Revista espanola de cardiologia最新文献

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Ultrafiltración de acceso periférico en adultos con cardiopatías congénitas complejas y congestión refractaria 患有复杂先天性心脏病和难治性梗塞的成人周边通路超滤
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.08.010
Borja Guerrero Cervera , Raquel López-Vilella , Joaquín Rueda Soriano , Víctor Donoso Trenado , Francisco Buendía Fuentes , Luis Almenar Bonet
{"title":"Ultrafiltración de acceso periférico en adultos con cardiopatías congénitas complejas y congestión refractaria","authors":"Borja Guerrero Cervera , Raquel López-Vilella , Joaquín Rueda Soriano , Víctor Donoso Trenado , Francisco Buendía Fuentes , Luis Almenar Bonet","doi":"10.1016/j.recesp.2024.08.010","DOIUrl":"10.1016/j.recesp.2024.08.010","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 274-277"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comentarios a la guía ESC 2024 sobre el diagnóstico y el tratamiento de los síndromes coronarios crónicos 对《ESC 2024年慢性冠状动脉综合征诊断和治疗指南》的评论
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.10.009
Grupo de Trabajo de la SEC sobre la guía ESC 2024 sobre el diagnóstico y el tratamiento de los síndromes coronarios crónicos y el Comité de Guías de la SEC
{"title":"Comentarios a la guía ESC 2024 sobre el diagnóstico y el tratamiento de los síndromes coronarios crónicos","authors":"Grupo de Trabajo de la SEC sobre la guía ESC 2024 sobre el diagnóstico y el tratamiento de los síndromes coronarios crónicos y el Comité de Guías de la SEC","doi":"10.1016/j.recesp.2024.10.009","DOIUrl":"10.1016/j.recesp.2024.10.009","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 170-175"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Descarga precoz y evolución clínica en pacientes con miocarditis fulminante sometidos a ECMO-VA: resultados de un estudio retrospectivo multicéntrico 接受ECMO-VA治疗的暴发性心肌炎患者的早期出院和临床过程:一项多中心回顾性研究的结果
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.06.005
Minjung Bak , Junho Hyun , Hyukjin Park , Hyung Yoon Kim , Seonhwa Lee , In-Cheol Kim , So Ree Kim , Mi-Na Kim , Kyung-Hee Kim , Jeong Hoon Yang
{"title":"Descarga precoz y evolución clínica en pacientes con miocarditis fulminante sometidos a ECMO-VA: resultados de un estudio retrospectivo multicéntrico","authors":"Minjung Bak ,&nbsp;Junho Hyun ,&nbsp;Hyukjin Park ,&nbsp;Hyung Yoon Kim ,&nbsp;Seonhwa Lee ,&nbsp;In-Cheol Kim ,&nbsp;So Ree Kim ,&nbsp;Mi-Na Kim ,&nbsp;Kyung-Hee Kim ,&nbsp;Jeong Hoon Yang","doi":"10.1016/j.recesp.2024.06.005","DOIUrl":"10.1016/j.recesp.2024.06.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Although venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides effective cardiocirculatory support in patients with fulminant myocarditis, the most effective timing of venting is uncertain. We aimed to investigate the benefit of early venting among patients who underwent VA-ECMO for fulminant myocarditis.</div></div><div><h3>Methods</h3><div>Among 841 patients with acute myocarditis from 7 hospitals in the Republic of Korea, 217 patients with fulminant myocarditis who underwent VA-ECMO were included in this analysis. The patients were categorized into 2 groups: an early unloading group that underwent venting within 24<!--> <!-->hours of ECMO insertion, and the no or delayed unloading group. The primary outcome was a composite of death, cardiac replacement, or cardiovascular rehospitalization.</div></div><div><h3>Results</h3><div>Among 217 patients, 56 underwent early venting, 54 underwent delayed venting, and 107 did not undergo venting. On spline curves in 110 patients who underwent venting, rapid deterioration was observed as the timing of venting was delayed. The incidence of the primary outcome was lower in the early venting group than in the no or delayed unloading group (37.5% vs 58.4%; HR, 0.491; 95%CI, 0.279-0.863; <em>P</em> <!-->=<!--> <!-->.014). Among patients not experiencing the primary outcome within 6 months, clinical outcomes were similar after 6 months (<em>P</em> <!-->=<!--> <!-->.375).</div></div><div><h3>Conclusions</h3><div>Early left heart unloading within 24<!--> <!-->hours of ECMO insertion is associated with a lower risk of a composite of death, cardiac replacement therapy, and cardiovascular rehospitalization in patients with fulminant myocarditis undergoing VA-ECMO. Registered at ClinicalTrials.gov (NCT05933902).</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 176-184"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trombo intraventricular gigante con múltiples embolismos: ¿anticoagulación o cirugía? 伴有多重栓塞的巨大室内血栓:抗凝还是手术?
