Reviews in Medical Virology最新文献

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Enterovirus Antibodies: Friends and Foes. 肠病毒抗体:朋友与敌人
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70004
Chaldam Jespère Mbani, Corentin Morvan, Magloire Pandoua Nekoua, Cyril Debuysschere, Enagnon Kazali Alidjinou, Donatien Moukassa, Didier Hober
{"title":"Enterovirus Antibodies: Friends and Foes.","authors":"Chaldam Jespère Mbani, Corentin Morvan, Magloire Pandoua Nekoua, Cyril Debuysschere, Enagnon Kazali Alidjinou, Donatien Moukassa, Didier Hober","doi":"10.1002/rmv.70004","DOIUrl":"https://doi.org/10.1002/rmv.70004","url":null,"abstract":"<p><p>Enteroviruses (EV) initiate replication by binding to their cellular receptors, leading to the uncoating and release of the viral genome into the cytosol of the host cell. Neutralising antibodies (NAbs) binding to epitopes on enteroviral capsid proteins can inhibit this infectious process through several mechanisms of neutralisation in vitro. Fc-mediated antibody effector functions such as antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular phagocytosis have also been described for some EV. However, antibody binding to virions does not always result in viral neutralisation. Non-neutralising antibodies, or sub-neutralising concentrations of antibodies, can enhance infection of viruses, leading to more severe pathologies. This phenomenon, known as antibody-dependent enhancement (ADE) of infection, has been described in vitro and/or in vivo for EV including poliovirus, coxsackievirus B and EV-A71. It has been shown that ADE of EV infection is mediated by FcγRs expressed by monocytes, macrophages, B lymphocytes and granulocytes. Antibodies play a crucial role in the diagnosis and monitoring of infections. They are valuable markers that have been used to establish a link between enteroviral infection and chronic diseases such as type 1 diabetes. Monoclonal and polyclonal antibodies targeting enteroviral proteins have been developed and shown to be effective to prevent or combat EV infections in vitro and in vivo. In addition, vaccines are under development, and clinical trials of vaccines are underway or have been completed, providing hope for the prevention of diseases due to EV. However, the ADE of the infection should be considered in the development of anti-EV antibodies or safe vaccines.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplays Between Matrix Metalloproteinases and Neurotropic Viruses: An Overview. 基质金属蛋白酶与神经病毒之间的相互作用:综述。
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2585
Suad A Alghamdi, Mohammed Alissa, Abdullah Alghamdi, Mohammed A Alshehri, Abdullah Albelasi, Khalid J Alzahrani, Awaji Y Safhi
{"title":"Interplays Between Matrix Metalloproteinases and Neurotropic Viruses: An Overview.","authors":"Suad A Alghamdi, Mohammed Alissa, Abdullah Alghamdi, Mohammed A Alshehri, Abdullah Albelasi, Khalid J Alzahrani, Awaji Y Safhi","doi":"10.1002/rmv.2585","DOIUrl":"10.1002/rmv.2585","url":null,"abstract":"<p><p>Matrix metalloproteinases (MMPs) are a diverse group of proteases involved in various physiological and pathological processes through modulation of extracellular matrix (ECM) components, cytokines, and growth factors. In the central nervous system (CNS), MMPs play a major role in CNS development, plasticity, repair, and reorganisation contributing to learning, memory, and neuroimmune response to injury. MMPs are also linked to various neurological disorders such as Alzheimer's disease, Parkinson's disease, cerebral aneurysm, stroke, epilepsy, multiple sclerosis, and brain cancer suggesting these proteases as key regulatory factors in the nervous system. Moreover, MMPs have been involved in the pathogenesis of neurotropic viral infections via dysregulation of various cellular processes, which may highlight these factors as potential targets for the treatment and control of neurological complications associated with viral pathogens. This review provides an overview of the roles of MMPs in various physiological processes of the CNS and their interactions with neurotropic viral pathogens.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Assessment of Anti-SARS-CoV-2 Antibodies in Different Vaccine Platforms: A Systematic Review and Meta-Analysis of COVID-19 Vaccine Clinical Trial Studies. 不同疫苗平台中抗 SARS-CoV-2 抗体的评估:COVID-19疫苗临床试验研究的系统回顾和荟萃分析。
