Reumatologia最新文献

{"title":"Janus kinase inhibitors in giant cell arteritis: unmet needs and new challenges.","authors":"Arriana Gkouvi, Eleni Patrikiou, Maria G Grammatikopoulou, Dimitrios P Bogdanos","doi":"10.5114/reum/218349","DOIUrl":"10.5114/reum/218349","url":null,"abstract":"","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"1-3"},"PeriodicalIF":1.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on inflammatory disease research: a literature analysis of 77,575 PubMed articles.","authors":"Naruaki Ogasawara","doi":"10.5114/reum/211835","DOIUrl":"10.5114/reum/211835","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigated how the coronavirus disease 2019 (COVID-19) pandemic influenced research trends related to inflammatory diseases and biomarkers. By analyzing large-scale bibliographic data, the study aimed to clarify thematic transitions over the past 3 decades and to identify emerging perspectives that shape current and future directions.</p><p><strong>Material and methods: </strong>PubMed-indexed articles (<i>n</i> = 77,575) published from 1995 to 2024 were examined using Python (Version 3.10.5) in a PyCharm (Software Version 2022.1.3) environment. Titles, abstracts, and key words were preprocessed by removing stop words and symbols, and the 50 most frequent terms were extracted. A key word co-occurrence matrix was constructed to evaluate relationships between terms, and heatmaps were generated for visualization. To capture developmental stages, the dataset was divided into 3 periods (1995-2004, 2005-2014, 2015-2024), and thematic shifts were compared across intervals.</p><p><strong>Results: </strong>The analysis revealed distinct transitions. From 1995 to 2004, research emphasized immune pathways and molecular mechanisms. Between 2005 and 2014, the focus shifted toward translational and clinical applications. After 2015, particularly during the COVID-19 era, biomarker studies expanded into public health, epidemiology, and infection monitoring.</p><p><strong>Conclusions: </strong>Biomarker research in inflammatory diseases has progressed from molecular inquiry to clinical translation and now to population-level health strategies. The COVID-19 pandemic accelerated this trajectory, positioning biomarkers as pivotal tools that link laboratory science with public health preparedness and policy. Beyond clarifying historical shifts, this study demonstrates how quantitative bibliometric analysis can reveal overlooked relationships between research domains and highlight emerging perspectives. Such findings not only inform scientific agendas but also guide policymakers in strengthening healthcare systems. By framing biomarkers as both scientific markers and societal instruments, this study underscores their transformative role and offers a comprehensive foundation for shaping future investigations.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"17-27"},"PeriodicalIF":1.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Eosinophilic granulomatosis with polyangiitis across the eosinophilic spectrum: from molecular mechanisms to practical differential diagnosis and targeted therapy.","authors":"Joanna Kosałka-Węgiel, Mariusz Korkosz","doi":"10.5114/reum/218439","DOIUrl":"10.5114/reum/218439","url":null,"abstract":"","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"72-73"},"PeriodicalIF":1.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of public knowledge and awareness regarding rheumatological diseases: a cross-sectional study.","authors":"Raghda Saleem, Mustafa Omran, Lamis Aziz Hameed","doi":"10.5114/reum/209787","DOIUrl":"10.5114/reum/209787","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatology is a rapidly evolving medical specialty that focuses on autoimmune connective tissue diseases, inflammatory joint diseases, regional rheumatological conditions, some overuse injuries, and other inflammatory conditions. The study aimed to assess the knowledge of rheumatology and rheumatological diseases among the general population in Basrah City and to identify factors associated with this knowledge.</p><p><strong>Material and methods: </strong>In this cross-sectional, questionnaire-based study, participants were recruited from outpatient clinics and hospitals in Basrah City, excluding rheumatology clinics. Data collection took place from May 1, 2024 to September 1, 2024. A questionnaire was then developed for this study. The inclusion criteria were adults aged ≥ 18 years who were residents of Basrah City and showed a willingness to participate in the study. Participants were excluded if they had a known diagnosis of a rheumatological disease, were healthcare professionals, or were medical students.