Fernando Alfonso , Jorge Salamanca , Iván Núñez-Gil , Náyade Del Prado , Nicolás Rosillo , Javier Elola
{"title":"Tendencias en la frecuentación y mortalidad hospitalaria por síndrome de tako-tsubo en España","authors":"Fernando Alfonso , Jorge Salamanca , Iván Núñez-Gil , Náyade Del Prado , Nicolás Rosillo , Javier Elola","doi":"10.1016/j.recesp.2024.08.007","DOIUrl":"10.1016/j.recesp.2024.08.007","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 158-160"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"La onda P durante la estimulación de vena pulmonar para localizar reconexiones transitoriamente desenmascaradas por adenosina","authors":"Daniel Cantero Lozano , Isabel Cornejo Mazzuchelli , Paloma Lapunzina Soler , M. Teresa Barrio-López , Eduardo Castellanos Martínez , Jesús Almendral","doi":"10.1016/j.recesp.2024.08.005","DOIUrl":"10.1016/j.recesp.2024.08.005","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 153-156"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aneurisma gigante de la arteria pulmonar derecha en el síndrome de Eisenmenger","authors":"Xiang-Ting Lu, Yi-Bing Lu, Hai-Long Dai","doi":"10.1016/j.recesp.2024.08.003","DOIUrl":"10.1016/j.recesp.2024.08.003","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 2","pages":"Pages 161-162"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143211343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Alejandra Restrepo-Córdoba , Przemyslaw Chmielewski , Grażyna Truszkowska , María Luisa Peña-Peña , Miloš Kubánek , Alice Krebsová , Luis R. Lopes , Álvaro García-Ropero , Marco Merlo , Alessia Paldino , Stacey Peters , Ruxandra Jurcut , Roberto Barriales-Villa , Esther Zorio , Mark Hazebroek , Jens Mogensen , Pablo García-Pavía
{"title":"Embarazo en mujeres portadoras de variantes genéticas de miocardiopatía dilatada","authors":"María Alejandra Restrepo-Córdoba , Przemyslaw Chmielewski , Grażyna Truszkowska , María Luisa Peña-Peña , Miloš Kubánek , Alice Krebsová , Luis R. Lopes , Álvaro García-Ropero , Marco Merlo , Alessia Paldino , Stacey Peters , Ruxandra Jurcut , Roberto Barriales-Villa , Esther Zorio , Mark Hazebroek , Jens Mogensen , Pablo García-Pavía","doi":"10.1016/j.recesp.2024.04.002","DOIUrl":"10.1016/j.recesp.2024.04.002","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Limited information is available on the safety of pregnancy in patients with genetic dilated cardiomyopathy (DCM) and in carriers of DCM-causing genetic variants without the DCM phenotype. We assessed cardiac, obstetric, and fetal or neonatal outcomes in this group of patients.</div></div><div><h3>Methods</h3><div>We studied 48 women carrying pathogenic or likely pathogenic DCM-associated variants (30 with DCM and 18 without DCM) who had 83 pregnancies. Adverse cardiac events were defined as heart failure (HF), sustained ventricular tachycardia, ventricular assist device implantation, heart transplant, and/or maternal cardiac death during pregnancy, or labor and delivery, and up to the sixth postpartum month.</div></div><div><h3>Results</h3><div>A total of 15 patients, all with DCM (31% of the total cohort and 50% of women with DCM) experienced adverse cardiac events. Obstetric and fetal or neonatal complications were observed in 14% of pregnancies (10 in DCM patients and 2 in genetic carriers). We analyzed the 30 women who had been evaluated before their first pregnancy (12 with overt DCM and 18 without the phenotype). Five of the 12 (42%) women with DCM had adverse cardiac events despite showing NYHA class I or II before pregnancy. Most of these women had a history of cardiac events before pregnancy (80%). Among the 18 women without phenotype, 3 (17%) developed DCM toward the end of pregnancy.</div></div><div><h3>Conclusions</h3><div>Cardiac complications during pregnancy and postpartum were common in patients with genetic DCM and were primarily related to HF. Despite apparently good tolerance of pregnancy in unaffected genetic carriers, pregnancy may act as a trigger for DCM onset in a subset of these women.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 1","pages":"Pages 2-9"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Fe Montero-Torreiro , Mónica Pérez-Ríos , Cristina Candal-Pedreira , Carla Guerra-Tort , Guadalupe García , Julia Rey-Brandariz
