Reviews in Medical Virology最新文献_第7页

Breakthrough infection and reinfection in patients with mpox. 麻风病人的突破性感染和再感染。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2522

Wenyi Jiang, Yibo Hu, Xiu Yang, Lingli Hou, Jingjing Zhang, Hong Niu, Congxia Hu, Jihui Lin

{"title":"Breakthrough infection and reinfection in patients with mpox.","authors":"Wenyi Jiang, Yibo Hu, Xiu Yang, Lingli Hou, Jingjing Zhang, Hong Niu, Congxia Hu, Jihui Lin","doi":"10.1002/rmv.2522","DOIUrl":"10.1002/rmv.2522","url":null,"abstract":"Recently, patients with Mpox breakthrough infection or reinfection were constantly reported. However, the induction, risk factors, and important clinical symptoms of breakthrough infection and reinfection of Mpox virus (MPXV), as well as the factors affecting the effectiveness of Mpox vaccine are not characterized. Herein, a literature review was preformed to summarize the risk factors and important clinical symptoms of patients with Mpox breakthrough infection or reinfection, as well as the factors affecting the effectiveness of smallpox vaccine against Mpox. Results showed that MSM sexual behavior, condomless sexual behavior, multiple sexual partners, close contact, HIV infection, and the presence of comorbidity are important risk factors for Mpox breakthrough infection and reinfection. Genital ulcers, proctitis, and lymphadenopathy are the important clinical symptoms of Mpox breakthrough infection and reinfection. The effectiveness of emergent vaccination of smallpox vaccine for post-exposure of MPXV is associated with smallpox vaccination history, interval between exposure and vaccination, and history of HIV infection. This review provides a better understanding for the risk factors and important clinical symptoms of Mpox breakthrough infection and reinfection, as well as the formulation of Mpox vaccine vaccination strategies.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2522"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coinfections in human papillomavirus associated cancers and prophylactic recommendations. 人类乳头瘤病毒相关癌症的合并感染和预防建议。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2524

Gayathri Ashok, Soumya Basu, Priyamvada Priyamvada, Anand Anbarasu, Sreenivasulu Chintala, Sudha Ramaiah

引用次数: 0

Clinical and laboratory diagnosis of Mayaro virus (MAYV): Current status and opportunities for further development. 玛雅罗病毒（MAYV）的临床和实验室诊断：现状和进一步发展的机遇。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2528

Severino Jefferson Ribeiro da Silva, Larissa Krokovsky

引用次数: 0

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers. 在病毒性癌症的发展过程中，肿瘤病毒劫持并重新连接宿主CircRNA/miRNA/mRNA竞争性内源性RNA（ceRNA）调控网络。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2530

Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei

{"title":"Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers.","authors":"Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei","doi":"10.1002/rmv.2530","DOIUrl":"10.1002/rmv.2530","url":null,"abstract":"A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)-mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context. CircRNAs, a class of non-coding RNA molecules, can interact with other RNA molecules, such as mRNAs and microRNAs (miRNAs), through a process known as ceRNA crosstalk. This interaction occurs when circRNAs, acting as sponges, sequester miRNAs, thereby preventing them from binding to their target mRNAs and modulating their expression. By rewiring the host cell genome, oncoviruses have the ability to manipulate the expression and activity of circRNAs, thereby influencing the ceRNA networks that can profoundly impact cellular processes such as cell proliferation, differentiation, apoptosis, and immune responses. This review focuses on a comprehensive evaluation of the latest findings on the involvement of virus-induced reprogramming of host circRNA-mediated ceRNA networks in the development and pathophysiology of human viral cancers, including cervical cancer, gastric cancer, nasopharyngeal carcinoma, Kaposi's sarcoma, hepatocellular carcinoma, and diffuse large B cell lymphoma. Understanding these mechanisms can improve our knowledge of how oncoviruses contribute to human tumourigenesis and identify potential targets for developing optimised therapies and diagnostic tools for viral cancers.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2530"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next? 输血传播隐性乙型肝炎病毒感染的生物标志物：进展如何？

