Reviews in Medical Virology最新文献_第8页

Passive immunotherapies for the next influenza pandemic 下一次流感大流行的被动免疫疗法

IF 11.1 2区医学

Reviews in Medical Virology Pub Date : 2024-04-18 DOI: 10.1002/rmv.2533

Daniele Focosi, Massimo Franchini, Jonathon W. Senefeld, Michael J. Joyner, David J. Sullivan, Andrew Pekosz, Fabrizio Maggi, Arturo Casadevall

引用次数: 0

Modulation of immune responses in the central nervous system by Zika virus, West Nile virus, and dengue virus 寨卡病毒、西尼罗河病毒和登革热病毒对中枢神经系统免疫反应的影响

IF 11.1 2区医学

Reviews in Medical Virology Pub Date : 2024-04-13 DOI: 10.1002/rmv.2535

Shuhui Wu, Ting Zhang, Weidong Qiang, Yang Yang

引用次数: 0

Unravelling the triad of neuroinvasion, neurodissemination, and neuroinflammation of human immunodeficiency virus type 1 in the central nervous system 揭示人类免疫缺陷病毒 1 型在中枢神经系统中的神经入侵、神经传播和神经炎症三重作用

IF 11.1 2区医学

Reviews in Medical Virology Pub Date : 2024-04-08 DOI: 10.1002/rmv.2534

Marta Calado, Rita Ferreira, David Pires, Quirina Santos‐Costa, Elsa Anes, Dora Brites, José Miguel Azevedo‐Pereira

{"title":"Unravelling the triad of neuroinvasion, neurodissemination, and neuroinflammation of human immunodeficiency virus type 1 in the central nervous system","authors":"Marta Calado, Rita Ferreira, David Pires, Quirina Santos‐Costa, Elsa Anes, Dora Brites, José Miguel Azevedo‐Pereira","doi":"10.1002/rmv.2534","DOIUrl":"https://doi.org/10.1002/rmv.2534","url":null,"abstract":"Since the identification of human immunodeficiency virus type 1 (HIV‐1) in 1983, many improvements have been made to control viral replication in the peripheral blood and to treat opportunistic infections. This has increased life expectancy but also the incidence of age‐related central nervous system (CNS) disorders and HIV‐associated neurodegeneration/neurocognitive impairment and depression collectively referred to as HIV‐associated neurocognitive disorders (HAND). HAND encompasses a spectrum of different clinical presentations ranging from milder forms such as asymptomatic neurocognitive impairment or mild neurocognitive disorder to a severe HIV‐associated dementia (HAD). Although control of viral replication and suppression of plasma viral load with combination antiretroviral therapy has reduced the incidence of HAD, it has not reversed milder forms of HAND. The objective of this review, is to describe the mechanisms by which HIV‐1 invades and disseminates in the CNS, a crucial event leading to HAND. The review will present the evidence that underlies the relationship between HIV infection and HAND. Additionally, recent findings explaining the role of neuroinflammation in the pathogenesis of HAND will be discussed, along with prospects for treatment and control.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"164 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrospinal fluid viral escape in HIV patients on antiretroviral therapy: A systematic review of reported cases 接受抗逆转录病毒治疗的艾滋病患者脑脊液病毒外逸：对报告病例的系统回顾