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.08.008
Diana Ladera Santos , Ignacio Gallo Fernández , Manuel Anguita Sánchez
{"title":"Trombo intraventricular gigante con múltiples embolismos: ¿anticoagulación o cirugía?","authors":"Diana Ladera Santos ,&nbsp;Ignacio Gallo Fernández ,&nbsp;Manuel Anguita Sánchez","doi":"10.1016/j.recesp.2024.08.008","DOIUrl":"10.1016/j.recesp.2024.08.008","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 282-283"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intervención dirigida por catéter en la embolia aguda de pulmón. Posicionamiento SEC-Asociación de Cardiología Intervencionista/SEC-Asociación de Cardiopatía Isquémica y Cuidados Agudos Cardiovasculares/SEC-GT Hipertensión Pulmonar 导管引导干预急性肺栓塞。美国证券交易委员会介入心脏病学协会/美国证券交易委员会缺血性心脏病和急性心血管护理协会/美国证券交易委员会- gt肺动脉高压
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.09.006
Pablo Salinas , Ana Belén Cid Álvarez , Pablo Jorge Pérez , María Eugenia Vázquez-Álvarez , Alfonso Jurado-Román , Miriam Juárez , Miguel Corbí-Pascual , Maite Velázquez Martín , Jesús Jiménez-Mazuecos , Sandra Ofelia Rosillo Rodríguez , Valeriano Ruiz Quevedo , María Lázaro , Ana Viana-Tejedor , Javier Martín Moreiras , Roberto Martín-Asenjo
{"title":"Intervención dirigida por catéter en la embolia aguda de pulmón. Posicionamiento SEC-Asociación de Cardiología Intervencionista/SEC-Asociación de Cardiopatía Isquémica y Cuidados Agudos Cardiovasculares/SEC-GT Hipertensión Pulmonar","authors":"Pablo Salinas ,&nbsp;Ana Belén Cid Álvarez ,&nbsp;Pablo Jorge Pérez ,&nbsp;María Eugenia Vázquez-Álvarez ,&nbsp;Alfonso Jurado-Román ,&nbsp;Miriam Juárez ,&nbsp;Miguel Corbí-Pascual ,&nbsp;Maite Velázquez Martín ,&nbsp;Jesús Jiménez-Mazuecos ,&nbsp;Sandra Ofelia Rosillo Rodríguez ,&nbsp;Valeriano Ruiz Quevedo ,&nbsp;María Lázaro ,&nbsp;Ana Viana-Tejedor ,&nbsp;Javier Martín Moreiras ,&nbsp;Roberto Martín-Asenjo","doi":"10.1016/j.recesp.2024.09.006","DOIUrl":"10.1016/j.recesp.2024.09.006","url":null,"abstract":"<div><div>Pulmonary embolism (PE) is the leading cause of hospital death and the third most frequent cause of cardiovascular mortality. Traditionally, treatment options have included anticoagulation, thrombolysis, or surgery; however, catheter-directed interventions (CDI), including catheter-directed thrombolysis and aspiration thrombectomy, have been developed for patients with intermediate- or high-risk PE. These techniques can rapidly improve right ventricular function, hemodynamic status, and mortality in some patients, although there is a lack of evidence from randomized controlled trials. This document, prepared by the Interventional Cardiology Association, the Association of Ischemic Heart Disease and Acute Cardiovascular Care, and the Working Group on Pulmonary Hypertension of the Spanish Society of Cardiology (SEC), reviews the current recommendations and available evidence on the management of PE. It emphasizes the importance of rapid response teams, risk stratification, and early patient monitoring in identifying candidates for reperfusion. Based on existing clinical evidence on CDI, the document discusses various clinical scenarios and provides guidance on patient selection, particularly in situations of uncertainty due to insufficient evidence. Lastly, it describes periprocedural support, highlighting the necessary multidisciplinary approach to improve outcomes and reduce morbidity and mortality in patients with PE.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 239-251"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
¿Un marcapaso o un marcapasos? 起搏器或起搏器吗?
