Reviews in Medical Virology最新文献_第6页

A Deep Dive Into Oncogenic Viruses Understanding Their Role in Cancer and Approaches for Prevention. 深入研究致瘤病毒，了解它们在癌症中的作用和预防方法。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70121

Neetesh Jindal, Bipin Bihari Mishra, Ashish Kumar, Sindhuprava Rana, Krishna Pandey, Ganesh Chandra Sahoo

{"title":"A Deep Dive Into Oncogenic Viruses Understanding Their Role in Cancer and Approaches for Prevention.","authors":"Neetesh Jindal, Bipin Bihari Mishra, Ashish Kumar, Sindhuprava Rana, Krishna Pandey, Ganesh Chandra Sahoo","doi":"10.1002/rmv.70121","DOIUrl":"10.1002/rmv.70121","url":null,"abstract":"Oncogenic viruses, including Epstein-Barr virus (EBV), Human Papillomavirus (HPV), Kaposi's Sarcoma-Associated Herpesvirus (KSHV), Hepatitis B Virus (HBV), Merkel Cell Polyomavirus (MCPyV), Human T-cell Lymphotropic Virus (HTLV-1), and Hepatitis C Virus (HCV), are significant contributors to cancer development, each through distinct mechanisms. EBV is recognised for its association with cancers such as Burkitt lymphoma and nasopharyngeal carcinoma. High-risk types of HPV are primarily connected to cervical cancer. KSHV plays a crucial role in the development of Kaposi's sarcoma, especially among individuals with compromised immune systems. Both HBV and HCV are implicated in liver cancer due to chronic infections and resultant inflammation. MCPyV is linked to aggressive skin cancers, while HTLV-1 can lead to leukemia and various neurological complications. Collectively, these viruses account for approximately 20% of all cancers globally, providing valuable insights into cancer pathogenesis and potential treatment avenues. Effective management of these viruses includes the use of vaccines such as Gardasil for HPV and antiviral medications for HBV and HCV. Treatment options for cancers associated with EBV, KSHV, and MCPyV encompass targeted therapies and surgical interventions. Preventive measures emphasise vaccination, safe practices to curb virus transmission, routine screenings, and maintaining a healthy lifestyle. Ongoing research and public health initiatives are vital for enhancing prevention and treatment strategies, particularly in high-risk and resource-limited settings. By deepening our understanding of these viruses, we can improve the development of targeted therapies and strive to reduce the global burden of cancer.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70121"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update on Mpox: Focussing on Current and Emerging Antiviral Strategies. m痘最新情况：重点关注当前和新出现的抗病毒策略。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70116

Yizhuo Hou, Yu Su, Jixi Li, Jin Ding

引用次数: 0

Advances in Rapid Nucleic Acid Diagnostics for Hepatitis B and C Viruses: A Comprehensive Review. 乙型和丙型肝炎病毒核酸快速诊断研究进展综述

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70110

Hsin-Ying Ho, Chia-Yen Dai, I-Jung Feng, Yen-Hsu Chen, Ming-Lung Yu, Che-Hsin Lin, Ling-Shan Yu

