Reviews in Medical Virology最新文献_第2页

An Overview on Disease Burden and Management of Respiratory Syncytial Virus Infections in Older Adults in the Asia-Pacific Region. 亚太地区老年人呼吸道合胞病毒感染的疾病负担和管理概览。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70003

Chih-Cheng Lai, Po-Ren Hsueh

{"title":"An Overview on Disease Burden and Management of Respiratory Syncytial Virus Infections in Older Adults in the Asia-Pacific Region.","authors":"Chih-Cheng Lai, Po-Ren Hsueh","doi":"10.1002/rmv.70003","DOIUrl":"https://doi.org/10.1002/rmv.70003","url":null,"abstract":"Respiratory syncytial virus (RSV) represents a significant burden on older adults (aged ≥ 50 years) globally and can lead to acute respiratory tract infections with substantial morbidity and mortality. However, there is a significant gap in knowledge regarding RSV infection in older adults, particularly in the Asia-Pacific region. This knowledge gap underscores the need for targeted and comprehensive studies to fully understand the nuanced epidemiology of RSV in ageing populations. This review synthesises data from various countries, emphasising the impact of RSV on older populations in the Asia-Pacific region. The overall proportions of RSV-related ARIs among older patients ranged from 0.2% to 5.6%. Among older adult patients with CAP, RSV accounted for 1.1%-10.3% of cases. However, it is crucial to note that the diversity in reported percentages highlights the influence of factors such as geographic location, health care settings and diagnostic practices. The most common symptoms observed in older adults with RSV infection were cough, sputum production and fever, followed by dyspnoea, sore throat and rhinorrhoea. Most of the old adults with RSV infection had underlying diseases, and RSV can cause significant morbidity and mortality in old adults. Treatment of RSV infections predominantly involve supportive care, with aerosolised ribavirin reserved for severe cases, especially immunocompromised patients. Emerging antiviral agents, including fusion and nucleoprotein inhibitors, offer promising avenues for future therapeutics. The recent approval of the bivalent RSV prefusion F protein-based vaccine for individuals aged 60 and older represents a milestone in preventive strategies. In conclusion, RSV infection remains a significant threat to older adults in the Asia-Pacific region, necessitating ongoing research and surveillance efforts. The recent vaccine approval marks a positive milestone, but further studies are crucial for refining prevention and treatment approaches.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 6","pages":"e70003"},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Male Viral Infections and Infertility: A Systematic Review and Meta-Analysis. 男性病毒感染与不育之间的关系：系统回顾与元分析》。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70002

Yan Guo, Guozhong Zhou, Yun Feng, Jie Zhang, Yang Liu, Xianyao Yang, Pan Liu, Yue Feng, Xueshan Xia

{"title":"The Association Between Male Viral Infections and Infertility: A Systematic Review and Meta-Analysis.","authors":"Yan Guo, Guozhong Zhou, Yun Feng, Jie Zhang, Yang Liu, Xianyao Yang, Pan Liu, Yue Feng, Xueshan Xia","doi":"10.1002/rmv.70002","DOIUrl":"https://doi.org/10.1002/rmv.70002","url":null,"abstract":"Infertility affects approximately one-sixth of couples worldwide, with male factors contributing to half of all cases. However, infections, particularly those of reproductive tract, are increasingly recognized as important contributors to male infertility. Therefore, in this meta-analysis, we focused on the impact of various viral infections on male infertility. We searched PubMed, Embase, Web of Science and Cochrane Library on 20 October 2023. And included 135 studies involving 30,298 men of reproductive age. We found that the human papilloma virus (HPV)-infected group had a significantly higher DNA fragmentation index (DFI) than the non-infected group, with a mean difference (MD) of 5.64 (95% CI: 3.74-7.54). Conversely, the HPV-infected group had significantly lower sperm count, concentration, viability and normal morphology. Other viruses that affect semen quality include hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). HBV significantly decreased fertilization rate, with an odds ratio (OR) of 0.86 (95% CI: 0.76-0.99). HPV associated with lower clinical pregnancy rate (OR: 0.31 [95% CI: 0.16-0.62]) and higher miscarriage rate (OR: 5.28 [95% CI: 2.02-13.78]). Additionally, the fertility treatment group had a significantly higher rate of HPV infection (OR: 1.85 [95% CI: 1.10-3.12]) and adeno-associated virus (AAV) infection (OR: 8.49 [95% CI: 2.66-27.10]) than the fertility group. Conclusively, most viral infections affect semen quality, while HBV and HPV may affect assisted reproductive technology (ART) outcomes. HPV and AAV are risk factors for infertility.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 6","pages":"e70002"},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Sequencing Methods for Near-Real-Time Molecular Epidemiology of HIV and HCV. 用于近实时 HIV 和 HCV 分子流行病学的下一代测序方法。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70001