{"title":"Sedentarismo en la población española: un estudio transversal en el periodo 2011-2020","authors":"María Fe Montero-Torreiro , Mónica Pérez-Ríos , Cristina Candal-Pedreira , Carla Guerra-Tort , Guadalupe García , Julia Rey-Brandariz","doi":"10.1016/j.recesp.2024.07.002","DOIUrl":"10.1016/j.recesp.2024.07.002","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 1","pages":"Pages 71-73"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141711082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Rodríguez-González , Pablo Martínez-Legazpi , Teresa Mombiela , Ana González-Mansilla , Antonia Delgado-Montero , Juan A. Guzmán-De-Villoria , Fernando Díaz-Otero , Raquel Prieto-Arévalo , Miriam Juárez , María del Carmen García del Rey , Pilar Fernández-García , Óscar Flores , Andrea Postigo , Raquel Yotti , Manuel García-Villalba , Francisco Fernández-Avilés , Juan C. del Álamo , Javier Bermejo
{"title":"La imagen de estasis predice el riesgo de eventos cardioembólicos tras el infarto agudo de miocardio: el estudio ISBITAMI","authors":"Elena Rodríguez-González , Pablo Martínez-Legazpi , Teresa Mombiela , Ana González-Mansilla , Antonia Delgado-Montero , Juan A. Guzmán-De-Villoria , Fernando Díaz-Otero , Raquel Prieto-Arévalo , Miriam Juárez , María del Carmen García del Rey , Pilar Fernández-García , Óscar Flores , Andrea Postigo , Raquel Yotti , Manuel García-Villalba , Francisco Fernández-Avilés , Juan C. del Álamo , Javier Bermejo","doi":"10.1016/j.recesp.2024.04.017","DOIUrl":"10.1016/j.recesp.2024.04.017","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>In the setting of ST-segment elevation myocardial infarction (STEMI), imaging-based biomarkers could be useful for guiding oral anticoagulation to prevent cardioembolism. Our objective was to test the efficacy of intraventricular blood stasis imaging for predicting a composite primary endpoint of cardioembolic risk during the first 6 months after STEMI.</div></div><div><h3>Methods</h3><div>We designed a prospective clinical study, Imaging Silent Brain Infarct in Acute Myocardial Infarction (ISBITAMI), including patients with a first STEMI, an ejection fraction ≤ 45% and without atrial fibrillation to assess the performance of stasis metrics to predict cardioembolism. Patients underwent ultrasound-based stasis imaging at enrollment followed by heart and brain magnetic resonance at 1-week and 6-month visits. From the stasis maps, we calculated the average residence time, <em>R</em><sub><em>T</em></sub>, of blood inside the left ventricle and assessed its performance to predict the primary endpoint. The longitudinal strain of the 4 apical segments was quantified by speckle tracking.</div></div><div><h3>Results</h3><div>A total of 66 patients were assigned to the primary endpoint. Of them, 17 patients had 1 or more events: 3 strokes, 5 silent brain infarctions, and 13 mural thromboses. No systemic embolisms were observed. <em>R</em><sub><em>T</em></sub> (OR, 3.73; 95%CI, 1.75-7.9; <em>P</em> <!--><<!--> <!-->.001) and apical strain (OR, 1.47; 95%CI, 1.13-1.92; <em>P</em> <!-->=<!--> <!-->.004) showed complementary prognostic value. The bivariate model showed a c-index<!--> <!-->=<!--> <!