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2525

Michael X Fu, Peter Simmonds, Monique Andersson, Heli Harvala

{"title":"Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next?","authors":"Michael X Fu, Peter Simmonds, Monique Andersson, Heli Harvala","doi":"10.1002/rmv.2525","DOIUrl":"10.1002/rmv.2525","url":null,"abstract":"Blood transfusion is a vital procedure, where transfusion-transmitted infection of hepatitis B virus (HBV) remains an important issue, especially from blood donors with occult hepatitis B virus infection (OBI). Occult hepatitis B virus infection is a complex entity to detect using surrogate blood biomarkers for intrahepatic viral transcriptional activity, requiring a continually refined battery of tests utilised for screening. This review aims to critically evaluate the latest advances in the current blood biomarkers to guide the identification of OBI donors and discuss novel HBV markers that could be introduced in future diagnostic practice. Challenges in detecting low HBV surface antigen levels, mutants, and complexes necessitate ultrasensitive multivalent dissociation assays, whilst HBV DNA testing requires improved sensitivity but worsens inaccessibility. Anti-core antibody assays defer almost all potentially infectious donations but have low specificity, and titres of anti-surface antibodies that prevent infectivity are poorly defined with suboptimal sensitivity. The challenges associated with these traditional blood HBV markers create an urgent need for alternative biomarkers that would help us better understand the OBI. Emerging viral biomarkers, such as pre-genomic RNA and HBV core-related antigen, immunological HBV biomarkers of T-cell reactivity and cytokine levels, and host biomarkers of microRNA and human leucocyte antigen molecules, present potential advances to gauge intrahepatic activity more accurately. Further studies on these markers may uncover an optimal diagnostic algorithm for OBI using quantification of various novel and traditional blood HBV markers. Addressing critical knowledge gaps identified in this review would decrease the residual risk of transfusion-transmitted HBV infection without compromising the sustainability of blood supplies.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2525"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of reemerging mpox infection with a focus on neurological manifestations. 新发麻风腮病毒感染概述，重点关注神经系统表现。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2527

Mohammed Alissa, Abdullah Alghamdi, Suad A Alghamdi

引用次数: 0

Risk of kidney and liver diseases after COVID-19 infection: A systematic review and meta-analysis. 感染 COVID-19 后患肝肾疾病的风险：系统回顾与荟萃分析。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2523

Bei Pan, Xiaoman Wang, Honghao Lai, Robin W M Vernooij, Xiyuan Deng, Ning Ma, Dan Li, Jiajie Huang, Weilong Zhao, Jinling Ning, Jianing Liu, Jinhui Tian, Long Ge, Kehu Yang

{"title":"Risk of kidney and liver diseases after COVID-19 infection: A systematic review and meta-analysis.","authors":"Bei Pan, Xiaoman Wang, Honghao Lai, Robin W M Vernooij, Xiyuan Deng, Ning Ma, Dan Li, Jiajie Huang, Weilong Zhao, Jinling Ning, Jianing Liu, Jinhui Tian, Long Ge, Kehu Yang","doi":"10.1002/rmv.2523","DOIUrl":"10.1002/rmv.2523","url":null,"abstract":"COVID-19 is not only associated with substantial acute liver and kidney injuries, but also with an elevated risk of post-acute sequelae involving the kidney and liver system. We aimed to investigate whether COVID-19 exposure increases the long-term risk of kidney and liver disease, and what are the magnitudes of these associations. We searched PubMed, Embase, Web of Science, ClinicalTrials.gov, and the Living Overview of the Evidence COVID-19 Repository for cohort studies estimating the association between COVID-19 and kidney and liver outcomes. Random-effects meta-analyses were performed to combine the results of the included studies. We assessed the certainty of the evidence using the Grading of Recommendations Assessment, Development and Evaluation approach. Fifteen cohort studies with more than 32 million participants were included in the systematic review COVID-19 was associated with a 35% greater risk of kidney diseases (10 more per 1000 persons; low certainty evidence) and 54% greater risk of liver disease (3 more per 1000 persons; low certainty evidence). The absolute increases due to COVID-19 for acute kidney injury, chronic kidney disease, and liver test abnormality were 3, 8, and 3 per 1000 persons, respectively. Subgroup analyses found no differences between different type of kidney and liver diseases. The findings provide further evidence for the association between COVID-19 and incident kidney and liver conditions. The absolute magnitude of the effect of COVID-19 on kidney and liver outcomes was, however, relatively small.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2523"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferritin: Significance in viral infections. 铁蛋白：在病毒感染中的意义。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2531

