Revista espanola de cardiologia最新文献

{"title":"Shock cardiogénico en el infarto agudo de miocardio con enfermedad multivaso: estrategia de revascularización según el territorio isquémico","authors":"Ki Hong Choi ,&nbsp;Sang Yoon Lee ,&nbsp;Taek Kyu Park ,&nbsp;Joo Myung Lee ,&nbsp;Young Bin Song ,&nbsp;Joo-Yong Hahn ,&nbsp;Seung-Hyuk Choi ,&nbsp;Chul-Min Ahn ,&nbsp;Cheol Woong Yu ,&nbsp;Ik Hyun Park ,&nbsp;Woo Jin Jang ,&nbsp;Hyun-Joong Kim ,&nbsp;Jang-Whan Bae ,&nbsp;Sung Uk Kwon ,&nbsp;Hyun-Jong Lee ,&nbsp;Wang Soo Lee ,&nbsp;Jin-Ok Jeong ,&nbsp;Sang-Don Park ,&nbsp;Tae-Soo Kang ,&nbsp;Hyeon-Cheol Gwon ,&nbsp;Jeong Hoon Yang","doi":"10.1016/j.recesp.2024.05.010","DOIUrl":"10.1016/j.recesp.2024.05.010","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>The association of revascularization strategy with clinical outcomes according to the ischemic territory of nonculprit lesion has not been documented in patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS). This study aimed to compare outcomes between culprit-only and immediate multivessel percutaneous coronary intervention (PCI) according to ischemic territory in patients with AMI-CS.</div></div><div><h3>Methods</h3><div>A total of 536 patients with AMI-CS and multivessel disease from the SMART-RESCUE registry were categorized according to ischemic territory (nonculprit left main/proximal left anterior descending artery [LM/pLAD] vs culprit LM/pLAD vs no LM/pLAD). The primary outcome was a patient-oriented composite endpoint (POCE) consisting of all-cause death, myocardial infarction, rehospitalization due to heart failure, or repeat revascularization at 1 year.</div></div><div><h3>Results</h3><div>Among the total population, 108 patients had nonculprit LM/pLAD, 228 patients had culprit LM/pLAD, and 200 patients had no LM/pLAD, with the risk of POCE being higher in patients with large ischemic territory lesions (53.6% vs 53.4% vs 39.6%; <em>P</em> = .02). Multivessel PCI was associated with a significantly lower risk of POCE compared with culprit-only PCI in patients with nonculprit LM/pLAD (40.7% vs 66.9%; HR, 0.52; 95%<span>C</span>I, 0.29-0.91; <em>P<!--> </em>=<!--> <!-->.02), but not in those with culprit LM/pLAD (<em>P<!--> </em>=<!--> <!-->.46) or no LM/pLAD (<em>P<!--> </em>=<!--> <!-->.47). A significant interaction existed between revascularization strategy and large nonculprit ischemic territory (<em>P<!--> </em>=<!--> <!-->.03).</div></div><div><h3>Conclusions</h3><div>Large ischemic territory involvement was associated with worse clinical outcomes in patients with AMI-CS and multivessel disease. Immediate multivessel PCI might improve clinical outcomes in patients with a large nonculprit ischemic burden.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 97-106"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ejection fraction","authors":"Fernando A. Navarro","doi":"10.1016/j.recesp.2024.08.009","DOIUrl":"10.1016/j.recesp.2024.08.009","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Page 77"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo de eventos cardiovasculares graves tras agudizaciones de la EPOC: resultados del estudio EXACOS-CV en España","authors":"Salud Santos ,&nbsp;Nicolás Manito ,&nbsp;Joaquín Sánchez-Covisa ,&nbsp;Ignacio Hernández ,&nbsp;Carmen Corregidor ,&nbsp;Luciano Escudero ,&nbsp;Kirsty Rhodes ,&nbsp;Clementine Nordon","doi":"10.1016/j.recesp.2024.06.004","DOIUrl":"10.1016/j.recesp.2024.06.004","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>This real-world study—the first of its kind in a Spanish population—aimed to explore severe risk for cardiovascular events and all-cause death following exacerbations in a large cohort of patients with chronic obstructive pulmonary disease (COPD).</div></div><div><h3>Methods</h3><div>We included individuals with a COPD diagnosis code between 2014 and 2018 from the BIG-PAC health care claims database. The primary outcome was a composite of a first severe cardiovascular event (acute coronary syndrome, heart failure decompensation, cerebral ischemia, arrhythmia) or all-cause death following inclusion in the cohort. Time-dependent Cox proportional hazards models estimated HRs for associations between exposed time periods (1-7, 8-14, 15-30, 31-180, 181-365, and &gt;<!