痘病毒感染对神经系统的影响：痘病毒感染对神经系统的影响：发病机制、神经侵袭性和临床表现》（Pathogenesis, Neurotropism, and Clinical Manifestations）。

IF 9 2区医学 Q1 VIROLOGY

Reviews in Medical Virology Pub Date : 2024-09-01 DOI:10.1002/rmv.2581

Mohammed Alissa, Khalid J Alzahrani, Meshari A Alsuwat

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引用次数: 0

摘要

痘病毒科（Poxviridae）是一个多样化的双链 DNA 病毒家族，历史上曾因天花病毒（VARV）引起的天花等疾病而闻名于世。这些病毒表现出独特的细胞质复制策略、编码大量蛋白质的庞大基因组，以及引起严重皮肤病和全身性疾病的能力。最近，人们开始关注它们的神经潜能，包括入侵中枢神经系统的机制、免疫介导的损害以及脑炎和脊髓炎等临床表现。这篇综述综述了目前有关痘病毒神经侵袭性的知识，重点介绍了病理生理机制和临床影响。

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Neurological Implications of Poxvirus Infections: Pathogenesis, Neurotropism, and Clinical Manifestations.

Poxviridae is a diverse family of double-stranded DNA viruses, historically significant for diseases like smallpox caused by variola virus (VARV). These viruses exhibit unique cytoplasmic replication strategies, large genomes encoding numerous proteins, and the ability to cause severe cutaneous and systemic diseases. Recent attention has focused on their neurotropic potential, including mechanisms of CNS invasion, immune-mediated damage, and clinical manifestations such as encephalitis and myelitis. This review synthesises current knowledge on poxvirus neurotropism, highlighting pathophysiological mechanisms and clinical implications.

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来源期刊

Reviews in Medical Virology 医学-病毒学

CiteScore

21.40

自引率

0.90%

发文量

期刊介绍： Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.