Restorative neurology and neuroscience最新文献

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A rare case of undulatory rhythmic lingual myoclonus in a patient with intracranial hemorrhage and diffuse pontine lesion 一例罕见的伴有颅内出血及弥漫性脑桥病变的舌性肌阵挛
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-03-30 DOI: 10.33425/2692-7918.1026
C. Zachariadi, Ioanna Alexandratou, V. Katsaros, S. Gatzonis
{"title":"A rare case of undulatory rhythmic lingual myoclonus in a patient with intracranial hemorrhage and diffuse pontine lesion","authors":"C. Zachariadi, Ioanna Alexandratou, V. Katsaros, S. Gatzonis","doi":"10.33425/2692-7918.1026","DOIUrl":"https://doi.org/10.33425/2692-7918.1026","url":null,"abstract":"We describe a 35-year-old man, who suffered a severe intraventricular hemorrhage and was admitted to the intensive care unit of our tertiary clinic. Two weeks after the incident, while in ICU, a neurological examination revealed persistent, undulating, rhythmic, myoclonic tongue movements. The diagnostic evaluation via CT scan, MRI and EEGs elicited a diffuse brainstem lesion as well as multiple corpus callosum lesions as a considerable underlying etiology. This case presentation attempts to update the current investigation of the rare phenomenon of lingual myoclonus.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"23 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83994627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restorative Neurology and Neuroscience: Celebrating the 40th volume of an academic journal. 恢复性神经病学和神经科学:庆祝学术期刊的第40卷。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-239003
Bernhard A Sabel
{"title":"Restorative Neurology and Neuroscience: Celebrating the 40th volume of an academic journal.","authors":"Bernhard A Sabel","doi":"10.3233/RNN-239003","DOIUrl":"https://doi.org/10.3233/RNN-239003","url":null,"abstract":"<p><p>Since the first issue of the academic journal Restorative Neurology and Neuroscience (RNN) was published in 1989, 40 volumes with a total of 1,550 SCI publications have helped advance basic and clinical sciences in the fields of central and peripheral nervous system rescue, regeneration, restoration and plasticity in experimental and clinical disorders. In this way RNN helped advance the development of a range of neuropsychiatric intervention across a broad spectrum of approaches such as drugs, training (rehabilitation), psychotherapy or neuromodulation with current stimulation. Today, RNN remains a focused, innovative and viable source of scientific information in the neurosciences with high visibility in an ever changing world of academic publishing.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 4-6","pages":"209-215"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal nerve fiber and ganglion cell complex layer thicknesses mirror brain atrophy in patients with relapsing-remitting multiple sclerosis. 视网膜神经纤维和神经节细胞复合体层厚度反映了复发缓解型多发性硬化症患者的脑萎缩。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-211176
Paulina Glasner, Agnieszka Sabisz, Magdalena Chylińska, Jakub Komendziński, Adam Wyszomirski, Bartosz Karaszewski
{"title":"Retinal nerve fiber and ganglion cell complex layer thicknesses mirror brain atrophy in patients with relapsing-remitting multiple sclerosis.","authors":"Paulina Glasner,&nbsp;Agnieszka Sabisz,&nbsp;Magdalena Chylińska,&nbsp;Jakub Komendziński,&nbsp;Adam Wyszomirski,&nbsp;Bartosz Karaszewski","doi":"10.3233/RNN-211176","DOIUrl":"https://doi.org/10.3233/RNN-211176","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is associated with progressive brain atrophy, which in turn correlates with disability, depression, and cognitive impairment. Relapsing-remitting multiple sclerosis (RRMS) is a type of MS in which relapses of the disease are followed by remission periods. This is the most common type of the disease. There is a significant need for easy and low-cost methods to these cerebral changes. Changes in retinal layer thickness may reflect alterations in brain white and gray matter volumes. Therefore, this paper aims to determine whether retinal layer thickness, measured using optical coherence tomography (OCT), correlates with volumetric brain assessments obtained by magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>This retrospective cohort study recruited 53 patients with relapsing-remitting MS who underwent MRI and OCT examinations for evaluation of brain compartment volumes and thickness of retinal layers, respectively. OCT parameters, including central retinal thickness; retinal nerve fiber layer thickness (RNFL, peripapillary thickness); ganglion cell complex thickness (GCC, macular thickness); and Expanded Disability Status Scale (EDSS) results were compared with MRI parameters (cerebral cortex; cerebral cortex and basal ganglia combined; brain hemispheres without the ventricular system; and white matter plaques). We also checked whether there is a correlation between the number of RRMS and OCT parameters.