Revista espanola de cardiologia最新文献

{"title":"Migración de un ateroma gravemente calcificado durante el TAVI","authors":"Marta Herrero-Brocal , Almudena Ureña , Juan M. Ruiz-Nodar","doi":"10.1016/j.recesp.2025.01.019","DOIUrl":"10.1016/j.recesp.2025.01.019","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 9","pages":"Pages 831-832"},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la amiloidosis en los resultados tras el implante percutáneo de prótesis valvular aórtica","authors":"Luigi Gerra ,&nbsp;Tommaso Bucci ,&nbsp;Ho Man Lam ,&nbsp;Marta Mantovani ,&nbsp;Antonios A. Argyris ,&nbsp;Muath Alobaida ,&nbsp;Kully Sandhu ,&nbsp;Joseph Mills ,&nbsp;Giuseppe Boriani ,&nbsp;Gregory Y.H. Lip","doi":"10.1016/j.recesp.2025.01.018","DOIUrl":"10.1016/j.recesp.2025.01.018","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Data on the impact of amyloidosis on outcomes after transcatheter aortic valve implantation (TAVI) are limited. The objective of this study was to evaluate the 1-year risk of adverse events post-TAVI in patients with amyloidosis.</div></div><div><h3>Methods</h3><div>Patients undergoing TAVI (between 2005 and 2023) were categorized into 2 groups based on the presence of amyloidosis. The primary outcome was the 1-year risk of a composite endpoint: heart failure (HF), ischemic stroke, pacemaker implantation, acute kidney injury, and all-cause death. Secondary outcomes assessed the individual components of the composite. Propensity score matching was used to balance the groups, and Cox regression was used to assess the risk of adverse outcomes associated with amyloidosis. Composite outcomes were analyzed for early (30-days) and long-term (30-days to 1 year) follow-up.</div></div><div><h3>Results</h3><div>Data from 589 TAVI patients with amyloidosis (mean age 78.9<!--> <!-->±<!--> <!-->8.2 years, 31.9% female) were compared with 52 296 individuals without amyloidosis (mean age 78.1<!--> <!-->±<!--> <!-->8.8 years, 40.3% female). After propensity score matching, patients with amyloidosis had a significantly higher 1-year risk of adverse events (HR, 1.27; 95%CI, 1.08-1.49). Specifically, patients with amyloidosis showed an increased risk of HF (HR, 1.37; 95%CI, 1.10-1.70). Stroke risk (HR, 1.67; 95%CI, 1.16–2.40) and pacemaker implantation (HR, 2.25; 95%CI, 1.15-4.41) were higher during long-term follow-up, while no differences were found for acute kidney injury or all-cause mortality between the 2 groups.</div></div><div><h3>Conclusions</h3><div>Among patients undergoing TAVI, those with amyloidosis are at a higher risk of adverse events, particularly HF, and have an increased risk of pacemaker implantation and stroke in the long-term.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Pages 886-895"},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervención en la dieta mediterránea y evolución de la placa coronaria tras síndrome coronario agudo. El ensayo clínico MEDIMACS","authors":"Ana I. Fernández-Ávila ,&nbsp;Enrique Gutiérrez-Ibañes ,&nbsp;Álvaro Gabaldón ,&nbsp;Josep Gómez-Lara ,&nbsp;Miguel Ángel Martínez-González ,&nbsp;Javier Bermejo ,&nbsp;en representación de los investigadores del estudio MEDIMACS ,&nbsp;Irene Martín de Miguel ,&nbsp;Ricardo Sanz-Ruiz ,&nbsp;Elena Jurado ,&nbsp;Francisco Fernández-Avilés ,&nbsp;Cristina Razquin Burillo ,&nbsp;Rafael de la Torre ,&nbsp;Pablo Martínez-Legazpi ,&nbsp;Raquel Yotti ,&nbsp;Alex Mira ,&nbsp;Uri Gophna ,&nbsp;Roger Karlsson ,&nbsp;Reem Al-Daccak ,&nbsp;Dominique Charron","doi":"10.1016/j.recesp.2025.01.008","DOIUrl":"10.1016/j.recesp.2025.01.008","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 9","pages":"Pages 822-825"},"PeriodicalIF":5.