Reviews in Medical Virology最新文献_第6页

Neurological Implications of Poxvirus Infections: Pathogenesis, Neurotropism, and Clinical Manifestations. 痘病毒感染对神经系统的影响：痘病毒感染对神经系统的影响：发病机制、神经侵袭性和临床表现》（Pathogenesis, Neurotropism, and Clinical Manifestations）。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-09-01 DOI: 10.1002/rmv.2581

Mohammed Alissa, Khalid J Alzahrani, Meshari A Alsuwat

引用次数: 0

Role of Neurotropic Viruses in Brain Metastasis of Breast Cancer: Mechanisms and Therapeutic Implications. 神经性病毒在乳腺癌脑转移中的作用：机制与治疗意义》。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-09-01 DOI: 10.1002/rmv.2584

Ziran Qiu, Xinyu Liu, Wenqing Cao, Rui Li, Jun Yang, Chengyu Wang, Zhong Li, Xiaoqin Yao, Yuan Chen, Chunhua Ye, Shanzheng Chen, Na Jin

引用次数: 0

Role of Gut Microbiota in Dengue. 肠道微生物群在登革热中的作用。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-09-01 DOI: 10.1002/rmv.2577

Adriana Pedreañez, Yenddy Carrero, Renata Vargas, Juan P Hernandez-Fonseca, Hugo Hernandez-Fonseca, Jesús A Mosquera

{"title":"Role of Gut Microbiota in Dengue.","authors":"Adriana Pedreañez, Yenddy Carrero, Renata Vargas, Juan P Hernandez-Fonseca, Hugo Hernandez-Fonseca, Jesús A Mosquera","doi":"10.1002/rmv.2577","DOIUrl":"10.1002/rmv.2577","url":null,"abstract":"Dengue is a disease caused by a flavivirus (DENV) and transmitted by the bite of a mosquito, primarily the Aedes aegypti and Aedes albopictus species. Previous studies have demonstrated a relationship between the host gut microbiota and the evolution of dengue. It seems to be a bidirectional relationship, in which the DENV can affect the microbiota by inducing alterations related to intestinal permeability, leading to the release of molecules from microbiota dysbiosis that can influence the evolution of dengue. The role of angiotensin II (Ang II) in the microbiota/dengue relationship is not well understood, but it is known that the renin-angiotensin system (RAS) is present in the intestinal tract and interacts with the gut microbiota. The possible effect of Ang II on the microbiota/Ang II/dengue relationship can be summarised as follows: the presence of Ang II induced hypertension, the increase in angiotensinogen, chymase, and microRNAs during the disease, the induction of vascular dysfunction, the production of trimethylamine N-oxide and the brain/microbiota relationship, all of which are elements present in dengue that could be part of the microbiota/Ang II/dengue interactions. These findings suggest the potential use of Ang II synthesis blockers and the use of AT1 receptor antagonists as therapeutic drugs in dengue.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 5","pages":"e2577"},"PeriodicalIF":9.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle-Based Therapies for Neurotropic Viral Infections: Mechanisms, Challenges, and Future Prospects. 基于纳米粒子的神经病毒感染疗法：机制、挑战和未来展望》。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-09-01 DOI: 10.1002/rmv.2575

Min Yang, Chuanbo Ding, Ting Zhao, Ge Song, Tingting Liu, Zeqi Li, Ying Zhang

引用次数: 0

Virus-Induced Host Chemokine CCL2 in COVID-19 Pathogenesis: Potential Prognostic Marker and Target of Anti-Inflammatory Strategy. COVID-19发病机制中的病毒诱导宿主趋化因子CCL2：潜在的预后标志物和抗炎策略的目标。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-09-01 DOI: 10.1002/rmv.2578

Abdul Wahid Ansari, Fareed Ahmad, Majid Ali Alam, Thesni Raheed, Ahmed Zaqout, Muna Al-Maslamani, Aamir Ahmad, Joerg Buddenkotte, Abdullatif Al-Khal, Martin Steinhoff

