Oxidative stress may be a contributing factor in fibromyalgia patients' pain mechanisms.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-18 DOI:10.4081/reumatismo.2023.1550

H Beyaztas, S Aktas, E M Guler, E Ata

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引用次数: 0

Abstract

Objective: The pathophysiology of fibromyalgia (FM), a continuously painful syndrome with no known origin, has been related to mitochondrial dysfunction, oxidative stress, and inflammation. Recent studies have shown that FM may be associated with an oxidative balance disorder. The objective of this study was to measure the levels of oxidative stress in FM patients and try to understand the association between FM and free radicals.

Methods: This study was performed on 100 volunteers admitted to the University of Health Sciences, Sultan 2, Abdulhamid Han Health Application and Research Center Physical Therapy and Rehabilitation Clinic, including 50 healthy controls and 50 patients with FM. To analyze oxidative stress biomarkers, total oxidant status (TOS) and total antioxidant status (TAS) levels were measured. Total thiol (TT) and native thiol (NT) concentrations were measured to determine the relationship between thiol groups. Disulfide (DIS) and oxidative stress index (OSI) were calculated with mathematical formulas.

Results: While TOS and OSI levels were statistically higher in FM patients, TAS levels were significantly lower compared to the healthy control group (p<0.001). In comparison to the healthy control group, FM patients had considerably decreased TT and NT levels. DIS levels were significantly higher in FM patients than in controls (p<0.001).

Conclusions: Reactive oxygen species have several negative impacts on the human body. As a result of the measurements we analyzed, the relationship between FM and oxidative stress should be studied in terms of disease progression and may help improve the treatment process.

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氧化应激可能是纤维肌痛患者疼痛机制的一个促进因素。

目的:纤维肌痛(FM)是一种来源不明的持续性疼痛综合征，其病理生理学与线粒体功能障碍、氧化应激和炎症有关。最近的研究表明，FM可能与氧化平衡紊乱有关。本研究的目的是测量FM患者的氧化应激水平，并试图了解FM与自由基之间的关系。方法:本研究以健康科学大学Sultan 2, Abdulhamid Han健康应用与研究中心物理治疗与康复诊所的100名志愿者为研究对象，其中50名健康对照组和50名FM患者。为了分析氧化应激生物标志物，测量了总氧化状态(TOS)和总抗氧化状态(TAS)水平。测定总硫醇(TT)和天然硫醇(NT)浓度，以确定硫醇组之间的关系。用数学公式计算了二硫化物(DIS)和氧化应激指数(OSI)。结果:与健康对照组相比，FM患者的TOS和OSI水平有统计学意义上的升高，而TAS水平有统计学意义上的降低(结论:活性氧对人体有多种负面影响。根据我们分析的测量结果，应该从疾病进展的角度研究FM和氧化应激之间的关系，并可能有助于改善治疗过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.