Reumatismo最新文献_第10页

Retention rate of tumor necrosis factor inhibitors, anti-interleukin 17, and anti-interleukin 12/23 drugs in a single-center cohort of psoriatic arthritis patients. 银屑病关节炎患者单中心队列中肿瘤坏死因子抑制剂、抗白介素17和抗白介素12/23药物的保留率

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1544

M Ferrito, G Cincinelli, M Manara, R Di Taranto, E G Favalli, R Caporali

{"title":"Retention rate of tumor necrosis factor inhibitors, anti-interleukin 17, and anti-interleukin 12/23 drugs in a single-center cohort of psoriatic arthritis patients.","authors":"M Ferrito, G Cincinelli, M Manara, R Di Taranto, E G Favalli, R Caporali","doi":"10.4081/reumatismo.2023.1544","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1544","url":null,"abstract":"The objective of this study was to evaluate biological disease-modifying anti-rheumatic drugs (bDMARDs) survival in several therapy courses of patients affected by psoriatic arthritis (PsA) and to compare tumor necrosis factor inhibitors (TNFi) and non-TNFi retention rates. A total of 241 bDMARD therapy courses (155 TNFi drugs, 65 anti-interleukin (IL)-17 drugs, and 21 anti-IL12/23) were analyzed. Bivariate analyses were performed to assess the presence of demographic and clinical features, as well as comorbidities, associated with bDMARD discontinuation in TNFi and non-TNFi groups. In the bivariate analyses of TNFi and non-TNFi groups, we found a lower age at the start of TNFi therapy in the former group [46 years, interquartile range (IQR) 45-54 vs 50.5 years, IQR 42-61; p=0.004] as well as a lower proportion of patients with skin psoriasis (65.8% vs 88.4%; p<0.001). Survival analysis showed no significant differences between TNFi and non-TNFi groups. Cox regression found fibromyalgia as a predictor of drug failure [hazard ratio (HR) 3.40, confidence interval (CI) 1.92-6.03; p<0.001] and first-line bDMARDs as a protective factor (HR 0.46, CI 0.25-0.88; p=0.019). Lastly, among TNFi courses, fibromyalgia was associated with drug suspension (HR 6.52, CI 3.16-13.46; p<0.001), while only a trend of significance for skin psoriasis as a risk factor for drug failure was shown (HR 2.38, CI 1.00-5.66, p=0.05). This study provides information about clinical and demographic factors associated with retention rates of bDMARDs from a real-life, single-center cohort of PsA patients.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 2","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9853517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathergy-like reaction induced by laser hair removal in a patient with Behçet disease. 激光脱毛致behaperet病患者病理样反应1例。

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1509

R Nicolau, T Martins Rocha, L Costa

引用次数: 0

Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients. 巴拉圭系统性红斑狼疮患者不同表型相关的临床特征和遗传生物标志物

IF 1.4

Reumatismo Pub Date : 2023-07-17 DOI: 10.4081/reumatismo.2023.1541

I Acosta-Colman, Z Morel, A Ayala Lugo, V Jolly, I De Guillén, P Langjahr, M Vazquez, M T Martínez de Filártiga, M E Acosta

{"title":"Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients.","authors":"I Acosta-Colman, Z Morel, A Ayala Lugo, V Jolly, I De Guillén, P Langjahr, M Vazquez, M T Martínez de Filártiga, M E Acosta","doi":"10.4081/reumatismo.2023.1541","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1541","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a heterogeneous clinical picture that makes the diagnosis and follow-up of these patients difficult. This study aimed to identify correlations between clinical, immunological, and genetic biomarkers and clinical manifestations in SLE. A retrospective study of data from medical records and immunological and genetic studies of SLE patients in Paraguay was carried out. A descriptive analysis was performed based on the type of variable. Human leukocyte antigen (HLA) allele frequencies (DPA1, DPB1, DQA1, DQB1, and DRB1) were calculated, and univariate logistic regression analyses were performed between each of the explanatory variables and the presence or absence of each phenotype. Odds ratios, 95% confidence intervals, and p values were recorded. Associations with p<0.05 were considered statistically significant. 104 SLE patients were included: 86% were female, with a mean age of 32.80±10.36 years. An association was identified between anti-double stranded DNA (anti-dsDNA) and the presence of the renal phenotype and between anti-dsDNA and the absence of the joint and hematological phenotypes. Immunoglobulin M isotype rheumatoid factor was associated with the absence of a renal phenotype. HLA-DQB1*02:02 and HLA-DRB1*07:01 were associated with the cutaneous phenotype. An association was identified between age at disease onset over 30 years and the presence of the joint phenotype. No other associations were identified. Potential clinical, immunological, and genetic biomarkers of phenotypes have been identified in SLE Paraguayan patients.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 2","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10213068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uveitis in patients with oligoarticular juvenile idiopathic arthritis and juvenile spondyloarthritis/enthesitis related arthritis: is there any difference? 少关节幼年特发性关节炎患者的葡萄膜炎与幼年脊柱炎/感染性关节炎患者的葡萄膜炎有区别吗?