</p><p><strong>Results: </strong>A total of 400 participants participated in this study. Their ages ranged from 18 to 65 years. 56% of them were female. Seventy-one had attended secondary schools and colleges. More than half of the participants had unsatisfactory knowledge (62%), and only 38% had good knowledge about rheumatology as a medical branch and had a sufficient understanding of the main rheumatological illnesses. Of those with satisfactory knowledge, 52.3% were female and 47.0% had a college education. Analysis of this pattern demonstrated a significant association between knowledge and educational level (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The knowledge and awareness of rheumatological disorders in our locality are deficient and limited. This study revealed the weak role of media and mass education campaigns in expanding awareness about these growing and potentially detrimental disorders.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"28-35"},"PeriodicalIF":1.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of nailfold capillaroscopic features with cardiac block and arrhythmias due to systemic sclerosis-related primary heart involvement.","authors":"Maryam Salimi-Beni, Leila Azizi, Maryam Mohebi, Negin Mohtasham, Ali Kabir, Hadi Poormoghim","doi":"10.5114/reum/213279","DOIUrl":"10.5114/reum/213279","url":null,"abstract":"<p><strong>Introduction: </strong>Impaired microvascular function has been implicated as a complication affecting multiple organs in systemic sclerosis (SSc). We investigated the correlation between microvascular damage on nailfold video capillaroscopy (NVC) and cardiac arrhythmias or conduction blocks in patients with primary heart involvement (pHI).</p><p><strong>Material and methods: </strong>One hundred ten patients with SSc underwent an NVC study. Thirty-one patients with arrhythmias or conduction blocks were included in the study group. No patients in this group had pulmonary arterial hypertension, systemic hypertension, or ischemic heart disease. Seventy-nine patients with no arrhythmia or block were included in the control group. Qualitative, quantitative, and semi-quantitative capillaroscopic parameters were compared between the 2 groups.</p><p><strong>Results: </strong>In the qualitative NVC analysis the odds ratio (OR) for the early pattern in groups of patients with and without a cardiac outcome was 0.93 (95% CI: 0.35-2.45; <i>p</i> = 0.89). The ORs for the active and late patterns in the 2 groups of patients were 0.92 (95% CI: 0.37-2.30, <i>p</i> = 0.86) and 1.07 (95% CI: 0.52-2.19; <i>p</i> = 0.84), respectively. Semi-quantitative assessment in 6 NVC parameters showed that the mean score for capillary density was higher in the outcome group than in the non-outcome group (mean ±standard deviation: 2.19 ±0.910 vs. 1.72 ±1.120; <i>p</i> = 0.04). Capillary disorganization also showed a higher score in patients with cardiac involvement than in those without (1.00 ±0.01 vs. 0.95 ±0.221, <i>p</i> = 0.001). Low capillary density in NVC was associated with sensitivity (Se) of 96.7%, and specificity (Sp) of 18.9%. Disorganized capillaries showed Se of 96.7% and Sp of 5%. However, no significant differences were observed in enlarged capillaries, giant capillaries, microhemorrhages, or ramifications.</p><p><strong>Conclusions: </strong>Lower capillary density and greater disorganization are associated with arrhythmias and conduction blocks in SSc-PHI. The quantitative capillaroscopic parameters were comparable between patients with arrhythmias due to SSc-PHI and those in the non-outcome group. A detailed semi-quantitative capillaroscopic assessment is recommended in scleroderma patients.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"11-16"},"PeriodicalIF":1.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rituximab as monotherapy and in combination with methotrexate or leflunomide in rheumatoid arthritis: a prospective cohort study in a Peruvian hospital.","authors":"Freddy Liñán-Ponce, Juan Leiva-Goicochea, Fernando Gross-Melo","doi":"10.5114/reum/213648","DOIUrl":"10.5114/reum/213648","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is an autoimmune disease whose treatment has evolved with the introduction of disease-modifying antirheumatic drugs and biological agents such as rituximab (RTX). The objective of this study was to evaluate the efficacy, safety, and treatment adherence of RTX used as monotherapy and in combination with methotrexate (MTX) or leflunomide (LFN) in patients with RA refractory to conventional therapy.