{"title":"Virus-Induced Host Chemokine CCL2 in COVID-19 Pathogenesis: Potential Prognostic Marker and Target of Anti-Inflammatory Strategy.","authors":"Abdul Wahid Ansari, Fareed Ahmad, Majid Ali Alam, Thesni Raheed, Ahmed Zaqout, Muna Al-Maslamani, Aamir Ahmad, Joerg Buddenkotte, Abdullatif Al-Khal, Martin Steinhoff","doi":"10.1002/rmv.2578","DOIUrl":"10.1002/rmv.2578","url":null,"abstract":"A wide variety of inflammatory mediators, mainly cytokines and chemokines, are induced during SARS CoV-2 infection. Among these proinflammatory mediators, chemokines tend to play a pivotal role in virus-mediated immunopathology. The C-C chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1) is a potent proinflammatory cytokine and strong chemoattractant of monocytes, macrophages and CD4+ T cells bearing C-C chemokine receptor type-2 (CCR2). Besides controlling immune cell trafficking, CCL2 is also involved in multiple pathophysiological processes including systemic hyperinflammation associated cytokine release syndrome (CRS), organ fibrosis and blood coagulation. These pathological features are commonly manifested in severe and fatal cases of COVID-19. Given the crucial role of CCL2 in COVID-19 pathogenesis, the CCL2:CCR2 axis may constitute a potential therapeutic target to control virus-induced hyperinflammation and multi-organ dysfunction. Herein we describe recent advances on elucidating the role of CCL2 in COVID-19 pathogenesis, prognosis, and a potential target of anti-inflammatory interventions.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 5","pages":"e2578"},"PeriodicalIF":9.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Response: Safety and Efficacy of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Controlled and Randomized Clinical Trials. 作者回复：COVID-19 疫苗的安全性和有效性：对照和随机临床试验的系统回顾和元分析》。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-09-01 DOI: 10.1002/rmv.2573

Jayesh Beladiya, Anup Kumar, Yogesh Vasava, Krupanshu Parmar, Dipanshi Patel, Sandip Patel, Sandip Dholakia, Devang Sheth, Sai H S Boddu, Chirag A Patel

引用次数: 0

Blood-borne viruses and neurological manifestations: An overview. 血源性病毒与神经系统表现：概述。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-07-01 DOI: 10.1002/rmv.2552

Yan Xu, Bo Yu

{"title":"Blood-borne viruses and neurological manifestations: An overview.","authors":"Yan Xu, Bo Yu","doi":"10.1002/rmv.2552","DOIUrl":"10.1002/rmv.2552","url":null,"abstract":"Infections caused by blood-borne viruses, such as human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis C virus (HCV), and hepatitis B virus (HBV), are systemic diseases that can lead to a wide range of pathological manifestations. Besides causing severe immune and hepatic disorders, these viral pathogens can also induce neurological dysfunctions via both direct and indirect mechanisms. Neurological dysfunctions are one of the most common manifestations caused by these viruses that can also serve as indicators of their infection, impacting the clinical presentation of the disease. The main neurological manifestations of these blood-borne viral pathogens consist of several central and peripheral nervous system (CNS and PNS, respectively) dysfunctions. The most common neurological manifestations of HIV, HTLV, HCV, and HBV include HIV-associated peripheral neuropathy (PN), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and HCV-/HBV-associated PN, respectively. Nonetheless, patients infected with these viruses may experience other neurological disorders, either associated with these conditions or manifesting in isolation, which can often go unnoticed or undiagnosed by physicians. The present review aims to provide an overview of the latest evidence on the relationship between blood-borne viruses and neurological disorders to highlight neurological conditions that may be somewhat overlooked by mainstream literature and physicians.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 4","pages":"e2552"},"PeriodicalIF":9.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluvoxamine and long COVID: Post-acute recovery. 氟伏沙明和长COVID：急性期后的恢复。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-07-01 DOI: 10.1002/rmv.2557

Angela M Reiersen, Charles F Zorumski, Eric J Lenze

引用次数: 0

Hepatitis A in Latin America: The current scenario. 拉丁美洲的甲型肝炎：现状。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-07-01 DOI: 10.1002/rmv.2566

Viviana E Ré, Ezequiel Ridruejo, Anabella C Fantilli, Bruna Damásio Moutinho, María Belén Pisano, Mário Guimarães Pessoa

