Falsetti,&nbsp;Stefano Gentileschi,&nbsp;Antonio Vitale,&nbsp;Salvatore Massimo Stella,&nbsp;Miriana D'Alessandro,&nbsp;Elena Bargagli,&nbsp;Luca Cantarini,&nbsp;Bruno Frediani","doi":"10.5114/reum.2022.123672","DOIUrl":"https://doi.org/10.5114/reum.2022.123672","url":null,"abstract":"<p><p>Among the rheumatic diseases whose symptoms are more often associated with the possibility of cancer and other malignancies are systemic sclerosis, dermatomyositis and rheumatic polymyalgia. However, a differential diagnosis should be performed in each case of non-typical rheumatic disease and/or other neoplastic disease risk factors. The article's aim was based on a literature review of this subject and presentation own a case description and discussion about arthritis as a paraneoplastic syndrome. The conclusions of our analysis were as follows: more often paraneoplastic arthritis occurs in men, in ages higher than 50 years old, in patients who poorly respond to treatment of arthritis with polyarticular symmetrical involvement of the limbs, seronegative type of inflammatory joint disease. In this group of patients, complete remission after treatment of the primary tumor and recurrence of the symptoms in the presence of metastasis was observed.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/63/RU-60-156257.PMC9847110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10581045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glomerulopathy in patients with dermatomyositis in early active disease: clinical, pathological and capillaroscopic manifestations, and response to treatment.","authors":"Saeedeh Shenavandeh,&nbsp;Mahsa TorabiJahromi,&nbsp;Sahand Mohammadzadeh","doi":"10.5114/reum.2022.117840","DOIUrl":"https://doi.org/10.5114/reum.2022.117840","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic inflammatory myopathies (IIMs) are a group of systemic connective tissue diseases that present with muscular and extra-muscular manifestations. There are few reports on kidney involvement, especially in dermatomyositis (DM) patients. We evaluated the clinical, laboratory, capillaroscopy, and kidney pathology of patients with DM, who presented with proteinuria during the first year, and followed them for response to treatment.</p><p><strong>Material and methods: </strong>We evaluated 205 patients with proximal muscle weakness or high muscle enzymes, who referred to the nailfold capillaroscopy clinic from April 2010 to October 2021. Seventy-four patients fulfilled the New 2017 EULAR/ACR Classification Criteria for adult and juvenile IM with probability of ≥ 90% for DM with duration of ≤ 12 months and proteinuria > 350 mg/24 hours. All manifestations of patients with glomerulopathy and their kidney biopsies were reviewed, and they were followed for their treatment response.</p><p><strong>Results: </strong>From 74 patients with DM, 52 female and 22 male, median age 37 (19-65) years, and disease duration of median 4.5 (1-12) months, 2 (2.7%) patients (25- and 28-year-old male) had proteinuria. Their kidney biopsy showed mesangioproliferative glomerulonephritis (GN). There was no case of acute or chronic kidney damage or rhabdomyolysis. Both had high disease activity, high erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), abnormal capillaroscopy, and high anti-Ro positivity with good early response of their kidney function, muscle weakness, and laboratory tests after immunosuppressive treatment for 3-6 months. One patient had capillaroscopy follow-up, and all abnormalities were resolved in 8 fingers. One patient, due to poor follow-up, after 8 months had recurrence of his disease.</p><p><strong>Conclusions: </strong>We found mesangioproliferative GN as a rare extra-muscular manifestation in patients with DM in the active and early phase of the disease. Full immunosuppressive treatment showed early complete recovery in these patients.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/8d/RU-60-47405.PMC9301663.