Reumatismo最新文献_第9页

Clinical characteristics and outcomes of patients with inflammatory and autoimmune rheumatological diseases admitted for intensive care in Colombia. 哥伦比亚接受重症监护的炎症性和自身免疫性风湿病患者的临床特征和结果

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1563

D G Fernández-Ávila, Ó R Vargas-Vanegas, L Galindo-Rozo, Á García-Peña, Ó Muñoz-Velandia

{"title":"Clinical characteristics and outcomes of patients with inflammatory and autoimmune rheumatological diseases admitted for intensive care in Colombia.","authors":"D G Fernández-Ávila, Ó R Vargas-Vanegas, L Galindo-Rozo, Á García-Peña, Ó Muñoz-Velandia","doi":"10.4081/reumatismo.2023.1563","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1563","url":null,"abstract":"Objective: Contemporary studies reporting outcomes of critical care in patients with inflammatory and autoimmune rheumatological diseases are scarce. This study describes 15 years of experience from 2005-2019 in a Colombian referral hospital.Methods: This observational, descriptive, consecutive case series study was performed on adult patients with inflammatory and autoimmune rheumatic diseases who were admitted to the intensive care unit (ICU) of the San Ignacio University Hospital in Bogotá (Colombia), from January 1, 2005, to December 21, 2019. We describe the sociodemographic characteristics, admission causes and criteria, lengths of stay, immunosuppressive treatment, systemic support, and mortality.Results: The study included 300 patients with a median age of 48 years [interquartile range (IQR) 31-62 years], predominantly female (76%). Disease exacerbations (30%), infections (17.6%), and cardiovascular diseases (15%) were the main causes of admission. Respiratory failure (23%) most commonly caused by septic shock (24%) was the principal indication for intensive care admission. The most frequent infections were community-acquired pneumonia (11.6%) and soft-tissue infections (9%). In 40.3% of patients, inotropic and vasopressor support was required. The median length of stay was 4 days (IQR 2-8), and global mortality was 21.6%.Conclusions: Rheumatic diseases in the ICU are still associated with high morbidity and mortality. Patients with inflammatory and autoimmune rheumatic diseases require a meticulous clinical approach, strict clinical monitoring, frequent assessment of complications, evaluation of systemic support needs, and specific management.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report. 急性严重痛风性关节炎继发于异维甲酸毒性的年轻男性:一个病例报告。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1566

D S Meena, D Kumar, G K Bohra

引用次数: 0

Oxidative stress may be a contributing factor in fibromyalgia patients' pain mechanisms. 氧化应激可能是纤维肌痛患者疼痛机制的一个促进因素。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1550

H Beyaztas, S Aktas, E M Guler, E Ata

{"title":"Oxidative stress may be a contributing factor in fibromyalgia patients' pain mechanisms.","authors":"H Beyaztas, S Aktas, E M Guler, E Ata","doi":"10.4081/reumatismo.2023.1550","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1550","url":null,"abstract":"Objective: The pathophysiology of fibromyalgia (FM), a continuously painful syndrome with no known origin, has been related to mitochondrial dysfunction, oxidative stress, and inflammation. Recent studies have shown that FM may be associated with an oxidative balance disorder. The objective of this study was to measure the levels of oxidative stress in FM patients and try to understand the association between FM and free radicals.Methods: This study was performed on 100 volunteers admitted to the University of Health Sciences, Sultan 2, Abdulhamid Han Health Application and Research Center Physical Therapy and Rehabilitation Clinic, including 50 healthy controls and 50 patients with FM. To analyze oxidative stress biomarkers, total oxidant status (TOS) and total antioxidant status (TAS) levels were measured. Total thiol (TT) and native thiol (NT) concentrations were measured to determine the relationship between thiol groups. Disulfide (DIS) and oxidative stress index (OSI) were calculated with mathematical formulas.Results: While TOS and OSI levels were statistically higher in FM patients, TAS levels were significantly lower compared to the healthy control group (p<0.001). In comparison to the healthy control group, FM patients had considerably decreased TT and NT levels. DIS levels were significantly higher in FM patients than in controls (p<0.001).Conclusions: Reactive oxygen species have several negative impacts on the human body. As a result of the measurements we analyzed, the relationship between FM and oxidative stress should be studied in terms of disease progression and may help improve the treatment process.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal hemorrhage and non-ST elevation myocardial infarction: an antiphospholipid syndrome dilemma. 肾上腺出血和非st段抬高型心肌梗死:抗磷脂综合征困境。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1584

