Fang Ba, Hui Li, Silu Ding, Tingyi Guo, Junmei Zhang, Yanli Sun
{"title":"Zika Virus-Related Birth Defects and Neurological Complications: A Systematic Review and Meta-Analysis.","authors":"Fang Ba, Hui Li, Silu Ding, Tingyi Guo, Junmei Zhang, Yanli Sun","doi":"10.1002/rmv.70019","DOIUrl":"10.1002/rmv.70019","url":null,"abstract":"<p><p>Zika virus (ZIKV) is a virus transmitted by arthropods that exhibits considerable pathogenicity, resulting in a significant health and economic impact worldwide. A rise in congenital anomalies has been noted in kids born to mothers who have infections during pregnancy, alongside a rise in neurological symptoms in adults. In this study, we reassessed the data on brain abnormalities in maternal infection with ZIKV during pregnancy through a systematic review and meta-analysis. A thorough search was carried out in the PubMed, Scopus, Web of Science and Embase databases to extract pertinent published data up to November, 2024. In this meta-analysis, 14 studies with 912 individuals were incorporated. Subgroup analyses, depending on the maternal age, gestational age at detection of brain abnormalities, the time of ZIKV diagnosis, type of sample and birth weight at delivery, were performed. Critical appraisal was completed using the Newcastle-Ottawa Scale (NOS) tools. In this analysis, we identified 14 studies that reported brain abnormalities in newborn infants with ZIKV-infected pregnant women, of which 58% studies were from Brazil. The overall birth defect with brain abnormalities was found to be (1.94 [95% CI: 1.3-2.7], P = 0.00). Of the most common brain abnormalities, microcephaly (OR: 2.7 [95% CI 1.5-4.7], P = 0.00), ventriculomegaly (OR: 1.7 [95% CI 0.91-3.3], P = 0.09) and corpus callosal anomaly (OR: 1.8 [95% CI 1.02-3.3], P = 0.04) had highest the risk in children with ZIKV-infected pregnant women. No publication bias was found when applying the Begg's rank correlation and Egger's linear regression tests (P = 1 and P = 0.44, respectively). subgroups of maternal age ≥ 30 years and gestational week of ZIKV diagnosis ≥ 25 weeks are important in zika-associated birth defects. This systematic review and meta-analysis evidenced a high risk of brain defects in ZIKV-infected pregnant women. Maternal age and gestational week of ZIKV diagnosis may modify this risk.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 2","pages":"e70019"},"PeriodicalIF":9.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sylvia Mink, Fabian Wilhelm, Janne Cadamuro, Patrick Reimann, Peter Fraunberger
{"title":"Anti-SARS-CoV-2 Antibodies in Long-COVID-Markers of Protection or Elevated Risk? A Systematic Review.","authors":"Sylvia Mink, Fabian Wilhelm, Janne Cadamuro, Patrick Reimann, Peter Fraunberger","doi":"10.1002/rmv.70027","DOIUrl":"10.1002/rmv.70027","url":null,"abstract":"<p><p>Long-COVID affects a significant number of COVID-19 survivors, profoundly impacting daily life and work. Although research suggests a potential link between antibody levels and long-COVID risk, findings remain inconclusive. Understanding antibody dynamics could support the identification of patients at risk, improve long-COVID diagnosis, and guide protective strategies such as vaccination. Despite growing evidence, no systematic review has yet evaluated the current literature on this topic. We therefore aimed to synthesise and evaluate existing evidence on the association between anti-SARS-CoV-2 antibody titres and long-COVID, with the goal of clarifying their potential role in predicting long-COVID risk, guiding patient management, and informing future research directions. Studies published in PubMed/Medline databases between January 2020 and October 2024 were included without language restrictions. Studies on body fluids other than serum/blood were excluded. Study selection and quality assessment was conducted independently by two researchers. After screening 949 studies, 58 studies encompassing 53,739 individuals, and 7812 long-COVID patients, were included. Evidence was highly heterogenous but most studies reported an association between anti-SARS-CoV-2-spike antibodies and long-COVID, although the nature of the association appeared to be dependent on time from acute infection. Low anti-SARS-CoV-2-spike antibodies during acute COVID-19 were associated with increased risk of long-COVID. The association between low anti-SARS-CoV-2-spike antibodies during acute COVID-19 and long-COVID suggests that maintaining sufficiently high antibody levels may be protective. However, the current evidence level is low and further studies with sufficient power are required to confirm this association and to potentially determine protective cutoffs.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 2","pages":"e70027"},"PeriodicalIF":9.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Doris Klingelhöfer, Markus Braun, Christina A Naser, Dörthe Brüggmann, David A Groneberg