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40621455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial stiffness and atherosclerosis in systemic lupus erythematosus patients.","authors":"Hanna Dziedzic-Oleksy,&nbsp;Adam Mazurek,&nbsp;Kamil Bugała,&nbsp;Carlo Perricone,&nbsp;Leszek Drabik,&nbsp;Wojciech Płazak","doi":"10.5114/reum.2022.117836","DOIUrl":"https://doi.org/10.5114/reum.2022.117836","url":null,"abstract":"Introduction Systemic lupus erythematosus (SLE) is characterized by early atherothrombosis. Pulse wave velocity (PWV) is a promising tool for the diagnosis of early vascular remodelling and initial atherosclerotic plaque formation. Our objective was to evaluate PWV and its relationship with coronary atherosclerosis and thrombotic biomarkers in patients with SLE. Material and methods In 26 patients with SLE with stable clinical conditions, mean age of 39.1 ±11.7 years and without a history of coronary artery disease, multidetector computed tomography (MDCT)-based coronary calcium scoring (CACS) was performed and PWV measured. Laboratory evaluation included serum levels of anticardiolipin and anti-β2-glycoprotein antibodies (anti-β2-GPI), lupus anticoagulant (LA), D-dimers, thrombin–antithrombin complexes (TAT), and von Willebrand factor (vWF). Results Multidetector computed tomography revealed coronary calcifications in 8 (30.8%) patients and the median CACS was 52.4 HU (range 2–843.2). The mean PWV was 9.0 ±3.2 m/s and was higher in patients aged > 50 years (+33.7% vs. < 50 years), those with positive LA (+28.2% vs. LA negative), TAT ≥ 10 μg/l (+18.1% vs. < 10 μg/l), vWF ≥ 200 IU/dl (+51.8% vs. < 200 IU/dl) and with coronary atherosclerosis (CACS > 0; +21.4% vs. CACS = 0). In contrast, the duration of the disease, D-dimers, anticardiolipin, and anti-β2-GPI antibodies did not influence PWV. In the group without atherosclerosis (CACS = 0, n =18), patients with vWF ≥ 200 IU/dl had a 19.3% higher PWV compared to the rest. Conclusions In patients with SLE, PWV was associated with the presence of coronary atherosclerotic lesions in MDCT. Furthermore, arterial stiffness was higher in patients with markers of endothelial dysfunction and a prothrombotic state, suggesting their contribution to the early stages of arterial remodelling in SLE.","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/47/RU-60-47401.PMC9301661.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40622961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of cryopreserved multipotent mesenchymal stromal cells in modulation of some indices of cell immunity in adjuvant arthritis.","authors":"Dmytro Vvedenskyi,&nbsp;Nataliia Volkova,&nbsp;Natalya Babenko,&nbsp;Yulia Gaevska,&nbsp;Mariia Yukhta,&nbsp;Anatoliy Goltsev","doi":"10.5114/reum.2022.117842","DOIUrl":"https://doi.org/10.5114/reum.2022.117842","url":null,"abstract":"<p><strong>Inroduction: </strong>The results of experimental and clinical studies in recent years indicate that the transplantation of multipotent mesenchymal stromal cells (MMSCs) is a possible approach for the \"restoration\" of the immune system of patients with autoimmune diseases, in particular, rheumatoid arthritis. However, the strength and duration of the effect vary greatly, which indicates incomplete correction of the tested parameters, thereby opening up the prospect of improving this method of treatment by choosing dose-time parameters and methods of their administration. The aim of this research was to determine the indices of cellular immunity in animals with adjuvant arthritis and therapy with cryopreserved MMSCs derived from adipose and cartilage tissues.</p><p><strong>Material and methods: </strong>Adjuvant arthritis in male rats was modeled by subplantar administration of Freund's complete adjuvant. On day 7 of modeling, experimental animals were administered with saline (control group) or cryopreserved MMSCs from adipose or cartilaginous tissue locally or generalized. On day 28 after therapy the body weight, spleen index and cellularity, and content of CD3+, CD4+, CD8+, CD4+CD25+ cells in the spleen were determined.</p><p><strong>Results: </strong>In the control group of animals, the inflammation was pronounced, as evidenced by a significant increase in the studied parameters throughout the observation period. The use of cryopreserved MMSCs from adipose and cartilaginous tissues led to the restoration of T regulatory cells (Treg) on day 28. Generalized administration of cells had a more pronounced therapeutic effect compared to the animals with local administration. These data can be used to justify and develop a therapeutic approach to rheumatoid arthritis in clinical practice.