Reviews in Medical Virology最新文献

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Measles Resurgence: Could a Third Vaccine Dose Be the Solution? 麻疹卷土重来:第三剂疫苗能解决问题吗?
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70134
Huynh Tran Bao Chau, Bui Cong Minh, Jeza Muhamad Abdul Aziz, Hoang Bao Tran Van, Bui Nguyen Ha Tien, Abdelrahman Gad, Khanh Dang Nguyen, Pham Hong Gam, Javeria Hamraa, Le Thi Thuy Hang, Tran Thi Kim Ngan, Pham Thai Son, Nguyen Tien Huy
{"title":"Measles Resurgence: Could a Third Vaccine Dose Be the Solution?","authors":"Huynh Tran Bao Chau, Bui Cong Minh, Jeza Muhamad Abdul Aziz, Hoang Bao Tran Van, Bui Nguyen Ha Tien, Abdelrahman Gad, Khanh Dang Nguyen, Pham Hong Gam, Javeria Hamraa, Le Thi Thuy Hang, Tran Thi Kim Ngan, Pham Thai Son, Nguyen Tien Huy","doi":"10.1002/rmv.70134","DOIUrl":"10.1002/rmv.70134","url":null,"abstract":"<p><p>Measles remains a highly infectious viral disease and continues to pose a major global public health concern, with recurrent outbreaks occurring despite the implementation of effective vaccination strategies. This review examines multifactorial drivers of current measles outbreaks, summarises current recommendations for the standard two-dose measles-containing vaccine schedule, and evaluates emerging immunological evidence regarding the administration of a third dose. Some studies indicate that a third measles-containing vaccine dose can result in an enhanced response for both humoral and cellular immune responses among individuals with declining antibody levels. However, existing evidence is largely derived from small, context-specific studies and does not yet demonstrate durable clinical protection or population-level impact on measles transmission. Consequently, the role of a routine third dose remains uncertain. In conclusion, addressing the multifactorial drivers of measles resurgence, including strengthening two-dose vaccination coverage, reducing vaccine hesitancy, improving surveillance, and closing immunity gaps, remains the primary priority for measles control. A third dose may be considered as an investigational strategy, but further large-scale epidemiologic and effectiveness data are needed before any policy implementation can be considered.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70134"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chapare Virus: A Re-Emerging Zoonotic Arenavirus With Limited Preparedness. Chapare病毒:一种重新出现的人畜共患沙粒病毒,防范措施有限。
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70111
Sabrina Sharmin, Asef Raj, Md Atik Zawad, Afnan Jahan, Zubaier Ahmed, Mossamat Umul Khair Fatema
{"title":"Chapare Virus: A Re-Emerging Zoonotic Arenavirus With Limited Preparedness.","authors":"Sabrina Sharmin, Asef Raj, Md Atik Zawad, Afnan Jahan, Zubaier Ahmed, Mossamat Umul Khair Fatema","doi":"10.1002/rmv.70111","DOIUrl":"10.1002/rmv.70111","url":null,"abstract":"<p><p>Chapare virus (CHAPV) is an emerging New World arenavirus that causes Chapare haemorrhagic fever (CHHF), a severe and often fatal illness. First identified in Bolivia in 2003, CHAPV remains geographically limited but has shown potential for nosocomial transmission. It causes symptoms similar to other viral haemorrhagic fevers, including fever, muscle pain, bleeding, and neurological complications. The virus is primarily spread through contact with infected rodents, although limited human-to-human transmission has been documented. CHAPV has a bisegmented RNA genome with ambisense polarity. It shares structural features with other arenaviruses but contains unique mutations that may affect its ability to replicate and evade the immune system. The virus targets immune cells, disrupts normal responses, and causes widespread inflammation and vascular damage. No vaccine or antiviral treatment is currently available. This review compares CHAPV with other arenaviruses such as Lassa, Junín, Machupo, Guanarito, and Sabia viruses. While some of these viruses have vaccines or experimental treatments, CHAPV lacks both. Diagnostic challenges, poor surveillance, and underreporting further limit understanding of its true burden. We highlight the urgent need for improved diagnostics, genomic surveillance, and development of medical countermeasures. A One Health approach-linking human, animal, and environmental health is essential for early detection and prevention of future outbreaks. Given its clinical severity and potential for spread, CHAPV represents a neglected but serious global health threat that requires immediate research and policy attention.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70111"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Surge to Stability: Navigating MPOX Epidemics Across the Globe With Genomic Insights, Paving the Way for Effective Management Plan. 从激增到稳定:用基因组学见解导航全球MPOX流行病,为有效的管理计划铺平道路。
