Reviews in Medical Virology最新文献_第9页

Global Epidemiology and Disease Burden of Human Parainfluenza Virus in Adults: A Systematic Review. 成人副流感病毒的全球流行病学和疾病负担：系统综述。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70105

Oliver Martyn, Clemens Vlasich, Veronika Khariv, Lauren C Boudewyn, Peter J M Openshaw, Rolf Kramer

{"title":"Global Epidemiology and Disease Burden of Human Parainfluenza Virus in Adults: A Systematic Review.","authors":"Oliver Martyn, Clemens Vlasich, Veronika Khariv, Lauren C Boudewyn, Peter J M Openshaw, Rolf Kramer","doi":"10.1002/rmv.70105","DOIUrl":"10.1002/rmv.70105","url":null,"abstract":"Parainfluenza virus (PIV) is a common cause of respiratory illness in children and immunocompromised adults, but little is known about its epidemiology or disease burden in the general adult population. This review evaluates published global epidemiological and disease burden for PIV in adults, including high-risk patients (immunocompromised or with chronic illnesses), and identifies existing data gaps. A PRISMA systematic review of publications from 2014 to 2023 in PubMed reporting PIV prevalence and disease burden (including hospitalisations, mortality) in adults (≥ 18 years) and high-risk patients was performed. Sixty-five studies were included; which skewed towards Asia, Europe, and North America, highlighting a data gap in global PIV prevalence. Overall prevalence of PIV (all strains) ranged from 0 to 15.2% [median 2%] in the general adult population (not considered high-risk but tested for infection). PIV3 was the most prevalent strain (0.6-15.2% [2.9]), followed by PIV4 (0.4-6.5% [1.9]), PIV1 (0.5-2.8% [1.1]), and PIV2 (0-2.9% [1.1]). PIV prevalence was generally higher in high-risk adults (up to 41% in certain risk groups) and those aged ≥ 65. Mortality rates ranged from 2 to 40% in those high-risk, while need for respiratory assistance ranged from 0.9% to 64.2% and hospitalisation from 3.7% to 45.3%. None of the studies reported cost-related healthcare resource utilisation. Variability of study designs, data stratification, and patient populations in the selected studies challenged evaluating the true prevalence of PIV and its burden. PIV infection carries an underappreciated burden, with substantial morbidity and mortality risks, especially in high-risk patients. Significant knowledge gaps exist regarding global prevalence and economic burden in the general adult population.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70105"},"PeriodicalIF":6.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forecasting Influenza Epidemics and Pandemics in the Age of AI and Machine Learning. 预测人工智能和机器学习时代的流感流行和流行病。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70107

Oleksandr Kamyshnyi, Iryna Halabitska, Valentyn Oksenych, Iryna Kamyshna, Pavlo Petakh, Denis E Kainov

{"title":"Forecasting Influenza Epidemics and Pandemics in the Age of AI and Machine Learning.","authors":"Oleksandr Kamyshnyi, Iryna Halabitska, Valentyn Oksenych, Iryna Kamyshna, Pavlo Petakh, Denis E Kainov","doi":"10.1002/rmv.70107","DOIUrl":"10.1002/rmv.70107","url":null,"abstract":"Influenza's rapid evolution, driven by its segmented RNA genome, high mutation rate, and extensive animal reservoirs, underpins its capacity to cause recurring epidemics and unpredictable pandemics. Recent advances in artificial intelligence (AI) and machine learning (ML) are transforming influenza forecasting by enabling the prediction of viral evolution and the optimisation of public health preparedness. This review synthesises insights from historical data (1890-2025) and contemporary research to examine the evolving role of AI in influenza prediction. It highlights major developments including transformer-based models for viral evolution, real-time integration of mobility and environmental data, hybrid quantum, which are classical algorithms, and multimodal data fusion frameworks, it also consideres critical risk modifiers such as meteorological variation, armed conflict, and host genetics. Importantly, the review distinguishes between retrospective, proof-of-concept analyses and prospective, real-time forecasting applications, clarifying their respective contributions to operational public health preparedness and informed decision-making.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70107"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncoviruses as Emerging Players in Cardiovascular Pathogenesis: Evidence, Mechanisms and Clinical Perspectives. 肿瘤病毒在心血管发病中的作用：证据、机制和临床观点。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70097