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identificación de fenotipos en la insuficiencia cardiaca con fracción de eyección conservada a partir de 8.161 pacientes de 3 cohortes españolas","authors":"Òscar Miró ,&nbsp;Olivier Peyrony ,&nbsp;Joan Carles Trullàs ,&nbsp;Aitor Alquézar-Arbé ,&nbsp;Julio Núñez ,&nbsp;Pedro López-Ayala ,&nbsp;Javier Jacob ,&nbsp;Héctor Bueno ,&nbsp;Manuel Montero-Pérez-Barquero ,&nbsp;José Carlos Arévalo-Lorido ,&nbsp;Rafael de la Espriella ,&nbsp;Gema Miñana ,&nbsp;Juan Sanchis ,&nbsp;Pere Llorens","doi":"10.1016/j.recesp.2025.02.019","DOIUrl":"10.1016/j.recesp.2025.02.019","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>To identify phenotypes in heart failure with preserved ejection fraction (HFpEF), compare mortality, and investigate whether treatments have different effects according to phenotype.</div></div><div><h3>Methods</h3><div>We performed a secondary analysis of 8161 patients with HFpEF included in Spanish cardiology (INCLIVA), internal medicine (RICA), and emergency (EAHFE) registries. Phenotypic clusters based on 16 baseline characteristics were identified using latent class analysis. We analyzed crude and treatment-adjusted 1-year survival, the associations between each treatment and mortality, and their interactions with phenotype.</div></div><div><h3>Results</h3><div>We identified 4 distinct clusters. One-year mortality was 18.7%. Cluster 4 (younger women with a valvular heart disease phenotype) had the lowest mortality (13.7%; reference category), which increased progressively in cluster 2 (cardiometabolic phenotype; mortality: 15.7%; adjusted HR, 1.28; 95%<span>C</span>I, 1.06-1.54), cluster 3 (very elderly female phenotype; mortality: 20.4%; adjusted HR, 1.63; 95%CI, 1.40-1.90), and cluster 1 (male cardiorespiratory phenotype; mortality: 24.0%; adjusted HR, 1.81; 95%CI, 1.53-2.13). The results were very similar when each registry was analyzed individually. Treatment with renin-angiotensin system inhibitors was associated with better survival in all clusters, beta-blockers were beneficial in cluster 1, and anticoagulants in cluster 4. However, none of the treatments showed a differential association with prognosis according to phenotype.</div></div><div><h3>Conclusions</h3><div>This study defines 4 HFpEF phenotypes with significantly different prognoses. Among the treatments analyzed, only renin-angiotensin system inhibitors seemed to have a generalized survival benefit, and none demonstrated a differential effect based on phenotype.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Pages 896-905"},"PeriodicalIF":5.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocarditis infecciosa: una amenaza creciente a pesar de los avances médicos. Una mirada a las tendencias en España","authors":"Lucía Cayuela ,&nbsp;Pablo del Valle Loarte ,&nbsp;Beatriz Valle Borrego ,&nbsp;Aurelio Cayuela","doi":"10.1016/j.recesp.2025.01.004","DOIUrl":"10.1016/j.recesp.2025.01.004","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Infective endocarditis (IE) is a serious public health problem both in Spain and worldwide. This study aimed to analyze the trends in the incidence of IE in Spain from 1992 to 2021.</div></div><div><h3>Methods</h3><div>We used IE incidence data from the Global Health Data Exchange and population data from the Spanish National Statistics Institute to analyze changes in age-standardized incidence rates. Joinpoint and Age-Period-Cohort (A-P-C) models were applied to identify significant trend changes and the effects of age, period, and birth cohort.