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70112
Tooba Malik, Muhammad Shahzad, Tasleem Akhtar
{"title":"From Surge to Stability: Navigating MPOX Epidemics Across the Globe With Genomic Insights, Paving the Way for Effective Management Plan.","authors":"Tooba Malik, Muhammad Shahzad, Tasleem Akhtar","doi":"10.1002/rmv.70112","DOIUrl":"10.1002/rmv.70112","url":null,"abstract":"<p><p>MPOX has been declared endemic in Central Africa by WHO in 2017. More recently (2018-2021), MPOX cases have been reported in various regions (endemic as well as non-endemic) all over the world. The sudden, unexpected and simultaneously emerging cases at geographically disparate areas indicate the probable undetected transmission pattern of the disease. The double stranded DNA virus has evolved over the time into multiple sub-lineages. Clade I MPXV variant is considered to be more virulent as compared to clade II variety. Mutations in certain sub-lineages may alter transmission routes, potentially shifting from direct contact to airborne transmission. The clinical presentation involves an incubation phase of 7-9 days, during this phase extensive viral dissemination occurs into the neighbouring cells causing systemic inflammation. The viral prodrome comprising of fever, malaise and myalgias may or may not precede the cutaneous eruptions that evolve over a period of 1-2 weeks, followed by desquamation and scabbing. Treatments include antiviral agents such as tecovirimat, bocindofovir and cidofovir in addition to standard supportive therapy for severe cases or immunocompromised patients. Vaccines such as ACAM2000, JYNNEOS and LC16m8 are available, although they are linked with some risks such as myopericarditis in certain patients. Ongoing global spread and virus mutations highlight the urgent need to accelerate research focused on early MPOX detection, novel treatment options and prevention in order to properly handle potential long-term challenges such as drug-resistant strains and future outbreaks. Prioritising the development of targeted, efficient, and less resistance-prone anti-MPOX medicines and rapid response systems for effective MPOX management.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70112"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colchicine in COVID-19: Mechanistic Insights and Clinical Uncertainties. 秋水仙碱在COVID-19中的作用:机制见解和临床不确定性。
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70126
Abrar S Alsulami, Hayder M Al-Kuraishy, Tasnim S Waheeb, Gaber El-Saber Batiha
{"title":"Colchicine in COVID-19: Mechanistic Insights and Clinical Uncertainties.","authors":"Abrar S Alsulami, Hayder M Al-Kuraishy, Tasnim S Waheeb, Gaber El-Saber Batiha","doi":"10.1002/rmv.70126","DOIUrl":"10.1002/rmv.70126","url":null,"abstract":"<p><p>Coronavirus Disease 2019 (COVID-19) which caused by the novel coronavirus SARS-CoV-2 has been emerged as a global health crisis characterised by severe immune dysregulation and inflammatory complications. The hyper-activation of the immune response in COVID-19 patients is associated with disease progression and severity. As a result, immunomodulatory therapies such as colchicine have been suggested to control exaggerated immune response in COVID-19. However, the therapeutic role of colchicine in COVID-19 remains a subject of debate due to conflicting evidence. This review highlights both the beneficial and potentially harmful effects of colchicine in the context of COVID-19. Notably, the therapeutic advantages of colchicine are linked to the suppression of immune cell over-activation, attenuation of oxidative stress, and prevention of thrombo-inflammatory events. Conversely, colchicine may exert negative effects by disrupting microtubule function, impairing autophagic processes, and inducing mitochondrial dysfunction in COVID-19. In conclusion, the overall clinical impact of colchicine plays a critical role in the management of COVID-19. However, its dual effects underscore the need for well-designed clinical studies to confirm its safety and efficacy in COVID-19 management.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70126"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards Ending HIV/AIDS by 2030: Trajectory of Sub-Saharan Africa-A Post-COVID-19 (2019-2024) Review. 《实现到2030年消除艾滋病毒/艾滋病:撒哈拉以南非洲的发展轨迹——后covid -19(2019-2024)审查》。