-->0.86 (95%CI, 0.73-0.95), a negative predictive value of 1.00 (95%CI, 0.94-1.00), and positive predictive value of 0.45 (95%CI, 0.37-0.77). The results were confirmed in a multiple imputation sensitivity analysis. Conventional ultrasound-based metrics were of limited predictive value.</div></div><div><h3>Conclusions</h3><div>In patients with STEMI and left ventricular systolic dysfunction in sinus rhythm, the risk of cardioembolism may be assessed by echocardiography by combining stasis and strain imaging. Registered at ClinicalTrials.gov (NCT02917213).</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 1","pages":"Pages 22-33"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roger Benet-Pozo , Montserrat Fitó , Jaume Marrugat , Cosme García-García , Isaac Subirana , Roberto Elosua
{"title":"La cantidad y la intensidad de la actividad física, ¿son importantes en la oxidación de las lipoproteínas de baja densidad?","authors":"Roger Benet-Pozo , Montserrat Fitó , Jaume Marrugat , Cosme García-García , Isaac Subirana , Roberto Elosua","doi":"10.1016/j.recesp.2024.06.011","DOIUrl":"10.1016/j.recesp.2024.06.011","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 1","pages":"Pages 66-68"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143321382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ZhongHui Xie , Tao Chen , Xu Lu , MaoXiang Zhao , Yating Chen , XinYan Wang , Hang Zhou , Juan Shen , Jun Guo , Yang Li
{"title":"Biomarcadores proteómicos para la predicción no invasiva de trombos en la orejuela izquierda de pacientes con fibrilación auricular","authors":"ZhongHui Xie , Tao Chen , Xu Lu , MaoXiang Zhao , Yating Chen , XinYan Wang , Hang Zhou , Juan Shen , Jun Guo , Yang Li","doi":"10.1016/j.recesp.2024.04.015","DOIUrl":"10.1016/j.recesp.2024.04.015","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>The CHA<sub>2</sub>DS<sub>2</sub>-VASc score, used to assess the risk of left atrial appendage thrombus (LAAT) formation in patients with atrial fibrillation (AF), has limited predictive value. Moreover, transesophageal echocardiography imaging, the gold standard diagnostic method to identify thrombi, is semi-invasive. Consequently, there is a need for alternative and noninvasive diagnostic methods for LAAT risk assessment.</div></div><div><h3>Methods</h3><div>Deep proteomic analysis was conducted in plasma samples from 8 patients with nonvalvular AF, divided into thrombus and control groups (4 patients in each group) based on the presence or absence of LAAT. Biomarkers associated with LAAT were validated using an enzyme-linked immunosorbent assay in a cohort of 179 patients with available clinical, transthoracic, and transesophageal echocardiography data. Predictive models were developed to assess the improvement in LAAT identification.</div></div><div><h3>Results</h3><div>The LAAT group had higher CHA<sub>2</sub>DS<sub>2</sub>-VASc scores, larger LA diameter, and lower LAA flow velocities. Deep proteomic analysis identified 30 differentially expressed proteins, including myosin light chain 4, prenylcysteine oxidase 1 (PCYOX1), and decorin as potential diagnostic biomarkers of LAAT. The model showed that PCYOX1 and decorin provided an area under the curve (AUC) of 0.970 for LAAT prediction compared with 0.672 in a model including the CHA<sub>2</sub>DS<sub>2</sub>-VASc score and LAA cauliflower morphology. The incremental value of proteomic biomarkers for LAAT in patients with nonvalvular AF was further confirmed with the net reclassification improvement and integrated discrimination improvement indices.</div></div><div><h3>Conclusions</h3><div>Protein levels of PCYOX1 and decorin improve the predictive performance for LAAT in patients with nonvalvular AF.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 1","pages":"Pages 47-55"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}