Reviews in Medical Virology最新文献_第9页

The Right to Know About CMV-Perspectives of Pregnant Women and Families With Lived Experience of CMV. 有巨细胞病毒病史的孕妇和家庭对巨细胞病毒的知情权

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70096

H Smithers-Sheedy, H Croker, A Adley, A W Shand, K Swinburn, T Tripathi, N Rode, L Hui

{"title":"The Right to Know About CMV-Perspectives of Pregnant Women and Families With Lived Experience of CMV.","authors":"H Smithers-Sheedy, H Croker, A Adley, A W Shand, K Swinburn, T Tripathi, N Rode, L Hui","doi":"10.1002/rmv.70096","DOIUrl":"10.1002/rmv.70096","url":null,"abstract":"Cytomegalovirus (CMV) is a common herpesvirus that is transmitted from person to person via bodily fluids, including urine, saliva, blood and semen. If a pregnant woman acquires CMV for the first time (maternal primary infection) or has CMV reactivation or reinfection with a new strain in pregnancy, a resulting congenital infection can cause damage to the developing foetus. CMV is the leading infectious cause of newborn disability in high income countries, where an estimated 1 in 200 babies are born with congenital infection. Around 20% of children with congenital CMV will experience significant long-term impacts, most commonly sensorineural hearing loss but also developmental delay, epilepsy and cerebral palsy. Hygiene precautions are the only effective primary prevention strategy, and it is widely recommended that all pregnant women, and those planning a pregnancy, should receive information about these strategies to help reduce the risk of infection. However, most women do not receive counselling about CMV. Here we explore commonly reported health professional capability and motivational barriers to antenatal CMV counselling and the perspectives of pregnant women and people with lived experience of CMV. This review provides an overview on what has been shared by pregnant women and those with lived experience in the literature and dispels some misconceptions about the acceptability and feasibility of CMV hygiene precautions.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70096"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arbovirus-Host Epigenetic Interplay: Unraveling the Neurological Mechanisms and Therapeutic Opportunities. 虫媒病毒-宿主表观遗传相互作用：揭示神经机制和治疗机会。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70086

Fayez M Saleh, Zaid Bassfar, Zuhair M Mohammedsaleh

{"title":"Arbovirus-Host Epigenetic Interplay: Unraveling the Neurological Mechanisms and Therapeutic Opportunities.","authors":"Fayez M Saleh, Zaid Bassfar, Zuhair M Mohammedsaleh","doi":"10.1002/rmv.70086","DOIUrl":"10.1002/rmv.70086","url":null,"abstract":"Globally, arboviral infections are major public health threats, and diseases caused by arboviruses-mainly Zika virus, Dengue virus, West Nile virus, and Japanese encephalitis virus-affect many people. Arboviruses can induce severe neurological disorders through complex interactions with host cellular and immune pathways. Recent global surges in infections highlight the urgent need to understand their neuropathogenic mechanisms. Increasing evidence shows that arboviruses exploit host epigenetic machinery, including DNA methylation, histone modification, and non-coding RNA regulation, to subvert antiviral defenses, modulate immune responses, and promote viral infection within the central nervous system. Here, we summarise current findings on the epigenetic regulation of arboviral infections and their contribution to neuropathology. We also discuss how the reversibility of epigenetic modifications presents novel therapeutic opportunities, with inhibitors targeting histone deacetylases, methyltransferases, and DNA methyltransferases emerging as potential antiviral interventions. Advances in epigenomic profiling offer unprecedented opportunities to dissect virus-host interactions, providing a foundation for precision therapies aimed at mitigating arboviral neuroinvasion and its long-term neurological consequences.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70086"},"PeriodicalIF":6.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements and Uncertainties in the Treatment of Congenital CMV Disease. 先天性巨细胞病毒病治疗的进展和不确定性。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70093

Yarlini Vipulanandan, David W Kimberlin

引用次数: 0

Global Landscape of Lenacapavir Resistance: Analysis of 52,927 Sequences Across 85 Countries. Lenacapavir耐药性的全球格局：85个国家52927个序列的分析。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70098

Yangyang Liu, Defu Yuan, Yueqi Yin, Qian He, Meng Zhao, Bei Wang, Pingmin Wei

引用次数: 0

SARS-CoV-2 Genome and S2 Spike Protein: IRF-Driven Interferon Regulation and Host Cell Responses. SARS-CoV-2基因组和S2刺突蛋白：irf驱动的干扰素调控和宿主细胞反应。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70094