--> <!-->365 days) following an exacerbation of any severity, and following moderate or severe exacerbations separately (vs unexposed time before a first exacerbation following cohort inclusion).</div></div><div><h3>Results</h3><div>During a median follow-up of 3.03 years, 18 901 of 24 393 patients (77.5%) experienced ≥ 1 moderate/severe exacerbation, and 8741 (35.8%) experienced the primary outcome. The risk of a severe cardiovascular event increased following moderate/severe COPD exacerbation onset vs the unexposed period, with rates being most increased during the first 1 to 7 days following exacerbation onset (HR, 10.10; 95%CI, 9.29-10.97) and remaining increased &gt;<!--> <!-->365 days after exacerbation onset (HR, 1.65; 95%CI, 1.49-1.82).</div></div><div><h3>Conclusions</h3><div>The risk of severe cardiovascular events or death increased following moderate/severe exacerbation onset, illustrating the need for proactive multidisciplinary care of patients with COPD to prevent exacerbations and address other cardiovascular risk factors.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 138-150"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sistema de reparación mitral DragonFly: primera experiencia en España","authors":"Claudio E. Guerreiro ,&nbsp;Rodrigo Estévez-Loureiro ,&nbsp;Manuel Barreiro-Pérez ,&nbsp;Rocío González-Ferreiro ,&nbsp;José A. Baz ,&nbsp;Andrés Íñiguez-Romo","doi":"10.1016/j.recesp.2024.07.012","DOIUrl":"10.1016/j.recesp.2024.07.012","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 151-153"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiempos para la revascularización multivaso en pacientes estables con IAMCEST: revisión sistemática y metanálisis en red","authors":"Felix Voll ,&nbsp;Constantin Kuna ,&nbsp;Maria Scalamogna ,&nbsp;Thorsten Kessler ,&nbsp;Sebastian Kufner ,&nbsp;Tobias Rheude ,&nbsp;Hendrik B. Sager ,&nbsp;Erion Xhepa ,&nbsp;Jens Wiebe ,&nbsp;Michael Joner ,&nbsp;Robert A. Byrne ,&nbsp;Heribert Schunkert ,&nbsp;Gjin Ndrepepa ,&nbsp;Barbara E. Stähli ,&nbsp;Adnan Kastrati ,&nbsp;Salvatore Cassese","doi":"10.1016/j.recesp.2024.06.002","DOIUrl":"10.1016/j.recesp.2024.06.002","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Multivessel percutaneous coronary intervention (MV-PCI) is recommended in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD) without cardiogenic shock. The present network meta-analysis investigated the optimal timing of MV-PCI in this context.</div></div><div><h3>Methods</h3><div>We pooled the aggregated data from randomized trials investigating stable STEMI patients with multivessel CAD treated with a strategy of either MV-PCI or culprit vessel-only PCI. The primary outcome was all-cause death. The main secondary outcomes were cardiovascular death, myocardial infarction, and unplanned ischemia-driven revascularization.</div></div><div><h3>Results</h3><div>Among 11 trials, a total of 10 507 patients were randomly assigned to MV-PCI (same sitting, n<!--> <!-->=<!--> <!-->1683; staged during the index hospitalization, n<!--> <!-->=<!--> <!-->3460; staged during a subsequent hospitalization within 45 days, n<!--> <!-->=<!--> <!-->3275) or to culprit vessel-only PCI (n<!--> <!-->=<!--> <!-->2089). The median follow-up was 18.6 months. In comparison with culprit vessel-only PCI, MV-PCI staged during the index hospitalization significantly reduced all-cause death (risk ratio, 0.73; 95%<span>C</span>I, 0.56-0.92; <em>P</em> <!-->=<!--> <!-->.008) and ranked as possibly the best treatment option for this outcome compared with all other strategies. In comparison with culprit vessel-only PCI, a MV-PCI reduced cardiovascular mortality without differences dependent on the timing of revascularization. MV-PCI within the index hospitalization, either in a single procedure or staged, significantly reduced myocardial infarction and unplanned ischemia-driven revascularization, with no significant difference between each other.