{"title":"Advances in Rapid Nucleic Acid Diagnostics for Hepatitis B and C Viruses: A Comprehensive Review.","authors":"Hsin-Ying Ho, Chia-Yen Dai, I-Jung Feng, Yen-Hsu Chen, Ming-Lung Yu, Che-Hsin Lin, Ling-Shan Yu","doi":"10.1002/rmv.70110","DOIUrl":"10.1002/rmv.70110","url":null,"abstract":"Chronic viral hepatitis, predominantly caused by HBV and HCV infections, remains a major global health burden and a leading cause of cirrhosis, hepatocellular carcinoma (HCC), and liver-related mortality. Achieving the World Health Organisation (WHO) target of diagnosing 90% of HBV and HCV infections by 2030 necessitates a fundamental transition from centralised laboratory-based testing towards rapid, accessible, and decentralised diagnostic solutions. This review provides a comprehensive and critical assessment of the current diagnostic landscape for viral hepatitis, spanning established commercial assays and emerging nucleic acid testing (NAT) technologies. We systematically examine recent advances in biosensor-enabled diagnostics, with particular emphasis on the integration of isothermal amplification and CRISPR-based molecular recognition into electrochemical and field-effect transistor (FET) platforms. These electronic sensing technologies enable label-free signal transduction, scalable miniaturisation, and seamless integration with point-of-care (POC) workflows, thereby addressing key limitations of conventional diagnostic pipelines. In addition, we discuss persistent challenges in sample preparation, signal amplification, and system integration, and highlight strategies that couple biochemical amplification with solid-state electronics to streamline diagnostic workflows. By synthesising the state of the art and identifying critical technological bottlenecks, this review describes the technological progression of next-generation diagnostic platforms required to accelerate the global elimination of viral hepatitis and to improve patient outcomes through earlier and more equitable access to diagnosis.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70110"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruption of Signalling Pathways Induced by HBV HBx, HCV Core, and EBV LMP1 in Gastric Cancer. HBV - HBx、HCV - Core和EBV - LMP1在胃癌中诱导的信号通路中断

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70090

Mengli Gao, Yanmin Wu, Yan Chen, Tongying Hao, Xiaojing Sun, Jing Ji

引用次数: 0

Insights Into Highly Associated Co-Factors on HPV-Related Cervical Cancer. 人乳头瘤病毒相关宫颈癌的高度相关的辅助因素的见解。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70131

Liyuan Zheng, Guangwei Zhao, Lili Zheng, Yujie Zou, Shengshuo Zhang, Jinhua Dong

引用次数: 0

Measles Resurgence: Could a Third Vaccine Dose Be the Solution? 麻疹卷土重来：第三剂疫苗能解决问题吗？

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70134

Huynh Tran Bao Chau, Bui Cong Minh, Jeza Muhamad Abdul Aziz, Hoang Bao Tran Van, Bui Nguyen Ha Tien, Abdelrahman Gad, Khanh Dang Nguyen, Pham Hong Gam, Javeria Hamraa, Le Thi Thuy Hang, Tran Thi Kim Ngan, Pham Thai Son, Nguyen Tien Huy

{"title":"Measles Resurgence: Could a Third Vaccine Dose Be the Solution?","authors":"Huynh Tran Bao Chau, Bui Cong Minh, Jeza Muhamad Abdul Aziz, Hoang Bao Tran Van, Bui Nguyen Ha Tien, Abdelrahman Gad, Khanh Dang Nguyen, Pham Hong Gam, Javeria Hamraa, Le Thi Thuy Hang, Tran Thi Kim Ngan, Pham Thai Son, Nguyen Tien Huy","doi":"10.1002/rmv.70134","DOIUrl":"10.1002/rmv.70134","url":null,"abstract":"Measles remains a highly infectious viral disease and continues to pose a major global public health concern, with recurrent outbreaks occurring despite the implementation of effective vaccination strategies. This review examines multifactorial drivers of current measles outbreaks, summarises current recommendations for the standard two-dose measles-containing vaccine schedule, and evaluates emerging immunological evidence regarding the administration of a third dose. Some studies indicate that a third measles-containing vaccine dose can result in an enhanced response for both humoral and cellular immune responses among individuals with declining antibody levels. However, existing evidence is largely derived from small, context-specific studies and does not yet demonstrate durable clinical protection or population-level impact on measles transmission. Consequently, the role of a routine third dose remains uncertain. In conclusion, addressing the multifactorial drivers of measles resurgence, including strengthening two-dose vaccination coverage, reducing vaccine hesitancy, improving surveillance, and closing immunity gaps, remains the primary priority for measles control. A third dose may be considered as an investigational strategy, but further large-scale epidemiologic and effectiveness data are needed before any policy implementation can be considered.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70134"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chapare Virus: A Re-Emerging Zoonotic Arenavirus With Limited Preparedness. Chapare病毒：一种重新出现的人畜共患沙粒病毒，防范措施有限。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70111

Sabrina Sharmin, Asef Raj, Md Atik Zawad, Afnan Jahan, Zubaier Ahmed, Mossamat Umul Khair Fatema

