Enrique Sánchez-Muñoz , Juan Antonio Requena-Ibáñez , Juan José Badimón
{"title":"Inhibición dual del SGLT1 y SGLT2: algo más que su suma","authors":"Enrique Sánchez-Muñoz , Juan Antonio Requena-Ibáñez , Juan José Badimón","doi":"10.1016/j.recesp.2024.01.005","DOIUrl":"10.1016/j.recesp.2024.01.005","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 7","pages":"Pages 510-514"},"PeriodicalIF":5.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139631262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albert Ariza-Solé , Francesc Formiga , David Monterde , Emili Vela , Elena Calvo , Josep Comín-Colet
{"title":"Grupos de morbilidad ajustada y valoración geriátrica integral en el paciente mayor con síndrome coronario agudo","authors":"Albert Ariza-Solé , Francesc Formiga , David Monterde , Emili Vela , Elena Calvo , Josep Comín-Colet","doi":"10.1016/j.recesp.2024.01.008","DOIUrl":"10.1016/j.recesp.2024.01.008","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 7","pages":"Pages 589-591"},"PeriodicalIF":5.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139879802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"En reconocimiento del origen español del CRISPR/Cas9. Implicaciones para el tratamiento de las cardiopatías familiares","authors":"María Sabater Molina , Juan Ramón Gimeno Blanes","doi":"10.1016/j.recesp.2024.01.012","DOIUrl":"10.1016/j.recesp.2024.01.012","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 7","pages":"Pages 597-598"},"PeriodicalIF":5.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandra Laricchia , Irene Bossi , Roberto A. Latini , Chuey Y. Lee , Ignacio S. Pérez , Fabrizio Tomai , Amin A. Nuruddin , Dario Buccheri , Giuseppe Seresini , Raymundo Ocaranza , Gunasekaran Sengottvelu , Nicola Pesenti , Antonio Mangieri , Bernardo Cortese , en representación de los investigadores del estudio EASTBOURNE
{"title":"Balón liberador de sirolimus en el tratamiento del síndrome coronario agudo y crónico: el estudio PEACE, un subanálisis del registro EASTBOURNE","authors":"Alessandra Laricchia , Irene Bossi , Roberto A. Latini , Chuey Y. Lee , Ignacio S. Pérez , Fabrizio Tomai , Amin A. Nuruddin , Dario Buccheri , Giuseppe Seresini , Raymundo Ocaranza , Gunasekaran Sengottvelu , Nicola Pesenti , Antonio Mangieri , Bernardo Cortese , en representación de los investigadores del estudio EASTBOURNE","doi":"10.1016/j.recesp.2023.11.013","DOIUrl":"10.1016/j.recesp.2023.11.013","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>The PEACE study (Performance of a sirolimus-eluting balloon strategy in acute and chronic coronary syndromes) investigated for the first time whether a sirolimus-coated balloon (SCB) (Magic Touch, Concept Medical, India) is associated with different outcomes depending on whether it is used in acute coronary syndromes (ACS) or chronic coronary syndromes (CCS).</p></div><div><h3>Methods</h3><p>This was a post-hoc analysis from the all-comers EASTBOURNE Registry (<span>NCT03085823</span><svg><path></path></svg>). Out of 2083 patients enrolled, an SCB was used to treat 968 (46.5%) ACS and 1115 (53.5%) CCS patients. The primary endpoint was target lesion revascularization at 12 months, while secondary endpoints were angiographic success and major adverse cardiovascular events.</p></div><div><h3>Results</h3><p>Baseline demographics, mean reference vessel diameter and mean lesion length were comparable between ACS and CCS. Predilatation was more commonly performed in ACS (<em>P</em> <!-->=<!--> <!-->.007). SCB was inflated at a standard pressure in both groups with a slight trend toward longer inflation time in ACS. Angiographic success was high in both groups (ACS 97.4% vs CCS 97.7%, <em>P</em> <!-->=<!--> <!-->.820) with limited bailout stenting. Similarly, at 12 months the cumulative incidence of target lesion revascularization (ACS 6.6% vs CCS 5.2%, <em>P</em> <!-->=<!--> <!-->.258) was comparable between ACS and CCS. Conversely, a higher rate of major adverse cardiovascular events in acute presenters was mainly driven by myocardial infarction recurrencies (ACS 10.4% vs CCS 8.3%, <em>P</em> <!-->=<!--> <!-->.009). In-stent restenosis showed a higher proportion of target lesion revascularization and major adverse cardiovascular events than de novo lesions, independently of the type of presentation at the index procedure.</p></div><div><h3>Conclusions</h3><p>This SCB shows good performance in terms of acute and 1-year outcomes independently of the clinical presentation.</p></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 7","pages":"Pages 527-536"},"PeriodicalIF":5.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ángela Prieto-Campo , Maruxa Zapata-Cachafeiro , Manuel Portela-Romero , María Piñeiro-Lamas , Adolfo Figueiras , Ángel Salgado-Barreira