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2579
Mohammad Mirzakhani, Maryam Bayat, Mohammadreza Dashti, Safa Tahmasebi, Maryam Rostamtabar, Hadi Esmaeili Gouvarchin Ghaleh, Jafar Amani
{"title":"The Assessment of Anti-SARS-CoV-2 Antibodies in Different Vaccine Platforms: A Systematic Review and Meta-Analysis of COVID-19 Vaccine Clinical Trial Studies.","authors":"Mohammad Mirzakhani, Maryam Bayat, Mohammadreza Dashti, Safa Tahmasebi, Maryam Rostamtabar, Hadi Esmaeili Gouvarchin Ghaleh, Jafar Amani","doi":"10.1002/rmv.2579","DOIUrl":"10.1002/rmv.2579","url":null,"abstract":"<p><strong>Background and objective: </strong>The COVID-19 pandemic spread rapidly throughout the world and caused millions of deaths globally. Several vaccines have been developed to control the COVID-19 pandemic and reduce the burden it placed on public health. This study aimed to assess the efficacy of different vaccine platforms in inducing potent antibody responses. Moreover, the seroconversion rate and common side effects of vaccine platforms were evaluated.</p><p><strong>Methods: </strong>This meta-analysis included clinical trials of COVID-19 vaccines that met the eligibility criteria. Electronic databases (including PubMed, Scopus, and Web of Science) and Google Scholar search engine were searched for eligible studies. Regarding the methodological heterogeneity between the included studies, we selected a random-effects model. The geometric mean ratio (GMR) was chosen as the effect size for this meta-analysis.</p><p><strong>Results: </strong>Of the 1838 records identified through screening and after removing duplicate records, the full texts of 1076 records were assessed for eligibility. After the full-text assessment, 56 records were eligible and included in the study. Overall, vaccinated participants had a 150.8-fold increased rate of anti-spike IgG titres compared with the placebo group (GMR = 150.8; 95% CI, 95.9-237.1; I<sup>2</sup> = 100%). Moreover, vaccinated participants had a 37.3-fold increased rate of neutralising antibody titres compared with the placebo group (GMR = 37.3; 95% CI, 28.5-48.7; I<sup>2</sup> = 99%). The mRNA platform showed a higher rate of anti-spike IgG (GMR = 1263.5; 95% CI, 431.1-3702.8; I<sup>2</sup> = 99%), while neutralising antibody titres were higher in the subunit platform (GMR = 53.4; 95% CI, 32.8-87.1; I<sup>2</sup> = 99%) than in other platforms. Different vaccine platforms showed different rates of both anti-spike IgG and neutralising antibody titres with interesting results. The seroconversion rate of anti-spike IgG and neutralising antibody titres was more than 98% in the vaccinated participants.</p><p><strong>Conclusion: </strong>Inactivated and subunit vaccines produced a high percentage of neutralising antibodies and had a low common adverse reaction rate compared to other platforms. In this regard, subunit and inactivated vaccines can still be used as the main vaccine platforms for effectively controlling infections with high transmission rates.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Post-Measles Encephalitis in a Returning Traveller: Highlighting the Need for MMR Vaccination. 一名回国旅行者的急性麻疹后脑炎:强调接种麻腮风疫苗的必要性。
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2588
Sarah May Johnson, Jane Hassell, Gerard Leslie Peter Manning, Sniya Sudhakar, Joe Brierley, Louis Grandjean, Judith Breuer, Seilesh Kadambari
{"title":"Acute Post-Measles Encephalitis in a Returning Traveller: Highlighting the Need for MMR Vaccination.","authors":"Sarah May Johnson, Jane Hassell, Gerard Leslie Peter Manning, Sniya Sudhakar, Joe Brierley, Louis Grandjean, Judith Breuer, Seilesh Kadambari","doi":"10.1002/rmv.2588","DOIUrl":"10.1002/rmv.2588","url":null,"abstract":"","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Evasion Mechanism of Neurotropic Viruses. 神经性病毒的免疫逃避机制
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2589
Yayun Yan, Yu Sun, Xinyuan Guo, Yuanchao An, Ying Chang
