Reviews in Medical Virology最新文献

{"title":"A Systematic Review and Meta-Analysis of Global DENV, CHIKV, and ZIKV Co-Infection.","authors":"Benedict Aurelio, Maria Mardalena Martini Kaisar, Vincent Wijaya, Sesilia Olivia Rachel Khustiawan, Anastasia Hengestu, Soegianto Ali","doi":"10.1002/rmv.70108","DOIUrl":"10.1002/rmv.70108","url":null,"abstract":"<p><p>Dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV) viruses are arboviruses with the same main vectors, Aedes aegypti and Ae. albopictus. These three viruses pose significant public health challenges globally, especially with their recent increase in prevalence and reports of co-infection worldwide. This is concerning, as they have similar early symptoms but may need different treatment. However, a comprehensive and up-to-date analysis of the global prevalence of these co-infections is lacking, and many health providers in DENV-endemic countries are unaware of other arbovirus infections. To address this issue, we conducted a systematic review and meta-analysis to determine the prevalence of co-infection among DENV, CHIKV, and ZIKV based on molecular and antigen detections. We searched and screened original studies from 2013 to 2023 from Medline, Proquest, OVID, EBSCO, medRxiv, and bioRxiv. Using a random effects model, 29 studies from 16 countries were analysed. The estimated co-infection rates were 2.10% (95% CI = 0.88%-4.91%; I² = 92%) for DENV-CHIKV, 1.91% (95% CI = 0.65-5.43; I² = 80%) for DENV-ZIKV, 1.30% (95% CI = 0.35%-4.68%; I² = 85%) for CHIKV-ZIKV, and 0.59% (95% CI = 0.20%-1.71%; I² = 71%) for DENV-CHIKV-ZIKV, with variations (0.30%-9.83%) observed across different regions. These findings will aid in raising awareness of arboviral co-infections and formulating better strategies for diagnosing and managing these infections.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70108"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Gastric Ulceration Due to Cytomegalovirus in Immunocompetent Adults - A Case Report and Systematic Review.","authors":"Zayn Al-Timimi, Ashleigh Geddes, Richard Lawrence","doi":"10.1002/rmv.70140","DOIUrl":"10.1002/rmv.70140","url":null,"abstract":"<p><p>This case report and systematic review describe the complete clinical course of chronic gastric ulceration complicating acute gastrointestinal CMV disease in a 72-year-old immunocompetent woman, with demonstrable response to ganciclovir but not valganciclovir. The unusual nature of this presentation prompted a systematic review to identify similar cases, which yielded 1432 records. Following de-duplication, title/abstract screening, and full article review 54 studies reporting 59 further cases of CMV-related gastric ulceration in immunocompetent patients were included. The derived epidemiologic, clinical and treatment features of this cohort indicated that CMV is an uncommon but potentially treatable cause of both acute and chronic gastric ulceration in immunocompetent adults. Acute gastric ulcers due to CMV in immunocompetent patients have been shown to respond well to antivirals but may also improve without specific antiviral treatment. Chronic gastric ulceration (lasting > 1 month) due to CMV in immunocompetent patients is a rare but distinct disease phenotype which may complicate both acute and non-acute CMV. For patients with chronic gastric ulceration, ganciclovir may have greater efficacy than valganciclovir based on the small subset of patients with this disease phenotype. Finally, CMV may represent an under-recognised and treatable contributor to the increasing cohort of patients, particularly older patients, with Helicobacter pylori and non-steroidal anti-inflammatory drug negative gastric ulcers, though CMV-associated gastric ulcers remain rare overall. Accordingly, diagnosis requires a high index of suspicion, with pursuit of CMV PCR and/or immunohistochemistry of gastric ulcer biopsies strongly encouraged.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70140"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Langat Virus Biology and Infection.","authors":"Zinaida Klestova, Daniel Sauter, Michael Schindler, Thomas Iftner","doi":"10.1002/rmv.70127","DOIUrl":"10.1002/rmv.70127","url":null,"abstract":"<p><p>Flaviviruses pose a major threat to global health and can cause severe disease in animals and humans. Among them, tick-borne encephalitis virus (TBEV) and related members of the tick-borne encephalitis (TBE) serocomplex are transmitted primarily by ticks and can lead to neurological disease, including encephalitis and death. Despite many years of research on the TBE-serocomplex, no specific antiviral treatment has been developed. Langat virus (LGTV), another member of this serocomplex typically causes asymptomatic infections in humans, but may cause severe neurological disease in rare cases. Moreover, experimentally LGTV-infected mice and monkeys show neurological symptoms. While viruses of the TBE-serocomplex are canonically transmitted by ticks, tick-independent transmission of LGTV has been reported in mice, suggesting a broader transmission potential. Notably, the full host range, vector competence and global distribution of LGTV remain poorly defined, and climate change-driven expansion of tick vectors may enable the emergence of this virus in new regions. In this review, we summarise our current knowledge of LGTV, focussing on vector competence, transmission routes, tissue and host tropism, pathogenicity and animal models. Furthermore, we discuss the potential application of LGTV as a vaccine candidate for TBEV. By highlighting the unique features of LGTV and identifying current research gaps, we aim to inspire interest in this understudied virus and its value as a tool to uncover fundamental aspects of tick-borne flavivirus biology and strategies for vaccine development.