Reumatologia最新文献

{"title":"Late-onset systemic sclerosis: current concepts, uncertainties, and future practice guidelines.","authors":"Chokan Baimukhamedov, Galiya Assanova","doi":"10.5114/reum/221033","DOIUrl":"10.5114/reum/221033","url":null,"abstract":"","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"75-76"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct profiles of circulating lymphocytes reflect clinical and serological variations in idiopathic inflammatory myopathies.","authors":"Aleksandra Opinc-Rosiak, Joanna Sarnik, Joanna Makowska","doi":"10.5114/reum/213516","DOIUrl":"10.5114/reum/213516","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune diseases characterized by muscle inflammation and systemic involvement. The study aimed to evaluate the immunophenotypic profile of circulating lymphocytes in patients with IIM and investigate its association with clinical manifestations, serological profiles, treatment regimens, and disease outcomes.</p><p><strong>Material and methods: </strong>This single-center, cross-sectional study included 40 patients with IIM and 5 age- and sex-matched healthy controls. Peripheral blood samples were collected and processed to isolate peripheral blood mononuclear cells using the density gradient centrifugation method. Flow cytometry analysis was performed to phenotype lymphocyte subpopulations, including T cells (CD3+CD4+ and CD3+CD8+), B cells (CD3-CD19+), and natural killer (NK) cells (CD3-CD16+CD56+). Statistical analysis was conducted to compare lymphocyte profiles between the study and control groups and to assess correlations with clinical features, serological markers, and treatment regimens.</p><p><strong>Results: </strong>The IIM group had a mean age of 58.55 ±12.70 years, with a predominance of females (60%). The most common IIM subtypes were antisynthetase syndrome (35%) and dermatomyositis (30%). No significant differences in the profiles of circulating lymphocytes were found between IIM patients and healthy controls. Patients with cardiac involvement had significantly higher proportions of double-positive T cells (<i>p</i> = 0.0035), while those with cutaneous ulcers and dysphagia showed significantly lower proportions of CD4+CD8+ T cells. Natural killer cells were significantly lower in patients with anti-Mi2 antibodies (<i>p</i> = 0.0155) but higher in anti-Ro52 positive patients (<i>p</i> = 0.0150). In contrast, B cells were notably higher in patients with anti-Mi2 (<i>p</i> = 0.0182) and lower in individuals with anti-Ro52 (<i>p</i> = 0.0124). Patients with anti-Ro52 positivity were also characterized by higher proportions of double-negative T cells (<i>p</i> = 0.0465). Treatment regimens did not impact the profiles of circulating lymphocytes.</p><p><strong>Conclusion: </strong>Patients with IIM exhibit distinct alterations in lymphocyte subpopulations, with specific immune cell profiles associated with clinical phenotypes and serological profiles.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"94-104"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial asymmetry and mandibular hypomobility as early indicators of temporomandibular joint involvement in juvenile idiopathic arthritis.","authors":"Tamara Pawlaczyk-Kamieńska","doi":"10.5114/reum/214399","DOIUrl":"10.5114/reum/214399","url":null,"abstract":"<p><p>Temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA) is often underrecognized. A comprehensive review highlights a frequent discrepancy between clinical symptoms and radiologic findings in TMJ arthritis among JIA patients. Key clinical indicators include facial asymmetry, limited mouth opening, and mandibular deviation. We present a case of a 9-year-old girl with JIA and no reported TMJ symptoms. Clinical assessment revealed facial asymmetry, mandibular deviation, and restricted mandibular mobility. Cone beam computed tomography showed the presence of unilateral condylar flattening and shortening of the mandibular ramus. This case underscores the importance of recognizing facial asymmetry and mandibular hypomobility as potential early indicators of TMJ arthritis in children with JIA, even in the absence of any symptoms or signs. Early detection through attention to subtle morphofunctional signs is imperative for improving patient outcomes in asymptomatic JIA cases.