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.09.001
Fernando A. Navarro
{"title":"¿Un marcapaso o un marcapasos?","authors":"Fernando A. Navarro","doi":"10.1016/j.recesp.2024.09.001","DOIUrl":"10.1016/j.recesp.2024.09.001","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Page 163"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vía transapical para reemplazo percutáneo de válvula mitral por valvulopatía: una experiencia ibérica 经腹瓣膜经皮替换二尖瓣:伊比利亚经验
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.07.009
Eva Gutiérrez-Ortiz , Javier Cobiella , Christian Muñoz-Guijosa , Rui C. Teles , Rodrigo Estévez-Loureiro , Vanessa Moñivas , Ander Regueiro , Sara Blasco-Turrión , Patricia Mahía , Danela Figuereo Beltre , Pedro Freitas , Miguel Piñón , Ignacio J. Amat-Santos , Ignasi Julià Amill , Tiago Nolasco , Daniel Pereda , Carlos Martín López , Luis Nombela-Franco
{"title":"Vía transapical para reemplazo percutáneo de válvula mitral por valvulopatía: una experiencia ibérica","authors":"Eva Gutiérrez-Ortiz ,&nbsp;Javier Cobiella ,&nbsp;Christian Muñoz-Guijosa ,&nbsp;Rui C. Teles ,&nbsp;Rodrigo Estévez-Loureiro ,&nbsp;Vanessa Moñivas ,&nbsp;Ander Regueiro ,&nbsp;Sara Blasco-Turrión ,&nbsp;Patricia Mahía ,&nbsp;Danela Figuereo Beltre ,&nbsp;Pedro Freitas ,&nbsp;Miguel Piñón ,&nbsp;Ignacio J. Amat-Santos ,&nbsp;Ignasi Julià Amill ,&nbsp;Tiago Nolasco ,&nbsp;Daniel Pereda ,&nbsp;Carlos Martín López ,&nbsp;Luis Nombela-Franco","doi":"10.1016/j.recesp.2024.07.009","DOIUrl":"10.1016/j.recesp.2024.07.009","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Transcatheter mitral valve replacement (TMVR) is an emerging treatment alternative for mitral valve (MV) disease in patients who were ineligible for surgical intervention or edge-to-edge repair. This study aimed to assess the short- and mid-term outcomes of this procedure.</div></div><div><h3>Methods</h3><div>We conducted a prospective registry to include the initial experience with symptomatic, consecutive patients who underwent TMVR using the transapical Tendyne system at 7 centers in the Iberian Peninsula. Baseline clinical and imaging data, periprocedural information, and follow-up assessments were collected at 1 month and 1 year.</div></div><div><h3>Results</h3><div>A total of 40 patients (mean age 78.5 years [76-82], 47,5% males) underwent TMVR. The majority had significant surgical risk, comorbidities, and advanced functional class. All patients had significant mitral regurgitation (MR), except for 2 with severe stenosis. Previous MV intervention and off-label indication for the procedure were present in 4 (10.0%) and 8 (20.0%) patients, respectively. Technical success was recorded in 100%, device success in 95.0%, and procedural success in 85.0% at 30-day. All-cause mortality was 2.5% and 17.5% at the 1-month and 1-year follow-up, respectively. MR reduction (≤ 1) and functional class improvement (NYHA I-II) were observed at 1 year in 93.9% and 87.9% of survivors, respectively.</div></div><div><h3>Conclusions</h3><div>Treatment with TMVR produced enduring resolution of MV disease and notable functional enhancement at 1 year of follow-up. The procedure demonstrated a satisfactory early safety profile, although 1-year mortality remained relatively high in this high-risk population.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 229-238"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacto de la natriuresis en el empeoramiento de la función renal durante un episodio de insuficiencia cardiaca aguda 急性心力衰竭发作期间钠对肾功能恶化的影响
