ReumatismoPub Date : 2023-03-21DOI: 10.4081/reumatismo.2022.1555
M Cutolo, A Sulli, V Smith, E Gotelli
{"title":"Emerging nailfold capillaroscopic patterns in COVID-19: from acute patients to survivors.","authors":"M Cutolo, A Sulli, V Smith, E Gotelli","doi":"10.4081/reumatismo.2022.1555","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1555","url":null,"abstract":"<p><p>The SARS-CoV-2 infection causing the Coronavirus disease-19 (COVID-19) is characterized by a broad range of clinical manifestations, implicating microvascular damage with endothelial dysfunction and different organ involvement.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 4","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2023-03-21DOI: 10.4081/reumatismo.2022.1502
B Cigdem Karacay, T Sahbaz, C Medin Ceylan
{"title":"The vicious cycle of physical inactivity, fatigue and kinesiophobia in patients with fibromyalgia syndrome.","authors":"B Cigdem Karacay, T Sahbaz, C Medin Ceylan","doi":"10.4081/reumatismo.2022.1502","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1502","url":null,"abstract":"<p><p>This study aims to determine the association between fatigue, kinesiophobia, disease severity, and physical inactivity by comparing fibromyalgia syndrome (FMS) patients with healthy controls. Pain and fatigue are significant barriers to the participation in functional activities. Inactivity is a result of fatigue, but exercise is the foundation of FMS treatment. This case-control study included a total of 203 participants (107 patients with FMS and 96 healthy volunteers). The fibromyalgia impact questionnaire, the fatigue severity scale, the international physical activity questionnaire, and the Tampa scale for kinesiophobia were assessed. The FMS group scored significantly higher on the fatigue severity scale and kinesiophobia than the control group (p<0.001). Significantly lower metabolic task equivalent (MET) scale values were observed in the FMS group compared to the control group (p<0.001). The severity of fatigue and kinesiophobia correlated positively with the FMS impact questionnaire (p=0.001, r=0.621) and negatively with the MET scale (p=0.009, r= -0.287). Patients with FMS experience greater fatigue, kinesiophobia, and inactivity. As the severity of FMS worsens, so do disability, kinesiophobia, and fatigue. This study highlights the importance of breaking the cycle of fatigue and inactivity in the treatment of FMS.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 4","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9154409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2023-03-21DOI: 10.4081/reumatismo.2022.1556
A Tincani, G Fontana, C Mackworth-Young
{"title":"The history of antiphospholipid syndrome.","authors":"A Tincani, G Fontana, C Mackworth-Young","doi":"10.4081/reumatismo.2022.1556","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1556","url":null,"abstract":"Antiphospholipid Syndrome (APS) is an autoimmune disease which was defined in the early 1980s. The principal features include thromboembolic events and/or pregnancy losses in association with antiphospholipid antibodies (aPL). As an historical note, the full-blown picture of the syndrome resembles the illness suffered by Anne Stuart, Queen of England in the XVIII century, whose repeated miscarriages caused the end of the royal Stuart line and the Hanoverian succession. The identification of aPL started in the early XX century and was linked to the introduction of the serological test for the diagnosis of syphilis. This involves a reaction between an antibody (reagin) and a phospholipid antigen derived from bovine heart (cardiolipin). Later on, it was observed that not all subjects with a positive test had syphilis, and that the so called \"false positive reaction\" was often reported in patients with systemic lupus erythematosus. Different tests for the identification of aPL were subsequently developed: first lupus anticoagulant (1971) and then immunoassays for anticardiolipin (1983) and anti-beta2 glycoprotein I (1990) antibodies. In the same period the association between the presence of circulating aPL and thrombotic and obstetric events was established, both in patients with autoimmune diseases and in otherwise healthy subjects, leading to the identification of APS as a distinct autoimmune disease. This has allowed better diagnosis and more targeted treatment for many patients.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 4","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2023-03-21DOI: 10.4081/reumatismo.2022.1528
I Pantano, D Mauro, D Simone, L Costa, D Capocotta, M Raimondo, D Birra, G Cuomo, T D'Errico, M Ferrucci, F Comentale, G Italiano, P Moscato, N Pappone, R Russo, S Scarpato, R Tirri, P Buono, A Postiglione, R Guida, R Scarpa, U Trama, E Tirri, F Ciccia