Xia Zhao, Yuntao Zhou, Yong Zhang, Yan Zhang

{"title":"Ferritin: Significance in viral infections.","authors":"Xia Zhao, Yuntao Zhou, Yong Zhang, Yan Zhang","doi":"10.1002/rmv.2531","DOIUrl":"10.1002/rmv.2531","url":null,"abstract":"As an indispensable trace element, iron is essential for many biological processes. Increasing evidence has shown that virus infection can perturb iron metabolism and play a role in the occurrence and development of viral infection-related diseases. Ferritin plays a crucial role in maintaining the body's iron homoeostasis. It is an important protein to stabilise the iron balance in cells. Ferritin is a 24-mer hollow iron storage protein composed of two subunits: ferritin heavy chain and ferritin light chain. It was reported that ferritin is not only an intra-cellular iron storage protein, but also a pathogenic mediator that enhances the inflammatory process and stimulates the further inflammatory pathway, which is a key member of the vicious pathogenic cycle to perpetuate. Ferritin exerts immuno-suppressive and pro-inflammatory functions during viral infection. In this review, we describe in detail the basic information of ferritin in the first section, including its structural features, the regulation of ferritin. In the second part, we focus on the role of ferritin in viral infection-related diseases and the molecular mechanisms by which viral infection regulates ferritin. The last section briefly outlines the potential of ferritin in antiviral therapy. Given the importance of iron and viral infection, understanding the role of ferritin during viral infection helps us understand the relationship between iron metabolic dysfunction and viral infection, which provides a new direction for the development of antiviral therapeutic drugs.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2531"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands: A systematic review and meta-analysis. 太平洋岛屿登革热、寨卡病毒和基孔肯雅病毒的临床表现：系统回顾和荟萃分析。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2521

Sahil Kharwadkar, Nipun Herath

{"title":"Clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands: A systematic review and meta-analysis.","authors":"Sahil Kharwadkar, Nipun Herath","doi":"10.1002/rmv.2521","DOIUrl":"10.1002/rmv.2521","url":null,"abstract":"Dengue, Zika and chikungunya outbreaks pose a significant public health risk to Pacific Island communities. Differential diagnosis is challenging due to overlapping clinical features and limited availability of laboratory diagnostic facilities. There is also insufficient information regarding the complications of these arboviruses, particularly for Zika and chikungunya. We conducted a systematic review and meta-analysis to calculate pooled prevalence estimates with 95% confidence intervals (CI) for the clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands. Based on pooled prevalence estimates, clinical features that may help to differentiate between the arboviruses include headache, haemorrhage and hepatomegaly in dengue; rash, conjunctivitis and peripheral oedema in Zika; and the combination of fever and arthralgia in chikungunya infections. We estimated that the hospitalisation and mortality rates in dengue were 9.90% (95% CI 7.67-12.37) and 0.23% (95% CI 0.16-0.31), respectively. Severe forms of dengue occurred in 1.92% (95% CI 0.72-3.63) of reported cases and 23.23% (95% CI 13.58-34.53) of hospitalised patients. Complications associated with Zika virus included Guillain-Barré syndrome (GBS), estimated to occur in 14.08 (95% CI 11.71-16.66) per 10,000 reported cases, and congenital brain malformations such as microcephaly, particularly with first trimester maternal infection. For chikungunya, the hospitalisation rate was 2.57% (95% CI 1.30-4.25) and the risk of GBS was estimated at 1.70 (95% CI 1.06-2.48) per 10,000 reported cases. Whilst ongoing research is required, this systematic review enhances existing knowledge on the clinical manifestations of dengue, Zika and chikungunya infections and will assist Pacific Island clinicians during future arbovirus outbreaks.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2521"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS-CoV-2 and other respiratory viruses: A comprehensive review. miRNA 在 SARS-CoV-2 和其他呼吸道病毒感染期间人类免疫和炎症反应中的调控作用：综述。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-03-01 DOI: 10.1002/rmv.2526

Chiranjib Chakraborty, Manojit Bhattacharya, Sang-Soo Lee

{"title":"Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS-CoV-2 and other respiratory viruses: A comprehensive review.","authors":"Chiranjib Chakraborty, Manojit Bhattacharya, Sang-Soo Lee","doi":"10.1002/rmv.2526","DOIUrl":"10.1002/rmv.2526","url":null,"abstract":"miRNAs are single-stranded ncRNAs that act as regulators of different human body processes. Several miRNAs have been noted to control the human immune and inflammatory response during severe acute respiratory infection syndrome (SARS-CoV-2) infection. Similarly, many miRNAs were upregulated and downregulated during different respiratory virus infections. Here, an attempt has been made to capture the regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS-CoV-2 and other respiratory viruses. Firstly, the role of miRNAs has been depicted in the human immune and inflammatory response during the infection of SARS-CoV-2. In this direction, several significant points have been discussed about SARS-CoV-2 infection, such as the role of miRNAs in human innate immune response; miRNAs and its regulation of granulocytes; the role of miRNAs in macrophage activation and polarisation; miRNAs and neutrophil extracellular trap formation; miRNA-related inflammatory response; and miRNAs association in adaptive immunity. Secondly, the miRNAs landscape has been depicted during human respiratory virus infections such as human coronavirus, respiratory syncytial virus, influenza virus, rhinovirus, and human metapneumovirus. The article will provide more understanding of the miRNA-controlled mechanism of the immune and inflammatory response during COVID-19, which will help more therapeutics discoveries to fight against the future pandemic.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 2","pages":"e2526"},"PeriodicalIF":9.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0