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70138
Perpetual Nyame, Olayinka S Okoh, Akua K Yalley, Nicholas I Nii-Trebi
{"title":"Towards Ending HIV/AIDS by 2030: Trajectory of Sub-Saharan Africa-A Post-COVID-19 (2019-2024) Review.","authors":"Perpetual Nyame, Olayinka S Okoh, Akua K Yalley, Nicholas I Nii-Trebi","doi":"10.1002/rmv.70138","DOIUrl":"10.1002/rmv.70138","url":null,"abstract":"<p><p>Globally, the COVID-19 pandemic perturbed HIV services, jeopardising progress towards the Joint United Nations Programme on HIV/AIDS (UNAIDS) 95-95-95 targets in sub-Saharan Africa (SSA). This review is an evaluation of sub-Saharan Africa's progress towards attaining the UNAIDS target of ending HIV/AIDS by the year 2030 in the context of COVID-19. Data from UNAIDS, the World Health Organisation (WHO), and peer-reviewed literature were analysed to assess HIV service delivery in SSA from 2019 to 2024, with special attention to regional disparities and health system adaptations before, during, and after the pandemic. Before the COVID-19 pandemic, Southern and Eastern Africa were nearing the 90-90-90 goals while West and Central Africa made slower progress because of weaker health systems and other situational challenges. Between 2020 and 2022, lockdowns and service disruptions reduced HIV testing, delayed the start of antiretroviral therapy (ART), and led to fewer viral load analyses. To adapt, health systems provided ART for longer periods, offered more community-based care, expanded health worker roles, and used digital tools to maintain services, especially where infrastructure was strong. By 2023 and 2024, most countries in Southern and Eastern Africa were closer to achieving the 95-95-95 targets, while West and Central Africa continued to recover more slowly. The pandemic revealed both strengths and weaknesses in the HIV response in sub-Saharan Africa. Institutionalising innovations developed during the pandemic and addressing persistent regional disparities, which reflect uneven progress across the sub-region, are essential to sustaining progess and achieving epidemic control by 2030.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70138"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review and Meta-Analysis of Global DENV, CHIKV, and ZIKV Co-Infection. 全球DENV、CHIKV和ZIKV合并感染的系统回顾和荟萃分析。
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70108
Benedict Aurelio, Maria Mardalena Martini Kaisar, Vincent Wijaya, Sesilia Olivia Rachel Khustiawan, Anastasia Hengestu, Soegianto Ali
{"title":"A Systematic Review and Meta-Analysis of Global DENV, CHIKV, and ZIKV Co-Infection.","authors":"Benedict Aurelio, Maria Mardalena Martini Kaisar, Vincent Wijaya, Sesilia Olivia Rachel Khustiawan, Anastasia Hengestu, Soegianto Ali","doi":"10.1002/rmv.70108","DOIUrl":"10.1002/rmv.70108","url":null,"abstract":"<p><p>Dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV) viruses are arboviruses with the same main vectors, Aedes aegypti and Ae. albopictus. These three viruses pose significant public health challenges globally, especially with their recent increase in prevalence and reports of co-infection worldwide. This is concerning, as they have similar early symptoms but may need different treatment. However, a comprehensive and up-to-date analysis of the global prevalence of these co-infections is lacking, and many health providers in DENV-endemic countries are unaware of other arbovirus infections. To address this issue, we conducted a systematic review and meta-analysis to determine the prevalence of co-infection among DENV, CHIKV, and ZIKV based on molecular and antigen detections. We searched and screened original studies from 2013 to 2023 from Medline, Proquest, OVID, EBSCO, medRxiv, and bioRxiv. Using a random effects model, 29 studies from 16 countries were analysed. The estimated co-infection rates were 2.10% (95% CI = 0.88%-4.91%; I<sup>2</sup> = 92%) for DENV-CHIKV, 1.91% (95% CI = 0.65-5.43; I<sup>2</sup> = 80%) for DENV-ZIKV, 1.30% (95% CI = 0.35%-4.68%; I<sup>2</sup> = 85%) for CHIKV-ZIKV, and 0.59% (95% CI = 0.20%-1.71%; I<sup>2</sup> = 71%) for DENV-CHIKV-ZIKV, with variations (0.30%-9.83%) observed across different regions. These findings will aid in raising awareness of arboviral co-infections and formulating better strategies for diagnosing and managing these infections.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70108"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Langat Virus Biology and Infection. Langat病毒生物学与感染。