</p><p><strong>Material and methods: </strong>A prospective cohort study was conducted including 157 patients, divided into 3 groups: RTX monotherapy (<i>n</i> = 48), RTX + MTX (<i>n</i> = 66), and RTX + LFN (<i>n</i> = 43). Efficacy, safety, and adherence were evaluated at weeks 1, 24, and 48 using the Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 joints (DAS28), American College of Rheumatology 70% response (ACR70), and Treat-to-Target (T2T) criteria. Ethical approval was obtained from the local institutional ethics committee.</p><p><strong>Results: </strong>All 3 therapeutic regimens demonstrated comparable clinical efficacy, with no statistically significant differences in disease activity scores. Adverse events were more frequent in the RTX + LFN group, although not statistically significant. Treatment adherence was highest in the RTX monotherapy group (100%).</p><p><strong>Conclusions: </strong>No significant differences in efficacy or safety were found among the 3 study groups; However, treatment adherence was significantly higher in the RTX monotherapy group (100%).</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"4-10"},"PeriodicalIF":1.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zumba Gold dance compared to conventional balance exercises as a proposed approach to improving balance and reducing the risk of falls in older adults.","authors":"Teresa Sadura-Sieklucka, Beata Sokołowska, Joanna Anita Sikora, Ewa Kądalska, Ewa Sokołowska, Tomasz Targowski","doi":"10.5114/reum/213410","DOIUrl":"10.5114/reum/213410","url":null,"abstract":"<p><strong>Introduction: </strong>The aging population is growing worldwide, and according to a 2015 World Health Organization report, the number of seniors over the age of 65 will be as high as 1.6 billion in 2050, representing 16.7% of the world's population. Moreover, the number of falls among people aged ≥ 65 is expected to increase by 47% by 2050, since coordination and balance, both static and dynamic, have a huge impact on the incidence of falls in seniors. This study was designed to determine whether there are differences in the effectiveness of Zumba Gold (ZG) dance training and conventional balance exercises (BE) in the context of static and dynamic balance and whether ZG may reduce the risk of falls in older adults.</p><p><strong>Material and methods: </strong>The study involved 38 subjects aged 61 to 83, 19 in both groups, who participated in ten 45-minute classes three times a week. Pre- and post-training balance tests were conducted to evaluate the effectiveness of the exercise sessions.</p><p><strong>Results: </strong>The results showed significant improvements in a battery of clinical tests, after training sessions, such as the Timed Up and Go test (<i>p</i> ≤ 0.01), Tandem Stance Test (<i>p</i> ≤ 0.03), Tandem Walk Test (<i>p</i> ≤ 0.02), Tandem Pivot Test (<i>p</i> ≤ 0.02), Four Square Step Test (<i>p</i> ≤ 0.001), and Functional Reach Test (<i>p</i> ≤ 0.004). Zumba Gold, like BE, positively affects static and dynamic balance and is an effective physical activity in preventing falls.</p><p><strong>Conclusions: </strong>The findings suggest that just 10 ZG or BE sessions are sufficient to observe beneficial improvements in functional fitness and balance, which may result in a reduction in fall risk. Moreover, ZG training, like other exercise classes with dynamic music, can also be called active leisure.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"36-45"},"PeriodicalIF":1.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating skin biopsy findings in fibromyalgia: a systematic review.","authors":"Natalia Bejm, Katarzyna Gruszecka","doi":"10.5114/reum/209912","DOIUrl":"10.5114/reum/209912","url":null,"abstract":"<p><p>Fibromyalgia syndrome (FMS) is a condition characterized by widespread musculoskeletal pain, often involving a neuropathic component. While pathophysiology remains vague, increasing evidence suggests that small fiber pathology (SFP) may be present in a significant subset of patients, indicating a peripheral nervous system contribution. This systematic review aims to evaluate the utility of skin biopsy as a diagnostic tool for patients with FMS, with special focus on SFP. A comprehensive database search was conducted to identify studies assessing intraepidermal nerve fiber density (IENFD) via skin biopsy in individuals diagnosed with FMS. The included studies demonstrated a reduction in IENFD in a substantial proportion of FMS patients, with reported prevalence ranging widely from 30% to over 85%. Small fiber pathology occurs in a significant proportion of individuals with FMS. Skin biopsy emerges as a valuable diagnostic tool. Further research is needed to better understand the underlying mechanism of SFP in FMS.