IF 11.1 2区医学

Reviews in Medical Virology Pub Date : 2024-04-05 DOI: 10.1002/rmv.2536

Goodluck G. Nyondo, Belinda J. Njiro, George M. Bwire

{"title":"Cerebrospinal fluid viral escape in HIV patients on antiretroviral therapy: A systematic review of reported cases","authors":"Goodluck G. Nyondo, Belinda J. Njiro, George M. Bwire","doi":"10.1002/rmv.2536","DOIUrl":"https://doi.org/10.1002/rmv.2536","url":null,"abstract":"Cerebrospinal fluid (CSF) viral escape rarely occurs when HIV is detected in the CSF, while it is undetectable in the blood plasma or detectable in CSF at levels that exceed those in the blood plasma. We conducted this review to comprehensively synthesise its clinical presentation, diagnosis, management strategies and treatment outcomes. A review registered with PROSPERO (CRD42023475311) searched evidence across PubMed/MEDLINE, Embase, Web of Science, Scopus, and Google Scholar to gather articles (case reports/series) that report on CSF viral escape in people living with HIV (PLHIV) on antiretroviral therapy (ART). The quality of studies was assessed based on the domains of selection, ascertainment, causality, and reporting. A systematic search identified 493 articles and 27 studies that include 21 case reports, and six case series were involved in the review. The studies reported 62 cases of CSF viral escape in PLHIV. The majority were men (66.67%), with a median age of 43 (range: 28–73) years. Approximately, 31 distinct symptoms were documented, mostly being cognitive dysfunction, gait abnormalities, and tremors (12.51%). Diagnosis involved blood and CSF analysis, magnetic resonance imaging, and neuropsychological assessments. Over 36 ART regimens were employed, with a focus on ART intensification; almost one‐third of the regimens contained Raltegravir (integrase strand transfer inhibitor). The outcomes showed 64.49% full recovery, 30.16% partial recovery, and 4.76% died. When neuropsychological symptoms manifest in PLHIV, monitoring for CSF viral escape is essential, regardless of plasma viral suppression. Personalised treatment strategies, particularly ART intensification, are strongly advised for optimising treatment outcomes in PLHIV diagnosed with CSF HIV escape.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"55 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological advances in anti-retroviral therapy for human immunodeficiency virus-1 infection: A comprehensive review. 人类免疫缺陷病毒-1 感染的抗逆转录病毒疗法的药理进展：全面回顾。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2529

Nursyuhada Azzman, Muhammad Shoaib Ali Gill, Sharifah Syed Hassan, Frauke Christ, Zeger Debyser, Wan Ahmad Syazani Mohamed, Nafees Ahemad

{"title":"Pharmacological advances in anti-retroviral therapy for human immunodeficiency virus-1 infection: A comprehensive review.","authors":"Nursyuhada Azzman, Muhammad Shoaib Ali Gill, Sharifah Syed Hassan, Frauke Christ, Zeger Debyser, Wan Ahmad Syazani Mohamed, Nafees Ahemad","doi":"10.1002/rmv.2529","DOIUrl":"10.1002/rmv.2529","url":null,"abstract":"The discovery of anti-retroviral (ARV) drugs over the past 36 years has introduced various classes, including nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitor, fusion, and integrase strand transfer inhibitors inhibitors. The introduction of combined highly active anti-retroviral therapies in 1996 was later proven to combat further ARV drug resistance along with enhancing human immunodeficiency virus (HIV) suppression. As though the development of ARV therapies was continuously expanding, the variation of action caused by ARV drugs, along with its current updates, was not comprehensively discussed, particularly for HIV-1 infection. Thus, a range of HIV-1 ARV medications is covered in this review, including new developments in ARV therapy based on the drug's mechanism of action, the challenges related to HIV-1, and the need for combination therapy. Optimistically, this article will consolidate the overall updates of HIV-1 ARV treatments and conclude the significance of HIV-1-related pharmacotherapy research to combat the global threat of HIV infection.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2529"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breakthrough infection and reinfection in patients with mpox. 麻风病人的突破性感染和再感染。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2522

Wenyi Jiang, Yibo Hu, Xiu Yang, Lingli Hou, Jingjing Zhang, Hong Niu, Congxia Hu, Jihui Lin

{"title":"Breakthrough infection and reinfection in patients with mpox.","authors":"Wenyi Jiang, Yibo Hu, Xiu Yang, Lingli Hou, Jingjing Zhang, Hong Niu, Congxia Hu, Jihui Lin","doi":"10.1002/rmv.2522","DOIUrl":"10.1002/rmv.2522","url":null,"abstract":"Recently, patients with Mpox breakthrough infection or reinfection were constantly reported. However, the induction, risk factors, and important clinical symptoms of breakthrough infection and reinfection of Mpox virus (MPXV), as well as the factors affecting the effectiveness of Mpox vaccine are not characterized. Herein, a literature review was preformed to summarize the risk factors and important clinical symptoms of patients with Mpox breakthrough infection or reinfection, as well as the factors affecting the effectiveness of smallpox vaccine against Mpox. Results showed that MSM sexual behavior, condomless sexual behavior, multiple sexual partners, close contact, HIV infection, and the presence of comorbidity are important risk factors for Mpox breakthrough infection and reinfection. Genital ulcers, proctitis, and lymphadenopathy are the important clinical symptoms of Mpox breakthrough infection and reinfection. The effectiveness of emergent vaccination of smallpox vaccine for post-exposure of MPXV is associated with smallpox vaccination history, interval between exposure and vaccination, and history of HIV infection. This review provides a better understanding for the risk factors and important clinical symptoms of Mpox breakthrough infection and reinfection, as well as the formulation of Mpox vaccine vaccination strategies.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2522"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coinfections in human papillomavirus associated cancers and prophylactic recommendations. 人类乳头瘤病毒相关癌症的合并感染和预防建议。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2524