{"title":"Emerging Nipah Virus With Pandemic Potential and High Mortality Rates: Is the Scientific Community Learning From Former Pandemics?","authors":"Doris Klingelhöfer, Markus Braun, Christina A Naser, Dörthe Brüggmann, David A Groneberg","doi":"10.1002/rmv.70028","DOIUrl":"10.1002/rmv.70028","url":null,"abstract":"<p><p>As Nipah virus (NiV) infection is characterised by a possible pandemic risk, being currently limited to a small but deadly belt, the attention of other countries is essential. It has often been pointed out that NiV is an under-researched virus with a high-risk potential. This study aimed to show the global research history and status quo based on analyses of various chronological and geographical parameters, including socioeconomic characteristics and research funding. For this purpose, advanced analysis methods and visualisation techniques were applied, such as density equalisation mapping and cluster analysis. The correlation between the number of articles on NiV and the economic strength or intensity of financing per country is significant. However, the comparatively low scientific commitment of countries that are usually among the major players in global scientific publications and the declining scientific interest in NiV research combined with the prevailing knowledge gaps in NiV infectiology in conjunction with the risk of NiV spreading to other areas is extremely threatening. Research on previous viruses such as Corona and mpox shows an equally short-term interest, which has led to an insufficiently prepared situation in the run-up to outbreaks, making it hard to find quick and effective solutions. As often said, the NiV infection belt is small but deadly, but global travel and trade increase the risk of spreading. The scientific community worldwide must be prepared for the possible spread of infections that pose a pandemic risk.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 2","pages":"e70028"},"PeriodicalIF":9.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti-Alphavirus Therapies.","authors":"Sainan Wang, Suresh Mahalingam, Andres Merits","doi":"10.1002/rmv.70030","DOIUrl":"10.1002/rmv.70030","url":null,"abstract":"<p><p>Alphaviruses are re-emerging vector-born pathogens that cause arthralgia or encephalitic diseases on a global scale. While a vaccine against chikungunya virus was recently approved, no vaccines currently exist for other alphaviruses, nor are there antiviral drugs for the treatment of alphavirus infections. Alphaviruses have positive-strand RNA genomes, and their RNA replication is coordinated by activities of the multifunctional nonstructural protein 2 (nsP2), a helicase-protease and a subunit of viral RNA replicase. We provide a comprehensive overview of nsP2 functions and inhibitors of its activities for their potential as effective antivirals. Furthermore, analysis of nsP2 activities suggests that it could be targeted to develop advanced live attenuated vaccines and strategies for controlling alphavirus transmission by mosquito vectors.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 2","pages":"e70030"},"PeriodicalIF":9.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nuclear Factor of Activated T Cells Signalling and Viral Pathogens: A Dynamic Cross-Talk.","authors":"Sayyad Khanizadeh, Kiana Shahzamani, Mohsen Nakhaie, Ali Pormohammad, Gholamreza Talei, Habibollah Mirzaei","doi":"10.1002/rmv.70023","DOIUrl":"10.1002/rmv.70023","url":null,"abstract":"<p><p>The signalling pathway of the nuclear factor of activated T cells (NFAT) plays a crucial role in regulating various cellular processes such as cardiac hypertrophy, adipose differentiation, chondrocyte development, angiogenesis, inflammation, immune system activation, organogenesis, cancer cell migration, differentiation and survival. In addition, the NFAT signalling pathway acts as a key regulator of viral infections. Accordingly, it is plausible to assume that viruses have developed different mechanisms to manipulate this pathway to promote their pathogenicity. Viral pathogens can either inhibit or upregulate NFAT signalling through various mechanisms, including modulation of calcineurin activity, calcineurin/NFAT interaction, NFAT stability and translocation, NFAT-DNA-binding activity and NFAT-transcription partner interaction. Therefore, the NFAT signalling pathway can be regarded as a promising target to control viral infections. This review discusses the dynamic interactions between the NFAT signalling pathway and viral pathogens. It also addresses several drugs and agents that can target the NFAT signalling pathway at different levels to control viral infections.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 2","pages":"e70023"},"PeriodicalIF":9.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Wang, Zongze Yu, Zhigui Chen, Fangdie Ye, Zhou Sun