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"151-158"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum low-density lipoprotein and synovial vascularity in patients with active rheumatoid arthritis and psoriatic arthritis.","authors":"Michał Jakubaszek, Brygida Kwiatkowska, Mateusz Płaza, Maria Maślińska","doi":"10.5114/reum/213263","DOIUrl":"10.5114/reum/213263","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between lipid metabolism and inflammatory activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) remains unclear. This study evaluated whether serum low-density lipoprotein cholesterol (LDL-C) levels are associated with synovial vascularization measured by quantitative power Doppler ultrasonography (PDUS) in patients with active RA and PsA.</p><p><strong>Material and methods: </strong>The single-center study enrolled 60 patients diagnosed with RA and a group of 20 patients with PsA with the clinical presentation resembling RA. Serum LDL-C levels were measured, and disease activity was assessed using the Disease Activity Score in 28 joints with erythrocyte sedimentation rate and the Simplified Disease Activity Index. Synovial membrane vascularization was quantified using PDUS, and a vascularity index - the PDUS index (INDEX%) - was calculated in the region of interest.</p><p><strong>Results: </strong>No significant correlation was found between serum LDL-C concentration and INDEX% for both groups (<i>r</i> = 0.2). The majority of patients in both groups (76.2%) had LDL-C levels in the normal range, consistent with the lipid paradox in inflammation.</p><p><strong>Conclusions: </strong>Serum LDL-C levels were not correlated with INDEX%. These findings suggest that LDL-C levels do not significantly influence synovial membrane vascularization in patients with active RA or PsA.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"77-82"},"PeriodicalIF":2.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary and serum magnesium in children with juvenile idiopathic arthritis: a case-control study.","authors":"Oksana Boyarchuk, Nataliia Kovalchuk, Vira Synytska","doi":"10.5114/reum/214398","DOIUrl":"10.5114/reum/214398","url":null,"abstract":"<p><strong>Introduction: </strong>Magnesium is essential in numerous physiological processes, including the inflammatory response. However, its role in the pathogenesis and progression of juvenile idiopathic arthritis (JIA) remains underexplored. This study aimed to assess dietary magnesium intake and serum magnesium levels in children with JIA and to evaluate their potential impact on the clinical course of the disease.</p><p><strong>Material and methods: </strong>This case-control study included 42 children with JIA and 67 healthy controls aged 2 to 18 years. Juvenile idiopathic arthritis was diagnosed according to International League of Associations for Rheumatology criteria. Dietary magnesium intake was assessed in 26 JIA patients using a food frequency questionnaire, which collected information on the weekly consumption of foods rich in magnesium. The average weekly and daily magnesium intake was calculated and compared with national and international dietary recommendations. Serum magnesium levels were measured using the colorimetric method.</p><p><strong>Results: </strong>Children with JIA had significantly lower dietary magnesium intake (median: 227.71 mg/day vs. 261.18 mg/day, <i>p</i> = 0.040) and serum magnesium concentrations (mean: 0.79 mmol/l vs. 0.94 mmol/l, <i>p</i> = 0.009) than healthy controls. Insufficient dietary intake was more prevalent in the JIA group (50.0%) compared to controls (26.9%) (<i>p</i> < 0.034). Juvenile idiopathic arthritis patients with insufficient dietary magnesium intake were more likely to be male (<i>p</i> = 0.006), older than 12 years (<i>p</i> = 0.049), and residing in urban areas (<i>p</i> = 0.002). Hypomagnesemia was more common in boys (<i>p</i> = 0.030). However, neither low magnesium intake nor hypomagnesemia significantly influenced JIA disease activity.</p><p><strong>Conclusions: </strong>Children with JIA demonstrate significantly lower dietary and serum magnesium levels than their healthy peers. Larger pediatric studies are needed to clarify the potential contribution of magnesium to the development and clinical course of JIA.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 3","pages":"200-208"},"PeriodicalIF":2.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicentre study for clinical phenotype prediction in juvenile dermatomyositis: categorical principal component analysis-based hierarchical clustering.","authors":"Rüya Torun, Müşerref Kasap Cüceoğlu, Elif Arslanoğlu Aydın, Selen Duygu Arık, Aybüke Günalp, Kadir Ulu, Hülya Köse, Çisem Yıldız, Nihal Şahin, Özge Baba, Ceyhun Açarı, Kübra Öztürk, Gülşah Kılbaş, Hatice Adıgüzel Dündar, Selçuk Yüksel, Mukaddes Kalyoncu, Hafize Emine Sönmez, Sevcan Bakkaloğlu, Sara Şebnem Kılıç, Betül Sözeri, Özgür Kasapçopur, Nuray Aktay Ayaz, Esra Bağlan, Yelda Bilginer, Pembe Keskinoğlu, Erbil Ünsal","doi":"10.5114/reum/209913","DOIUrl":"10.5114/reum/209913","url":null,"abstract":"<p><strong>Introduction: </strong>Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in childhood and exhibits a heterogeneous disease course. This study aimed to analyse and identify phenotypic clusters by examining the laboratory findings, nailfold capillaroscopy results, and myositis-specific autoantibodies (MSAs) in patients with JDM.