Revista Brasileira De Ciencias Farmaceuticas最新文献_第8页

Capacidade antioxidante de frutas

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-06-01 DOI: 10.1590/S1516-93322008000200005

E. A. Melo, M. Maciel, V. Lima, R. J. Nascimento

{"title":"Capacidade antioxidante de frutas","authors":"E. A. Melo, M. Maciel, V. Lima, R. J. Nascimento","doi":"10.1590/S1516-93322008000200005","DOIUrl":"https://doi.org/10.1590/S1516-93322008000200005","url":null,"abstract":"Aqueous and acetone extracts from 15 fruits have been screened for antioxidant activity using DPPH method and s-carotene/linoleic acid model. All fruits studied showed antioxidant activity, but in different extent. Acerola, cashew-apple, papaya \"formosa\", papaya \"solo\", orange and guava showed the higher antioxidant activity (>;70%) in DPPH method, followed by pineapple, bergamont, mango \"rosa\", melon \"reticulares\", melon \"inodorus\", melon \"orange flesh\" and sugar-apple aqueous extract (moderate, 60-70%) and mango \"espada\" and watermelon aqueous extract, the lowest activity. Acerola, cashew-apple, sugar-apple and guava acetone extracts exhibited higher scavenging activity toward DPPH radicals (>;70%).β-carotene/linoleic acid model index of sugar-apple aqueous extract and guava acetone extract demonstrated moderate antioxidant activity (60-70%), meanwhile acerola aqueous extract and papaya \"formosa\" acetone extract the lower. According to antioxidant activity, fruits can be indicated as natural antioxidants sources, pointing out acerola, cashew-apple, papaya \"solo\", papaya \"formosa\", guava, orange and sugar-apple as the highest in antioxidant capacity.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"460 1","pages":"193-201"},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82978178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 138

Effect of cosurfactant on the supramolecular structure and physicochemical properties of non-ionic biocompatible microemulsions 助表面活性剂对非离子生物相容性微乳的超分子结构和理化性质的影响

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100005

Kélia Xavier Resende, M. Correa, A. G. Oliveira, M. V. Scarpa

{"title":"Effect of cosurfactant on the supramolecular structure and physicochemical properties of non-ionic biocompatible microemulsions","authors":"Kélia Xavier Resende, M. Correa, A. G. Oliveira, M. V. Scarpa","doi":"10.1590/S1516-93322008000100005","DOIUrl":"https://doi.org/10.1590/S1516-93322008000100005","url":null,"abstract":"Microemulsions are transparent, homogeneous and thermodynamically stable systems, formed spontaneously under a specific set of experimental conditions from mixtures of water and oil phases stabilized by a surfactant or a mixture of surfactant and cosurfactant. These systems exhibit some unique properties that make them particularly interesting as delivery systems, as much for the oral as for the topical route. In the present work, we have studied the domain of existence of non-ionic microemulsion systems within pseudo-ternary phase diagrams. The results show a large area of microemulsion domain for O/W and W/O microemulsions. Depending on the proportion of components the apparent viscosity of the systems varied significantly. We have found that the presence of ethanol as cosurfactant affects the physical properties particularly the apparent viscosity and relative density. Analysis of the data indicated that the studied systems behave as non-Newtonian pseudoplastic shear-thinning fluids appropriated for pharmaceutical and cosmetic applications.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"9 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74766318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Antiplatelet activity of Croton celditifolius 巴豆抗血小板活性研究