G El Hasbani, M Del Pilar Morel, B Tandoh, J F Vargas, R Crusio

引用次数: 0

Vasculitis associated with adenosine deaminase 2 deficiency: at the crossroads between Behçet's disease and autoinflammation. A viewpoint. 血管炎与腺苷脱氨酶2缺乏相关:在behet病和自身炎症之间的十字路口。一个观点。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1578

A Colangelo, F Tromby, G Cafaro, R Gerli, E Bartoloni, C Perricone

{"title":"Vasculitis associated with adenosine deaminase 2 deficiency: at the crossroads between Behçet's disease and autoinflammation. A viewpoint.","authors":"A Colangelo, F Tromby, G Cafaro, R Gerli, E Bartoloni, C Perricone","doi":"10.4081/reumatismo.2023.1578","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1578","url":null,"abstract":"Adenosine deaminase 2 deficiency (DADA2) is a rare monogenic vasculopathy caused by loss-of-function homozygous or compound heterozygous mutations in ADA2, formerly CECR1 (cat eye syndrome chromosome region 1) gene. The DADA2 phenotype is widely heterogeneous, and patients may present with fever, weight loss, livedo reticularis/racemosa, digital ischemia, cutaneous ulceration, peripheral neuropathy, abdominal pain, bowel perforation, and portal or nephrogenic hypertension. More specific manifestations include early-onset ischemic or hemorrhagic stroke, mild immunodeficiency and hypogammaglobinemia, cytopenia, and vision disturbances. Herein, we present the case of a young male with vasculitis associated with DADA2. The presence of HLA-B51 and the clinical features of this patient raised the question of similarities between ADA2 deficiency, Behçet's disease, and NOD2-associated diseases. Treatment of this rare monogenic disease is challenging and based on small case series. The long-term experience of this patient proved the difficulties of prednisone tapering and the lack of satisfactory therapeutic strategies.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myositis after SARS-CoV-2 vaccination occurs more frequently than assumed and is probably causally related. 接种SARS-CoV-2疫苗后发生肌炎的频率比假设的要高，并且可能存在因果关系。

IF 1.4

Reumatismo Pub Date : 2023-09-18 DOI: 10.4081/reumatismo.2023.1601

J Finsterer, A S MohanaSundaram, F Scorza

引用次数: 1

Arthur Conan Doyle, Sherlock Holmes, and gout. 阿瑟·柯南·道尔，夏洛克·福尔摩斯，还有痛风。

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1570

E Damiani

{"title":"Arthur Conan Doyle, Sherlock Holmes, and gout.","authors":"E Damiani","doi":"10.4081/reumatismo.2023.1570","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1570","url":null,"abstract":"Arthur Conan Doyle, the creator of Sherlock Holmes, was an experienced physician who treated gouty patients. A gouty character appears in The Adventure of the Missing Three-Quarter, a Sherlock Holmes novel. This offers the possibility of discussing gout from the peculiar perspective of a medical writer in light of the historical-medical context of the time. This study was conducted using Conan Doyle's autobiographical, scientific, and literary primary sources, as well as past and current medical literature. The Adventure of the Missing Three-Quarter was autobiographical. Conan Doyle himself was a rugby player and his wife died of tuberculosis. Furthermore, in 1884, in The Lancet, he described the hereditary case of a female gouty patient, presenting with ocular manifestations. In agreement with the concept of rich man's gout, the gouty patient of Sherlock Holmes' story, Lord Mount James, was a rich irascible noble but he was not addicted to the pleasures of food and sex. Following the usual funny representation of gouty patients, Conan Doyle made fun of Lord Mount James, but he misquoted a true case of gout cited in the literature. In his scientific and literary production on gout, Conan Doyle stuck to the most updated medical concepts of the time, demonstrating an uncommon knowledge of scientific literature.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 2","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in severe outcomes in SARS-CoV-2-positive hospitalized patients with rheumatic diseases: a monocentric observational and case-control study in northern Italy. 伴有风湿病的sars - cov -2阳性住院患者严重结局的趋势:意大利北部的一项单中心观察和病例对照研究