{"title":"Immune Evasion Mechanism of Neurotropic Viruses.","authors":"Yayun Yan, Yu Sun, Xinyuan Guo, Yuanchao An, Ying Chang","doi":"10.1002/rmv.2589","DOIUrl":"10.1002/rmv.2589","url":null,"abstract":"<p><p>The persistent challenge posed by viruses that infect the central nervous system lies in their sophisticated ability to evade the host immune system. This review explores into the complex mechanisms of immune evasion employed by these neurotropic viruses, focussing on their modulation of host immune responses, evasion of adaptive immunity, and the cellular and molecular strategies that enable their persistence. Key areas explored include viral latency and reactivation, the inhibition of apoptosis, and antigenic variation, with a detailed examination of viral proteins and their interactions with host cellular processes.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-Generation Sequencing Methods for Near-Real-Time Molecular Epidemiology of HIV and HCV. 用于近实时 HIV 和 HCV 分子流行病学的下一代测序方法。
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70001
Bethany A Horsburgh, Gregory J Walker, Anthony Kelleher, Andrew R Lloyd, Rowena A Bull, Francesca Di Giallonardo
{"title":"Next-Generation Sequencing Methods for Near-Real-Time Molecular Epidemiology of HIV and HCV.","authors":"Bethany A Horsburgh, Gregory J Walker, Anthony Kelleher, Andrew R Lloyd, Rowena A Bull, Francesca Di Giallonardo","doi":"10.1002/rmv.70001","DOIUrl":"10.1002/rmv.70001","url":null,"abstract":"<p><p>The World Health Organisation has set targets of reducing the transmission of new hepatitis C (HCV) infections by 90%, and ending human immunodeficiency virus-1 (HIV) as a public health threat, by 2030. To achieve this, efficient and timely viral surveillance, and effective public health interventions, are required. Traditional epidemiological methods are largely dependent on the recognition of incident cases with symptomatic illness; acute HIV and HCV infections are commonly asymptomatic, which may lead to delays in the recognition of such new infections. Instead, for these viruses, molecular epidemiology may improve the detection of, and response to, clusters of viral transmission. Molecular epidemiology using historical datasets has highlighted key populations that may have benefitted from a timely intervention. Similar analyses performed on contemporary samples are needed to underpin the 2030 targets, but this requires the generation of a cohesive dataset of viral genome sequences in near-real-time. To generate such data, methodologies harnessing next-generation sequencing (NGS) should be utilised. Here we discuss the opportunity presented by NGS for public health surveillance of HIV and HCV, and discuss three methods that can generate sequences for such analysis. These include full-length genome amplification, utilised for analysis of HCV in the research space; tiling PCR, which was the method of choice for many diagnostic laboratories in the SARS-CoV-2 pandemic; and bait-capture hybridisation, which has been utilised in local HIV outbreaks. These techniques could be applied for near-real-time HIV and HCV surveillance, informing public health strategies that will be key to achieving 2030 targets.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated Cardiomyopathy. 病毒性心肌炎导致扩张型心肌病的先天性免疫与自噬之间的相互关系
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2586
Chen Wang, Honglin Luo
{"title":"Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated Cardiomyopathy.","authors":"Chen Wang, Honglin Luo","doi":"10.1002/rmv.2586","DOIUrl":"10.1002/rmv.2586","url":null,"abstract":"<p><p>Viral myocarditis, characterised by inflammation of the heart muscle, presents a significant challenge to global public health, particularly affecting younger individuals and often progressing to dilated cardiomyopathy (DCM), a leading cause of heart failure. Despite ongoing research efforts, viable treatments for this condition remain elusive. Recent studies have shed light on the complex interplay between the innate immune response and autophagy mechanisms, revealing their pivotal roles in the pathogenesis of viral myocarditis and subsequent DCM development. This review aims to delve into the recent advancements in understanding the molecular mechanisms and pathways that intersect innate immunity and autophagy in the context of viral myocarditis. Furthermore, it explores the potential therapeutic implications of these findings, offering insights into promising avenues for the management and treatment of this debilitating condition.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next Generation RNA/Protein-Carrying Vector With Pleiotropic Activity. 具有多基因活性的下一代 RNA/Protein Carrying Vector。