</p><p><strong>Material and methods: </strong>This retrospective cohort study included data from patients with JDM treated at the Paediatric Rheumatology Departments of 14 advanced health centres in Turkey. A categorical principal component analysis (CATPCA)-based hierarchical cluster analysis method was employed for clustering.</p><p><strong>Results: </strong>A total of 176 JDM patients were enrolled, and 5 phenotypic clusters were identified using 23 categorical variables. These clusters were interpreted as follows: Cluster A with severe muscle weakness and oesophageal involvement requiring intensive immunosuppressive treatment; Cluster B with amyopathic/hypomyopathic patients; Cluster C with skin manifestations and lung involvement; Cluster D with complicated skin manifestations; and Cluster E with classic JDM. The clinical and laboratory findings and treatments of these 5 clusters were compared. Fatigue, myalgia, photosensitivity, Raynaud's phenomenon, and the use of pulse glucocorticosteroids, intravenous immunoglobulin, and cyclophosphamide treatments differed between the groups (<i>p</i> < 0.001, <i>p</i> = 0.002, <i>p</i> = 0.015, <i>p</i> = 0.036, <i>p</i> = 0.002, <i>p</i> = 0.006, and <i>p</i> = 0.024, respectively). Myositis-specific autoantibodies results were available for 119 patients (65.3%). The most frequent MSAs were antinuclear matrix protein 2 (26.1%) and anti-transcription intermediary factor 1 (20.9%). However, no significant differences were found in MSAs or nailfold capillaroscopy findings.</p><p><strong>Conclusions: </strong>We identified 5 clusters based on patient symptoms and findings. The identification of these 5 clusters can guide more effective treatment strategies in clinical practice. Additionally, these approaches may contribute to improving patients' quality of life and long-term outcomes by increasing the feasibility of individualised treatment.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"83-93"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular complications in psoriasis and psoriatic arthritis.","authors":"Raman Nitskovich, Anna Suchecka, Maria Maślińska, Dorota Kopacz, Weronika Herniczek, Irena Walecka","doi":"10.5114/reum/217810","DOIUrl":"10.5114/reum/217810","url":null,"abstract":"<p><p>Ophthalmologic symptoms are reported in 10-67% of psoriasis (Ps) cases and affect up to 31% of patients with psoriatic arthritis (PsA). The most common include blepharitis, eyelid involvement, uveitis, dry eye syndrome, conjunctivitis, corneal changes, and cataract. Despite the relatively common eye involvement, these symptoms are often overlooked or inadequately managed. Therefore, dermatologists and rheumatologists should interview patients for eye-related complaints to effectively identify and treat patients with ocular manifestations. In some cases, direct collaboration with ophthalmologists is also necessary for comprehensive patient management. The purpose of this intradisciplinary review is to discuss the most common eye symptoms among Ps and PsA patients, which should be considered as a basis for formulating guidelines for Ps treatment by dermatologists, ophthalmologists, rheumatologists, general practitioners and other specialists. In addition, we propose a simple diagnostic and therapeutic algorithm to facilitate the management of patients with Ps and accompanying symptoms of uveitis.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 3","pages":"230-241"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathic pain in rheumatoid arthritis: prevalence and associated factors.","authors":"Selma Bouden, Haifa Khemir, Leila Rouached, Aicha Ben Tekaya, Siwar Ben Dhia, Ines Mahmoud, Rawdha Tekaya, Olfa Saidane, Leila Abdelmoula","doi":"10.5114/reum/208944","DOIUrl":"10.5114/reum/208944","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess the prevalence of neuropathic pain in rheumatoid arthritis (RA) patients, and to identify associated factors.</p><p><strong>Material and methods: </strong>We conducted a cross-sectional study in patients with RA. Neuropathic pain was evaluated using the DN4 (Douleur Neuropathique 4) and PainDETECT scores. Agreement between the 2 questionnaires was estimated through Cohen's <b>k</b>. Factors associated with neuropathic pain were assessed.