Effects of diaphragmatic breathing exercise on sleeping quality, cortisol, cardiovascular autonomic functions, depression, and fatigue: a randomized-controlled trial in women with systemic sclerosis.

IF 1.7 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI:10.5114/reum/200193
Ali Mohamed Ali Ismail, Nadia Saad Sayed Ahmed El Gressy, Mona Darwish Hegazy, Omnia Saeed Mahmoud Ahmed, Ahmed Mohamed Abdel-Halim Elfahl
{"title":"Effects of diaphragmatic breathing exercise on sleeping quality, cortisol, cardiovascular autonomic functions, depression, and fatigue: a randomized-controlled trial in women with systemic sclerosis.","authors":"Ali Mohamed Ali Ismail, Nadia Saad Sayed Ahmed El Gressy, Mona Darwish Hegazy, Omnia Saeed Mahmoud Ahmed, Ahmed Mohamed Abdel-Halim Elfahl","doi":"10.5114/reum/200193","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The available pharmacotherapies (immunosuppressant therapies) for systemic sclerosis (SSc) are not curative, especially in cases with non-lethal but challenging manifestations or complications of the disease. Fatigue, anxiety, depression, an over-activated hypothalamic-pituitary- adrenal axis (stress axis), and low sleeping quality are the common SSc-induced non-lethal manifestations that need close management. Diaphragmatic breathing tele-exercise (DBTE), as a standalone deep breathing retraining and tele-interventional technique, has not been utilized in the rehabilitation context of non-lethal complications in women with SSc. This online interventional study aimed to explore the efficacy of DBTE in controlling depression, cardiovascular autonomic functions, stress, sleep, and anxiety in women with SSc.</p><p><strong>Material and methods: </strong>This randomized controlled tele-interventional trial recruited 40 non-obese women with SSc (aged > 18 years old) from an Egyptian teaching hospital. Women were randomly assigned to the DBTE group (<i>n</i> = 20) or non-DBTE group (<i>n</i> = 20). The DBTE group underwent 12-week 20-minute morning and evening DBTE sessions (sessions were supervised daily through the Zoom video conference program). The non-DBTE group served as a waitlist control group. The outcomes of this study were diastolic blood pressure (BPD), serum cortisol, the total score of the Hamilton Anxiety Rating Scale (HARS-TS), systolic blood pressure (BPS), the general score of the Pittsburgh Sleep Quality Index (PSQI-GS), pulse rate (PR), the eight-item Patient Health Questionnaire (EI-PHQ<sub>8</sub>), respiratory rate (RR), and the Visual Analogue Scale of fatigue (VAS-F).</p><p><strong>Results: </strong>In the DBTE group, there were significantly lowered values of PSQI-GS, HARS-TS, EI-PHQ<sub>8</sub>, serum cortisol, VAS-F, and cardiovascular/respiratory autonomic functions (BPS, BPD, RR, and PR). In the non-DBTE group, no significant changes were observed for any variables.</p><p><strong>Conclusions: </strong>It can be concluded from this tele-interventional trial that the 12-week application of DBTE may reduce cortisol, EI-PHQ<sub>8</sub>, PSQI-GS, HARS-TS, BPS, BPD, RR, PR, and VAS-F in women with SSc.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"63 2","pages":"89-96"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138990/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reumatologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/reum/200193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: The available pharmacotherapies (immunosuppressant therapies) for systemic sclerosis (SSc) are not curative, especially in cases with non-lethal but challenging manifestations or complications of the disease. Fatigue, anxiety, depression, an over-activated hypothalamic-pituitary- adrenal axis (stress axis), and low sleeping quality are the common SSc-induced non-lethal manifestations that need close management. Diaphragmatic breathing tele-exercise (DBTE), as a standalone deep breathing retraining and tele-interventional technique, has not been utilized in the rehabilitation context of non-lethal complications in women with SSc. This online interventional study aimed to explore the efficacy of DBTE in controlling depression, cardiovascular autonomic functions, stress, sleep, and anxiety in women with SSc.

Material and methods: This randomized controlled tele-interventional trial recruited 40 non-obese women with SSc (aged > 18 years old) from an Egyptian teaching hospital. Women were randomly assigned to the DBTE group (n = 20) or non-DBTE group (n = 20). The DBTE group underwent 12-week 20-minute morning and evening DBTE sessions (sessions were supervised daily through the Zoom video conference program). The non-DBTE group served as a waitlist control group. The outcomes of this study were diastolic blood pressure (BPD), serum cortisol, the total score of the Hamilton Anxiety Rating Scale (HARS-TS), systolic blood pressure (BPS), the general score of the Pittsburgh Sleep Quality Index (PSQI-GS), pulse rate (PR), the eight-item Patient Health Questionnaire (EI-PHQ8), respiratory rate (RR), and the Visual Analogue Scale of fatigue (VAS-F).

Results: In the DBTE group, there were significantly lowered values of PSQI-GS, HARS-TS, EI-PHQ8, serum cortisol, VAS-F, and cardiovascular/respiratory autonomic functions (BPS, BPD, RR, and PR). In the non-DBTE group, no significant changes were observed for any variables.

Conclusions: It can be concluded from this tele-interventional trial that the 12-week application of DBTE may reduce cortisol, EI-PHQ8, PSQI-GS, HARS-TS, BPS, BPD, RR, PR, and VAS-F in women with SSc.

横膈膜呼吸运动对睡眠质量、皮质醇、心血管自主神经功能、抑郁和疲劳的影响:一项系统性硬化症女性的随机对照试验
系统性硬化症(SSc)的现有药物治疗(免疫抑制疗法)无法治愈,特别是在非致命性但具有挑战性的表现或疾病并发症的情况下。疲劳、焦虑、抑郁、过度激活的下丘脑-垂体-肾上腺轴(应激轴)和低睡眠质量是ssc引起的常见非致命性表现,需要密切治疗。膈肌呼吸远程训练(DBTE)作为一种独立的深呼吸再训练和远程介入技术,尚未应用于SSc女性非致命性并发症的康复。本在线介入研究旨在探讨DBTE在控制SSc女性抑郁、心血管自主神经功能、压力、睡眠和焦虑方面的疗效。材料和方法:这项随机对照远程介入试验从埃及一家教学医院招募了40名患有SSc的非肥胖女性(年龄在0 ~ 18岁)。女性被随机分配到DBTE组(n = 20)和非DBTE组(n = 20)。DBTE组接受了为期12周的早晚20分钟DBTE课程(课程每天通过Zoom视频会议程序进行监督)。非dbte组作为等待名单对照组。研究结果包括:舒张压(BPD)、血清皮质醇、汉密尔顿焦虑评定量表(HARS-TS)总分、收缩压(BPS)、匹兹堡睡眠质量指数(PSQI-GS)总分、脉搏率(PR)、患者健康问卷(EI-PHQ8)、呼吸频率(RR)、疲劳视觉模拟量表(VAS-F)。结果:DBTE组PSQI-GS、HARS-TS、EI-PHQ8、血清皮质醇、VAS-F、心血管/呼吸自主神经功能(BPS、BPD、RR、PR)均显著降低。在非dbte组中,没有观察到任何变量的显著变化。结论:远程介入试验表明,应用DBTE 12周可降低SSc女性的皮质醇、EI-PHQ8、PSQI-GS、HARS-TS、BPS、BPD、RR、PR和VAS-F。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信