</p><p><strong>Objective: </strong>Our primary objective was to identify whether these patients had retinal thickness changes, and our secondary objective was to check if those changes correlated with the MRI brain anatomical changes.</p><p><strong>Results: </strong>RNFL and GCC thicknesses were strongly (p-value < 0.05) associated with (i) cerebral cortex volume, (ii) combination of brain cortex and basal ganglia volumes, and (iii) the hemispheres but without the ventricular system. White matter plaques (combined) showed only weak or no correlation with RNFL and GCC. There was no correlation between central retinal thickness and brain compartment volumes, and there were weak or no correlations between the summary EDSS scores and OCT results.</p><p><strong>Conclusions: </strong>Retinal layer thickness measured by OCT correlates with select volumetric brain assessments on MRI. During the course of RRMS, the anatomo-pathological structure of the retina might serve as a surrogate marker of brain atrophy and clinical progression within selected domains.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 1","pages":"35-42"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39935486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Retraction notice regarding several articles published in Restorative Neurology and Neuroscience. 关于发表在《恢复性神经病学》和《神经科学》上的几篇文章的撤回通知。
IF 1.9 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-239001
{"title":"Retraction notice regarding several articles published in Restorative Neurology and Neuroscience.","authors":"","doi":"10.3233/RNN-239001","DOIUrl":"10.3233/RNN-239001","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 4-6","pages":"289-290"},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activity dependent stimulation increases synaptic efficacy in spared pathways in an anesthetized rat model of spinal cord contusion injury. 在脊髓挫伤损伤的麻醉大鼠模型中,活性依赖性刺激增加了备用通路中的突触功效。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-211214
Jordan A Borrell, Dora Krizsan-Agbas, Randolph J Nudo, Shawn B Frost
{"title":"Activity dependent stimulation increases synaptic efficacy in spared pathways in an anesthetized rat model of spinal cord contusion injury.","authors":"Jordan A Borrell,&nbsp;Dora Krizsan-Agbas,&nbsp;Randolph J Nudo,&nbsp;Shawn B Frost","doi":"10.3233/RNN-211214","DOIUrl":"10.3233/RNN-211214","url":null,"abstract":"<p><strong>Background: </strong>Closed-loop neuromodulation systems have received increased attention in recent years as potential therapeutic approaches for treating neurological injury and disease.</p><p><strong>Objective: </strong>The purpose of this study was to assess the ability of intraspinal microstimulation (ISMS), triggered by action potentials (spikes) recorded in motor cortex, to alter synaptic efficacy in descending motor pathways in an anesthetized rat model of spinal cord injury (SCI).</p><p><strong>Methods: </strong>Experiments were carried out in adult, male, Sprague Dawley rats with a moderate contusion injury at T8. For activity-dependent stimulation (ADS) sessions, a recording microelectrode was used to detect neuronal spikes in motor cortex that triggered ISMS in the spinal cord grey matter. SCI rats were randomly assigned to one of four experimental groups differing by: a) cortical spike-ISMS stimulus delay (10 or 25 ms) and b) number of ISMS pulses (1 or 3). Four weeks after SCI, ADS sessions were conducted in three consecutive 1-hour conditioning bouts for a total of 3 hours. At the end of each conditioning bout, changes in synaptic efficacy were assessed using intracortical microstimulation (ICMS) to examine the number of spikes evoked in spinal cord neurons during 5-minute test bouts. A multichannel microelectrode recording array was used to record cortically-evoked spike activity from multiple layers of the spinal cord.</p><p><strong>Results: </strong>The results showed that ADS resulted in an increase in cortically-evoked spikes in spinal cord neurons at specific combinations of spike-ISMS delays and numbers of pulses. Efficacy in descending motor pathways was increased throughout all dorsoventral depths of the hindlimb spinal cord.</p><p><strong>Conclusions: </strong>These results show that after an SCI, ADS can increase synaptic efficacy in spared pathways between motor cortex and spinal cord. This study provides further support for the potential of ADS therapy as an effective method for enhancing descending motor control after SCI.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 1","pages":"17-33"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/9b/rnn-40-rnn211214.PMC9108576.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39961109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Training with optic flow stimuli promotes recovery in cortical blindness. 光流刺激训练促进皮质性失明的恢复。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-211223