Chuang Yang, Zhibo Li, Zhuo Zhao, Ziyuan Guo

{"title":"Oncoviruses as Emerging Players in Cardiovascular Pathogenesis: Evidence, Mechanisms and Clinical Perspectives.","authors":"Chuang Yang, Zhibo Li, Zhuo Zhao, Ziyuan Guo","doi":"10.1002/rmv.70097","DOIUrl":"10.1002/rmv.70097","url":null,"abstract":"Oncogenic viruses, with their significant capacity to drive malignant transformation, are currently known as a major factor involved in cardiovascular diseases (CVDs) by intricate immunometabolic and inflammatory processes. In this context, viral pathogens such as Hepatitis B and C viruses (HBV/HCV), Human Cytomegalovirus (HCMV), Human Papillomavirus (HPV), Epstein-Barr Virus (EBV), and Human T-Lymphotropic Virus (HTLV) have been detected in vascular tissues and are hypothesised to contribute to endothelial dysfunction, atherogenesis, and myocarditis. These viruses can modulate host cell signalling, induce chronic inflammation, and promote oxidative stress, thereby accelerating vascular remodelling and plaque instability. Emerging evidence also suggests that viral oncogenes interfere with cardiomyocyte survival pathways and disrupt vascular smooth muscle cell homoeostasis. Despite growing interest, the causal relationship between oncoviral infection and cardiovascular disease remains underexplored, and current clinical guidelines do not address viral-driven cardiopathology. This review synthesises current mechanistic insights and highlights epidemiological links, aiming to bridge gaps between oncology and cardiovascular virology. Understanding the dual oncogenic and cardiotropic potential of these viruses may open new therapeutic perspectives and support the development of targeted antiviral and immunomodulatory strategies for cardiovascular prevention in high-risk populations.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70097"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastics and Nanoplastics as Carriers for Viral Transmission: Effects on Viral Properties, Infection, Immune Response, and Public Health. 微塑料和纳米塑料作为病毒传播的载体：对病毒特性、感染、免疫反应和公共卫生的影响。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70106

Cosmina Mija, Giuseppe Sberna, Fabrizio Maggi

{"title":"Microplastics and Nanoplastics as Carriers for Viral Transmission: Effects on Viral Properties, Infection, Immune Response, and Public Health.","authors":"Cosmina Mija, Giuseppe Sberna, Fabrizio Maggi","doi":"10.1002/rmv.70106","DOIUrl":"10.1002/rmv.70106","url":null,"abstract":"The extensive use of plastics since the industrial revolution has raised significant environmental and health concerns. Despite their advantages in terms of durability, affordability, and ease of production, the accumulation of plastics has resulted in considerable pollution. The SARS-CoV-2 pandemic further exacerbated plastic consumption, particularly in medical supplies, intensifying the plastic waste crisis. The majority of plastics are not recycled and eventually degrade into microplastics (MPs) and nanoplastics (NPs), which pose substantial risks to ecosystems and human health. MPs and NPs enter the body through inhalation, ingestion, or skin contact and have been found in biological samples such as blood, faeces, and lung fluids. Their presence has been linked to diseases affecting the lungs, cardiovascular system, and intestines, as well as cancer and viral infections. This review highlights how MPs and NPs contribute to the spread of infectious diseases by creating a habitat called the \"plastisphere,\" which promotes microbial growth and serves as a reservoir for pathogens, emphasising their effects on viral persistence, infection dynamics, and immune modulation. Unlike previous reviews mainly focused on toxicological or microbiological aspects, this work integrates environmental, virological, and immunological evidence to outline how MPs/NPs may reshape virus-host interactions. By identifying critical knowledge gaps, such as the quantitative impact of MPs/NPs on viral stability and immune disruption, this review provides a background for future experimental and epidemiological research. This value-added perspective not only advances scientific understanding but also supports policy development in waste management.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70106"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12808005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overlapping Environmental Shocks and Arboviral Risk: Earthquakes as an Underrecognized Catalyst. 重叠的环境冲击和虫媒病毒风险：地震作为未被认识的催化剂。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70104

Giancarlo Ceccarelli, Francesco Branda, Marta Giovanetti, Fabio Scarpa, Gabriella D'Ettorre, Massimo Ciccozzi

引用次数: 0

Adaptive Evolution of Dengue Virus: Interplay Between Viral Genetics and Host Immunity. 登革病毒的适应性进化：病毒遗传与宿主免疫的相互作用。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70082

Md Eram Hosen, Sumaiya Jahan Supti, Paul F Horwood, Subir Sarker

{"title":"Adaptive Evolution of Dengue Virus: Interplay Between Viral Genetics and Host Immunity.","authors":"Md Eram Hosen, Sumaiya Jahan Supti, Paul F Horwood, Subir Sarker","doi":"10.1002/rmv.70082","DOIUrl":"10.1002/rmv.70082","url":null,"abstract":"Dengue virus (DENV), a major arboviral pathogen of global concern, evolves rapidly through a combination of intrinsic molecular mechanisms, vector adaptation, and host immune pressures. Despite extensive research, major gap remains in understanding how these forces, collectively generate, shape, and fix adaptive mutations that drive DENV evolution. In this review, we explore the molecular mechanisms underlying DENV evolution, with emphasising the error-prone RNA-dependent RNA polymerase, template switching, recombination, and the modulatory effects of viral RNA secondary structures. We also highlight the replicase complex's intrinsic tolerance to mutations as a driver of evolutionary plasticity. At the protein level, we summarise adaptive mutation in capsid, envelop, NS1 and NS5 protein that influence virulence, transmission efficiency, and immune escape. Additionally, we also address the role of vector adaptation, whereby DENV overcomes midgut and salivary gland infection barriers in Aedes mosquitoes, often through bottleneck-driven selection and compensatory mutations, consequently enhancing transmission potential. Finally, we discuss host immune-driven selection including T cell-mediated immune responses, and the regulation of IFN, NF-κB, and PI3K/Akt/mTOR signalling pathways shapes the evolution of DENV. Together, these insights highlight the dynamic interplay between viral genetics, mosquito vectors, and host immunity in shaping the evolutionary trajectory of DENV.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70082"},"PeriodicalIF":6.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery, Diversity and Evolution of Emerging Jingmenviruses. 新兴泾渭环境的发现、多样性与演化。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70084