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.07.011
Pedro Caravaca Pérez , Ignacio Fernández-Herrero , José Jesús Broseta , Nikein Ibarra-Márquez , Zorba Blázquez-Bermejo , Juan Carlos López-Azor , César Del Castillo Gordillo , Marta Cobo Marcos , Javier de Juan Bagudá , María Dolores García Cosío , Ana García-Álvarez , Marta Farrero , Juan F. Delgado
{"title":"Impacto de la natriuresis en el empeoramiento de la función renal durante un episodio de insuficiencia cardiaca aguda","authors":"Pedro Caravaca Pérez ,&nbsp;Ignacio Fernández-Herrero ,&nbsp;José Jesús Broseta ,&nbsp;Nikein Ibarra-Márquez ,&nbsp;Zorba Blázquez-Bermejo ,&nbsp;Juan Carlos López-Azor ,&nbsp;César Del Castillo Gordillo ,&nbsp;Marta Cobo Marcos ,&nbsp;Javier de Juan Bagudá ,&nbsp;María Dolores García Cosío ,&nbsp;Ana García-Álvarez ,&nbsp;Marta Farrero ,&nbsp;Juan F. Delgado","doi":"10.1016/j.recesp.2024.07.011","DOIUrl":"10.1016/j.recesp.2024.07.011","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Worsening renal function (WRF) is a frequent complication in acute heart failure (AHF) with a controversial prognostic value. We aimed to study the usefulness of natriuresis to evaluate WRF.</div></div><div><h3>Methods</h3><div>We conducted an observational, prospective, multicenter study of patients with AHF who underwent a furosemide stress test. The patients were classified according to whether WRF was present or absent and according to the median natriuretic response. The main endpoint was the combination of mortality, rehospitalization due to HF, and heart transplant at 6 months of follow-up.</div></div><div><h3>Results</h3><div>One hundred and fifty-six patients were enrolled, and WRF occurred in 60 (38.5%). The patients were divided into 4 groups: <em>a)</em> 47 (30.1%) no WRF/low UNa (UNa ≤ 109 mEq/L); <em>b)</em> 49 (31.4%) no WRF/high UNa (UNa &gt;<!--> <!-->109 mEq/L); <em>c)</em> 31 (19.9%) WRF/low UNa and <em>d)</em> 29 (18.6%) WRF/high UNa. The parameters of the WRF/low UNa group showed higher clinical severity and worse diuretic and decongestive response. The development of WRF was associated with a higher risk of the combined event (HR, 1.88; 95%CI, 1.01-3.50; <em>P</em> <!-->=<!--> <!-->.046). When stratified by natriuretic response, WRF was associated with an increased risk of adverse events in patients with low natriuresis (HR, 2.28; 95%CI, 1.15-4.53; <em>P</em> <!-->=<!--> <!-->.019), but not in those with high natriuresis (HR, 1.18; 95%CI, 0.26-5.29; <em>P</em> <!-->=<!--> <!-->.826).</div></div><div><h3>Conclusions</h3><div>Natriuresis could be a useful biomarker for interpreting and prognosticating WRF in AHF. WRF is associated with a higher risk of adverse events only in the context of low natriuresis.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 196-205"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibidores del cotransportador 2 de sodio-glucosa, agonistas del receptor de péptido 1 similar al glucagón y mortalidad por cáncer. Registro de la práctica real 钠-葡萄糖共转运体2抑制剂,胰高血糖素样肽受体1激动剂和癌症死亡率。实际实践的记录
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.07.004
David García-Vega , Sergio Cinza-Sanjurjo , Carlos Tilves-Bellas , Sonia Eiras , José R. González-Juanatey