</p><p><strong>Conclusions: </strong>Cell therapy with cryopreserved MMSCs from investigated sources provided by both local and generalized administration to animals with adjuvant arthritis has a correcting effect on the cellular immunity.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/25/RU-60-47407.PMC9301669.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40622962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone-sparing effects of tocilizumab in rheumatoid arthritis: a monocentric observational study.","authors":"Suhel Gabriele Al Khayyat,&nbsp;Roberto D'Alessandro,&nbsp;Edoardo Conticini,&nbsp;Serena Pierguidi,&nbsp;Paolo Falsetti,&nbsp;Caterina Baldi,&nbsp;Marco Bardelli,&nbsp;Stefano Gentileschi,&nbsp;Antonella Nicosia,&nbsp;Bruno Frediani","doi":"10.5114/reum.2022.120756","DOIUrl":"https://doi.org/10.5114/reum.2022.120756","url":null,"abstract":"<p><strong>Introduction: </strong>Bone loss is a common feature in several autoimmune and chronic inflammatory diseases, such as rheumatoid arthritis (RA). Indeed, the high levels of pro-inflammatory cytokines seem to enhance bone resorption and to diminish bone formation, thus producing an uncoupling between osteoclast and osteoblast function and favoring the onset of juxtarticular as well as systemic osteoporosis. Many papers underline the high prevalence of osteoporosis in RA, as well as the negative correlation between interleukin 6 (IL-6) serum levels and bone mineral density (BMD). The aim of this study was to assess the effectiveness of one-year treatment with tocilizumab (TCZ), the first approved IL-6 receptor inhibitor, in reducing bone loss in RA.</p><p><strong>Material and methods: </strong>We enrolled 18 patients fulfilling 2010 ACR and EULAR criteria for RA from our arthritis outpatient clinic, assessing clinical and biochemical parameters during a 12-month period. The patients received TCZ 8 mg/kg <i>i.v</i>. every 4 weeks and underwent dual energy X-ray absorptiometry (DXA) for the measurement of bone mineral density (BMD) at baseline and at the end of study. Serum levels of C-reactive protein (CRP), erythrocytes sedimentation rate (ESR), IL-6, serum CrossLaps, osteoprotegerin (OPG), receptor activator of nuclear factor κβ ligand (RANK-L) and dickkopf-1 (DKK-1) were measured at baseline, at 6 months and 1 year.</p><p><strong>Results: </strong>No significant difference in IL-6, RANK-L, DKK-1, OPG and serum CrossLaps levels between baseline, 6 months and 1 year were found. A significant increase of lumbar spine BMD was evidenced after 1 year of TCZ treatment. No difference in total body and femoral neck BMD was documented the end of the study.</p><p><strong>Conclusions: </strong>This study suggest the bone-sparing effect of TCZ in RA affected individuals.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/01/RU-60-48072.PMC9661410.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40687222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opening report of the Polish National Consultant in the field of rheumatology.","authors":"Brygida Kwiatkowska","doi":"10.5114/reum.2022.115988","DOIUrl":"https://doi.org/10.5114/reum.2022.115988","url":null,"abstract":"In Poland the National Consultants for the Ministry of Health operate in the fields of health care associated with medical specialties they represent. They are appointed by the Minister of Health from among specialists in the fields of medicine, pharmaceutics and other disciplines which find application in health management [1]. Primary tasks of the National Consultants include initiating national epidemiological research, assessment of methods and results of such research and forecasting health needs with the use of the obtained results. National Consultants advise on the creation of government health care programs, including the National Health Program. They also evaluate patients’ applications for receiving treatment or diagnostic services abroad. Finally, they play an important role in the system of training of medical specialists, advising on the tasks fulfilled by the Centre for Medical Exams, the Centre of Medical Postgraduate Education and the Centre of Medical Postgraduate Education for Nurses and Midwives. Each National Consultant