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70127"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of SARS-CoV-2 on Male Infertility: A Systematic Review and Meta-Analysis of Cohort Studies.","authors":"Mehdi Gholami Barzoki, Mohammad Farahmand, Mohamad Javad Mahmodi, Naser Amirjannati, Somayeh Shatizadeh Malekshahi","doi":"10.1002/rmv.70128","DOIUrl":"10.1002/rmv.70128","url":null,"abstract":"<p><p>Several conclusions have emerged regarding the impact of COVID-19 on the male reproductive system. This systematic review and meta-analysis aimed to provide a comprehensive update on the relationship between COVID-19 and male reproductive health. We investigated the effects of SARS-CoV-2 on various semen parameters, including semen volume, sperm concentration, sperm total count, total motility, progressive motility, morphology, and DNA fragmentation index (DFI). A literature review was conducted on all studies evaluating the impact of SARS-CoV-2 infection on male infertility from the beginning of 2019 through December 2023. Main electronic databases such as PubMed, Scopus, Cochrane Library, and Web of Science were used. The research question was based on the PECO framework, focusing on (Population) exposed to SARS-CoV-2 (Exposure), compared to uninfected men (Comparator), with conventional sperm parameters as the measured Outcome. The studies were divided into two groups for analysis: between-group comparisons, which compared sperm parameters of men recovered from COVID-19 to uninfected controls, and within-subject comparisons, which assessed sperm parameters in the same individuals before and after infection. Standardized mean differences (SMD) were calculated as effect sizes with 95% confidence intervals (CI) for each outcome. The DerSimonian-Laird method estimated between-study variance (τ²), while the Jackson method calculated confidence intervals for τ² and τ. Publication bias was assessed using funnel plots and Egger's test. This meta-analysis included two types of cohort studies: single-arm studies and those with a control group. In the single-arm studies, a statistically significant decrease in semen volume (p = 0.0023) was observed. Additionally, in the cohort studies with controls, there were statistically significant reductions in sperm concentration (p < 0.0001), total count (p = 0.0001), total motility (p = 0.0009), progressive sperm motility (0.0391), and DFI (0.04). This is the most up-to-date systematic review and meta-analysis incorporating cohort study data. The findings provide compelling evidence that SARS-CoV-2 infection adversely affects male reproductive health, particularly in terms of semen quality. The analysis reveals significant reductions in key semen parameters, including sperm count, concentration, total motility, and progressive motility. Adult maleand DFI.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70128"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CMV Preventive and Treatment Studies in Children Undergoing Haematopoietic Stem Cell Transplant: A Systematic Review.","authors":"Lara Fusani, Eleonora Fusco, Mariana Fonseca, Judith Breuer, Kanchan Rao, Luisa Galli, Alasdair Bamford, Seilesh Kadambari","doi":"10.1002/rmv.70120","DOIUrl":"10.1002/rmv.70120","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) is one of the most important infectious causes of morbidity and mortality in children undergoing haematopoietic stem cell transplant (HSCT). However, the evidence for preventing and treating CMV disease in children in this context remains limited. We sought to review the current available evidence regarding the prevention and management of CMV infection and disease in children with HSCT and propose future research areas which could better inform evidence-based management.