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70127
Zinaida Klestova, Daniel Sauter, Michael Schindler, Thomas Iftner
{"title":"Langat Virus Biology and Infection.","authors":"Zinaida Klestova, Daniel Sauter, Michael Schindler, Thomas Iftner","doi":"10.1002/rmv.70127","DOIUrl":"10.1002/rmv.70127","url":null,"abstract":"<p><p>Flaviviruses pose a major threat to global health and can cause severe disease in animals and humans. Among them, tick-borne encephalitis virus (TBEV) and related members of the tick-borne encephalitis (TBE) serocomplex are transmitted primarily by ticks and can lead to neurological disease, including encephalitis and death. Despite many years of research on the TBE-serocomplex, no specific antiviral treatment has been developed. Langat virus (LGTV), another member of this serocomplex typically causes asymptomatic infections in humans, but may cause severe neurological disease in rare cases. Moreover, experimentally LGTV-infected mice and monkeys show neurological symptoms. While viruses of the TBE-serocomplex are canonically transmitted by ticks, tick-independent transmission of LGTV has been reported in mice, suggesting a broader transmission potential. Notably, the full host range, vector competence and global distribution of LGTV remain poorly defined, and climate change-driven expansion of tick vectors may enable the emergence of this virus in new regions. In this review, we summarise our current knowledge of LGTV, focussing on vector competence, transmission routes, tissue and host tropism, pathogenicity and animal models. Furthermore, we discuss the potential application of LGTV as a vaccine candidate for TBEV. By highlighting the unique features of LGTV and identifying current research gaps, we aim to inspire interest in this understudied virus and its value as a tool to uncover fundamental aspects of tick-borne flavivirus biology and strategies for vaccine development.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70127"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Gastric Ulceration Due to Cytomegalovirus in Immunocompetent Adults - A Case Report and Systematic Review. 免疫正常成人巨细胞病毒所致慢性胃溃疡1例报告及系统评价
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70140
Zayn Al-Timimi, Ashleigh Geddes, Richard Lawrence
{"title":"Chronic Gastric Ulceration Due to Cytomegalovirus in Immunocompetent Adults - A Case Report and Systematic Review.","authors":"Zayn Al-Timimi, Ashleigh Geddes, Richard Lawrence","doi":"10.1002/rmv.70140","DOIUrl":"10.1002/rmv.70140","url":null,"abstract":"<p><p>This case report and systematic review describe the complete clinical course of chronic gastric ulceration complicating acute gastrointestinal CMV disease in a 72-year-old immunocompetent woman, with demonstrable response to ganciclovir but not valganciclovir. The unusual nature of this presentation prompted a systematic review to identify similar cases, which yielded 1432 records. Following de-duplication, title/abstract screening, and full article review 54 studies reporting 59 further cases of CMV-related gastric ulceration in immunocompetent patients were included. The derived epidemiologic, clinical and treatment features of this cohort indicated that CMV is an uncommon but potentially treatable cause of both acute and chronic gastric ulceration in immunocompetent adults. Acute gastric ulcers due to CMV in immunocompetent patients have been shown to respond well to antivirals but may also improve without specific antiviral treatment. Chronic gastric ulceration (lasting > 1 month) due to CMV in immunocompetent patients is a rare but distinct disease phenotype which may complicate both acute and non-acute CMV. For patients with chronic gastric ulceration, ganciclovir may have greater efficacy than valganciclovir based on the small subset of patients with this disease phenotype. Finally, CMV may represent an under-recognised and treatable contributor to the increasing cohort of patients, particularly older patients, with Helicobacter pylori and non-steroidal anti-inflammatory drug negative gastric ulcers, though CMV-associated gastric ulcers remain rare overall. Accordingly, diagnosis requires a high index of suspicion, with pursuit of CMV PCR and/or immunohistochemistry of gastric ulcer biopsies strongly encouraged.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70140"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Risk HPV in Men: A Hidden Threat to Public Health? 男性高危HPV:对公众健康的潜在威胁?