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100014

T. Neiva, Ana Carolina Rabello de Moraes, C. Buchele, M. Pizzolatti, E. D’Amico, D. Fries, T. F. Rocha

{"title":"Antiplatelet activity of Croton celditifolius","authors":"T. Neiva, Ana Carolina Rabello de Moraes, C. Buchele, M. Pizzolatti, E. D’Amico, D. Fries, T. F. Rocha","doi":"10.1590/S1516-93322008000100014","DOIUrl":"https://doi.org/10.1590/S1516-93322008000100014","url":null,"abstract":"Croton celtidifolius Baill is a tree found in the Atlantic Forest South of Brazil, mainly in Santa Catarina. The bark and leaf infusions of this medicinal plant have been popularly used for the treatment of inflammatory diseases. The anti-aggregant activity of C. celtidifolius crude extract (CE) and the column chromatography (CC) isolated compounds flavonoids, catechin and gallocatechin were evaluated in human blood platelets. The platelet-rich plasma (PRP) was incubated with different concentrations of flavonoides (50 - 200 µg/mL) to be tested before platelet aggregation was induced by the agonists adenosine 5'diphosphate (ADP) and collagen. At 200 µg/mL the CE, catechin and gallocatechin markedly inhibited platelet aggregation with the aggregant agents. Using ATP production as an index of platelet secretory capacity, we observed a decreased production of ATP in platelets treated with flavonoids when stimulated by collagen. On the other hand, the flavonoids did not promote inhibitory effect on prothrombin time (PT), thromboplastin time (APTT) and thrombin time (TT). In conclusion, these observations suggest that C. celtidifolius is likely to exert an inhibitory action on platelets in vitro by suppressing secretion and platelet aggregation.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"31 1","pages":"127-132"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81739642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Análise de custo do tratamento medicamentoso da artrite reumatóide 类风湿性关节炎药物治疗的成本分析

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100004

R. Monteiro, A. C. Zanini

{"title":"Análise de custo do tratamento medicamentoso da artrite reumatóide","authors":"R. Monteiro, A. C. Zanini","doi":"10.1590/S1516-93322008000100004","DOIUrl":"https://doi.org/10.1590/S1516-93322008000100004","url":null,"abstract":"With the aim to compare the cost of treatment for rheumatoid arthritis therapy with desease-modifying antirheumatic drugs (DMARDs) for a 48-month period, were studied five different treatment stage based on clinical protocols recommended by the Brazilian Society of Rheumatology, and then five therapy cycles. The analytical model based on the Markov Analysis, considered chaces for the patient continue in some stages or change between them according with a positive effect on outcomes. Only direct costs were comprised in the analyzed data, like drugs, materials and tests used for monitoring these patients. The results of the model show that the stage in with metotrexato drug is used like monotherapy was cost-effective (R$ 113,900.00 for patient during 48 months), followed by refractory patient (R$ 1,554,483.43), those that use therapy triplicate followed by infleximabe drug (R$ 1,701,286.76), the metotrexato intolerant patient (R$ 2,629,919.14), and final the result from that use metotrexato and infliximabe in the beginning (R$ 9,292,879.31). The sensitivity analysis confirm this results, when alternate the efficacy of metotrexato and infliximabe.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"81 1","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91180807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Origens e trajetórias da indústria farmacêutica no Brasil 巴西制药工业的起源和发展轨迹

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100020

Leoberto Costa Tavares

引用次数: 8

In vitro safety assessment of papain on human skin: A qualitative Light and Transmission Electron Microscopy (TEM) study 木瓜蛋白酶对人体皮肤的体外安全性评价:定性光学和透射电子显微镜(TEM)研究

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100017

P. S. Lopes, G. W. Ruas, A. Baby, C. A. S. O. Pinto, I. Watanabe, M. V. Velasco, T. M. Kaneko

引用次数: 12

Apoptosis, senescence and cancer 细胞凋亡，衰老和癌症

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100021

T. P. Ong

引用次数: 0

Potencialização do efeito metemoglobinizante da dapsona em ratos pela N-acetilcisteína N-乙酰半胱氨酸对氨苯砜大鼠高血红蛋白作用的增强

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100011

Natália Valadares de Moraes, M. Mello, A. Souza, Suely V. Sampaio, Regina Helena Costa Queiroz