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70008
Tetsuya Nosaka, Junpei Ohtsuka, Tomomi Ohtsuka, Masayuki Fukumura
{"title":"Next Generation RNA/Protein-Carrying Vector With Pleiotropic Activity.","authors":"Tetsuya Nosaka, Junpei Ohtsuka, Tomomi Ohtsuka, Masayuki Fukumura","doi":"10.1002/rmv.70008","DOIUrl":"10.1002/rmv.70008","url":null,"abstract":"<p><p>Human parainfluenza virus type 2 (hPIV2), one of the causative agents of infantile common cold, is a non-segmented negative-sense RNA virus with a robust gene expression system. It infects recurrently throughout human life without causing severe disease. Because hPIV2 has a viral envelope that can carry ectopic proteins, we developed a non-propagative RNA/protein-carrying vector BC-PIV by deleting the F gene from hPIV2. BC-PIV can be vigorously proliferated in the stable packaging cell line Vero/BC-F cells expressing the hPIV2 F gene but not in other cells. BC-PIV can deliver exogenous gene(s) on a multigenic RNA genome as an inserted gene fragment(s) and simultaneously deliver exogenous protein(s) on its envelope in a membrane-anchored form. For example, influenza virus M2e protein, Ebola virus GP protein, and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) spike protein were shown to be highly expressed in packaging cells and incorporated into the virion. The Ebola virus GP protein and SARS-CoV-2 spike protein, each delivered via BC-PIV, efficiently induced neutralising antibodies against each virus, even after prior treatment with recombinant BC-PIV in mice and hamsters, respectively. In this review, we describe the properties of BC-PIV as a promising vaccine vector, and also demonstrate its application as an anti-tumour virus.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Underlying Factors Predisposing to Viral-Induced Neurological Diseases. 病毒诱发神经系统疾病的潜在因素。
IF 9 2区 医学
Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2587
Zahra Heydarifard, Paul Shapshak, Milad Zandi
{"title":"Underlying Factors Predisposing to Viral-Induced Neurological Diseases.","authors":"Zahra Heydarifard, Paul Shapshak, Milad Zandi","doi":"10.1002/rmv.2587","DOIUrl":"10.1002/rmv.2587","url":null,"abstract":"","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoantibodies in COVID‐19 and Other Viral Diseases: Molecular, Cellular, and Clinical Perspectives COVID-19 和其他病毒性疾病中的自身抗体:分子、细胞和临床视角
IF 11.1 2区 医学
Reviews in Medical Virology Pub Date : 2024-09-18 DOI: 10.1002/rmv.2583
Srijan Chatterjee, Manojit Bhattacharya, Sanskriti Saxena, Sang‐Soo Lee, Chiranjib Chakraborty
{"title":"Autoantibodies in COVID‐19 and Other Viral Diseases: Molecular, Cellular, and Clinical Perspectives","authors":"Srijan Chatterjee, Manojit Bhattacharya, Sanskriti Saxena, Sang‐Soo Lee, Chiranjib Chakraborty","doi":"10.1002/rmv.2583","DOIUrl":"https://doi.org/10.1002/rmv.2583","url":null,"abstract":"Autoantibodies are immune system‐produced antibodies that wrongly target the body's cells and tissues for attack. The COVID‐19 pandemic has made it possible to link autoantibodies to both the severity of pathogenic infection and the emergence of several autoimmune diseases after recovery from the infection. An overview of autoimmune disorders and the function of autoantibodies in COVID‐19 and other infectious diseases are discussed in this review article. We also investigated the different categories of autoantibodies found in COVID‐19 and other infectious diseases including the potential pathways by which they contribute to the severity of the illness. Additionally, it also highlights the probable connection between vaccine‐induced autoantibodies and their adverse outcomes. The review also discusses the therapeutic perspectives of autoantibodies. This paper advances our knowledge about the intricate interaction between autoantibodies and COVID‐19 by thoroughly assessing the most recent findings.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":null,"pages":null},"PeriodicalIF":11.1,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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