is chosen for a 5-year term. In May 2021 I was appointed to the post of National Consultant in the field of rheumatology. As in 2021 the COVID-19 pandemic continued, the ongoing struggle with this virus affected the availability of the rheumatologic care for patients. In this situation my activity concentrated initially on the identification of the most pressing problems faced by rheumatologists and health care managers. In order to obtain the proper knowledge in this respect, I turned to the Provincial Consultants, asking them to prepare reports on the availability of rheumatologic care in the particular provinces of Poland. On my request, experts in the field of rheumatology, possessing both clinical and scientific experience alike – Prof. Maria Majdan, Prof. Joanna Makowska, Maria Maślińska PhD and the director of the National Institute of Geriatrics, Rheumatology and Rehabilitation Marek Tombarkiewicz PhD (a health care manager and a medical doctor) – prepared, along with myself, the “Opening report” of the National Consultant in the field of rheumatology, intended both as a review of the state of affairs existing at the beginning of my term in office and as a plan of action for the years to come [2]. The priority targets for the National Consultant are defined as: the improvement of the hospital and ambulatory rheumatic care availability in the time of the COVID-19 pandemic and the curtailment of the delays in the diagnosis of rheumatic diseases though the introduction of so-called complex care for patients with early arthritis. The complex care project was previously presented and submitted to the Ministry of Health [3]. It will also be vital to establish a network of medical centres for patients most diagnostically challenging and requiring the most advanced treatments. Such centres should co-operate closely with other rheumatologic facilities of lower health care levels, as well as other high-level cen","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/82/RU-60-46974.PMC9238306.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adhesion molecules: a way to understand lupus.","authors":"Karolina Nowak,&nbsp;Olga Gumkowska-Sroka,&nbsp;Przemysław Kotyla","doi":"10.5114/reum.2022.115664","DOIUrl":"https://doi.org/10.5114/reum.2022.115664","url":null,"abstract":"<p><p>Systemic lupus erythematosus is a connective disease in which all vitally important organs may be affected. The etiology of the disease is largely unknown and almost all immunological mechanisms have been proposed as the pathophysiological background of the disease. Among them, endothelial damage and dysfunction seem to play a pivotal role. Endothelial damage can be accurately measured using adhesion molecules such asintercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), platelet endothelial cell adhesion molecule (PECAM) and selectins. In this review we discuss the role of well-known cellular adhesion molecules as pathogenic factors in disease development as well as disease activity biomarkers.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/20/f3/RU-60-46888.PMC9238314.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity.","authors":"Yany Magali Chamorro-Melo,&nbsp;Omar-Javier Calixto,&nbsp;Juan Manuel Bello-Gualtero,&nbsp;Wilson Bautista-Molano,&nbsp;Adriana Beltran-Ostos,&nbsp;Consuelo Romero-Sánchez","doi":"10.5114/reum.2022.117839","DOIUrl":"https://doi.org/10.5114/reum.2022.117839","url":null,"abstract":"<p><strong>Introduction: </strong>Adipokines may play a role in the early stages of rheumatoid arthritis. This study evaluated the performance of adipokines in a Colombian population with early rheumatoid arthritis and its relationship with disease activity.</p><p><strong>Material and methods: </strong>A cross-sectional study evaluated serum adipokine levels (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis (eRA), evaluating demographic and clinical variables, along with a control group matched by age and gender. A factorial analysis was performed using principal components analysis (PCA), and a Spearman correlation analysis was performed. Similarly, a cut-off point for serum levels is proposed based on the receiver operating characteristic (ROC) curve between eRA and controls and sensitivity analysis.