{"title":"Impacto del uso previo de antiagregantes plaquetarios en la susceptibilidad, la progresión y la gravedad de la COVID-19: un estudio poblacional","authors":"Ángela Prieto-Campo , Maruxa Zapata-Cachafeiro , Manuel Portela-Romero , María Piñeiro-Lamas , Adolfo Figueiras , Ángel Salgado-Barreira","doi":"10.1016/j.recesp.2023.12.012","DOIUrl":"10.1016/j.recesp.2023.12.012","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Hypercoagulability and thromboembolism are processes that arise from severe acute respiratory syndrome coronavirus 2 infection and are responsible for a high degree of coronavirus disease 2019 (COVID-19)-related morbidity and mortality. This study sought to assess the effect of antiplatelet drugs on COVID-19 severity (risk of hospitalization and mortality), susceptibility to severe acute respiratory syndrome coronavirus 2 infection, and progression to severe COVID-19.</p></div><div><h3>Methods</h3><p>We conducted a population-based case-control study in a northwestern region of Spain in 2020. The study involved 3060 participants with a positive polymerase chain reaction test who were hospitalized, 26 757 participants with a positive polymerase chain reaction test who were not hospitalized, and 56 785 healthy controls.</p></div><div><h3>Results</h3><p>Triflusal seemed to be associated with a significant increase in risk of hospitalization (aOR, 1.97; 95%<span>C</span>I, 1.27-3.04) and susceptibility to infection (OR, 1.45; 95%CI, 1.07-1.96). It also appeared to lead to a nonsignificant increase in the risk of mortality (OR, 2.23; 95%CI, 0.89-5.55) and/or progression to more severe disease stages (OR, 1.42; 95%CI, 0.8-2.51). Aspirin seemed to be associated with a statistically significant decrease in susceptibility to severe acute respiratory syndrome coronavirus 2 infection (OR, 0.92; 95%CI, 0.86-0.98).</p></div><div><h3>Conclusions</h3><p>Triflusal use appears to increase the risk of susceptibility to COVID-19 infection and an even higher risk of hospitalization, whereas the other antiplatelets could be associated with a reduction in the risk of the various outcomes or have no effect on risk. These findings could support reconsideration of triflusal prescription in COVID-19 pandemic situations.</p></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 7","pages":"Pages 539-546"},"PeriodicalIF":5.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0300893223005420/pdfft?md5=11dd102338e22969e5ae455791b06f7e&pid=1-s2.0-S0300893223005420-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139828792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gladys Juncà , Albert Teis , Gizem Kasa , Elena Ferrer-Sistach , Nuria Vallejo , Jorge López-Ayerbe , Germán Cediel , Antoni Bayés-Genís , Victoria Delgado
{"title":"Tiempo de realización de la resonancia magnética cardiaca y valor diagnóstico en pacientes con infarto de miocardio sin obstrucción de arterias coronarias","authors":"Gladys Juncà , Albert Teis , Gizem Kasa , Elena Ferrer-Sistach , Nuria Vallejo , Jorge López-Ayerbe , Germán Cediel , Antoni Bayés-Genís , Victoria Delgado","doi":"10.1016/j.recesp.2023.11.009","DOIUrl":"10.1016/j.recesp.2023.11.009","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>The present study sought to establish the diagnostic yield of cardiovascular magnetic resonance (CMR) in a large cohort of patients admitted with myocardial infarction (MI) with nonobstructive coronary artery disease (MINOCA) based on the timing of referral to CMR.</p></div><div><h3>Methods</h3><p>Consecutive patients referred to CMR from January 2009 to February 2022 with a working diagnosis of MINOCA were retrospectively evaluated. Cine, T<sub>2</sub>-weighted, early, and late gadolinium-enhanced images were acquired and analyzed. The frequency of the underlying diagnosis and the association between timing of CMR and relative frequency of each diagnosis were assessed.