</p><p><strong>Results: </strong>A total of 121 patients with RA were included, with a mean age of 57 ±12.2 years, and a predominance of women (83%). The mean duration of RA was 16 ±1.0 years. The mean Disease Activity Score in 28 joints (DAS28) was 4.28 ±1.0, indicating moderate activity of the RA. According to the DN4 score, 61.2% of patients had neuropathic pain, and according to the PainDETECT score, 47.1% of patients were identified as having possible or likely neuropathic pain. Eighty-four patients (69.4%) had a positive DN4 score and/or a positive PainDETECT score. The coefficient of agreement k between the 2 tests was 0.233, indicating a fair agreement. Factors significantly associated with the presence of neuropathic pain were: female sex (<i>p</i> = 0.01), prolonged morning stiffness duration (<i>p</i> = 0.01), number of painful joints (<i>p</i> = 0.01), and number of swollen joints (<i>p</i> = 0.03). Additionally, the use of glucocorticosteroids (<i>p</i> = 0.001), analgesics (<i>p</i> = 0.03) and anti-CD20 drugs (<i>p</i> = 0.03) were significantly associated with neuropathic.</p><p><strong>Conclusion: </strong>Our study suggests a potentially high prevalence of neuropathic pain in patients with RA, highlighting the need for early detection and appropriate management.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"132-138"},"PeriodicalIF":2.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seronegative polymyalgia rheumatica: an update.","authors":"Ciro Manzo","doi":"10.5114/reum/218505","DOIUrl":"10.5114/reum/218505","url":null,"abstract":"","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"159-160"},"PeriodicalIF":2.5,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and laboratory differences in characteristics of patients with early-onset and late-onset systemic lupus erythematosus: a single-center retrospective study.","authors":"Radosław Dziedzic, Lech Zaręba, Andżelika Siwiec-Koźlik, Magdalena Spałkowska, Agnieszka Padjas, Stanisława Bazan-Socha, Mariusz Korkosz, Joanna Kosałka-Węgiel","doi":"10.5114/reum/208170","DOIUrl":"10.5114/reum/208170","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic lupus erythematosus (SLE) is a complex autoimmune disease with clinical and laboratory characteristics influenced by the age of onset. Despite its significance, data on late-onset SLE (Lo-SLE) compared to early-onset SLE (Eo-SLE) remain limited, particularly in the Polish population. We investigated differences between Lo-SLE and Eo-SLE patients (using 50 years as a cutoff), aiming to improve the diagnosis and management of SLE patients across different age groups.</p><p><strong>Material and methods: </strong>We conducted a retrospective analysis of medical records from all SLE patients treated at the University Hospital in Krakow, Poland, from 2012 to 2022. All included patients met the 2019 European Alliance of Associations for Rheumatology and American College of Rheumatology classification criteria for SLE.</p><p><strong>Results: </strong>We analyzed 710 patients with Eo-SLE (77.9%) and 201 patients with Lo-SLE (22.1%). Compared to the Eo-SLE group, the Lo-SLE group exhibited shorter disease duration (<i>p</i> < 0.001), a higher mortality rate (<i>p</i> < 0.001), and distinct clinical features: less involvement of the central nervous system (<i>n</i> = 5, 2.5% vs. <i>n</i> = 51, 7.23%, <i>p</i> = 0.014) and kidney (<i>n</i> = 49, 24.38% vs. <i>n</i> = 294, 41.41%, <i>p</i> < 0.001), more frequent interstitial lung disease (<i>n</i> = 19, 9.45% vs. <i>n</i> = 27, 3.84%, <i>p</i> = 0.001), and a higher prevalence of cardiovascular, metabolic, and neoplastic comorbidities (<i>p</i> < 0.05, for all). Autoantibody profiles also differed: in Lo-SLE compared to Eo-SLE patients, anti-SSB were more common, while anti-histone, anti-nucleosome, anti-RNP, and anti-dsDNA antibodies were less prevalent. Late-onset SLE patients received immunosuppressive treatment less often than Eo-SLE patients.</p><p><strong>Conclusions: </strong>Late-onset SLE patients exhibit different disease manifestations but with a higher prevalence of interstitial lung disease, internal medicine comorbidities, malignancies, and cardiovascular events compared to Eo-SLE. Our findings highlight the need for tailored management strategies in elderly SLE patients.</p>","PeriodicalId":21312,"journal":{"name":"Reumatologia","volume":"64 2","pages":"105-115"},"PeriodicalIF":2.5,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}