Reviews in Medical Virology最新文献

{"title":"A Review of Arboviral-Induced Liver Damage: Acute Manifestations and Speculative Links to Chronic Inflammation.","authors":"Bin Wang, Zhihao Wang","doi":"10.1002/rmv.70047","DOIUrl":"10.1002/rmv.70047","url":null,"abstract":"<p><p>Arboviruses are a heterogeneous group of vector-borne viruses from various viral families. The clinical manifestations associated with these viruses can vary from self-limiting conditions to life-threatening complications with haemorrhagic disorders. As a class of viruses with systemic infections, arboviruses can either directly or indirectly affect different parts of the body causing systemic complications such as cardiovascular diseases, coagulation dysfunctions, and various liver complications. The present review presents clinical, epidemiological, and mechanistic evidence describing liver involvement during acute arboviral infections, including those caused by Dengue Virus (DENV), Yellow Fever Virus (YFV), Zika Virus (ZIKV), and Chikungunya Virus (CHIKV). While much of the available data pertains to acute liver damage, such as H, hepatomegaly, or fulminant hepatitis, it also discusses the possibility that such acute injuries may, in certain cases, predispose to chronic liver inflammation and fibrosis. Although current direct evidence for long-term hepatic sequelae is limited, this underexplored area may hold important clinical relevance in endemic settings. Therefore, this review emphasises the need for longitudinal research to establish whether arboviral infections pose a significant risk for chronic liver disease. Furthermore, it discusses the potential underlying mechanisms by which these viruses can induce hepatic disorders, including direct viral effects, immune-caused complications, and interactions with various hepatic cells and components. Finally, this review addresses several future research directions to improve clinical outcomes of arbovirus-caused liver complications.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70047"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Emerging/Re-Emerging RNA Viruses in Bone-Related Diseases With a Focus on DENV, CHIKV, and SARS-CoV-2.","authors":"Jinxi Zhang, Jiandong Guo, Jian Li, Jiawei Gao, Jie Liu, Shuying Shen, Jianglong Zhu","doi":"10.1002/rmv.70053","DOIUrl":"10.1002/rmv.70053","url":null,"abstract":"<p><p>Emerging and re-emerging RNA viruses represent a persistent and evolving global health threat. While primarily recognized for their acute systemic or respiratory illnesses, a growing body of evidence implicates several of these pathogens in the development or exacerbation of bone-related diseases. This review critically describes the multifaceted roles of selected major RNA viruses-Dengue Virus (DENV), Chikungunya Virus (CHIKV), and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)- in bone-related diseases. It discusses the current understanding of the clinical manifestations, ranging from arthralgia and arthritis to more severe outcomes such as osteopenia, osteoporosis, and bone erosions. The review describes the potential pathogenic mechanisms, including direct viral infection of bone cells (osteoblasts, osteoclasts, and osteocytes), as well as virus-induced dysregulation of host immune responses that lead to pro-inflammatory cytokine storms and altered signalling pathways, collectively driving aberrant bone remodelling. By discussing current knowledge, this review aims to highlight the significant, yet often underappreciated, impact of these RNA viruses on bone health, identify existing knowledge gaps, and underscore the need for further mechanistic research to inform targeted therapeutic and preventive strategies that reduce bone morbidity in affected populations.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70053"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation of Arboviruses With the Risk of Diabetes Mellitus: A Systematic Review and Meta-Analysis of Current Evidence.","authors":"Jiangchen Ma, Xiaowei Ding","doi":"10.1002/rmv.70039","DOIUrl":"10.1002/rmv.70039","url":null,"abstract":"<p><p>Arboviruses have become endemic worldwide in the recent years. Growing evidence have shown that diabetes increases the risk of severe complications these virus infections, but previous results is conflicting. This systematic review and meta-analysis reassessed the data associated with this correlation to response to the question of whether patients with diabetes have an elevated susceptibility to virus. Four electronic databases of PubMed, Scopus, Web of Science (WoS) and Embase were searched as systematic to evoke relevant data to the risk of virus infection in individuals with diabetes up to January 31, 2025. A random-effects model was used to estimate the summary odds ratio (OR). Subgroup analyses depending on the geographic area, clinical symptoms of virus, study design and the diagnostic techniques of virus were conducted. Quality appraisal for primary outcome and quality assessment was preformed by the Grading of recommendation, assessment, development and evaluation (GRADE) and Newcastle-Ottawa scale (NOS), respectively. This study was registered with PROSPERO, code (CRD42025638835). In total, 33 studies were identified based on different in virus type and phenotype of diabetes. The summary OR between virus infection and the risk of diabetes was (0.81, [95% CI 0.51-1.12], p < 0.05). The separate analysis for each of virus showed an increased risk of severe clinical symptoms of both DENV (OR = 1.04, [95% CI 0.53-1.55], p = 0.00) and WNV (OR = 1.94, [95% CI 1.02-2.87], p = 0.00) except CHIKV (OR = 0.24, [95% CI -0.28-0.76], p = 0.36). No publication bias was observed using Begg's (p = 0.54) and Egger's (P = 0.38) tests. Subgroups of geographic area and severe clinical symptoms of viruses such as dengue fever and West Nile fever had higher risk in diabetic patients. Our results provide strong evidence suggesting the association between diabetes and higher risk of DENV and WNV. These findings will help to physicians to early detection and appropriate management for reducing the morbidity and mortality rates in diabetes patients with DENV and WNV. As a result, diabetes involvement in Arboviruses is usual, especially in DENV and WNV patients.