{"title":"The Potential Role of Zika and Dengue Virus Infection in the Urogenital System Disorders: An Overview.","authors":"Jie Wang, Zongze Yu, Zhigui Chen, Fangdie Ye, Zhou Sun","doi":"10.1002/rmv.70010","DOIUrl":"10.1002/rmv.70010","url":null,"abstract":"<p><p>Arboviruses currently are regarded as a major worldwide public health concern. The clinical outcomes associated with this group of viruses may vary from asymptomatic infections to severe forms of haemorrhagic fever characterised by bleeding disorders. Similar to other systemic viral infections, arboviruses can either directly or indirectly affect different parts of the body, such as the urogenital system. The human urogenital system anatomically consists of two major subdivisions: (i) the urinary system, including the kidneys, ureters, bladder, and urethra, which plays a significant role in osmoregulation, control of blood volume, pressure, and PH, absorption/excretion of different ions, and toxin metabolism, and (ii) the genital system, composed of the prostate, uterus, testes, ovaries, penis, and vagina, which are responsible for reproductive functions. Arboviruses can impair normal urogenital system functions by direct viral pathogen activity, systemic forms of inflammation, haemorrhagic events and related dysfunctions, and the nephrotoxic side effects of specific medications employed for treatment leading to various urogenital disorders. The present review provides an overview of the potential capacity of two main arboviruses, known as Zika and dengue viruses, to affect the urogenital system. Moreover, it addresses Zika virus as a potential therapeutic oncolytic virus for urogenital cancers.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 1","pages":"e70010"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular Evolution of the H5 and H7 Highly Pathogenic Avian Influenza Virus Haemagglutinin Cleavage Site Motif.","authors":"Jasmina M Luczo, Erica Spackman","doi":"10.1002/rmv.70012","DOIUrl":"10.1002/rmv.70012","url":null,"abstract":"<p><p>Avian influenza viruses are ubiquitous in the Anatinae subfamily of aquatic birds and occasionally spill over to poultry. Infection with low pathogenicity avian influenza viruses generally leads to subclinical or mild clinical disease. In contrast, highly pathogenic avian influenza viruses emerge from low pathogenic forms and can cause severe disease associated with extraordinarily high mortality rates. Here, we describe the natural history of avian influenza virus, with a focus on H5Nx and H7Nx subtypes, and the emergence of highly pathogenic forms; we review the biology of AIV; we examine cleavage of haemagglutinin by host cell enzymes with a particular emphasis on the biochemical properties of the proprotein convertases, and trypsin and trypsin-like proteases; we describe mechanisms implicated in the functional evolution of the haemagglutinin cleavage site motif that leads to emergence of HPAIVs; and finally, we discuss the diversity of H5 and H7 haemagglutinin cleavage site sequence motifs. It is crucial to understand the molecular attributes that drive the emergence and evolution of HPAIVs with pandemic potential to inform risk assessments and mitigate the threat of HPAIVs to poultry and human populations.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 1","pages":"e70012"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11680514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Om Saswat Sahoo, Daina Sapam, Swati Ajmeria, Hiya Aidasani, Ruby Dhar, Subhradip Karmakar
{"title":"Immunobiology of MPox Infection and Its Management: Experience From Developing Nations.","authors":"Om Saswat Sahoo, Daina Sapam, Swati Ajmeria, Hiya Aidasani, Ruby Dhar, Subhradip Karmakar","doi":"10.1002/rmv.70015","DOIUrl":"10.1002/rmv.70015","url":null,"abstract":"<p><strong>Purpose: </strong>As humanity grapples with the COVID-19 pandemic caused by the novel SARS-CoV-2 virus, the rising threats of the MPox virus (MPXV) in 2022 and 2024 have shown signs of global transmission and the potential to spark another pandemic. Though MPXV has been present for over 5 decades, with cases traditionally confined to endemic regions in West and Central Africa, recent outbreaks have occurred in multiple non-endemic regions, declaring itself as a Public Health Emergency of International Concern. This study aims to examine the patterns of MPXV transmission, its zoonotic potential, associated complications, and viable strategies to control its spread.</p><p><strong>Methods: </strong>The study examines recent outbreak data, case reports, and literature on MPXV transmission, emphasising zoonotic pathways and healthcare-associated cases. A bibliometric analysis has also been performed to deepen the understanding and identify emerging research trends.