Asmara Awada, Shahab Bakhtiari, Catherine Legault, Celine Odier, Christopher C Pack
{"title":"Training with optic flow stimuli promotes recovery in cortical blindness.","authors":"Asmara Awada,&nbsp;Shahab Bakhtiari,&nbsp;Catherine Legault,&nbsp;Celine Odier,&nbsp;Christopher C Pack","doi":"10.3233/RNN-211223","DOIUrl":"https://doi.org/10.3233/RNN-211223","url":null,"abstract":"<p><strong>Background: </strong>Cortical blindness is a form of severe vision loss that is caused by damage to the primary visual cortex (V1) or its afferents. This condition has devastating effects on quality of life and independence. While there are few treatments currently available, accumulating evidence shows that certain visual functions can be restored with appropriate perceptual training: Stimulus sensitivity can be increased within portions of the blind visual field. However, this increased sensitivity often remains highly specific to the trained stimulus, limiting the overall improvement in visual function.</p><p><strong>Objective: </strong>Recent advances in the field of perceptual learning show that such specificity can be overcome with training paradigms that leverage the properties of higher-level visual cortical structures, which have greater capacity to generalize across stimulus positions and features. This targeting can be accomplished by using more complex training stimuli that elicit robust responses in these visual structures.</p><p><strong>Methods: </strong>We trained cortically blind subjects with a complex optic flow motion stimulus that was presented in a location of their blind field. Participants were instructed to train with the stimulus at home for approximately 30 minutes per day. Once performance plateaued, the stimulus was moved deeper into the blind field. A battery of pre- and post-training measures, with careful eye tracking, was performed to quantify the improvements.</p><p><strong>Results: </strong>We show that 1) optic flow motion discrimination can be relearned in cortically blind fields; 2) training with an optic flow stimulus can lead to improvements that transfer to different tasks and untrained locations; and 3) such training leads to a significant expansion of the visual field. The observed expansion of the visual field was present even when eye movements were carefully controlled. Finally, we show that regular training is critical for improved visual function, as sporadic training reduced the benefits of training, even when the total numbers of training sessions were equated.</p><p><strong>Conclusions: </strong>These findings are consistent with the hypothesis that complex training stimuli can improve outcomes in cortical blindness, provided that patients adhere to a regular training regimen. Nevertheless, such interventions remain limited in their ability to restore functional vision.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 1","pages":"1-16"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39961110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Speech arrest by repetitive Transcranial Magnetic Stimulation - does it still work? Old experiences with new improvements. 通过重复经颅磁刺激来抑制语言——它还有效吗?旧的经验加上新的改进。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-211237
Martyna Borowczyk, Magdalena Wojtysiak, Anna Chmielarz-Czarnocińska, Małgorzata Braszka, Piotr Danielewski, Aleksandra Bryndal, Michał Michalak, Juliusz Huber
{"title":"Speech arrest by repetitive Transcranial Magnetic Stimulation - does it still work? Old experiences with new improvements.","authors":"Martyna Borowczyk,&nbsp;Magdalena Wojtysiak,&nbsp;Anna Chmielarz-Czarnocińska,&nbsp;Małgorzata Braszka,&nbsp;Piotr Danielewski,&nbsp;Aleksandra Bryndal,&nbsp;Michał Michalak,&nbsp;Juliusz Huber","doi":"10.3233/RNN-211237","DOIUrl":"https://doi.org/10.3233/RNN-211237","url":null,"abstract":"<p><strong>Background: </strong>Traditional repetitive Transcranial Magnetic Stimulation (rTMS) remains applicable in speech studies on healthy participants. Although the procedure of inducing speech arrest by rTMS has been used for over 25 years, there are still significant discrepancies in its methodology.</p><p><strong>Objective: </strong>The study aimed to simplify and improve the old methodology of triggering speech arrest by (rTMS). Our goal was to establish the best step-by-step algorithm and verify the procedure on a representative group of participants.