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70120"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Basis of MERS-CoV Receptor Interactions and Antibody Neutralisations.","authors":"Edem Gavor, Yeu Khai Choong, Sunil Singh, Hariharan Sivaraman, Er Shi Yin, J Sivaraman","doi":"10.1002/rmv.70113","DOIUrl":"10.1002/rmv.70113","url":null,"abstract":"<p><p>Increasing outbreaks of coronaviruses underscore the importance of antivirals and vaccines that can combat a wide range of coronaviruses. Neutralising antibodies (nAbs), along with vaccines and small-molecule drugs, are among the most promising treatments and prevention options against coronaviruses. Here, we focus on Middle East Respiratory Syndrome coronavirus (MERS-CoV) and discuss receptor usage and current progress in antibody research against MERS-CoV infections. First detected in Saudi Arabia and Jordan in 2012, MERS-CoV is a lethal zoonotic pathogen. MERS-CoV infections have been reported by 27 countries between April 2012 till now, with 953 deaths (∼35% mortality) (5 new infections and 4 fatalities reported as of 1 October 2024). WHO identified MERS-CoV as a high-threat pathogen due to its severity, high mortality rate, and potential for epidemic or pandemic spread with recent outbreaks and deaths raising more concerns amidst the COVID-19 pandemic. As of now, there is no antiviral drugs or vaccine against MERS-CoV available. Here we provide a perspective on receptor usage, the risk of MERS-CoV and other CoVs evolution on future pandemics, and the mechanisms of MERS-CoV-derived nAbs. We offer insight into how these antibodies cross-react and cross-neutralise by analysing available structures of spike glycoprotein-antibody complexes. This review provides an update and a basis for the development of antibodies and vaccines for MERS-CoV, and possibly for the designing of next-generation pan-coronavirus vaccines and antivirals.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70113"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Risk HPV in Men: A Hidden Threat to Public Health?","authors":"Keesha L Coker, Ethan L Morgan","doi":"10.1002/rmv.70115","DOIUrl":"10.1002/rmv.70115","url":null,"abstract":"<p><p>High-risk human papillomavirus (HR-HPV) infection is a leading cause of several cancers, including those of the genital and oropharyngeal regions. While public health efforts have largely focused on women due to its link to cervical cancer, HPV also poses significant risks to men, particularly in the oropharyngeal regions. HR-HPV prevalence in men is high, with global estimates of 21% for male genital infections. While the HPV vaccination programme has expanded to include boys, challenges remain, including a decline in vaccine uptake due to COVID-19 disruptions, vaccine hesitancy, and misinformation. These barriers hinder the full potential of vaccination efforts. Furthermore, HPV transmission is complex and multifactorial, making it difficult to track, while its prevalence, clearance, and persistence vary based on factors such as sexual behaviour and immune status. Additionally, data from lower socio-economic regions is limited, highlighting a critical gap in research. Specific data on these epidemiological characteristics for male patients is lacking, prompting the need for gender-balanced approaches. Here, we explore the prevalence, risks, and public health implications of high-risk HPV (HR-HPV) in men. We suggest a more inclusive approach to HPV prevention, emphasising the need for targeted vaccination and screening programs for men. A gender-neutral approach is crucial to reducing the global burden of HPV-related diseases and moving closer to the goal of eradicating HPV infections worldwide.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70115"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Japanese Encephalitis: Understanding Its Impact, Prevention, and the Role of Vaccination.","authors":"Mohd Sayeed Shaikh, Zaid Z Khan, Shaikh Shahbaz A Majeed, Shaikh Shoaib Iftekhar, Syed J Imran, Md Faiyazuddin, Sakshi Sharma, Aroop Mohanty, Sanjit Sah, Rachana Mehta, Shriyansh Srivastava, Thamir M Alshammari, Lysien Zambrano, Juan Felipe López-Marín, Alfonso J Rodriguez-Morales","doi":"10.1002/rmv.70123","DOIUrl":"10.1002/rmv.70123","url":null,"abstract":"<p><p>Japanese encephalitis (JE) is a mosquito-borne viral disease and remains an important cause of viral encephalitis in Asia and parts of the Western Pacific. Earlier WHO-supported global burden estimates published around 2014 suggested approximately 68,000 clinical cases and up to 20,400 deaths annually; however, the World Health Organization emphasises that the true burden of JE is difficult to quantify due to substantial underreporting and heterogeneous surveillance systems. Although vaccination programs have led to marked declines in incidence in several countries, JE transmission persists in endemic regions, and sporadic outbreaks continue to occur. In the absence of specific antiviral therapy, prevention remains the cornerstone of JE control, with vaccination representing the most effective public health intervention. Among available vaccines, the live-attenuated SA14-14-2 vaccine has played a central role in reducing the burden of JE in endemic countries. Its high effectiveness, long-term protection following a single dose, favourable safety profile, WHO prequalification, and incorporation into national immunisation programs have made it the backbone of JE prevention in Asia. Inactivated vaccines, such as IXIARO, and chimaeric vaccines, such as IMOJEV, provide important complementary options, particularly for travellers and non-endemic populations. This review synthesises current knowledge on JE epidemiology, transmission, clinical manifestations, diagnostics, pathogenesis, and advances in vaccination strategies. By integrating recent outbreak data, immunological insights, and vaccine developments, we highlight the continued public health relevance of JE and the critical importance of sustained vaccination programs, surveillance strengthening, and equitable vaccine access to further reduce its global impact.