</div></div><div><h3>Results</h3><div>The age-standardized incidence rates of IE increased from 17.5 cases per 100 000 population in 1992 to 30.8 per 100,000 in 2021 among men and from 16.8 per 100 000 in 1992 to 22.9 per 100 000 in 2021 among women. Joinpoint analysis revealed distinct trend changes, with men having a faster rate of increase (1.9%) compared with women (1.1%). The male-to-female incidence rate ratio peaked at 1.4, indicating a higher risk of IE among men. The incidence of IE was significantly influenced by age, period, and cohort. Both sexes showed increasing risk with age. Risk increased in women born in the late 20th and early 21st centuries compared with earlier cohorts. Men in these later cohorts showed a decreasing risk. Period effects increased from the 1990s to the mid-2000s and then declined, especially among men.</div></div><div><h3>Conclusions</h3><div>This study reveals a significant increase in the incidence of IE in Spain, especially among older adults and men. These trends reflect demographic changes, medical advances, and changing risk factors.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 8","pages":"Pages 717-723"},"PeriodicalIF":5.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la tortuosidad de las arterias coronarias en los resultados del implante de stent farmacoactivo de nueva generación: un análisis de los estudios aleatorizados BIOFLOW","authors":"Nader Mankerious ,&nbsp;Ralph Toelg ,&nbsp;Mohammad Abdelghani ,&nbsp;Hector M. Garcia-Garcia ,&nbsp;Serdar Farhan ,&nbsp;Abdelhakim Allali ,&nbsp;Stephan Windecker ,&nbsp;Thierry Lefèvre ,&nbsp;Shigeru Saito ,&nbsp;David E. Kandzari ,&nbsp;Ron Waksman ,&nbsp;Gert Richardt ,&nbsp;Rayyan Hemetsberger","doi":"10.1016/j.recesp.2024.12.011","DOIUrl":"10.1016/j.recesp.2024.12.011","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Patients undergoing percutaneous coronary intervention in vessels with moderate-to-severe tortuosity are at higher risk of adverse outcomes, but data are scarce in the era of newer-generation stents. We compared outcomes following percutaneous coronary intervention in vessels with moderate-to-severe tortuosity using a bioresorbable-polymer sirolimus-eluting stent (BP-SES) vs a durable-polymer everolimus-eluting stent (DP-EES).</div></div><div><h3>Methods</h3><div>A total of 2350 patients from the BIOFLOW II, IV, and V randomized trials were stratified into 2 groups based on target-vessel tortuosity: none-to-mild and moderate-to-severe. The primary endpoints included target lesion failure (TLF)—a composite of cardiac death, target-vessel myocardial infarction (TV-MI), or ischemia-driven target lesion revascularization (TLR)—and probable/definite stent thrombosis at 3 years.</div></div><div><h3>Results</h3><div>Patients with moderate-to-severe tortuosity (n<!--> <!-->=<!--> <!-->903) had more comorbidities than those with none-to-mild tortuosity (n<!--> <!-->=<!--> <!-->1447). Rates of TLF (<em>P</em> <!-->=<!--> <!-->.354), cardiac death (<em>P</em> <!-->=<!--> <!-->.690), TLR (<em>P</em> <!-->=<!--> <!-->.447), and stent thrombosis (<em>P</em> <!-->=<!--> <!-->.084) were similar between the 2 groups, whereas TV-MI occurred more frequently in the moderate-to-severe tortuosity group (<em>P</em> <!-->=<!--> <!-->.031). However, on multivariate analysis, moderate-to-severe tortuosity was not an independent predictor of TV-MI (adjusted HR, 1.06; 95% CI, 0.72-1.55; <em>P</em> <!-->=<!--> <!-->.772). Among patients with moderate-to-severe tortuosity, the use of BP-SES was associated with significantly lower rates of TLF compared with the DP-EES (7.8% vs 13.4%; HR, 0.57; 95% CI, 0.37-0.87; <em>P</em> <!