IF 1.4

Reumatismo Pub Date : 2023-05-08 DOI: 10.4081/reumatismo.2023.1561

A Martins, S Ganhão, F Oliveira Pinheiro, C Granjo Morais, M Rodrigues, M Leuzinger-Dias, L Figueira, I Brito

引用次数: 0

Diagnosis and treatment of interstitial lung disease related to systemic autoimmune myopathies: a narrative review. 与全身性自身免疫性肌病相关的间质性肺疾病的诊断和治疗:叙述性综述

IF 1.4

Reumatismo Pub Date : 2023-05-08 DOI: 10.4081/reumatismo.2023.1571

F H C De Souza, D B De Araújo, L S Hoff, B G Baldi, M S M S Faria, L F Da Rocha Junior, L R S Da Silva, G L Behrens Pinto, M C Bezerra, R Miossi, R A Cordeiro, S K Shinjo

{"title":"Diagnosis and treatment of interstitial lung disease related to systemic autoimmune myopathies: a narrative review.","authors":"F H C De Souza, D B De Araújo, L S Hoff, B G Baldi, M S M S Faria, L F Da Rocha Junior, L R S Da Silva, G L Behrens Pinto, M C Bezerra, R Miossi, R A Cordeiro, S K Shinjo","doi":"10.4081/reumatismo.2023.1571","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1571","url":null,"abstract":"Systemic autoimmune myopathies (SAMs) are rare diseases that lead to muscle inflammation and may be associated with a variety of systemic manifestations. Although there is great heterogeneity in the spectrum of extra-muscular involvement in SAMs, interstitial lung disease (ILD) is the most frequent lung manifestation. SAM-related ILD (SAM-ILD) presents significant variations according to geographic location and temporal trends and is associated with increased morbidity and mortality. Several myositis autoantibodies have been discovered over the last decades, including antibodies targeting aminoacyl-tRNA synthetase enzymes, which are associated with a variable risk of developing ILD and a myriad of other clinical features. In this review, the most relevant topics regarding clinical manifestations, risk factors, diagnostic tests, autoantibodies, treatment, and prognosis of SAM-ILD are highlighted. We searched PubMed for relevant articles published in English, Portuguese, or Spanish from January 2002 to September 2022. The most common SAM-ILD patterns are nonspecific interstitial pneumonia and organizing pneumonia. The combination of clinical, functional, laboratory, and tomographic features is usually sufficient for diagnostic confirmation, without the need for additional invasive methods. Glucocorticoids remain the first-line treatment for SAM-ILD, although other traditional immunosuppressants, such as azathioprine, mycophenolate, and cyclophosphamide have demonstrated some efficacy and, therefore, have an important role as steroid-sparing agents.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-streptococcal scleredema an unusual rare mimicker of scleroderma: a case report. 链球菌感染后硬化水肿是一种罕见的硬皮病的模拟物:1例报告。

IF 1.4

Reumatismo Pub Date : 2023-05-08 DOI: 10.4081/reumatismo.2023.1551

F I Gorial, N I Awadh, A D Al-Obaidi, M N Al-Obaidi, H T Hashim, H J Hasan

引用次数: 0

Prof. Innocenzo Caruso. Innocenzo Caruso教授。

IF 1.4

Reumatismo Pub Date : 2023-05-08 DOI: 10.4081/reumatismo.2023.1591

The Editors

引用次数: 0

Epidemiology and demographics of cutaneous lupus erythematosus in Colombia between 2015 and 2019. 2015 - 2019年哥伦比亚皮肤红斑狼疮的流行病学和人口统计学

IF 1.4

Reumatismo Pub Date : 2023-05-08 DOI: 10.4081/reumatismo.2023.1568

D G Fernández Ávila, M Rivera Maldonado, L P Charry Anzola

引用次数: 0

Secukinumab retention rate is greater in patients with psoriatic arthritis presenting with axial involvement. 伴有轴向受累的银屑病关节炎患者的Secukinumab保留率更高。