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70123"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147309639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Modulation of Pattern Recognition Receptor Sensing in Human Oncoviral Infections: Shared and Virus-Specific Innate Immune Strategies.","authors":"Jingnan Zhang, Xin Li, Kai Zhang, Zhaowei Zhang, Haipeng Qi, Weibo Li, Yuting Li, Long Zhao","doi":"10.1002/rmv.70133","DOIUrl":"10.1002/rmv.70133","url":null,"abstract":"<p><p>Human oncogenic viruses can selectively modulate the innate immune system to regulate the recognition, strength, timing, and intracellular localization of pattern recognition receptors (PRRs) signalling in the host to their advantage. Manipulation of innate immune sensing allows the virus to affect the quality of sensing and ensure its long-term persistence in the cell without completely evading immunity or shutting down the innate immune system. The consequences of this reprogramming are altered interferon responses, reshaping inflammatory signalling, or, in other words, an insufficient innate immune activation to achieve complete viral clearance. On the other hand, continuous reprogramming of the immune system itself can lead to changes in the tissue microenvironment (TME) and change this environment in favour of tumour cell establishment and survival. In this review article, we intend to provide a conceptual framework for understanding the common viral pathways (convergent) and the different tissue-depend and virus-dependent effects (divergent), focussing on common oncoviruses such as human papillomavirus (HPV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV). We try to review the interaction between oncogene viruses and the innate immune system, its effects on the TME, and the possibility of tumourigenesis, from a different perspective. This review proposes a spatial-temporal model of qualitative PRR modulation, distinguishing convergent interferon dampening from virus-specific microenvironmental reprogramming and also attempt to highlight the existing knowledge gaps and potential therapeutic targeting of innate sensing pathways.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70133"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Relationship Between Cytomegalovirus and Cardiovascular Disease: Evidence From Observational Studies.","authors":"Benjamin Doty, Kevork Ourfalian, Sandeep Basnet, Colin Kunzweiler, Adva Gadoth, Rhonda L Bohn, John Diaz-Decaro","doi":"10.1002/rmv.70141","DOIUrl":"10.1002/rmv.70141","url":null,"abstract":"<p><p>Cytomegalovirus (CMV), a member of the herpesvirus family, is a ubiquitous pathogen with high global seroprevalence. While generally asymptomatic in healthy individuals, CMV infection has been linked to certain long-term outcomes, including cardiovascular disease (CVD). This review of the epidemiological literature investigates the relationship between CMV infection and CVD by synthesising findings from population-based observational studies. A targeted literature search identified 18 studies published since 2000 that reported on laboratory-confirmed CMV and CVD outcomes, including myocardial infarction, stroke, thrombosis, embolism, and cardiovascular mortality. The most frequently examined outcomes were composite cardiovascular events (39%) and cardiovascular mortality (33%). Nine studies reported significant associations between CMV and CVD-related outcomes, with hazard and odds ratios typically below three. For instance, CMV infection was associated with stroke in women, venous thromboembolism, and elevated risk of cardiovascular mortality in specific subgroups. However, findings were inconsistent across studies, reflecting differences in study populations, study designs, outcome definitions, and approaches to measuring CMV exposure. Most studies relied on serologic assays of CMV, limiting the ability to distinguish between recent/new (i.e., primary) infection, reactivation of latent virus, or reinfection and potentially contributing to heterogeneity in the results. Overall, while evidence suggests a potential link between CMV infection and some CVD outcomes, significant gaps remain in understanding this relationship. Future research should focus on refining exposure and outcome definitions, exploring sex-specific differences, and accounting for inflammatory and other confounding factors to clarify CMV's role in CVD pathogenesis.</p>","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70141"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}