-->=<!--> <!-->.009), driven by reductions in TV-MI (5.0% vs 9.2%; HR, 0.54; 95% CI, 0.32-0.90; <em>P</em> <!-->=<!--> <!-->.018) and TLR (2.7% vs 6.1%; HR, 0.45; 95% CI, 0.23-0.90; <em>P</em> <!-->=<!--> <!-->.021).</div></div><div><h3>Conclusions</h3><div>This pooled analysis of the randomized BIOFLOW trials demonstrates that patients with none-to-mild and moderate-to-severe tortuosity have comparable long-term adverse event rates. However, the use of BP-SES in patients with moderate-to-severe tortuosity may help mitigate potential ischemic risks.</div><div>Clinical trial registration: Clinicaltrials.gov <span><span>NCT01356888</span><svg><path></path></svg></span>, <span><span>NCT01939249</span><svg><path></path></svg></span>, <span><span>NCT02389946</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 8","pages":"Pages 682-691"},"PeriodicalIF":5.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asociación entre enfermedades autoinmunitarias y mortalidad por cualquier causa en pacientes con arritmias cardiacas","authors":"Le Li,&nbsp;Lingmin Wu,&nbsp;Zhicheng Hu,&nbsp;Limin Liu,&nbsp;Likun Zhou,&nbsp;Zhuxin Zhang,&nbsp;Minghao Zhao,&nbsp;Yulong Xiong,&nbsp;Zhenhao Zhang,&nbsp;Lihui Zheng,&nbsp;Ligang Ding,&nbsp;Yan Yao","doi":"10.1016/j.recesp.2024.12.004","DOIUrl":"10.1016/j.recesp.2024.12.004","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Autoimmune diseases (ADs) are associated with an increased risk of developing certain cardiac arrhythmias. However, their prognostic effect in patients with cardiac arrhythmias has not been comprehensively investigated. We aimed to assess the association between ADs and prognosis in this population.</div></div><div><h3>Methods</h3><div>Based on a large retrospective observational cohort, this study included patients with various cardiac arrhythmias, including atrial fibrillation/atrial flutter (AF/AFl), ventricular tachycardia/ventricular fibrillation (VT/VF), and bradyarrhythmias. ADs were considered an exposure factor. The endpoint was all-cause mortality. Cox proportional hazards regression analyses were performed to calculate hazard ratios (HR) and 95% confidence intervals (95%CI) to quantify associations. Propensity score matching was used to mitigate potential confounding bias.</div></div><div><h3>Results</h3><div>The analysis included 14 225 patients (mean age, 73.9<!--> <!-->±<!--> <!-->12.5 years, 59.2% women), of whom 4552 (32.0%) died within 1 year of discharge. After adjustment for various covariates, patients with ADs showed a higher risk of mortality in AF/AFl (HR, 1.23; 95%CI, 1.1-1.33; <em>P</em> <!-->&lt;<!--> <!-->.001) and VT/VF (HR, 1.28; 95%CI, 1.02-1.60, <em>P</em> <!-->=<!--> <!-->.032). For bradyarrhythmias, although a potential association was observed, the trend did not reach statistical significance (HR, 1.20; 95%CI, 0.93-1.56; <em>P</em> <!-->=<!--> <!-->.168). The association persisted among multiple sensitivity analyses and remained consistent after adjustment for a wide range of covariates.</div></div><div><h3>Conclusions</h3><div>ADs were significantly associated with an increased risk of all-cause mortality in patients with cardiac arrhythmias, particularly in those with AF/AFl and VT/VF.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 7","pages":"Pages 609-617"},"PeriodicalIF":5.