{"title":"Inhibidores del cotransportador 2 de sodio-glucosa, agonistas del receptor de péptido 1 similar al glucagón y mortalidad por cáncer. Registro de la práctica real","authors":"David García-Vega ,&nbsp;Sergio Cinza-Sanjurjo ,&nbsp;Carlos Tilves-Bellas ,&nbsp;Sonia Eiras ,&nbsp;José R. González-Juanatey","doi":"10.1016/j.recesp.2024.07.004","DOIUrl":"10.1016/j.recesp.2024.07.004","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1ra) reduce cardiovascular events through different mechanisms, but their association with cancer remains unclear. The aim of this study was to compare the effect of combined treatment (SGLT2i and GLP1ra) and monotherapy (SGLT2i or GLP1ra) on hospitalization and/or death from cancer in a general population and a subgroup of patients with cardiovascular disease (CVD).</div></div><div><h3>Methods</h3><div>We conducted a nonconcurrent observational prospective study of patients prescribed SGLT2i, GLP1ra, or both. Multinomial propensity scores were performed in the entire population and in a subgroup of patients with CVD. A multivariate Cox regression analysis was used to determine the hazard ratio (HR) for age, sex, risk factors, and treatment for each outcome.</div></div><div><h3>Results</h3><div>We included 14 709 patients (11366 with SGLT2i, 1016 with GLP1ra, and 2327 with both treatments) from treatment initiation. Diabetes was present in 97% of the patients. The subgroup with CVD included 4957 (33.7%) patients. After a median of 33 months of follow-up, the risk of adverse cancer events was similar between patients with and without CVD (3.4% or 3.7%, respectively). The main risk factors for cancer mortality were male sex and age. Combined treatment and its duration reduced the risk of cancer mortality compared with monotherapy with SGLT2i or GLP1ra in the overall population (HR, 0.2216; 95%<span>C</span>I, 0.1106-0.4659; <em>P</em> <!-->&lt;<!--> <!-->.001; and HR, 0.1928; 95%CI, 0.071-0.5219; <em>P</em> <!-->=<!--> <!-->.001, respectively) and in the subgroup of patients with CVD (HR, 0.2879; 95%CI, 0.0878-0.994; <em>P</em> <!-->&lt;<!--> <!-->.049; and HR, 0.1329; 95%CI, 0.024-0.6768; <em>P</em> <!-->=<!--> <!-->.014, respectively).</div></div><div><h3>Conclusions</h3><div>Initiation of combined therapy (SGLT2i and GLP1ra) vs monotherapy with SGLT2i or GLP1ra was associated with a lower risk of cancer mortality, mostly in diabetic patients with or without CVD. Although clinical trials are needed, these results might be explained by the complementary mechanisms of these drugs, including their antiproliferative, anti-inflammatory, and metabolic effects. Future clinical trials and mechanistic studies will clarify the possible role of these drugs in carcinogenesis.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 218-228"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Planos transgástricos: complemento en la evaluación de la orejuela izquierda 经胃平面图:对左耳评估的补充
IF 5.9 2区 医学
Revista espanola de cardiologia Pub Date : 2025-03-01 DOI: 10.1016/j.recesp.2024.10.015
Lucía Fernández Gassó , Esther Pérez David , Raúl Moreno
{"title":"Planos transgástricos: complemento en la evaluación de la orejuela izquierda","authors":"Lucía Fernández Gassó ,&nbsp;Esther Pérez David ,&nbsp;Raúl Moreno","doi":"10.1016/j.recesp.2024.10.015","DOIUrl":"10.1016/j.recesp.2024.10.015","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 3","pages":"Pages 284-285"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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