{"title":"The data project: a shared approach between stakeholders of the healthcare system in definition of a therapeutic algorithm for inflammatory arthritis.","authors":"I Pantano, D Mauro, D Simone, L Costa, D Capocotta, M Raimondo, D Birra, G Cuomo, T D'Errico, M Ferrucci, F Comentale, G Italiano, P Moscato, N Pappone, R Russo, S Scarpato, R Tirri, P Buono, A Postiglione, R Guida, R Scarpa, U Trama, E Tirri, F Ciccia","doi":"10.4081/reumatismo.2022.1528","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1528","url":null,"abstract":"<p><p>Rheumatic musculoskeletal diseases or RMD [rheumatoid arthritis (RA) and spondyloarthritis (SpA)] are systemic inflammatory diseases for which there are no biomarkers capable of predicting treatments with a higher likelihood of response in naive patients. In addition, the expiration of the anti-TNF blocking drugs' patents has resulted in the availability of anti-TNF biosimilar drugs with the same efficacy and safety than originators but at significantly reduced prices. To guarantee a personalized therapeutic approach to RMD treatment, a board of rheumatologists and stakeholders from the Campania region, Italy, developed a clinically applicable arthritis therapeutic algorithm to guide rheumatologists (DATA project). The general methodology relied on a Delphi technique forecast to produce a set of statements that summarized the experts' consensus. Selected clinical scenarios were discussed in light of the available evidence, and there were two rounds of voting on the therapeutic approaches. Separate discussions were held regarding rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. The decision-making factors for each disease were clinical presentation, demographics, and comorbidities. In this paper, we describe a virtuous process between rheumatologists and healthcare system stakeholders that resulted in the development of a shared therapeutic algorithm for RMD patients naive to bDMARDs.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 4","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2022-12-29DOI: 10.4081/reumatismo.2022.1452
G Torres Vilarino, D Reis Coimbra, G Guimarães Bevilacqua, P Diotaiuti, L Falese, A Andrade
{"title":"Can different degrees of resistance training improve mood states in patients with fibromyalgia? A randomized controlled trial.","authors":"G Torres Vilarino, D Reis Coimbra, G Guimarães Bevilacqua, P Diotaiuti, L Falese, A Andrade","doi":"10.4081/reumatismo.2022.1452","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1452","url":null,"abstract":"<p><p>The purpose of this study was to look at the effects of low and high intensity resistance training (RT) on the mood states of fibromyalgia patients (FM). A total of 69 women participated in the study, with 31 healthy women serving as control group (HC), and 28 women diagnosed with FM being randomly assigned to one of two RT groups: low intensity or high intensity. Ten women diagnosed with FM formed a group of preferred intensity (PI). FM patients were subjected to 8 weeks of supervised RT with low, high, or PI doses. The exercise protocol was the same for both groups, with large muscle group exercises. Each intervention group performed a specific number of repetitions and rest periods based on the intensity. Training sessions took place twice a week. The HC received no type of intervention. The Brunel mood scale was used to assess mood states. When the mood profiles of patients with FM and healthy women were compared, patients with FM showed a worse mood profile. Low and high intensity RT for eight weeks did not improve the mood profile of FM patients. Anger showed a significant difference between LIRT and HIRT groups in the follow-up period (p=0.01); similarly significant differences between HIRT and HC were seen at baseline and at the 4 week evaluation in vigor (p=0.01 and p=0.001) and fatigue (p=0.01 and p=0.03). FM patients have a worse mood profile than healthy women, and eight weeks of low and high intensity RT did not result in significant improvements.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2022-12-29DOI: 10.4081/reumatismo.2022.1508
F Ingegnoli, M Cornalba, R De Angelis, S Guiducci, D Giuggioli, C Pizzorni, V Riccieri, M Sebastiani, A Sulli, M Cutolo
{"title":"Nailfold capillaroscopy in the rheumatological current clinical practice in Italy: results of a national survey.","authors":"F Ingegnoli, M Cornalba, R De Angelis, S Guiducci, D Giuggioli, C Pizzorni, V Riccieri, M Sebastiani, A Sulli, M Cutolo","doi":"10.4081/reumatismo.2022.1508","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1508","url":null,"abstract":"<p><p>This cross-sectional online study was designed by the study group on Capillaroscopy and Microcirculation in Rheumatic Diseases (CAP) of the Italian Society of Rheumatology (SIR) to provide an overview of the management of nailfold capillaroscopy in Italian rheumatology centers. Therefore, SIR distributed the survey to its members in July 2021, and each center's physician with the most expertise in capillaroscopy completed the questionnaire. The survey was completed by 102 centers, with at least one representative from each Italian region. Ninety-three centers perform capillaroscopy, and 52 (56) conduct more than 200 investigations annually. Seventy-eight (84%) of respondents have more than five years of experience with the technique, and 75 centers (80.6%) have received certification from specific national or international training courses. In 85 centers, a videocapillaroscope with 200x magnification is employed (91.4%). The average waiting period for the examination is 2.4 months, and less than 3 months in 64 of the locations (68.8%). The study demonstrates that capillaroscopy is an integral part of both the diagnostic phase of Raynaud's phenomenon and the monitoring of autoimmune connective tissue diseases (CTDs). However, the reporting methods and timing of patient followup are heterogeneous.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2022-12-29DOI: 10.4081/reumatismo.2022.1534