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70039"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arboviruses and Osteogenesis-Associated Signalling Pathways: A Potential Therapeutic Target for Musculoskeletal Complications.","authors":"Jian Li, Jiandong Guo, Jinxi Zhang, Yongfeng Cui, Shuying Shen, Hongchang Zhao","doi":"10.1002/rmv.70055","DOIUrl":"10.1002/rmv.70055","url":null,"abstract":"<p><p>Arthropod-borne viruses (arboviruses), such as Chikungunya virus (CHIKV), Zika virus (ZIKV), and Dengue virus (DENV), represent significant global health threats. Beyond their acute systemic illnesses, many arboviral infections are characterized by debilitating and often chronic musculoskeletal complications, including arthralgia, arthritis, myalgia, and bone pain. Evidence suggests that these pathologies may stem, at least in part, from the viruses' direct or indirect interference with fundamental cellular processes governing skeletal homoeostasis, particularly osteogenesis (bone formation) and bone remodelling. Key signalling pathways critical for osteoblast differentiation and function, such as Wnt/β-catenin, Bone Morphogenetic Protein (BMP), Notch, and Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL) pathways, are potential targets for viral manipulation or dysregulation by the host inflammatory response. This article reviews the current understanding of how arboviruses might interact with osteogenesis-associated signalling pathways, explores the link between this interaction and musculoskeletal disease, and proposes that targeting these pathways could represent a novel therapeutic strategy to mitigate the long-term skeletal sequelae of arboviral infections.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70055"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Use of Zinc in Treatment of Human Papillomavirus Cervical Infection and Viral Warts: A Systematic Review and Meta-Analysis.","authors":"Mohammadreza Shafiei, Kamyar Feyzi, Ali Hosseinpour, Pegah Zaryab, Sofia Saeedi, Shayan Mardi, Reihane Ahmadi, Atefeh Bahavar, Sayed-Hamidreza Mozhgani","doi":"10.1002/rmv.70054","DOIUrl":"10.1002/rmv.70054","url":null,"abstract":"<p><p>Human papillomavirus (HPV) is a global public health issue with a lack of therapeutic strategies that can eradicate the virus. This study investigates the efficacy of zinc and nitric-zinc complex solution (NZCS) in viral warts and cervical HPV infection and associated lesions. A systematic review and meta-analysis of clinical trials investigating efficacy, safety, dosage, and duration of treatment was performed by searching Medline, Web of Science, and Scopus libraries. A total of 33 clinical trials on 2728 patients were included in our study. We calculated and reported the response rate (RR) for each component and the log odds ratio (OR) to compare the efficacy of zinc to placebo. The log OR was 2.97 [95% CI: 0.96; 4.97], I² = 74.74% for oral zinc, and 1.33 [95% CI: 0.63; 2.03], I² = 0%, for topical zinc. Zinc was also significantly efficacious for clearance of cervical HPV infection (log OR = 2.23 [95% CI: 1.65; 2.81] I² = 0%), but not significantly efficacious as adjuvant therapy in combination with other treatments such as cryotherapy (0.41 [95% CI: -0.28; 1.10], I² = 0%). The results of the recurrence of lesions and the side effects of treatments were reported. Sensitivity analysis and subgroup meta-analysis were provided based on the types and locations of warts to address the source of heterogeneity and compare the efficacy of zinc-based treatments in different sorts of warts. Our findings demonstrated that zinc compounds and NZCS are efficacious and safe choices for patients with viral warts and cervical HPV infection.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70054"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on 'Confounding Variable in Recent Clinical Trial on ORFV-Based Therapeutics'.","authors":"Matthias Helmold, Ralf Amann","doi":"10.1002/rmv.70052","DOIUrl":"https://doi.org/10.1002/rmv.70052","url":null,"abstract":"","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70052"},"PeriodicalIF":9.