</div></div><div><h3>Conclusions</h3><div>In patients with STEMI and multivessel CAD without cardiogenic shock, multivessel PCI within the index hospitalization, either in a single procedure or staged, represents the safest and most efficacious approach. The different timings of multivessel PCI did not result in any significant differences in all-cause death.</div><div>This study is registered at PROSPERO (CRD42023457794).</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 127-137"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NT-proBNP en el ventrículo derecho sistémico, ¿un nuevo valor de corte para la estratificación del riesgo?","authors":"Fabian Tran ,&nbsp;Francisco Javier Ruperti-Repilado ,&nbsp;Philip Haaf ,&nbsp;Pedro Lopez-Ayala ,&nbsp;Matthias Greutmann ,&nbsp;Markus Schwerzmann ,&nbsp;Judith Bouchardy ,&nbsp;Harald Gabriel ,&nbsp;Dominik Stambach ,&nbsp;Juerg Schwitter ,&nbsp;Kerstin Wustmann ,&nbsp;Michael Freese ,&nbsp;Christian Mueller ,&nbsp;Daniel Tobler","doi":"10.1016/j.recesp.2024.05.013","DOIUrl":"10.1016/j.recesp.2024.05.013","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the risk prediction of patients with systemic right ventricles (sRV) is not well defined. The aim of this study was to analyze the prognostic value of NT-proBNP in patients with an sRV.</div></div><div><h3>Methods</h3><div>The prognostic value of NT-proBNP was assessed in 98 patients from the SERVE trial. We used an adjusted Cox proportional hazards model, survival analysis, and c-statistics. The composite primary outcome was the occurrence of clinically relevant arrhythmia, heart failure, or death. Correlations between baseline NT-proBNP values and biventricular volumes and function were assessed by adjusted linear regression models.</div></div><div><h3>Results</h3><div>The median age [interquartile range] at baseline was 39 [32-48] years and 32% were women. The median NT-proBNP was 238 [137-429] ng/L. Baseline NT-proBNP concentrations were significantly higher among the 20 (20%) patients developing the combined primary outcome compared with those who did not (816 [194-1094] vs 205 [122-357]; <em>P</em> <!-->=<!--> <!-->.003). In patients with NT-proBNP concentrations<!--> <!-->&gt; 75th percentile (&gt; 429 ng/L), we found an exponential increase in the sex- and age-adjusted hazard ratio for the primary outcome. The prognostic value of NT-proBNP was comparable to right ventricular ejection fraction and peak oxygen uptake on exercise testing (c-statistic: 0.71, 0.72, and 0.71, respectively).</div></div><div><h3>Conclusions</h3><div>In patients with sRVs, NT-proBNP concentrations correlate with sRV volumes and function and may serve as a simple tool for predicting adverse outcomes.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 107-116"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación invasiva de la disfunción microvascular coronaria y resultados cardiovasculares en todo el espectro de la EC: un metanálisis","authors":"Yang Xu ,&nbsp;Xiaochen Liu ,&nbsp;Yingying Guo ,&nbsp;Yuyao Qiu ,&nbsp;Yushi Zhang ,&nbsp;Xiao Wang ,&nbsp;Shaoping Nie","doi":"10.1016/j.recesp.2024.05.015","DOIUrl":"10.1016/j.recesp.2024.05.015","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Coronary microvascular dysfunction (CMD) is highly prevalent and is recognized as an important clinical entity in patients with coronary heart disease (CHD). Nevertheless, the association of CMD with adverse cardiovascular events in the spectrum of CHD has not been systemically quantified.</div></div><div><h3>Methods</h3><div>We searched electronic databases for studies on patients with CHD in whom coronary microvascular function was measured invasively, and clinical events were recorded. The primary endpoint was major adverse cardiac events (MACE), and the secondary endpoint was all-cause death. Estimates of effect were calculated using a random-effects model from published risk ratios.</div></div><div><h3>Results</h3><div>We included 27 studies with 11 404 patients. Patients with CMD assessed by invasive methods had a higher risk of MACE (RR, 2.18; 95%<span>C</span>I, 1.80-2.64; <em>P</em> <!-->&lt;<!--> <!-->.01) and all-cause death (RR, 1.88; 95%CI, 1.55-2.27; <em>P</em> <!-->&lt;<!--> <!-->.01) than those without CMD. There was no significant difference in the impact of CMD on MACE (interaction <em>P</em> value<!--> <!-->=<!