基于纳米粒子的神经病毒感染疗法：机制、挑战和未来展望》。

IF 9 2区医学 Q1 VIROLOGY

Reviews in Medical Virology Pub Date : 2024-09-01 DOI:10.1002/rmv.2575

Min Yang, Chuanbo Ding, Ting Zhao, Ge Song, Tingting Liu, Zeqi Li, Ying Zhang

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引用次数: 0

摘要

神经性病毒感染能够以中枢神经系统为目标并引起严重的神经系统并发症，因此构成了一项重大挑战。传统的抗病毒疗法在有效治疗这些感染方面受到限制，主要原因是血脑屏障限制了治疗药物向中枢神经系统的输送。基于纳米粒子的疗法已成为克服这些挑战的一种有前途的方法。纳米粒子具有独特的特性，有助于药物穿过血脑屏障等生物屏障，并可被设计成具有抗病毒活性。

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Nanoparticle-Based Therapies for Neurotropic Viral Infections: Mechanisms, Challenges, and Future Prospects.

Neurotropic viral infections pose a significant challenge due to their ability to target the central nervous system and cause severe neurological complications. Traditional antiviral therapies face limitations in effectively treating these infections, primarily due to the blood-brain barrier, which restricts the delivery of therapeutic agents to the central nervous system. Nanoparticle-based therapies have emerged as a promising approach to overcome these challenges. Nanoparticles offer unique properties that facilitate drug delivery across biological barriers, such as the blood-brain barrier, and can be engineered to possess antiviral activities.

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来源期刊

Reviews in Medical Virology 医学-病毒学

CiteScore

21.40

自引率

0.90%

发文量

期刊介绍： Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.