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cierre percutáneo de fístulas coronarias múltiples: una clasificación anatómica basada en la angiografía por tomografía computarizada coronaria","authors":"Peijian Wei ,&nbsp;Yihang Li ,&nbsp;Fengwen Zhang ,&nbsp;Zhongying Xu ,&nbsp;Liang Xu ,&nbsp;Junyi Wan ,&nbsp;Shiguo Li ,&nbsp;Wenbin Ouyang ,&nbsp;Shouzheng Wang ,&nbsp;Gejun Zhang ,&nbsp;Gary Tse ,&nbsp;Jeffrey Shi Kai Chan ,&nbsp;Fang Fang ,&nbsp;Xiangbin Pan","doi":"10.1016/j.recesp.2024.06.012","DOIUrl":"10.1016/j.recesp.2024.06.012","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>This study aimed to retrospectively analyze the anatomical characteristics and classification of multiple coronary artery fistulas (MCAFs), and to compare the outcomes of transcatheter closure between MCAFs and single fistulas.</div></div><div><h3>Methods</h3><div>All patients who underwent attempts at transcatheter closure of coronary artery fistulas (CAFs) at Fuwai Hospital from 2010 to 2023 were retrospectively reviewed. Patients were categorized into single fistula and MCAFs groups, and anatomical characteristics and transcatheter closure outcomes were compared between the 2 groups.</div></div><div><h3>Results</h3><div>This retrospective study included 146 patients who underwent attempted transcatheter closure of CAFs, with a 14.38% failure rate. Among the 146 patients with CAFs, 32.19% were identified as having MCAFs, with types I, II, and III constituting 40.43%, 42.55%, and 17.02%, respectively. Unlike single fistulas, which predominantly originated from the right coronary artery and terminated in the left ventricle, MCAFs mainly had simultaneous origins from the right coronary artery and left anterior descending artery (29.79%), and predominantly drained into the pulmonary artery (70.21%), with a notable prevalence of plexus-like morphology (38.3% vs 2.02%, <em>P</em> <!-->&lt;<!--> <!-->.001). The success rate of transcatheter closure was significantly lower for multiple fistulas compared with single fistula (64.29% vs 84.34%, <em>P</em> <!-->=<!--> <!-->.011). Multivariate regression analysis indicated that the risk of closure failure for MCAFs was 2.64 times that of single fistulas.</div></div><div><h3>Conclusions</h3><div>MCAFs are common among CAFs and can be classified into 3 types based on the number and location of their origins and terminations. The risk of failure of transcatheter closure is significantly higher in MCAFs than in single fistulas.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 206-217"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avances en nutrición de precisión y enfermedades cardiometabólicas","authors":"Miguel A. Martínez-González ,&nbsp;Francisco J. Planes ,&nbsp;Miguel Ruiz-Canela ,&nbsp;Estefanía Toledo ,&nbsp;Ramón Estruch ,&nbsp;Jordi Salas-Salvadó ,&nbsp;Rafael Valdés-Más ,&nbsp;Pedro Mena ,&nbsp;Olga Castañer ,&nbsp;Montse Fitó ,&nbsp;Clary Clish ,&nbsp;Rikard Landberg ,&nbsp;Clemens Wittenbecher ,&nbsp;Liming Liang ,&nbsp;Marta Guasch-Ferré ,&nbsp;Rosa M. Lamuela-Raventós ,&nbsp;Dong D. Wang ,&nbsp;Nita Forouhi ,&nbsp;Cristina Razquin ,&nbsp;Frank B. Hu","doi":"10.1016/j.recesp.2024.09.005","DOIUrl":"10.1016/j.recesp.2024.09.005","url":null,"abstract":"<div><div>A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: <em>a)</em> developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; <em>b)</em> incorporating more diverse populations and a broader range of dietary patterns; and <em>c)</em> conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 263-271"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historia clínica electrónica modelo agujero negro. ¡Basta ya!","authors":"Héctor Bueno","doi":"10.1016/j.recesp.2024.11.010","DOIUrl":"10.1016/j.recesp.2024.11.010","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 286-287"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}