</p></div><div><h3>Results</h3><p>We included 207 patients (median age 50 years, 60% men). Final diagnosis after CMR was achieved in 91% of the patients (myocarditis in 45%, MI in 20%, tako-tsubo cardiomyopathy in 19%, and other cardiomyopathies in 7%). The performance of CMR within 7 days of admission with MINOCA (median, 5 days; 117 patients) allowed a higher diagnostic yield compared with CMR performed later (median, 10 days; 88 patients) (96% vs 86%, <em>P</em> <!-->=<!--> <!-->.02). Although myocarditis was the most frequent diagnosis in both groups according to time to CMR, its frequency was higher among patients with a CMR performed within the first 7 days (53% vs 35%, <em>P</em> <!-->=<!--> <!-->.02). The frequency of other underlying diagnoses was not influenced by CMR timing.</p></div><div><h3>Conclusions</h3><p>CMR led to an underlying diagnosis of MINOCA in 91% of patients and its diagnostic yield increased to 96% when CMR was performed within 7 days of admission. The most frequent diagnosis was myocarditis.</p></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 7","pages":"Pages 515-523"},"PeriodicalIF":5.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140274515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryoung-Eun Ko , Jihye Lee , Sungeun Kim , Joong Hyun Ahn , Soo Jin Na , Jeong Hoon Yang
{"title":"Métodos de aprendizaje automático para el desarrollo de un modelo predictivo de delirio durante el ingreso en unidades de cuidados intensivos cardiacos","authors":"Ryoung-Eun Ko , Jihye Lee , Sungeun Kim , Joong Hyun Ahn , Soo Jin Na , Jeong Hoon Yang","doi":"10.1016/j.recesp.2023.12.015","DOIUrl":"10.1016/j.recesp.2023.12.015","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Delirium, recognized as a crucial prognostic factor in the cardiac intensive care unit (CICU), has evolved in response to the changing demographics among critically ill cardiac patients. This study aimed to create a predictive model for delirium for patients in the CICU.</p></div><div><h3>Methods</h3><p>This study included consecutive patients admitted to the CICU of the Samsung Medical Center. To assess the candidate variables for the model: we applied the following machine learning methods: random forest, extreme gradient boosting, partial least squares, and Plmnet-elastic.net. After selecting relevant variables, we performed a logistic regression analysis to derive the model formula. Internal validation was conducted using 100-repeated hold-out validation.</p></div><div><h3>Results</h3><p>We analyzed 2774 patients, 677 (24.4%) of whom developed delirium in the CICU. Machine learning-based models showed good predictive performance. Clinically significant and frequently important predictors were selected to construct a delirium prediction scoring model for CICU patients. The model included albumin level, international normalized ratio, blood urea nitrogen, white blood cell count, C-reactive protein level, age, heart rate, and mechanical ventilation. The model had an area under the receiver operating characteristics curve (AUROC) of 0.861 (95%CI, 0.843-0.879). Similar results were obtained in internal validation with 100-repeated cross-validation (AUROC, 0.854; 95%CI, 0.826-0.883).</p></div><div><h3>Conclusions</h3><p>Using variables frequently ranked as highly important in four machine learning methods, we created a novel delirium prediction model. This model could serve as a useful and simple tool for risk stratification for the occurrence of delirium at the patient's bedside in the CICU.</p></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 7","pages":"Pages 547-555"},"PeriodicalIF":5.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140088056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcos Ferrández-Escarabajal, Solomon W. Bienstock, Gina LaRocca
{"title":"Evaluación multimodal de un aneurisma de arteria coronaria con fístula arteriovenosa","authors":"Marcos Ferrández-Escarabajal, Solomon W. Bienstock, Gina LaRocca","doi":"10.1016/j.recesp.2024.05.007","DOIUrl":"10.1016/j.recesp.2024.05.007","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"77 11","pages":"Page 973"},"PeriodicalIF":5.9,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}