</p><p><strong>Results: </strong>The findings suggest that while MPXV has traditionally been endemic in certain regions of Africa, recent outbreaks indicate an increased transmission risk in non-endemic countries, raising concerns about potential global spread. Data reveals that much of the transmission has occurred within healthcare settings. Additionally, global research on the outbreak remains limited and requires further exploration from various perspectives, emphasising the need for prompt intervention.</p><p><strong>Conclusion: </strong>Containing MPXV's spread is essential to prevent another potential pandemic. Effective management and control strategies, including enhanced surveillance, public health interventions, and targeted education within at-risk communities, are critical to mitigate the spread and impact of MPXV globally. This study advocates for a proactive approach to MPXV control to avoid its escalation into a widespread health crisis.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 1","pages":"e70015"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Feifan Zhou, Yuanze Xu, Xing Liu, Yan Xu, Yan Wang, Donghui Jiang, Pengfei Du
{"title":"Zika and Dengue Virus Autoimmunity: An Overview of Related Disorders and Their Potential Mechanisms.","authors":"Feifan Zhou, Yuanze Xu, Xing Liu, Yan Xu, Yan Wang, Donghui Jiang, Pengfei Du","doi":"10.1002/rmv.70014","DOIUrl":"10.1002/rmv.70014","url":null,"abstract":"<p><p>Zika virus (ZIKV) and dengue virus (DENV) are two major mosquito-borne flaviviruses that pose a significant threat to the global public health system, particularly in tropical regions. The clinical outcomes related to these viral pathogens can vary from self-limiting asymptomatic infections to various forms of life-threatening pathological conditions such as haemorrhagic disorders. In addition to the direct effects of the viral pathogens, immune processes play also a significant function in the development of diseases mediated by ZIKV and DENV. Studing these processes is important for developing safer vaccines and targeted therapeutic strategies. These viruses have been reported to trigger various autoimmune disorders affecting different parts of human organ systems. It also has been shown that preexisting immunity to ZIKV or DENV can impact the outcome of subsequent infections caused by another virus. ZIKV and DENV infection can promote the development of autoimmune disorders by different mechanisms, such as molecular mimicry and autoantibody formation. The present review provides an overview of various autoimmune disorders associated with ZIKV and DENV infection and their potential underlying mechanisms.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 1","pages":"e70014"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tonggang Zhu, Xue Xiao, Xiaoming Zhu, Xiujiang Wang
{"title":"Hospitalised Dengue Patients and Risk of Hypertension: A Systematic Review and Meta-Analysis.","authors":"Tonggang Zhu, Xue Xiao, Xiaoming Zhu, Xiujiang Wang","doi":"10.1002/rmv.70013","DOIUrl":"10.1002/rmv.70013","url":null,"abstract":"<p><p>Identification and management of hypertension is a crucial part in hospitalised patients suffering from dengue infection (DV). Several studies with data conflicting have shown that DI may be linked to an elevated risk of hypertension in hospitalised patients. To gain a comprehensive understanding of this association, a systematic review and meta-analysis was performed. A systematic search was conducted across electronic databases including PubMed, SCOPUS, Embase and Web of Science to gather pertinent published data up to 10 November 2024. A total of five articles were incorporated into the systematic review and meta-analysis. DerSimonian and Liard random-effects model was applied to determine the pooled odds ratio (OR). Sensitivity analysis was performed to evaluate the strength of the pooled findings by excluding every individual study from the overall effect size. Subgroup analyses were performed based on age, duration of dengue infection, study design, and geographical area to identify the source of considerable heterogeneity. We included five articles retrieved from the literature search in the meta-analysis. The findings indicate a statistically significant correlation between dengue infection and elevated risk of hypertension (OR: 4.2; 95% CI 1.05-16.9; p = 0.04). A notable degree of heterogeneity was observed among the included studies. The Begg's correlation (p = 0.80) and Egger's linear regression (p = 0.45) tests revealed no evidence of publication bias. Furthermore, meta-regression analysis demonstrated a significant relationship between high blood pressure and age, duration of dengue infection, study design and geographical area. Our finding supports risk of hypertension in patients with dengue infection. This result can help clinicians recognise risk of hypertension in the dengue infection in order to manage and treat it promptly.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"35 1","pages":"e70013"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}