</p><p><strong>Results: </strong>Fifty-one eRA subjects were included; there were 41 women. The body mass index (BMI) was 25.12 ±3.8. A statistically significant correlation was identified between adipsin, BMI, and RAPID3. Vaspin and leptin were correlated with BMI. Resistin levels were higher in patients with RAPID3 near remission (<i>p</i> = 0.041), and adiponectin, vaspin, and leptin levels were lower in patients with DAS28 ESR in remission (<i>p</i> = 0.033, <i>p</i> = 0.012, and <i>p</i> = 0.017, respectively). Principal components analysis in component 1 adipokines as adipsin and leptin with BMI and RAPID3 as disease activity index are grouped. Moreover, component 2 had a strong relation between ESR and CRP with an inverse correlation with cholesterol levels and vaspin. A cut-off point was established for each adipokine, thus identifying the best performance for leptin levels greater than 0.58 ng/ml with a sensitivity of 76.5% and specificity of 74.5%.</p><p><strong>Conclusions: </strong>Adipokine levels are relevant in eRA, especially with disease activity indexes. Resistin levels were higher in patients with an activity index near remission. Otherwise, adiponectin, vaspin, and leptin levels were lower in patients with low activity indexes. RAPID3 correlated with adipsin. It is complementary to the previously published analysis of adipokines.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/e3/RU-60-47404.PMC9301668.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40622963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjögren's syndrome and pregnancy: a Portuguese case-control study.","authors":"Tânia Barros,&nbsp;Jorge Braga,&nbsp;Maria Inês Abreu,&nbsp;Mariana Brandão,&nbsp;Fátima Farinha,&nbsp;António Marinho,&nbsp;António Braga","doi":"10.5114/reum.2022.120754","DOIUrl":"https://doi.org/10.5114/reum.2022.120754","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnancy in patients with autoimmune disorders is associated with an increased risk of adverse outcomes. Sjögren's syndrome (SS) is one of the most common among autoimmune diseases. Presently data regarding the impact of SS on obstetric outcomes are scarce and inconclusive. This study aims to evaluate the impact of SS on maternal-fetal and neonatal outcomes compared with pregnancy outcomes in the general population.</p><p><strong>Material and methods: </strong>A retrospective case-control study included 26 pregnancies in SS patients and a healthy control group (CG), followed in a Portuguese tertiary center, between 2015 and 2020. Baseline maternal data were collected, and maternal-fetal and neonatal outcomes were evaluated. Statistical analysis used SPSS 25.0, and a <i>p</i>-value of 0.05 was considered statistically significant.</p><p><strong>Results: </strong>All pregnancies occurred after the diagnosis of SS, with a mean exposure time between diagnosis and pregnancy of 4.92 ±2.78 years. In the SS group, the incidence of ANA, anti-Ro/SSA, and anti-La/SSB antibodies positivity was 80.8%, 61.5%, and 46.2%, respectively. Hydroxychloroquine (HCQ) was used in 57.7%.Miscarriage was significantly higher in the SS group (19.2% vs. 1.8%, <i>p</i> < 0.01). There was a higher prevalence of fetal growth restriction (OR 11.16, 95% CI: 0.96-129.26). Preterm delivery (9.5% vs. 5.6%, <i>p</i> = 0.503) and mean birth weight (2998.16 g vs. 3155.79 g, <i>p</i> = 0.178) did not differ significantly between the groups. In the SS group, admission to the neonatal intensive care unit (NICU) rate was increased (OR 71.67, 95% CI: 3.78-1357.16). Three pregnancies were complicated by congenital heart block (CHB) (14.3% vs. 0%, <i>p</i> = 0.015). In all cases, the diagnosis was performed during second trimester of pregnancy, and betamethasone was administered.</p><p><strong>Conclusions: </strong>Women with SS had a significantly higher incidence of miscarriage, admission to NICU, and CHB than controls. Congenital heart block was the most critical condition that affects the offspring of mothers with SS. Successful pregnancy in the study group was possible with prenatal monitoring and a multidisciplinary approach.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/5b/RU-60-48070.PMC9661414.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40687220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}