{"title":"Chapare Virus: A Re-Emerging Zoonotic Arenavirus With Limited Preparedness.","authors":"Sabrina Sharmin, Asef Raj, Md Atik Zawad, Afnan Jahan, Zubaier Ahmed, Mossamat Umul Khair Fatema","doi":"10.1002/rmv.70111","DOIUrl":"10.1002/rmv.70111","url":null,"abstract":"Chapare virus (CHAPV) is an emerging New World arenavirus that causes Chapare haemorrhagic fever (CHHF), a severe and often fatal illness. First identified in Bolivia in 2003, CHAPV remains geographically limited but has shown potential for nosocomial transmission. It causes symptoms similar to other viral haemorrhagic fevers, including fever, muscle pain, bleeding, and neurological complications. The virus is primarily spread through contact with infected rodents, although limited human-to-human transmission has been documented. CHAPV has a bisegmented RNA genome with ambisense polarity. It shares structural features with other arenaviruses but contains unique mutations that may affect its ability to replicate and evade the immune system. The virus targets immune cells, disrupts normal responses, and causes widespread inflammation and vascular damage. No vaccine or antiviral treatment is currently available. This review compares CHAPV with other arenaviruses such as Lassa, Junín, Machupo, Guanarito, and Sabia viruses. While some of these viruses have vaccines or experimental treatments, CHAPV lacks both. Diagnostic challenges, poor surveillance, and underreporting further limit understanding of its true burden. We highlight the urgent need for improved diagnostics, genomic surveillance, and development of medical countermeasures. A One Health approach-linking human, animal, and environmental health is essential for early detection and prevention of future outbreaks. Given its clinical severity and potential for spread, CHAPV represents a neglected but serious global health threat that requires immediate research and policy attention.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70111"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colchicine in COVID-19: Mechanistic Insights and Clinical Uncertainties. 秋水仙碱在COVID-19中的作用：机制见解和临床不确定性。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70126

Abrar S Alsulami, Hayder M Al-Kuraishy, Tasnim S Waheeb, Gaber El-Saber Batiha

{"title":"Colchicine in COVID-19: Mechanistic Insights and Clinical Uncertainties.","authors":"Abrar S Alsulami, Hayder M Al-Kuraishy, Tasnim S Waheeb, Gaber El-Saber Batiha","doi":"10.1002/rmv.70126","DOIUrl":"10.1002/rmv.70126","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) which caused by the novel coronavirus SARS-CoV-2 has been emerged as a global health crisis characterised by severe immune dysregulation and inflammatory complications. The hyper-activation of the immune response in COVID-19 patients is associated with disease progression and severity. As a result, immunomodulatory therapies such as colchicine have been suggested to control exaggerated immune response in COVID-19. However, the therapeutic role of colchicine in COVID-19 remains a subject of debate due to conflicting evidence. This review highlights both the beneficial and potentially harmful effects of colchicine in the context of COVID-19. Notably, the therapeutic advantages of colchicine are linked to the suppression of immune cell over-activation, attenuation of oxidative stress, and prevention of thrombo-inflammatory events. Conversely, colchicine may exert negative effects by disrupting microtubule function, impairing autophagic processes, and inducing mitochondrial dysfunction in COVID-19. In conclusion, the overall clinical impact of colchicine plays a critical role in the management of COVID-19. However, its dual effects underscore the need for well-designed clinical studies to confirm its safety and efficacy in COVID-19 management.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70126"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards Ending HIV/AIDS by 2030: Trajectory of Sub-Saharan Africa-A Post-COVID-19 (2019-2024) Review. 《实现到2030年消除艾滋病毒/艾滋病：撒哈拉以南非洲的发展轨迹——后covid -19（2019-2024）审查》。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70138

