Evolving strategies in the treatment of rheumatoid arthritis: a historical perspective.

IF 1.7 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI:10.5114/reum/195012
Julia Domańska-Poboża, Małgorzata Wisłowska
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引用次数: 0

Abstract

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by joint inflammation, degradation of cartilage and bone, and potential systemic effects. This paper provides a comprehensive historical overview of RA treatment, tracing the evolution from ancient empirical methods to modern targeted therapies. Advancements in the understanding of RA's immunopathology have led to the development of conventional, biological, and targeted disease-modifying antirheumatic drugs, including tumor necrosis factor α inhibitors and Janus kinase inhibitors. These innovations have been pivotal in transforming RA management, allowing for more personalized and effective treatment strategies. The historical progression in RA treatment reflects a shift from symptomatic management to targeted interventions aimed at the underlying mechanisms of the disease. This shift has not only improved clinical outcomes but also enhanced the quality of life for those affected by RA, underscoring the importance of ongoing research and adaptation of therapeutic strategies.

类风湿关节炎治疗策略的演变:一个历史的视角。
类风湿性关节炎(RA)是一种慢性全身性炎症疾病,其特征是关节炎症、软骨和骨骼退化以及潜在的全身影响。本文对类风湿关节炎的治疗进行了全面的历史回顾,追溯了从古老的经验方法到现代靶向治疗的演变。对风湿性关节炎免疫病理的理解的进步导致了常规的、生物的和靶向的疾病改善抗风湿药物的发展,包括肿瘤坏死因子α抑制剂和Janus激酶抑制剂。这些创新在改变类风湿性关节炎的管理方面发挥了关键作用,允许更个性化和有效的治疗策略。类风湿关节炎治疗的历史进展反映了从症状管理到针对疾病潜在机制的有针对性干预的转变。这种转变不仅改善了临床结果,而且提高了RA患者的生活质量,强调了正在进行的研究和适应治疗策略的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
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