Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-18 DOI:10.4081/reumatismo.2023.1530

V Bruzzese, C Marrese, P Scolieri, J Pepe

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引用次数: 0

Abstract

Objective: Dietary interventions to improve fibromyalgia (FM) symptoms reported conflicting results. This study aimed to treat FM patients with a gluten-free diet (GFD), alternated with a non-restricted gluten-containing diet, followed by a rechallenge of the GFD.

Methods: Twenty postmenopausal women with FM and no history of celiac disease participated. A GFD was assigned for 6 months. This was followed by 3 months of a non-restricted gluten-containing diet and then a new GFD for another 6 months. At each visit, the widespread pain index (WPI) and the symptom severity scale (SS) scores were evaluated.

Results: The mean age of the patients enrolled was 53.9±10 years. None of the patients had a diagnosis of irritable bowel disease, although they reported vague gastrointestinal symptoms. After 6 months of a GFD, a statistically significant reduction was observed for the WPI (10.3±1.8 vs 7.7±1.4; p<0.0001) and the SS scale (6.4±1.8 vs 4.15±1.6; p=0.0002). The D percentage reduction of the WPI after 6 months of GFD was -24%±9%, while for the SS scale, it was -36%±21%. The following reintroduction of a gluten-containing diet brought about a statistically significant rise in the absolute SS scale and WPI, as well as a D modification of the WPI (21%±13%) and of the SS scale (74%±90%). The rechallenge of the GFD showed a significant improvement in absolute and D WPI (-24%±7%) and SS (-36%±11%). No modifications to the body mass index were found.

Conclusions: A GFD improved FM symptoms evaluated with WPI and SS. This was confirmed for the first time, also with a rechallenge of the GFD that followed a non-restricted gluten-containing diet.

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无麸质饮食在降低纤维肌痛患者普遍疼痛指数和症状严重程度量表中的疗效。

目的:饮食干预改善纤维肌痛(FM)症状的报道结果相互矛盾。本研究旨在用无麸质饮食(GFD)治疗FM患者，交替使用非限制性含麸质饮食，然后再进行GFD治疗。方法:20例绝经后无乳糜泻病史的FM妇女参与研究。指派一名GFD，为期6个月。接下来是3个月的无限制含谷蛋白饮食，然后是6个月的新的GFD。在每次访问时，评估广泛疼痛指数(WPI)和症状严重程度量表(SS)评分。结果:入组患者平均年龄为53.9±10岁。这些患者都没有被诊断为肠易激病，尽管他们报告了模糊的胃肠道症状。GFD治疗6个月后，WPI显著降低(10.3±1.8 vs 7.7±1.4;结论:用WPI和SS评估的GFD改善了FM症状。这是第一次得到证实，也是在非限制性含麸质饮食后对GFD的再次挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.