Perpetual Nyame, Olayinka S Okoh, Akua K Yalley, Nicholas I Nii-Trebi

{"title":"Towards Ending HIV/AIDS by 2030: Trajectory of Sub-Saharan Africa-A Post-COVID-19 (2019-2024) Review.","authors":"Perpetual Nyame, Olayinka S Okoh, Akua K Yalley, Nicholas I Nii-Trebi","doi":"10.1002/rmv.70138","DOIUrl":"10.1002/rmv.70138","url":null,"abstract":"Globally, the COVID-19 pandemic perturbed HIV services, jeopardising progress towards the Joint United Nations Programme on HIV/AIDS (UNAIDS) 95-95-95 targets in sub-Saharan Africa (SSA). This review is an evaluation of sub-Saharan Africa's progress towards attaining the UNAIDS target of ending HIV/AIDS by the year 2030 in the context of COVID-19. Data from UNAIDS, the World Health Organisation (WHO), and peer-reviewed literature were analysed to assess HIV service delivery in SSA from 2019 to 2024, with special attention to regional disparities and health system adaptations before, during, and after the pandemic. Before the COVID-19 pandemic, Southern and Eastern Africa were nearing the 90-90-90 goals while West and Central Africa made slower progress because of weaker health systems and other situational challenges. Between 2020 and 2022, lockdowns and service disruptions reduced HIV testing, delayed the start of antiretroviral therapy (ART), and led to fewer viral load analyses. To adapt, health systems provided ART for longer periods, offered more community-based care, expanded health worker roles, and used digital tools to maintain services, especially where infrastructure was strong. By 2023 and 2024, most countries in Southern and Eastern Africa were closer to achieving the 95-95-95 targets, while West and Central Africa continued to recover more slowly. The pandemic revealed both strengths and weaknesses in the HIV response in sub-Saharan Africa. Institutionalising innovations developed during the pandemic and addressing persistent regional disparities, which reflect uneven progress across the sub-region, are essential to sustaining progess and achieving epidemic control by 2030.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70138"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Surge to Stability: Navigating MPOX Epidemics Across the Globe With Genomic Insights, Paving the Way for Effective Management Plan. 从激增到稳定：用基因组学见解导航全球MPOX流行病，为有效的管理计划铺平道路。

IF 5.5 2区医学

Reviews in Medical Virology Pub Date : 2026-03-01 DOI: 10.1002/rmv.70112

Tooba Malik, Muhammad Shahzad, Tasleem Akhtar

{"title":"From Surge to Stability: Navigating MPOX Epidemics Across the Globe With Genomic Insights, Paving the Way for Effective Management Plan.","authors":"Tooba Malik, Muhammad Shahzad, Tasleem Akhtar","doi":"10.1002/rmv.70112","DOIUrl":"10.1002/rmv.70112","url":null,"abstract":"MPOX has been declared endemic in Central Africa by WHO in 2017. More recently (2018-2021), MPOX cases have been reported in various regions (endemic as well as non-endemic) all over the world. The sudden, unexpected and simultaneously emerging cases at geographically disparate areas indicate the probable undetected transmission pattern of the disease. The double stranded DNA virus has evolved over the time into multiple sub-lineages. Clade I MPXV variant is considered to be more virulent as compared to clade II variety. Mutations in certain sub-lineages may alter transmission routes, potentially shifting from direct contact to airborne transmission. The clinical presentation involves an incubation phase of 7-9 days, during this phase extensive viral dissemination occurs into the neighbouring cells causing systemic inflammation. The viral prodrome comprising of fever, malaise and myalgias may or may not precede the cutaneous eruptions that evolve over a period of 1-2 weeks, followed by desquamation and scabbing. Treatments include antiviral agents such as tecovirimat, bocindofovir and cidofovir in addition to standard supportive therapy for severe cases or immunocompromised patients. Vaccines such as ACAM2000, JYNNEOS and LC16m8 are available, although they are linked with some risks such as myopericarditis in certain patients. Ongoing global spread and virus mutations highlight the urgent need to accelerate research focused on early MPOX detection, novel treatment options and prevention in order to properly handle potential long-term challenges such as drug-resistant strains and future outbreaks. Prioritising the development of targeted, efficient, and less resistance-prone anti-MPOX medicines and rapid response systems for effective MPOX management.","PeriodicalId":21180,"journal":{"name":"Reviews in Medical Virology","volume":"36 2","pages":"e70112"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0