G A Minetti, M Parodi, S Banderali, E Silvestri, G Garlaschi, M A Cimmino
{"title":"Magnetic resonance imaging as a structural refinement to the American College of Rheumathology clinical classification criteria for knee osteoarthritis.","authors":"G A Minetti, M Parodi, S Banderali, E Silvestri, G Garlaschi, M A Cimmino","doi":"10.4081/reumatismo.2022.1534","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1534","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate if fulfilment of the definition of osteoarthritis (OA) based on the American College of Rheumatology (ACR) clinical criteria corresponds to pathological knee findings evaluated by magnetic resonance imaging (MRI). To evaluate if any such criteria is associated with a specific MRI pattern.</p><p><strong>Methods: </strong>Forty-six consecutive patients aged 50 years or more referred by their general practitioners (GPs) to a radiology department because of non-traumatic knee pain underwent MRI using a dedicated low field (0.2 T) machine.</p><p><strong>Results: </strong>MRI results were compared against the ACR criteria for knee OA. Patients with knee pain fulfilling the ACR criteria showed more severe synovial fluid effusion (OR 6.2, 95% CI 2.02 to 19.1), cartilage lesions in the medial area (OR 2.4, 95% CI 1.2 to 5) and higher mean number of osteophytes (OR 2.3, 95% CI 1.1 to 4.5). The association between single criteria and MRI features was more difficult to establish. Nonetheless, crepitus at joint movement was associated with synovial fluid effusion (p=0.02); bone enlargement was more frequent in patients with lesions of the posterior cruciate ligament (p=0.0001); no palpable warmth was associated with cartilage lesions (p=0.02), and morning stiffness shorter than 30 minutes was associated with the surface of bone edema (p=0.02).</p><p><strong>Conclusions: </strong>The ACR clinical criteria identify patients showing the most important features of OA. The association between individual clinical ACR criteria and OA pathology depicted by MRI may be difficult to explain on the basis of anatomical changes and needs further evaluation.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10464975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2022-12-29DOI: 10.4081/reumatismo.2022.1487
Z Tamartash, A Javinani, Y Pehlivan, B N Coskun, R A Yekta, E Dalkilic, B Yağız, N Khavandgar, M Pournazari, A Hajiabbasi, O Sakar, H Zayeni, I S Masoleh, M R Shakibi, F Yazdi, M Mahmoudi, M Masoumi, A M Mohammadzadegan, F Sima, S Salehi, S T Faezi, A R Jamshidi, H Kavosi
{"title":"Comparison of clinicodemographic characteristics and pattern of vascular involvement in 126 patients with Takayasu arteritis: a report from Iran and Turkey.","authors":"Z Tamartash, A Javinani, Y Pehlivan, B N Coskun, R A Yekta, E Dalkilic, B Yağız, N Khavandgar, M Pournazari, A Hajiabbasi, O Sakar, H Zayeni, I S Masoleh, M R Shakibi, F Yazdi, M Mahmoudi, M Masoumi, A M Mohammadzadegan, F Sima, S Salehi, S T Faezi, A R Jamshidi, H Kavosi","doi":"10.4081/reumatismo.2022.1487","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1487","url":null,"abstract":"<p><p>Takayasu arteritis (TA) is an extremely uncommon vasculitis that primarily affects the aorta and its branches. Due to the genetic and ethnicity effect, a diverse array of TA clinical manifestations has been reported worldwide. The purpose of the present study was to compare the clinicodemographic characteristics and pattern of vascular involvement of Iranian and Turkish TA patients. This study was a retrospective, cross-sectional investigation of 126 TA patients in Iran and Turkey. All of the variables analyzed were extracted from historical medical records. In 126 TA patients, the ratio of females to males was 8.6:1, and the average age at onset of disease was 30.5±11.1 years. Fatigue (49.2%) and a weak or absent pulse (79.4%) were the most prevalent symptoms and signs, respectively. The most prevalent angiographic classifications were types V and I in Iranian patients (41.09%) and type I in the Turkish population (47.7%) The left subclavian artery was the vessel most frequently affected by TA (66.6%). Our findings indicated that there were no significant differences between the two countries in terms of clinicodemographic characteristics or vascular involvement. Some clinical manifestations, such as claudication, were more prevalent in the Turkish population due to a higher incidence of occlusive lesions in the right subclavian artery.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ReumatismoPub Date : 2022-12-29DOI: 10.4081/reumatismo.2022.1527
B Joob, V Wiwanitkit
{"title":"Comment to: Disseminated cutaneous herpes simplex, COVID-19 vaccination and rheumatoid arthritis patient: a case report and review.","authors":"B Joob, V Wiwanitkit","doi":"10.4081/reumatismo.2022.1527","DOIUrl":"https://doi.org/10.4081/reumatismo.2022.1527","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"74 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10464972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}