--> <!-->.95) among different invasive measurement modalities. The magnitude of risk of CMD assessed by invasive measurements for MACE was greater in acute coronary syndrome patients (RR, 2.84, 95%CI, 2.26-3.57; <em>P</em> <!-->&lt;<!--> <!-->.01) than in chronic coronary syndrome patients (RR, 1.77, 95%CI, 1.44-2.18; <em>P</em> <!-->&lt;<!--> <!-->.01) (interaction <em>P</em> value<!--> <!-->&lt;<!--> <!-->.01).</div></div><div><h3>Conclusions</h3><div>CMD based on invasive measurements was associated with a high incidence of MACE and all-cause death in patients with CHD. The magnitude of risk for cardiovascular events in CMD as assessed by invasive measurements was similar among different methods but varied among CHD populations.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 117-126"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revascularización en la miocardiopatía isquémica. ¿Siguen siendo viables los test de viabilidad?","authors":"James F. Howick V ,&nbsp;Bernard J. Gersh","doi":"10.1016/j.recesp.2024.10.010","DOIUrl":"10.1016/j.recesp.2024.10.010","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 78-81"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervención coronaria percutánea y TAVI: cuanto más sencillo, mejor","authors":"Manel Sabaté","doi":"10.1016/j.recesp.2024.08.012","DOIUrl":"10.1016/j.recesp.2024.08.012","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 94-96"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la intervención coronaria percutánea compleja en el estudio previo al TAVI","authors":"Marisa Avvedimento ,&nbsp;Francisco Campelo-Parada ,&nbsp;Luis Nombela-Franco ,&nbsp;Quentin Fischer ,&nbsp;Pierre Donaint ,&nbsp;Vicenç Serra ,&nbsp;Gabriela Veiga ,&nbsp;Enrique Gutiérrez ,&nbsp;Anna Franzone ,&nbsp;Victoria Vilalta ,&nbsp;Alberto Alperi ,&nbsp;Ander Regueiro ,&nbsp;Lluis Asmarats ,&nbsp;Henrique B. Ribeiro ,&nbsp;Anthony Matta ,&nbsp;Antonio Muñoz-García ,&nbsp;Gabriela Tirado ,&nbsp;Marina Urena ,&nbsp;Damien Metz ,&nbsp;Eduard Rodenas-Alesina ,&nbsp;Josep Rodés-Cabau","doi":"10.1016/j.recesp.2024.05.002","DOIUrl":"10.1016/j.recesp.2024.05.002","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>In patients undergoing percutaneous coronary intervention (PCI) in the workup pre-transcatheter aortic valve replacement (TAVR), the clinical impact of coronary revascularization complexity remains unknown. This study sought to examine the impact of PCI complexity on clinical outcomes after TAVR in patients undergoing PCI in the preprocedural workup.</div></div><div><h3>Methods</h3><div>This was a multicenter study including consecutive patients scheduled for TAVR with concomitant significant coronary artery disease. Complex PCI was defined as having at least 1 of the following features: 3 vessels treated, ≥ 3 stents implanted, ≥ 3 lesions treated, bifurcation with 2 stents implanted, total stent length &gt;<!--> <!-->60<!--> <!-->mm, or chronic total occlusion. The rates of major adverse cardiac events (MACE), including cardiovascular mortality, myocardial infarction, and coronary revascularization were evaluated.</div></div><div><h3>Results</h3><div>A total of 1550 patients were included, of which 454 (29.3%) underwent complex PCI in the pre-TAVR workup. After a median follow-up period of 2 [1-3] years after TAVR, the incidence of MACE was 9.6 events per 100 patients-years. Complex PCI significantly increased the risk of cardiac death (HR, 1.44; 95%<span>C</span>I, 1.01-2.07), nonperiprocedural myocardial infarction (HR, 1.52; 95%CI, 1.04-2.21), and coronary revascularization (HR, 2.46; 95%CI, 1.44-4.20). In addition, PCI complexity was identified as an independent predictor of MACE after TAVR (HR, 1.31; 95%CI, 1.01-1.71; <em>P</em> <!-->=<!--> <!-->.042).</div></div><div><h3>Conclusions</h3><div>In TAVR candidates with significant coronary artery disease requiring percutaneous treatment, complex revascularization was associated with a higher risk of MACE. The degree of procedural complexity should be considered a strong determinant of prognosis in the PCI-TAVR population.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 82-93"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}