Jing-Jing Guo, Ru-Yi Chen, Zu-Xin Wang, Cheng-Feng Qin

引用次数: 0

COVID-19 in Diabetic Patients: Mechanisms, Risks, and Therapeutic Considerations. 糖尿病患者的COVID-19：机制、风险和治疗考虑

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70085

Rania Hamdy, Amal Z Barakat, Eman J Abuzaid, Tasneem M Elsayed, Mohamed I Husseiny

{"title":"COVID-19 in Diabetic Patients: Mechanisms, Risks, and Therapeutic Considerations.","authors":"Rania Hamdy, Amal Z Barakat, Eman J Abuzaid, Tasneem M Elsayed, Mohamed I Husseiny","doi":"10.1002/rmv.70085","DOIUrl":"10.1002/rmv.70085","url":null,"abstract":"The COVID-19 pandemic, caused by SARS-CoV-2, has had a profound global impact. Diabetes mellitus is a major comorbidity associated with higher infection risk, severe disease, and mortality in COVID-19 patients. This review examines the bidirectional relationship between COVID-19 and diabetes, focussing on immunometabolic mechanisms, post-COVID metabolic effects, and therapeutic implications. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science for articles published until May 2025 using the terms \"COVID-19,\" \"SARS-CoV-2,\" \"diabetes,\" and \"immunometabolism.\" Peer-reviewed studies addressing clinical, molecular, or therapeutic interactions between the two diseases were included. Evidence shows that SARS-CoV-2 infection aggravates metabolic dysfunction through immune dysregulation, cytokine-mediated inflammation, and β-cell injury. Hyperglycemia promotes viral replication and inflammatory damage, creating a vicious cycle that worsens outcomes. Reports also indicate an increased risk of new-onset and post-COVID diabetes. Certain antidiabetic agents, such as metformin and GLP-1 receptor agonists, may improve prognosis via anti-inflammatory and metabolic effects. Diabetes significantly amplifies the severity of COVID-19 through intertwined metabolic and immune mechanisms. Understanding these interactions provides new insights into disease management and supports the development of targeted immunometabolic therapies for improving outcomes in diabetic patients affected by COVID-19.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70085"},"PeriodicalIF":6.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Covid Syndrome and Role of Autonomic Nervous System. 长冠综合征与自主神经系统的作用。

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70101

A Vitiello

引用次数: 0

The Impact of the COVID-19 Pandemic on HPV Vaccination Coverage Among Adolescents From High-Income Countries and Challenges: A Scoping Review. COVID-19大流行对高收入国家青少年HPV疫苗接种覆盖率的影响和挑战：范围审查

IF 6.6 2区医学

Reviews in Medical Virology Pub Date : 2026-01-01 DOI: 10.1002/rmv.70102

Sasidharanpillai Sabeena, Caryl Beynon

{"title":"The Impact of the COVID-19 Pandemic on HPV Vaccination Coverage Among Adolescents From High-Income Countries and Challenges: A Scoping Review.","authors":"Sasidharanpillai Sabeena, Caryl Beynon","doi":"10.1002/rmv.70102","DOIUrl":"10.1002/rmv.70102","url":null,"abstract":"Persistent high-risk Human Papillomavirus (HPV) infection causes anogenital and oropharyngeal cancers across all genders. The primary cancer associated with HPV is cervical cancer and the HPV vaccination before sexual exposure is recommended for cervical cancer elimination globally. This scoping review aims to map the preliminary evidence regarding the determinants of adolescent HPV vaccine acceptance and hesitancy during the COVID-19 pandemic in high income countries. A scoping review was conducted as per the updated Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR) checklist. Using the PCC (Population, Concept, and Context) framework, search keywords and search strategies were developed. Electronic databases were searched using specific search terms and the last search date noted as February 8, 2025. A thematic content analysis was carried out to identify the themes and subthemes by a deductive approach. Fourteen studies were included as the potential sources of evidence in this review. The study population included 493,819 adolescents from Australia, Hong Kong, Italy, Poland, Saudi Arabia, and the USA. The themes identified were inequity, attitude and behaviour, knowledge and communication, and engagement and influence. The COVID-19 pandemic generated a negative parental attitude towards HPV vaccines for a brief period. The adolescent HPV vaccine acceptance mainly depended on strong parental support and appropriate access to healthcare professionals and vaccination services. Travel restrictions, lockdowns, school closures, and social distancing contributed to significant HPV vaccine hesitancy in high income countries.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 1","pages":"e70102"},"PeriodicalIF":6.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0