Bethany A Horsburgh, Gregory J Walker, Anthony Kelleher, Andrew R Lloyd, Rowena A Bull, Francesca Di Giallonardo

{"title":"Next-Generation Sequencing Methods for Near-Real-Time Molecular Epidemiology of HIV and HCV.","authors":"Bethany A Horsburgh, Gregory J Walker, Anthony Kelleher, Andrew R Lloyd, Rowena A Bull, Francesca Di Giallonardo","doi":"10.1002/rmv.70001","DOIUrl":"10.1002/rmv.70001","url":null,"abstract":"The World Health Organisation has set targets of reducing the transmission of new hepatitis C (HCV) infections by 90%, and ending human immunodeficiency virus-1 (HIV) as a public health threat, by 2030. To achieve this, efficient and timely viral surveillance, and effective public health interventions, are required. Traditional epidemiological methods are largely dependent on the recognition of incident cases with symptomatic illness; acute HIV and HCV infections are commonly asymptomatic, which may lead to delays in the recognition of such new infections. Instead, for these viruses, molecular epidemiology may improve the detection of, and response to, clusters of viral transmission. Molecular epidemiology using historical datasets has highlighted key populations that may have benefitted from a timely intervention. Similar analyses performed on contemporary samples are needed to underpin the 2030 targets, but this requires the generation of a cohesive dataset of viral genome sequences in near-real-time. To generate such data, methodologies harnessing next-generation sequencing (NGS) should be utilised. Here we discuss the opportunity presented by NGS for public health surveillance of HIV and HCV, and discuss three methods that can generate sequences for such analysis. These include full-length genome amplification, utilised for analysis of HCV in the research space; tiling PCR, which was the method of choice for many diagnostic laboratories in the SARS-CoV-2 pandemic; and bait-capture hybridisation, which has been utilised in local HIV outbreaks. These techniques could be applied for near-real-time HIV and HCV surveillance, informing public health strategies that will be key to achieving 2030 targets.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 6","pages":"e70001"},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Post-Measles Encephalitis in a Returning Traveller: Highlighting the Need for MMR Vaccination. 一名回国旅行者的急性麻疹后脑炎：强调接种麻腮风疫苗的必要性。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2588

Sarah May Johnson, Jane Hassell, Gerard Leslie Peter Manning, Sniya Sudhakar, Joe Brierley, Louis Grandjean, Judith Breuer, Seilesh Kadambari

引用次数: 0

Immune Evasion Mechanism of Neurotropic Viruses. 神经性病毒的免疫逃避机制

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2589

Yayun Yan, Yu Sun, Xinyuan Guo, Yuanchao An, Ying Chang

引用次数: 0

Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated Cardiomyopathy. 病毒性心肌炎导致扩张型心肌病的先天性免疫与自噬之间的相互关系

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2586

Chen Wang, Honglin Luo

引用次数: 0

Clinical Relevance of Oxidative Stress Biomarkers in Human Flavivirus Infections as Predictors of Disease Progression and Severity. 人类弗拉维夫病毒感染中的氧化应激生物标志物作为疾病进展和严重程度预测因子的临床意义

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70007

Maxim Van Herreweghe, Tess De Bruyne, Nina Hermans, Ralph Huits

{"title":"Clinical Relevance of Oxidative Stress Biomarkers in Human Flavivirus Infections as Predictors of Disease Progression and Severity.","authors":"Maxim Van Herreweghe, Tess De Bruyne, Nina Hermans, Ralph Huits","doi":"10.1002/rmv.70007","DOIUrl":"https://doi.org/10.1002/rmv.70007","url":null,"abstract":"Several Flaviviridae constitute an emerging threat to global health because of their continuing spread and the expansion of vector habitats, largely driven by climate change and intensified global travel. Infections can result in severe neurological or visceral pathologies. The relationship between oxidative stress (OS), an imbalance between generated reactive oxygen species and the antioxidant defences of the host, and flavivirus infection has been repeatedly demonstrated in in vitro and animal studies, but measuring biomarkers of oxidative stress in vivo could prove useful in clinical patient management. We summarise the knowledge and prospects of measuring peripheral OS biomarker levels for clinical case management and correlation with disease severity in six important human flavivirus infections (dengue virus (DENV), Japanese encephalitis virus, West Nile virus (WNV), tick-borne encephalitis virus (TBEV), yellow fever virus and zika virus). We searched the Medline and Web of Science databases for 'Oxidative Stress' AND 'Biomarkers' AND 'Flavivirus', combined with 'clinical', 'in vivo/in vivo', 'patient' and/or 'disease' and included 43 peer-reviewed publications. Correlation between OS and infection has been studied in all six Flaviviridae, but most clinically relevant data are available for DENV, TBEV and WNV. Plasma protein carbonyls, glutathione peroxidase activity and nitrogen monoxide are promising prognostic markers, but their measurement would benefit from methodological harmonisation. Future studies should investigate a broad range of OS biomarkers as predictors of clinically relevant outcomes. We advocate the validation and use of universal or disease-specific oxidative stress indexes that incorporate the most significant outcomes into one, easy-to-use clinical determinant.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 6","pages":"e70007"},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Underlying Factors Predisposing to Viral-Induced Neurological Diseases. 病毒诱发神经系统疾病的潜在因素。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.2587

