阻止病毒入侵神经的潜在治疗策略。

IF 9 2区医学 Q1 VIROLOGY

Reviews in Medical Virology Pub Date : 2024-05-01 DOI:10.1002/rmv.2539

Luping Zhang, Usama Ashraf, Huanchun Chen, Shengbo Cao, Jing Ye

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引用次数: 0

摘要

中枢神经系统病毒感染是一个重大的公共卫生问题。迄今为止，由于缺乏特效疗法，大多数神经病毒感染的临床病例都是通过支持性治疗和/或对症治疗来解决的。因此，需要开发特异性疗法来缓解神经系统症状和疾病。在这篇综述中，我们阐述了病毒进入大脑的分子方面，在体外和临床前体内模型系统中，使用特异性药物靶向治疗后显示出了良好的疗效。在临床试验中进一步评估这些药物的治疗潜力可能会为阻止病毒对人类神经系统的入侵提供机会。

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Potential therapeutic strategies to halt viral neuroinvasion.

The viral infection of the central nervous system is a significant public health concern. So far, most clinical cases of viral neuroinvasion are dealt with supportive and/or symptomatic treatments due to the unavailability of specific treatments. Thus, developing specific therapies is required to alleviate neurological symptoms and disorders. In this review, we shed light on molecular aspects of viruses' entry into the brain which upon targeting with specific drugs have shown promising efficacy in vitro and in preclinical in vivo model systems. Further assessing the therapeutic potential of these drugs in clinical trials may offer opportunities to halt viral neuroinvasion in humans.

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来源期刊

Reviews in Medical Virology 医学-病毒学

CiteScore

21.40

自引率

0.90%

发文量

期刊介绍： Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.