</p><p><strong>Methods: </strong>47 healthy, right-handed volunteers (23 men and 24 women) at a median age of 23 (range 19-34) were included in the study. Handedness was determined using the Edinburgh Handedness Inventory Test. After setting the individual's motor threshold (MT) and heuristic choice of the place of stimulation, which targeted Inferior Frontal Gyrus (IFG), participants were asked to count downwards from 20 to 10. While counting, a series of 2-second pulses was generated at a frequency of 2 Hz at 120% or 150% of MT. The procedure was video-recorded and subsequently assessed by 3 independent reviewers and self-assessed by participants on visual analogue scales for the effect and comfort of stimulation.</p><p><strong>Results: </strong>Speech arrest was induced in 45 people (95.7%). Language dominance was determined to be either left-sided (for 42.2%) or bilateral (55.3%). Total speech arrest was observed more often in participants for whom Broca's area was active exclusively in the left hemisphere.</p><p><strong>Conclusion: </strong>In our study, we present the step-by-step procedure for a simplified, as far as possible, methodology of inducing speech arrest using rTMS with its verification on a representative group of right-handed healthy individuals. Our results prove that the chosen stimulation parameters present a good efficacy ratio and seems to be justified. The traditional applications of rTMS in speech studies may be highly broadened if the methods used are further improved and simplified.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 3","pages":"125-135"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10352970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The assessment of biceps voluntary activation with transcranial magnetic stimulation in individuals with tetraplegia. 经颅磁刺激对四肢瘫痪患者二头肌自主激活的评估。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-221254
Thibault Roumengous, Carrie L Peterson
{"title":"The assessment of biceps voluntary activation with transcranial magnetic stimulation in individuals with tetraplegia.","authors":"Thibault Roumengous,&nbsp;Carrie L Peterson","doi":"10.3233/RNN-221254","DOIUrl":"https://doi.org/10.3233/RNN-221254","url":null,"abstract":"<p><strong>Background: </strong>Assessment of voluntary activation is useful in the study of neuromuscular impairments, particularly after spinal cord injury (SCI). Measurement of voluntary activation with transcranial magnetic stimulation (VATMS) is limited by technical challenges, including the difficulty in preferential stimulation of cortical neurons projecting to the target muscle and minimal stimulation of antagonists. Thus, the motor evoked potential (MEP) response to TMS in the target muscle compared to its antagonist may be an important parameter in the assessment of VATMS.</p><p><strong>Objective: </strong>The purpose of this study was to evaluate the effect of isometric elbow flexion angle on two metrics in individuals with tetraplegia following SCI: 1) the ratio of biceps/triceps MEP amplitude across a range of voluntary efforts, and 2) VATMS.</p><p><strong>Methods: </strong>Ten individuals with tetraplegia and ten nonimpaired individuals were recruited to participate in three sessions wherein VATMS was assessed at 45°, 90°, and 120° of isometric elbow flexion.</p><p><strong>Results: </strong>In SCI participants, the biceps/triceps MEP ratio was not modulated by elbow angle. In nonimpaired participants, the biceps/triceps MEP ratio was greater in the more flexed elbow angle (120° flexion) compared to 90° during contractions of 50% and 75% MVC, but VATMS was not different. VATMS assessed in the more extended elbow angle (45° flexion) was lower relative to 90° elbow flexion; this effect was dependent on the biceps/triceps MEP ratio. In both groups, VATMS was sensitive to the linearity of the voluntary moment and superimposed twitch relationship, regardless of elbow angle. Linearity was lower in SCI relative to nonimpaired participants.</p><p><strong>Conclusions: </strong>Increasing the MEP ratio via elbow angle did not enable estimation of VATMS in SCI participants. VATMS may not be a viable approach to assess neuromuscular function in individuals with tetraplegia.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 3","pages":"169-184"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10409322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-Carnitine prevents memory impairment induced by post-traumatic stress disorder. 左旋肉碱可以预防由创伤后应激障碍引起的记忆损伤。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-211191
Karem H Alzoubi, Arwa M Al-Dekah, Saied Jaradat, Nasr Alrabadi