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70115
Keesha L Coker, Ethan L Morgan
{"title":"High-Risk HPV in Men: A Hidden Threat to Public Health?","authors":"Keesha L Coker, Ethan L Morgan","doi":"10.1002/rmv.70115","DOIUrl":"10.1002/rmv.70115","url":null,"abstract":"<p><p>High-risk human papillomavirus (HR-HPV) infection is a leading cause of several cancers, including those of the genital and oropharyngeal regions. While public health efforts have largely focused on women due to its link to cervical cancer, HPV also poses significant risks to men, particularly in the oropharyngeal regions. HR-HPV prevalence in men is high, with global estimates of 21% for male genital infections. While the HPV vaccination programme has expanded to include boys, challenges remain, including a decline in vaccine uptake due to COVID-19 disruptions, vaccine hesitancy, and misinformation. These barriers hinder the full potential of vaccination efforts. Furthermore, HPV transmission is complex and multifactorial, making it difficult to track, while its prevalence, clearance, and persistence vary based on factors such as sexual behaviour and immune status. Additionally, data from lower socio-economic regions is limited, highlighting a critical gap in research. Specific data on these epidemiological characteristics for male patients is lacking, prompting the need for gender-balanced approaches. Here, we explore the prevalence, risks, and public health implications of high-risk HPV (HR-HPV) in men. We suggest a more inclusive approach to HPV prevention, emphasising the need for targeted vaccination and screening programs for men. A gender-neutral approach is crucial to reducing the global burden of HPV-related diseases and moving closer to the goal of eradicating HPV infections worldwide.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70115"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CMV Preventive and Treatment Studies in Children Undergoing Haematopoietic Stem Cell Transplant: A Systematic Review. 接受造血干细胞移植的儿童巨细胞病毒预防和治疗研究:系统综述。
IF 6.6 2区 医学
Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70120
Lara Fusani, Eleonora Fusco, Mariana Fonseca, Judith Breuer, Kanchan Rao, Luisa Galli, Alasdair Bamford, Seilesh Kadambari
{"title":"CMV Preventive and Treatment Studies in Children Undergoing Haematopoietic Stem Cell Transplant: A Systematic Review.","authors":"Lara Fusani, Eleonora Fusco, Mariana Fonseca, Judith Breuer, Kanchan Rao, Luisa Galli, Alasdair Bamford, Seilesh Kadambari","doi":"10.1002/rmv.70120","DOIUrl":"10.1002/rmv.70120","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) is one of the most important infectious causes of morbidity and mortality in children undergoing haematopoietic stem cell transplant (HSCT). However, the evidence for preventing and treating CMV disease in children in this context remains limited. We sought to review the current available evidence regarding the prevention and management of CMV infection and disease in children with HSCT and propose future research areas which could better inform evidence-based management.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70120"},"PeriodicalIF":6.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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