Ekta Singh, Nishita Nishi, Mudita Tripathi, Krishna Prakash

{"title":"SARS-CoV-2 Genome and S2 Spike Protein: IRF-Driven Interferon Regulation and Host Cell Responses.","authors":"Ekta Singh, Nishita Nishi, Mudita Tripathi, Krishna Prakash","doi":"10.1002/rmv.70094","DOIUrl":"10.1002/rmv.70094","url":null,"abstract":"Coronaviruses, members of the betacoronavirus genus. They are mostly enveloped and has +ve sense RNA which infects a wide range of hosts, including mammals and birds. This SARS-CoV-2 in December 2019 triggered a global pandemic, with transmission primarily occurring through respiratory droplets. SARS-CoV-2 comprises four structural proteins namely: spike, membrane, envelope and nucleocapsid protein (S, M, E, and N respectively) along with multiple non-structural proteins (nsp1-nsp16) essential for infections. The trimeric S protein, composed of S1 and S2 subunits which helps in virus entry into the cell after attachment to the ACE2 recpetor of host cell. Interferon regulatory factors (IRF-1 and IRF-2) are critical transcription factors in antiviral immune responses, yet their specific roles in SARS-CoV-2 infection remain insufficiently understood. Disruption of their regulatory functions may compromise host antiviral defenses and influence disease progression. Elucidating the mechanistic roles of IRF-1 and IRF-2 could facilitate the production of novel therapeutic strategies which further modulates the immune responses, mitigates the viral pathogenicity, and hence clinical outcomes will be improved. A deep insight of these immune pathways is pivotal for designing targeted interventions to strengthen host resilience against coronavirus infections.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70094"},"PeriodicalIF":6.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forecasting Influenza Epidemics and Pandemics in the Age of AI and Machine Learning. 预测人工智能和机器学习时代的流感流行和流行病。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70107

Oleksandr Kamyshnyi, Iryna Halabitska, Valentyn Oksenych, Iryna Kamyshna, Pavlo Petakh, Denis E Kainov

{"title":"Forecasting Influenza Epidemics and Pandemics in the Age of AI and Machine Learning.","authors":"Oleksandr Kamyshnyi, Iryna Halabitska, Valentyn Oksenych, Iryna Kamyshna, Pavlo Petakh, Denis E Kainov","doi":"10.1002/rmv.70107","DOIUrl":"10.1002/rmv.70107","url":null,"abstract":"Influenza's rapid evolution, driven by its segmented RNA genome, high mutation rate, and extensive animal reservoirs, underpins its capacity to cause recurring epidemics and unpredictable pandemics. Recent advances in artificial intelligence (AI) and machine learning (ML) are transforming influenza forecasting by enabling the prediction of viral evolution and the optimisation of public health preparedness. This review synthesises insights from historical data (1890-2025) and contemporary research to examine the evolving role of AI in influenza prediction. It highlights major developments including transformer-based models for viral evolution, real-time integration of mobility and environmental data, hybrid quantum, which are classical algorithms, and multimodal data fusion frameworks, it also consideres critical risk modifiers such as meteorological variation, armed conflict, and host genetics. Importantly, the review distinguishes between retrospective, proof-of-concept analyses and prospective, real-time forecasting applications, clarifying their respective contributions to operational public health preparedness and informed decision-making.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70107"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global Epidemiology and Disease Burden of Human Parainfluenza Virus in Adults: A Systematic Review. 成人副流感病毒的全球流行病学和疾病负担：系统综述。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70105

Oliver Martyn, Clemens Vlasich, Veronika Khariv, Lauren C Boudewyn, Peter J M Openshaw, Rolf Kramer

{"title":"Global Epidemiology and Disease Burden of Human Parainfluenza Virus in Adults: A Systematic Review.","authors":"Oliver Martyn, Clemens Vlasich, Veronika Khariv, Lauren C Boudewyn, Peter J M Openshaw, Rolf Kramer","doi":"10.1002/rmv.70105","DOIUrl":"10.1002/rmv.70105","url":null,"abstract":"Parainfluenza virus (PIV) is a common cause of respiratory illness in children and immunocompromised adults, but little is known about its epidemiology or disease burden in the general adult population. This review evaluates published global epidemiological and disease burden for PIV in adults, including high-risk patients (immunocompromised or with chronic illnesses), and identifies existing data gaps. A PRISMA systematic review of publications from 2014 to 2023 in PubMed reporting PIV prevalence and disease burden (including hospitalisations, mortality) in adults (≥ 18 years) and high-risk patients was performed. Sixty-five studies were included; which skewed towards Asia, Europe, and North America, highlighting a data gap in global PIV prevalence. Overall prevalence of PIV (all strains) ranged from 0 to 15.2% [median 2%] in the general adult population (not considered high-risk but tested for infection). PIV3 was the most prevalent strain (0.6-15.2% [2.9]), followed by PIV4 (0.4-6.5% [1.9]), PIV1 (0.5-2.8% [1.1]), and PIV2 (0-2.9% [1.1]). PIV prevalence was generally higher in high-risk adults (up to 41% in certain risk groups) and those aged ≥ 65. Mortality rates ranged from 2 to 40% in those high-risk, while need for respiratory assistance ranged from 0.9% to 64.2% and hospitalisation from 3.7% to 45.3%. None of the studies reported cost-related healthcare resource utilisation. Variability of study designs, data stratification, and patient populations in the selected studies challenged evaluating the true prevalence of PIV and its burden. PIV infection carries an underappreciated burden, with substantial morbidity and mortality risks, especially in high-risk patients. Significant knowledge gaps exist regarding global prevalence and economic burden in the general adult population.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70105"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncoviruses as Emerging Players in Cardiovascular Pathogenesis: Evidence, Mechanisms and Clinical Perspectives. 肿瘤病毒在心血管发病中的作用：证据、机制和临床观点。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70097