{"title":"L-Carnitine prevents memory impairment induced by post-traumatic stress disorder.","authors":"Karem H Alzoubi,&nbsp;Arwa M Al-Dekah,&nbsp;Saied Jaradat,&nbsp;Nasr Alrabadi","doi":"10.3233/RNN-211191","DOIUrl":"https://doi.org/10.3233/RNN-211191","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) is a genuine obstructing mental disorder. As indicated by the name, it is related to the patients' stress augmented by life-threatening conditions or accidents. The PTSD has linked to oxidative stress that can result in neurodegeneration. L-carnitine (L-CAR) is known for its antioxidant properties, which can protect against neuronal damage.</p><p><strong>Objective: </strong>In the current study, we investigated the beneficial effects of L-CAR on the memory impairment induced by PTSD using a rat model.</p><p><strong>Methods: </strong>A model of single-prolonged stress (a cycle of restraining, forced swimming, rest, and finally diethyl ether exposure for 2 h, 20 min, 15 min, and 1-2 min, respectively) was used to induce PTSD-like behavior. Intraperitoneal L-CAR treatment (300 mg/kg/day) was introduced for four weeks. Both memory and special learning were evaluated utilizing the radial arm water maze (RAWM). Moreover, the levels of glutathione peroxidase (GPx), glutathione reduced (GSH), and glutathione oxidized (GSSG) were assessed as biomarkers oxidative stress in the hippocampus.</p><p><strong>Results: </strong>The results demonstrated that both the short and long-term memories were impaired by PTSD/SPS model (P < 0.05), while L-CAR treatment prevented this memory impairment in PTSD rats. Besides, L-CAR prevented the reduction in GPx activity and increase in GSSG, which were altered in the hippocampus of the PTSD/SPS rats (P < 0.05). Levels of GSH were not changed in PTSD and/or L-CAR rats.</p><p><strong>Conclusions: </strong>L-CAR administration prevented short- and long-term memories' impairments induced in the PTSD/SPS rat model. This is probably related to its antioxidant effects in the hippocampus.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 1","pages":"53-61"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39639063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Vision recovery with perceptual learning and non-invasive brain stimulation: Experimental set-ups and recent results, a review of the literature. 视觉恢复与知觉学习和非侵入性脑刺激:实验设置和最近的结果,文献综述。
IF 2.8 4区 医学
Restorative neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.3233/RNN-221261
Luca Battaglini, Michele Di Ponzio, Andrea Ghiani, Federica Mena, Paola Santacesaria, Clara Casco
{"title":"Vision recovery with perceptual learning and non-invasive brain stimulation: Experimental set-ups and recent results, a review of the literature.","authors":"Luca Battaglini,&nbsp;Michele Di Ponzio,&nbsp;Andrea Ghiani,&nbsp;Federica Mena,&nbsp;Paola Santacesaria,&nbsp;Clara Casco","doi":"10.3233/RNN-221261","DOIUrl":"https://doi.org/10.3233/RNN-221261","url":null,"abstract":"<p><strong>Background: </strong>Vision is the sense which we rely on the most to interact with the environment and its integrity is fundamental for the quality of our life. However, around the globe, more than 1 billion people are affected by debilitating vision deficits. Therefore, finding a way to treat (or mitigate) them successfully is necessary.</p><p><strong>Objective: </strong>This narrative review aims to examine options for innovative treatment of visual disorders (retinitis pigmentosa, macular degeneration, optic neuropathy, refractory disorders, hemianopia, amblyopia), especially with Perceptual Learning (PL) and Electrical Stimulation (ES).</p><p><strong>Methods: </strong>ES and PL can enhance visual abilities in clinical populations, inducing plastic changes. We describe the experimental set-ups and discuss the results of studies using ES or PL or their combination in order to suggest, based on literature, which treatment is the best option for each clinical condition.</p><p><strong>Results: </strong>Positive results were obtained using ES and PL to enhance visual functions. For example, repetitive transorbital Alternating Current Stimulation (rtACS) appeared as the most effective treatment for pre-chiasmatic disorders such as optic neuropathy. A combination of transcranial Direct Current Stimulation (tDCS) and visual training seems helpful for people with hemianopia, while transcranial Random Noise Stimulation (tRNS) makes visual training more efficient in people with amblyopia and mild myopia.</p><p><strong>Conclusions: </strong>This narrative review highlights the effect of different ES montages and PL in the treatment of visual disorders. Furthermore, new options for treatment are suggested. It is noteworthy to mention that, in some cases, unclear results emerged and others need to be more deeply investigated.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 3","pages":"137-168"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10348716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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