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"52-58"},"PeriodicalIF":1.7,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior ischemic optic neuropathy as the main manifestation of giant cell arteritis: a case-based literature review.","authors":"Nina Barankiewicz-Tyc, Norbert Wąsik, Przemysław Majewski, Karolina Kania, Jakub Moskal, Alicja Kalinowska","doi":"10.5114/reum/207774","DOIUrl":"10.5114/reum/207774","url":null,"abstract":"<p><p>This case-based literature review aims to challenge a common misconception that elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, halo sign on temporal artery ultrasound, and arteritic anterior ischemic optic neuropathy are essential to make a diagnosis of giant cell arteritis (GCA). Here, we present a case of a 70-year-old woman with a biopsy-proven GCA who met the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Giant Cell Arteritis. On admission she complained of left temporal headache, left scalp tenderness, constitutional symptoms and visual disturbances in her left eye that was diagnosed as posterior ischemic optic neuropathy. Erythrocyte sedimentation rate and CRP levels were within normal limits, and the patient had no halo sign on the temporal artery ultrasound. It is crucial to carefully evaluate visual disturbances in elderly patients, since missing a diagnosis of GCA can have catastrophic consequences, such as bilateral blindness, aortic dissection, stroke, or myocardial infarction.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 1","pages":"65-71"},"PeriodicalIF":1.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of remission in patients with radiographic axial spondyloarthritis using an ultrasonography-based enthesitis score: a cross-sectional study.","authors":"Emrah Koç, Burak Okyar, Sibel Bakırcı, Suade Özlem Badak, Ali Nail Demir, İsmail Uçar, Gökhan Sargın, Servet Yüce, Emine Duygu Ersözlü","doi":"10.5114/reum/208524","DOIUrl":"10.5114/reum/208524","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate ultrasonographic entheseal abnormalities in patients with radiographic axial spondyloarthritis (r-axSpA) who were in clinical remission for at least 6 months and receiving either nonsteroidal anti-inflammatory drugs (NSAIDs) or biologic agents.</p><p><strong>Material and methods: </strong>Seventy-two r-axSpA patients were included, divided into NSAID users (<i>n</i> = 23) and biologic agent users (<i>n</i> = 49). Demographic and clinical data were recorded. Ultrasound assessment was performed bilaterally at 10 entheseal sites using a 7-13 MHz linear probe. Elementary lesions defined by OMERACT - hypoechogenicity, thickening, power Doppler (PD) signal, calcification, enthesophyte, and bone erosion - were evaluated and scored on a scale of 0-3. Inflammation scores included hypoechogenicity, thickening, and PD signal; chronicity scores included bone erosion, enthesophyte, and calcification.</p><p><strong>Results: </strong>A total of 720 entheseal sites were analyzed. The quadriceps tendon was the most frequently affected site (98.6%), followed by the distal patellar tendon (94.4%), Achilles tendon (70.8%), and plantar fascia (70.8%). Hypoechogenicity, thickening, enthesophyte formation, and bone erosion were the most common abnormalities, while PD signals and calcifications were rare. Nonsteroidal anti-inflammatory drug users showed significantly higher C-reactive protein (CRP) (0.62 ±0.53 vs. 0.41 ±0.27 mg/dl, <i>p</i> = 0.027) and erythrocyte sedimentation rate (ESR) levels (11.91 ±7.72 vs. 7.65 ±5.66 mm/h, <i>p</i> = 0.010) than biologic users, despite similar Axial Spondyloarthritis Disease Activity Score with CRP score. Mean inflammation, tissue damage, and total ultrasound (US) enthesitis scores were 4.85 ±4.37, 6.44 ±4.44, and 11.24 ±8.21, respectively, with no significant difference between treatment groups. Seven biologic-treated, overweight, or obese patients had markedly elevated total US scores (30.43 ±5.83), suggesting persistent entheseal inflammation and structural damage.</p><p><strong>Conclusions: </strong>Ultrasound-based enthesitis scoring may reveal subclinical disease activity in r-axSpA patients in remission, highlighting the added value of integrating musculoskeletal US into disease monitoring.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"63 6","pages":"389-397"},"PeriodicalIF":1.7,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12824998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}