Chuang Yang, Zhibo Li, Zhuo Zhao, Ziyuan Guo

{"title":"Oncoviruses as Emerging Players in Cardiovascular Pathogenesis: Evidence, Mechanisms and Clinical Perspectives.","authors":"Chuang Yang, Zhibo Li, Zhuo Zhao, Ziyuan Guo","doi":"10.1002/rmv.70097","DOIUrl":"10.1002/rmv.70097","url":null,"abstract":"Oncogenic viruses, with their significant capacity to drive malignant transformation, are currently known as a major factor involved in cardiovascular diseases (CVDs) by intricate immunometabolic and inflammatory processes. In this context, viral pathogens such as Hepatitis B and C viruses (HBV/HCV), Human Cytomegalovirus (HCMV), Human Papillomavirus (HPV), Epstein-Barr Virus (EBV), and Human T-Lymphotropic Virus (HTLV) have been detected in vascular tissues and are hypothesised to contribute to endothelial dysfunction, atherogenesis, and myocarditis. These viruses can modulate host cell signalling, induce chronic inflammation, and promote oxidative stress, thereby accelerating vascular remodelling and plaque instability. Emerging evidence also suggests that viral oncogenes interfere with cardiomyocyte survival pathways and disrupt vascular smooth muscle cell homoeostasis. Despite growing interest, the causal relationship between oncoviral infection and cardiovascular disease remains underexplored, and current clinical guidelines do not address viral-driven cardiopathology. This review synthesises current mechanistic insights and highlights epidemiological links, aiming to bridge gaps between oncology and cardiovascular virology. Understanding the dual oncogenic and cardiotropic potential of these viruses may open new therapeutic perspectives and support the development of targeted antiviral and immunomodulatory strategies for cardiovascular prevention in high-risk populations.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70097"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastics and Nanoplastics as Carriers for Viral Transmission: Effects on Viral Properties, Infection, Immune Response, and Public Health. 微塑料和纳米塑料作为病毒传播的载体：对病毒特性、感染、免疫反应和公共卫生的影响。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70106

Cosmina Mija, Giuseppe Sberna, Fabrizio Maggi

{"title":"Microplastics and Nanoplastics as Carriers for Viral Transmission: Effects on Viral Properties, Infection, Immune Response, and Public Health.","authors":"Cosmina Mija, Giuseppe Sberna, Fabrizio Maggi","doi":"10.1002/rmv.70106","DOIUrl":"10.1002/rmv.70106","url":null,"abstract":"The extensive use of plastics since the industrial revolution has raised significant environmental and health concerns. Despite their advantages in terms of durability, affordability, and ease of production, the accumulation of plastics has resulted in considerable pollution. The SARS-CoV-2 pandemic further exacerbated plastic consumption, particularly in medical supplies, intensifying the plastic waste crisis. The majority of plastics are not recycled and eventually degrade into microplastics (MPs) and nanoplastics (NPs), which pose substantial risks to ecosystems and human health. MPs and NPs enter the body through inhalation, ingestion, or skin contact and have been found in biological samples such as blood, faeces, and lung fluids. Their presence has been linked to diseases affecting the lungs, cardiovascular system, and intestines, as well as cancer and viral infections. This review highlights how MPs and NPs contribute to the spread of infectious diseases by creating a habitat called the \"plastisphere,\" which promotes microbial growth and serves as a reservoir for pathogens, emphasising their effects on viral persistence, infection dynamics, and immune modulation. Unlike previous reviews mainly focused on toxicological or microbiological aspects, this work integrates environmental, virological, and immunological evidence to outline how MPs/NPs may reshape virus-host interactions. By identifying critical knowledge gaps, such as the quantitative impact of MPs/NPs on viral stability and immune disruption, this review provides a background for future experimental and epidemiological research. This value-added perspective not only advances scientific understanding but also supports policy development in waste management.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70106"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12808005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overlapping Environmental Shocks and Arboviral Risk: Earthquakes as an Underrecognized Catalyst. 重叠的环境冲击和虫媒病毒风险：地震作为未被认识的催化剂。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70104

Giancarlo Ceccarelli, Francesco Branda, Marta Giovanetti, Fabio Scarpa, Gabriella D'Ettorre, Massimo Ciccozzi

引用次数: 0