IF 1.4

Reumatismo Pub Date : 2023-05-08 DOI: 10.4081/reumatismo.2023.1559

G Adami, L Idolazzi, C Benini, E Fracassi, A Carletto, O Viapiana, D Gatti, M Rossini, A Fassio

{"title":"Secukinumab retention rate is greater in patients with psoriatic arthritis presenting with axial involvement.","authors":"G Adami, L Idolazzi, C Benini, E Fracassi, A Carletto, O Viapiana, D Gatti, M Rossini, A Fassio","doi":"10.4081/reumatismo.2023.1559","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1559","url":null,"abstract":"Psoriatic arthritis (PsA) is an inflammatory disease characterized by peripheral and axial involvement. Biological disease-modifying antirheumatic drugs (bDMARDs) are the mainstream treatment for PsA and bDMARDs retention rate is a proxy for the drug's overall effectiveness. However, it is unclear whether IL-17 inhibitors can have a higher retention rate than tumor necrosis factor (TNF) inhibitors, in particular in axial or peripheral PsA. A real-life observational study was conducted on bDMARD naïve PsA patients initiating TNF inhibitors or secukinumab. Time-to-switch analysis was carried out with Kaplan-Meyer curves (log-rank test) truncated at 3 years (1095 days). Sub-analyses of Kaplan-Meyer curves between patients presenting with prevalent peripheral PsA or prevalent axial PsA were also conducted. Cox regression models were employed to describe predictors of treatment switch/swap. Data on 269 patients with PsA naïve to bDMARD starting either TNF inhibitors (n=220) or secukinumab (n=48) were retrieved. The overall treatment retention at 1 and 2 years was similar for secukinumab and TNF inhibitors (log-rank test p NS). We found a trend towards significance in the Kaplan-Meyer at 3 years in favor of secukinumab (log-rank test p 0.081). Predominant axial disease was significantly associated with a higher chance of drug survival in secukinumab users (adjusted hazard ratio 0.15, 95% confidence interval = 0.04-0.54) but not in TNF inhibitor users. In this real-life, single-center, study on bDMARD naïve PsA patients, axial involvement was associated with longer survival of secukinumab but not of TNF inhibitors. Drug retention of secukinumab and TNF inhibitors were similar in predominantly peripheral PsA.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9437883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Idiopathic inflammatory myopathies linked to vaccination against SARS-CoV-2: a systematic review. 与SARS-CoV-2疫苗接种相关的特发性炎性肌病:系统综述

IF 1.4

Reumatismo Pub Date : 2023-05-08 DOI: 10.4081/reumatismo.2023.1548

A Camargo-Coronel, H Quiñones-Moya, M R Hernández-Zavala, J R Hernández-Vázquez, M Á Vázquez-Zaragoza

{"title":"Idiopathic inflammatory myopathies linked to vaccination against SARS-CoV-2: a systematic review.","authors":"A Camargo-Coronel, H Quiñones-Moya, M R Hernández-Zavala, J R Hernández-Vázquez, M Á Vázquez-Zaragoza","doi":"10.4081/reumatismo.2023.1548","DOIUrl":"https://doi.org/10.4081/reumatismo.2023.1548","url":null,"abstract":"The COVID-19 pandemic represents a global health problem, which has been mitigated by the opportune introduction of vaccination programs. Although we already know the benefit that vaccines provide, these are not exempt from adverse events which can be mild to deadly, such as idiopathic inflammatory myopathies, in which a temporal association has not been defined. It is for this reason that we carried out a systematic review of all reported cases of vaccination against COVID-19 and myositis. To identify previously reported cases of idiopathic inflammatory myopathies associated with vaccination against SARS-CoV-2 we registered this protocol on the website of PROSPERO with identification number CRD42022355551. Of the 63 publications identified in MEDLINE and 117 in Scopus, 21 studies were included, reporting 31 cases of patients with vaccination-associated myositis. Most of these cases were women (61.3%); mean age was 52.3 years (range 19-76 years) and mean time of symptom onset post-vaccination was 6.8 days. More than half of the cases were associated with Comirnaty, 11 cases (35.5%) were classified as dermatomyositis, and 9 (29%) as amyopathic dermatomyositis. In 6 (19.3%) patients another probable trigger was identified. Case reports of inflammatory myopathies associated with vaccination have heterogeneous presentations without any specific characteristics: as a consequence, it is not possible to ensure a temporal association between vaccination and the development of inflammatory myopathies. Large epidemiological studies are required to determine the existence of a causal association.","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":"75 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1