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Relative Efficacy, Effectiveness and Safety of Newer And/Or Enhanced Seasonal Influenza Vaccines for the Prevention of Laboratory-Confirmed Influenza in Individuals Aged 18 Years and Over: Update of a Systematic Review\".","authors":"","doi":"10.1002/rmv.70062","DOIUrl":"10.1002/rmv.70062","url":null,"abstract":"","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70062"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Megakaryopoiesis Dysregulation, Thrombocytopaenia, and Dengue Virus Pathogenesis: Molecular Mechanisms and Therapeutic Advances.","authors":"Preeti Sokhal, Kinjal Singh, Riya Roy, Saumya Sinha, Simran Mehra, Y S Ravi Kumar, Sankar Bhattacharyya, Bhupendra Verma","doi":"10.1002/rmv.70050","DOIUrl":"10.1002/rmv.70050","url":null,"abstract":"<p><p>Megakaryopoiesis is a complex biological process through which haematopoietic stem cells differentiate into megakaryocyte, leading to the formation of platelets. This process is characterised by a unique differentiation pathway involving endomitosis, resulting in the polyploidisation of megakaryocyte nuclei. Megakaryopoiesis is controlled by various factors, including transcription factors, cytokines and hormones. Defects in this complex process can cause significant complications. A major issue associated with this is thrombocytopaenia, a condition characterised by abnormally low platelet counts. Thrombocytopaenia is often seen in certain cancer-related complications, genetic bone marrow disorders, autoimmune diseases, and particularly in many types of infectious diseases. Among these, dengue virus infection presents a major challenge due to its strong association with thrombocytopaenia, which greatly complicates disease management and outcomes. By integrating knowledge of megakaryopoiesis, thrombocytopaenia, and dengue infection, this review aims to provide a comprehensive understanding of megakaryopoiesis dysregulation, the molecular mechanisms of thrombocytopaenia in DENV pathogenesis and to identify potential areas for future research and clinical intervention. Additionally, this review highlights emerging insights into the role of non-coding RNAs in thrombocytopaenia and offers a better understanding of the mechanisms by which the dengue virus interferes with megakaryocyte function and platelet production, elucidating the intricate viral-host interactions that exacerbate platelet depletion.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70050"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the Treatment Strategies for Monkeypox Virus: Success and Bottlenecks.","authors":"Palakurthi Yanadaiah, Gali Avinash Kumar, Molakpogu Ravindra Babu, Sukriti Vishwas, M V N L Chaitanya, Biplab Pal, Rakesh Kumar, Milad Zandi, Gaurav Gupta, Ronan MacLoughlin, Brian G Oliver, Kamal Dua, Sachin Kumar Singh","doi":"10.1002/rmv.70051","DOIUrl":"10.1002/rmv.70051","url":null,"abstract":"<p><p>Monkeypox virus (MPXV) is a zoonotic orthopoxvirus (ORXV) that causes a significant public health concern due to its potential for human-to-human transmission and ability to cause severe disease. Despite the availability of a vaccine, there is currently no specific antiviral treatment for MPXV. The development of effective therapeutic strategies for MPXV is essential to mitigate its harmful impact on society. Various strategies used to treat the MPXV infection include antiviral drugs, immunoglobulins, and supportive care measures. Antiviral drugs, such as cidofovir, brincidofovir, and tecovirimat, have shown promising results in in vitro and animal models, but their efficacy in human MPXV cases is still uncertain. This article provides a comprehensive review of the therapeutic strategies that have been explored for the management of MPXV virus infection. The review further highlights the challenges and limitations associated with the development and implementation of therapeutic strategies for MPXV.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70051"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Efficacy in Herpes Zoster Ophthalmoplegia: A Systematic Review and Meta-Analysis of Case Reports and Series.","authors":"Mansoor Shahriari, Sadra Ashrafi, Seyyed Morteza Hosseini Imeni, Saeed Mohammad Soleymani, Hadi Esmaily","doi":"10.1002/rmv.70044","DOIUrl":"10.1002/rmv.70044","url":null,"abstract":"<p><p>Varicella zoster virus (VZV) causes herpes zoster ophthalmicus (HZO), a disease resulting from VZV reactivation in the eye branch of the trigeminal nerve, primarily affecting the elderly or immunocompromised. Current research on the relative prevalence of ocular HZO is limited to case series and reports. This study aims to conduct a systematic review and meta-analysis comparing the effects of antiviral drugs, corticosteroids, and their combination in published cases of ophthalmoplegic HZO. We reviewed the Scopus, PubMed, and Google Scholar databases for HZO-related studies, analysing all case reports and case series interventional studies. Our initial search yielded 14,100 articles, with 92 articles encompassing 111 patients included in the final analysis. Steroid treatment showed a greater improvement in visual score compared to antiviral treatment (ß = 0.80, 95% CI = 0.10, 1.50 = 1.10, p = 0.024). We found no significant relationship between treatment type and extraocular movement improvement (p > 0.05). While corticosteroid administration timing did not correlate with extraocular movement improvement (p = 0.108), increased acyclovir duration was associated with 3.64 times higher odds of improvement (OR = 3.64, 95% CI = 1.004, 13.23, p = 0.049). Patients with myositis had 19.42 times higher odds of skin involvement after orbital symptoms compared to those with orbital apex syndrome (OAS) (OR = 19.42, 95% CI = 1.16, 325.05, p = 0.039). Our findings suggest corticosteroid treatment may be more effective for visual outcomes than antiviral drugs or combination therapy. Additionally, longer antiviral therapy duration is linked to better extraocular motor outcomes. Most ophthalmoplegic HZO patients exhibited signs of aseptic meningitis in cerebrospinal fluid (CSF) examinations.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 4","pages":"e70044"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}