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1542

N Ughi, D P Bernasconi, C Gagliardi, F Del Gaudio, A Dicuonzo, A Maloberti, C Giannattasio, C Rossetti, M G Valsecchi, O M Epis

{"title":"Trends in severe outcomes in SARS-CoV-2-positive hospitalized patients with rheumatic diseases: a monocentric observational and case-control study in northern Italy.","authors":"N Ughi, D P Bernasconi, C Gagliardi, F Del Gaudio, A Dicuonzo, A Maloberti, C Giannattasio, C Rossetti, M G Valsecchi, O M Epis","doi":"10.4081/reumatismo.2023.1542","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1542","url":null,"abstract":"Rheumatic disease patients are at greater risk of infection due to their disease, comorbidities, and immunosuppressive therapy. COVID-19 outcomes in this patient setting appeared to be similar to those of the general population. However, data on this topic were mainly related to small studies on a limited number of patients. Consequently, to date, this field remains poorly explored, particularly in the pre-vaccine era. This monocentric study aimed to describe the intrahospital mortality in rheumatic patients with SARS-CoV-2 consecutively hospitalized from 21 February to 31 December 2020, before anti-SARS-CoV-2 vaccine administration spread, compared with non-rheumatic patients. Of 2491 included patients, 65 [3%, median (interquartile range) age 75 (64.76-82.239 years, 65% women] were suffering from rheumatic diseases. A total of 20 deaths were reported [case fatality rate 31%, 95% confidence interval (CI): 19-42] compared with 433 deaths (19%, 95% CI: 17-20) in patients without rheumatic diseases (p=0.024). However, the rheumatic disease was not associated with a significant increase in univariate mortality hazards (hazard ratio 1.374, 95% CI: 0.876-2.154), and after adjustment (hazard ratio 1.199, 95% CI: 0.759-1.894) by age, sex and Charlson comorbidity index. The incidence of intensive care unit admission, death, and discharge in the case-control study was comparable between rheumatic and non-rheumatic patients. The presence of rheumatic diseases in SARS-CoV-2-hospitalized patients did not represent an independent risk factor for severe disease or mortality.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 2","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage activation syndrome in a patient with systemic lupus erythematosus undergoing cyclophosphamide treatment: a case report. 巨噬细胞激活综合征的系统性红斑狼疮患者接受环磷酰胺治疗:1例报告。

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1597

L Fioravante da Silveira, A Zago, D Zanchet, D Chemello

引用次数: 0

A case of Sjögren syndrome and anti-neutrophil cytoplasmic antibody-associated vasculitis. Sjögren综合征合并抗中性粒细胞细胞质抗体相关性血管炎1例。

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1564

K Kaynar, B Güvercin, A Şengör, S Mungan

{"title":"A case of Sjögren syndrome and anti-neutrophil cytoplasmic antibody-associated vasculitis.","authors":"K Kaynar, B Güvercin, A Şengör, S Mungan","doi":"10.4081/reumatismo.2023.1564","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1564","url":null,"abstract":"Sjögren's syndrome (SS) is a rare disease with the highest reported prevalence of 0.01-0.09%. Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is another rare auto-immune disease (prevalence of 0.0009-0.01%). The co-occurrence of these two separate clinical entities in one patient might rarely be encountered as an overlap syndrome. Here, we present the case of a 60-year-old female patient who had complaints of headache, nausea, weakness, gritty sensation in her eyes, and dry mouth [unstimulated saliva production of 0.033 mL/minute (normal; >0.1 mL/minute)] with a blood pressure of 190/110 mmHg, hypertensive retinopathy, proteinuric kidney disease, positivity of myeloperoxidase anti-neutrophil cytoplasmic antibodies, anti-Ro-52, anti-Ro, and anti-La antibodies. Pauci-immune crescentic proliferative glomerulonephritis was found in a kidney biopsy and successfully treated with cyclophosphamide and methylprednisolone. The co-occurrence of these diseases was first reported in 1992 by Böttinger et al. Since then, nearly 37 cases of SS and AAV have been reported. By reporting this case of primary SS and AAV, we emphasize the importance of auto-antibody tests in searching for the etiology of patients with proteinuria.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 2","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10213066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0