不安腿会是其他疾病的征兆吗?脊柱关节炎伴有不安腿综合征的病例报告及文献综述。

IF 1.2 Q4 RHEUMATOLOGY
E Yılmaz
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引用次数: 0

摘要

不宁腿综合症(RLS)是一种慢性运动障碍,其特征是有移动四肢的冲动或需要,通常伴有腿部不舒服的感觉和睡眠障碍。一般来说,RLS 有两种临床形式:原发性和继发性。虽然原发性 RLS 有家族遗传因素,但其潜在机制仍不完全清楚,但似乎与中枢神经系统的多巴胺能和谷氨酸能通路异常有关。该综合征的继发性形式与缺铁、肾功能衰竭、妊娠、糖尿病、周围神经病变以及一些风湿性疾病(如类风湿性关节炎和斯约格伦综合征)有关。在一些临床试验中,脊柱关节炎患者发生 RLS 的频率有所增加。本报告介绍了一例同时患有脊柱关节炎和 RLS 的病例,该病例在接受保守治疗和加用萘普生后病情得到了满意的改善。风湿性疾病中出现的慢性贫血和相关的缺铁可能会导致 RLS 的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can restless legs be a sign of something else? A case report of spondyloarthritis presenting with restless legs syndrome and a review of the literature.

Restless legs syndrome (RLS) is a chronic movement disorder characterized by an urge or need to move the limbs, usually associated with uncomfortable sensations in the legs and sleep disorders. In general, two clinical forms of RLS are described: primary and secondary. Although primary RLS has a familial component, the underlying mechanism is still not fully understood but seems to be related to abnormalities in the dopaminergic and glutamatergic pathways of the central nervous system. The secondary forms of the syndrome are associated with iron deficiency, renal failure, pregnancy, diabetes mellitus, peripheral neuropathy, and several rheumatologic disorders such as rheumatoid arthritis and Sjögren's syndrome. In a few clinical trials, an increased frequency of RLS has been reported in patients with spondyloarthritis. In this report, a case of coexistence of spondyloarthritis and RLS is presented, showing satisfactory improvement with conservative treatment and additionally adding naproxen. Anemia of chronic disease occurring in rheumatic diseases, and associated iron deficiency may contribute to the development of RLS.

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来源期刊
Reumatismo
Reumatismo RHEUMATOLOGY-
CiteScore
2.10
自引率
7.10%
发文量
20
审稿时长
10 weeks
期刊介绍: Reumatismo is the official Journal of the Italian Society of Rheumatology (SIR). It publishes Abstracts and Proceedings of Italian Congresses and original papers concerning rheumatology. Reumatismo is published quarterly and is sent free of charge to the Members of the SIR who regularly pay the annual fee. Those who are not Members of the SIR as well as Corporations and Institutions may also subscribe to the Journal.
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