{"title":"Hepatitis A in Latin America: The current scenario.","authors":"Viviana E Ré, Ezequiel Ridruejo, Anabella C Fantilli, Bruna Damásio Moutinho, María Belén Pisano, Mário Guimarães Pessoa","doi":"10.1002/rmv.2566","DOIUrl":"10.1002/rmv.2566","url":null,"abstract":"This review aims to gather and disseminate updated information regarding hepatitis A virus (HAV) in Latin America (LA) in the last 11 years, including seroprevalence, post-vaccination studies, virus detection in aqueous matrices and food samples, and outbreak reports. Only 24 seroprevalence studies were published between 2012 and 2023 with 55%-100% reported prevalences of anti-HAV IgG. Among the 25 LA countries, only eight of them have introduced HAV vaccines into their immunisation programs. Outbreaks of hepatitis A occurred between 2017-2019, mainly affecting men who have sex with men in Argentina, Brazil and Chile, probably as a consequence of the abrupt decline of young adults' immunity. This could be due to that young adult have never been infected in childhood (due to socio-health improvements) and are above the cut-off ages to be included when the vaccination programs were introduced. Although scarce, studies focused on environmental and food HAV surveillance have shown viral presence in these samples. Surface waters presented HAV detections between 1.2% and 86.7%, and untreated wastewaters between 2.8% and 70.9%. Genotypes found in all cases were IA and IC. The only wastewater-based epidemiology study showed to be a useful tool as a complement of traditional epidemiological surveillance. Only four LA countries have looked for HAV in food samples, with genome detection rates between 9% and 33%. Latin American HAV circulation scenario is changing. In countries where socioeconomic and sanitary conditions have not improved, the virus persists with high endemicity and the access to the vaccine should be re-evaluated by local governments. In countries where access to clean water, better sanitary conditions and HAV immunisation programs have been implemented, the number of cases among young adults seems to be increasing, alerting health authorities.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 4","pages":"e2566"},"PeriodicalIF":9.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test accuracy of rapid diagnostic tests and reverse-transcription polymerase chain reaction against virus isolation in cell culture for assessing SARS-CoV-2 infectivity: Systematic review and meta-analysis. 快速诊断测试和反转录聚合酶链反应与细胞培养病毒分离在评估 SARS-CoV-2 感染性方面的测试准确性：系统回顾和荟萃分析。

IF 9 2区医学

Reviews in Medical Virology Pub Date : 2024-07-01 DOI: 10.1002/rmv.2569

Alexey Fomenko, Theo Dähne, Stephanie Weibel, Marcus Panning, Kathrin Grummich, Sabrina Schlesinger, Gerta Rücker, Hartmut Hengel

{"title":"Test accuracy of rapid diagnostic tests and reverse-transcription polymerase chain reaction against virus isolation in cell culture for assessing SARS-CoV-2 infectivity: Systematic review and meta-analysis.","authors":"Alexey Fomenko, Theo Dähne, Stephanie Weibel, Marcus Panning, Kathrin Grummich, Sabrina Schlesinger, Gerta Rücker, Hartmut Hengel","doi":"10.1002/rmv.2569","DOIUrl":"10.1002/rmv.2569","url":null,"abstract":"We aimed to assess the performance of Ag-RDT and RT-qPCR with regard to detecting infectious SARS-CoV-2 in cell cultures, as their diagnostic test accuracy (DTA) compared to virus isolation remains largely unknown. We searched three databases up to 15 December 2021 for DTA studies. The bivariate model was used to synthesise the estimates. Risk of bias was assessed using QUADAS-2/C. Twenty studies (2605 respiratory samples) using cell culture and at least one molecular test were identified. All studies were at high or unclear risk of bias in at least one domain. Three comparative DTA studies reported results on Ag-RDT and RT-qPCR against cell culture. Two studies evaluated RT-qPCR against cell culture only. Fifteen studies evaluated Ag-RDT against cell culture as reference standard in RT-qPCR-positive samples. For Ag-RDT, summary sensitivity was 93% (95% CI 78; 98%) and specificity 87% (95% CI 70; 95%). For RT-qPCR, summary sensitivity (continuity-corrected) was 98% (95% CI 95; 99%) and specificity 45% (95% CI 28; 63%). In studies relying on RT-qPCR-positive subsamples (n = 15), the summary sensitivity of Ag-RDT was 93% (95% CI 92; 93%) and specificity 63% (95% CI 63; 63%). Ag-RDT show moderately high sensitivity, detecting most but not all samples demonstrated to be infectious based on virus isolation. Although RT-qPCR exhibits high sensitivity across studies, its low specificity to indicate infectivity raises the question of its general superiority in all clinical settings. Study findings should be interpreted with caution due to the risk of bias, heterogeneity and the imperfect reference standard for infectivity.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"34 4","pages":"e2569"},"PeriodicalIF":9.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0