{"title":"Potencialização do efeito metemoglobinizante da dapsona em ratos pela N-acetilcisteína","authors":"Natália Valadares de Moraes, M. Mello, A. Souza, Suely V. Sampaio, Regina Helena Costa Queiroz","doi":"10.1590/S1516-93322008000100011","DOIUrl":"https://doi.org/10.1590/S1516-93322008000100011","url":null,"abstract":"Dapsona (DDS) (4,4'diaminodifenilsulfona), farmaco de escolha para o tratamento da hanseniase, frequentemente induz anemia hemolitica e metemoglobinemia. A N-hidroxilacao, uma de suas principais vias de biotransformacao, e constantemente relacionada com a metemoglobinemia observada com o uso do farmaco. Com o objetivo de prevenir a hemotoxicidade induzida pela DDS, N-acetilcisteina, farmaco precursor de glutationa, foi administrada em associacao com DDS em ratos machos Wistar pesando 220-240 g. Os animais foram anestesiados e o sangue coletado da aorta para determinacao da concentracao plasmatica de DDS por CLAE, determinacao dos niveis de metemoglobina e de glutationa eritrocitaria por espectrofotometria, e avaliacao de parâmetros bioquimicos e hematologicos. Os resultados obtidos mostraram que a N-acetilcisteina potenciou o efeito metemoglobinizante da dapsona devido ao aumento de sua concentracao plasmatica e consequente aumento da formacao da N-hidroxilamina. Concluimos que as interacoes medicamentosas com a dapsona exigem estudos individualizados a fim de evitar os efeitos adversos do farmaco.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"52 1","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81124906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Estudo dos fatores impregnao e secagem nas caractersticas de glbulos utilizados em homeopatia 顺势疗法细胞特性中浸渍和干燥因素的研究

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100016

Eliana Elisabeth Diehl, Diva Sonaglio, N. Lima, Sinara Backes

引用次数: 6

Prescription errors in a primary care university unit: urgency of pharmaceutical care in Mexico 处方错误在初级保健大学单位:在墨西哥药物护理的紧迫性

Revista Brasileira De Ciencias Farmaceuticas Pub Date : 2008-03-01 DOI: 10.1590/S1516-93322008000100013

Miriam Zavaleta-Bustos, Lucila I. Castro-Pastrana, Ivette Reyes-Hernández, M. López-Luna, Isis-Beatriz Bermúdez-Camps

{"title":"Prescription errors in a primary care university unit: urgency of pharmaceutical care in Mexico","authors":"Miriam Zavaleta-Bustos, Lucila I. Castro-Pastrana, Ivette Reyes-Hernández, M. López-Luna, Isis-Beatriz Bermúdez-Camps","doi":"10.1590/S1516-93322008000100013","DOIUrl":"https://doi.org/10.1590/S1516-93322008000100013","url":null,"abstract":"The purpose of this study was to assess prescription rationality and most common prescription errors at the primary care clinic of a Mexican university.A retrospective drug utilization review of indication-prescription type was carried out. A random sample of 370 medical records of patients assisted over a year period, were reviewed. Prescription appropriateness was evaluated according to the variables: indication, dosage regimen, administration route, contraindications, interactions, medication duplicity, unnecessary or missing medications. Prescriptions were rated as appropriate (no prescription errors found) or inappropriate (at least one prescription error found). The benefit-risk ratio was calculated for each prescription. This study revealed a 58% of inappropriate prescriptions in the Mexican primary care university clinic, mostly due to errors on dosage regimen and innapropiate drug selection. As a result of c2 analysis, it was found that the pharmacotherapeutic variables chosen for the prescription assessment in this study, were determinant in prescription appropriateness rating. Nimesulide, ciprofloxacin, ranitidine, ketorolac and paracetamol were the most prescribed drugs as well as the most common cause of errors found. The prescription error rate revealed by this study addresses the need for strategies to improve prescription's quality. Introducing pharmacists as a key part of health care team is a mean proposed to prevent medication errors and to solve the urgency of pharmaceutical care implementation in all primary care facilities in Mexico.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"52 1","pages":"115-125"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89703785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33