Gayathri Ashok, Soumya Basu, Priyamvada Priyamvada, Anand Anbarasu, Sreenivasulu Chintala, Sudha Ramaiah

引用次数: 0

Clinical and laboratory diagnosis of Mayaro virus (MAYV): Current status and opportunities for further development. 玛雅罗病毒（MAYV）的临床和实验室诊断：现状和进一步发展的机遇。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2528

Severino Jefferson Ribeiro da Silva, Larissa Krokovsky

引用次数: 0

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers. 在病毒性癌症的发展过程中，肿瘤病毒劫持并重新连接宿主CircRNA/miRNA/mRNA竞争性内源性RNA（ceRNA）调控网络。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2530

Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei

{"title":"Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers.","authors":"Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei","doi":"10.1002/rmv.2530","DOIUrl":"10.1002/rmv.2530","url":null,"abstract":"A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)-mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context. CircRNAs, a class of non-coding RNA molecules, can interact with other RNA molecules, such as mRNAs and microRNAs (miRNAs), through a process known as ceRNA crosstalk. This interaction occurs when circRNAs, acting as sponges, sequester miRNAs, thereby preventing them from binding to their target mRNAs and modulating their expression. By rewiring the host cell genome, oncoviruses have the ability to manipulate the expression and activity of circRNAs, thereby influencing the ceRNA networks that can profoundly impact cellular processes such as cell proliferation, differentiation, apoptosis, and immune responses. This review focuses on a comprehensive evaluation of the latest findings on the involvement of virus-induced reprogramming of host circRNA-mediated ceRNA networks in the development and pathophysiology of human viral cancers, including cervical cancer, gastric cancer, nasopharyngeal carcinoma, Kaposi's sarcoma, hepatocellular carcinoma, and diffuse large B cell lymphoma. Understanding these mechanisms can improve our knowledge of how oncoviruses contribute to human tumourigenesis and identify potential targets for developing optimised therapies and diagnostic tools for viral cancers.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2530"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next? 输血传播隐性乙型肝炎病毒感染的生物标志物：进展如何？

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2525

Michael X Fu, Peter Simmonds, Monique Andersson, Heli Harvala

{"title":"Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next?","authors":"Michael X Fu, Peter Simmonds, Monique Andersson, Heli Harvala","doi":"10.1002/rmv.2525","DOIUrl":"10.1002/rmv.2525","url":null,"abstract":"Blood transfusion is a vital procedure, where transfusion-transmitted infection of hepatitis B virus (HBV) remains an important issue, especially from blood donors with occult hepatitis B virus infection (OBI). Occult hepatitis B virus infection is a complex entity to detect using surrogate blood biomarkers for intrahepatic viral transcriptional activity, requiring a continually refined battery of tests utilised for screening. This review aims to critically evaluate the latest advances in the current blood biomarkers to guide the identification of OBI donors and discuss novel HBV markers that could be introduced in future diagnostic practice. Challenges in detecting low HBV surface antigen levels, mutants, and complexes necessitate ultrasensitive multivalent dissociation assays, whilst HBV DNA testing requires improved sensitivity but worsens inaccessibility. Anti-core antibody assays defer almost all potentially infectious donations but have low specificity, and titres of anti-surface antibodies that prevent infectivity are poorly defined with suboptimal sensitivity. The challenges associated with these traditional blood HBV markers create an urgent need for alternative biomarkers that would help us better understand the OBI. Emerging viral biomarkers, such as pre-genomic RNA and HBV core-related antigen, immunological HBV biomarkers of T-cell reactivity and cytokine levels, and host biomarkers of microRNA and human leucocyte antigen molecules, present potential advances to gauge intrahepatic activity more accurately. Further studies on these markers may uncover an optimal diagnostic algorithm for OBI using quantification of various novel and traditional blood HBV markers. Addressing critical knowledge gaps identified in this review would decrease the residual risk of transfusion-transmitted HBV infection without compromising the sustainability of blood supplies.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2525"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0