Zahra Heydarifard, Paul Shapshak, Milad Zandi

引用次数: 0

Next Generation RNA/Protein-Carrying Vector With Pleiotropic Activity. 具有多基因活性的下一代 RNA/Protein Carrying Vector。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70008

Tetsuya Nosaka, Junpei Ohtsuka, Tomomi Ohtsuka, Masayuki Fukumura

{"title":"Next Generation RNA/Protein-Carrying Vector With Pleiotropic Activity.","authors":"Tetsuya Nosaka, Junpei Ohtsuka, Tomomi Ohtsuka, Masayuki Fukumura","doi":"10.1002/rmv.70008","DOIUrl":"10.1002/rmv.70008","url":null,"abstract":"Human parainfluenza virus type 2 (hPIV2), one of the causative agents of infantile common cold, is a non-segmented negative-sense RNA virus with a robust gene expression system. It infects recurrently throughout human life without causing severe disease. Because hPIV2 has a viral envelope that can carry ectopic proteins, we developed a non-propagative RNA/protein-carrying vector BC-PIV by deleting the F gene from hPIV2. BC-PIV can be vigorously proliferated in the stable packaging cell line Vero/BC-F cells expressing the hPIV2 F gene but not in other cells. BC-PIV can deliver exogenous gene(s) on a multigenic RNA genome as an inserted gene fragment(s) and simultaneously deliver exogenous protein(s) on its envelope in a membrane-anchored form. For example, influenza virus M2e protein, Ebola virus GP protein, and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) spike protein were shown to be highly expressed in packaging cells and incorporated into the virion. The Ebola virus GP protein and SARS-CoV-2 spike protein, each delivered via BC-PIV, efficiently induced neutralising antibodies against each virus, even after prior treatment with recombinant BC-PIV in mice and hamsters, respectively. In this review, we describe the properties of BC-PIV as a promising vaccine vector, and also demonstrate its application as an anti-tumour virus.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 6","pages":"e70008"},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroinflammation in Post COVID-19 Sequelae: Neuroinvasion and Neuroimmune Crosstalk. COVID-19 后遗症中的神经炎症：神经入侵和神经免疫串联。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-11-01 DOI: 10.1002/rmv.70009

Roberta S Dos Reis, Sathish Selvam, Velpandi Ayyavoo

{"title":"Neuroinflammation in Post COVID-19 Sequelae: Neuroinvasion and Neuroimmune Crosstalk.","authors":"Roberta S Dos Reis, Sathish Selvam, Velpandi Ayyavoo","doi":"10.1002/rmv.70009","DOIUrl":"10.1002/rmv.70009","url":null,"abstract":"The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 triggered a swift global spread, leading to a devastating pandemic. Alarmingly, approximately one in four individuals diagnosed with coronavirus disease 2019 (COVID-19) experience varying degrees of cognitive impairment, raising concerns about a potential increase in neurological sequelae cases. Neuroinflammation seems to be the key pathophysiological hallmark linking mild respiratory COVID-19 to cognitive impairment, fatigue, and neurological sequelae in COVID-19 patients, highlighting the interaction between the nervous and immune systems following SARS-CoV-2 infection. Several hypotheses have been proposed to explain how the virus disrupts physiological pathways to trigger inflammation within the CNS, potentially leading to neuronal damage. These include neuroinvasion, systemic inflammation, disruption of the lung and gut-brain axes, and reactivation of latent viruses. This review explores the potential origins of neuroinflammation and the underlying neuroimmune cross-talk, highlighting important unanswered questions in the field. Addressing these fundamental issues could enhance our understanding of the virus's impact on the CNS and inform strategies to mitigate its detrimental effects.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 6","pages":"e70009"},"PeriodicalIF":9.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0