Restorative neurology and neuroscience最新文献

{"title":"Lateralized readiness potentials can identify hemisphere of recovery in stroke patients.","authors":"Nevine M. El Nahas, Tamer Roushdy, H. Shokri, R. Moustafa, Ahmed M. Elsayed, Randa M. Amin, A. Ashour, E. H. Abd Eldayem, G. Elhawary, Ahmed M. Elbokl","doi":"10.3233/rnn-211222","DOIUrl":"https://doi.org/10.3233/rnn-211222","url":null,"abstract":"Highlights• In healthy adults, the lateralized readiness potential (LRP) is localized to the hemisphere contralateral to a moving limb.• In stroke, the LRP can lateralize contra-, or ipsilateral to the paretic limb depending on the stage of recovery.• Identification of hemisphere of recovery can guide further measures for enhancing brain plasticity.\u0000\u0000\u0000BACKGROUND\u0000Event related cortical potentials related to motor action are referred to as movement related cortical potentials. The late component of which is the readiness potential (RP) and its polarity is more negative in the hemisphere responsible for planning of motor action. This lateralized nature of RP during unilateral hand movement is studied as lateralized readiness potential (LRP) by calculating the contralateral-minus-ipsilateral difference wave for each hand.\u0000\u0000\u0000OBJECTIVE\u0000The aim was to identify the hemisphere contributing to motor recovery in acute and chronic stroke patients through recording LRPs.\u0000\u0000\u0000METHODS\u0000Twenty-nine cases with cerebrovascular stroke (15 acute and 14 chronic) were included in the study. EEG was recorded in response to self-cued button presses by the paretic side to obtain the averaged LRP amplitude. The hemisphere with greater negativity was considered the side of recovery. Functional recovery was assessed by Fugl Meyer test.\u0000\u0000\u0000RESULTS\u0000In acute cases, recovery was more related to LRP activity in the contralesional hemisphere (73% ), whereas lateralization was equal in chronic cases; 50% in either group. LRP amplitude was higher in the contralesional hemisphere (p = 0.02). Functional recovery assessed by the Fugl Meyer test (FM) was similar whether recovery was ipsi- or contralesional.\u0000\u0000\u0000CONCLUSIONS\u0000Early after stroke, motor recovery is more likely to involve compensatory activity in the contralesional hemisphere, while in the chronic phase, the ipsilesional hemisphere may recover its function and become more active. Further research is needed to verify if the technique mentioned in our study could be used to guide customized NIBS protocols tailoring the optimal site and parameters for each patient.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46413723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effects of cerebellar tDCS and task-oriented circuit training in people with multiple sclerosis: A pilot randomized control trial.","authors":"Andrea Baroni, G. Magro, Carlotta Martinuzzi, Laura Brondi, S. Masiero, Giada Milani, G. Zani, Antonella Bergonzoni, N. Basaglia, S. Straudi","doi":"10.3233/RNN-211245","DOIUrl":"https://doi.org/10.3233/RNN-211245","url":null,"abstract":"BACKGROUND\u0000Balance and mobility impairments are frequent in people with multiple sclerosis, partly due to cerebellar dysfunctions. Task-oriented behavioural approaches were previously shown to promote physical function. The possibility exists that cerebellar transcranial direct current stimulation (ctDCS) applied during training, known to increase the excitability of the brain, can boost rehabilitation effects through modulation of cerebellum-brain inhibition.\u0000\u0000\u0000OBJECTIVE\u0000To test the efficacy of cerebellar ctDCS stimulation combined with motor training on mobility and balance in people with multiple sclerosis.\u0000\u0000\u0000METHODS\u000016 subjects were randomly assigned to receive real- or sham-ctDCS and task-oriented training daily over two weeks in a double-blind, randomised clinical pilot trial. Functional mobility, balance, walking performance and quality of life were tested before and after treatment and at two-week follow-up. Effects of cerebellar stimulation on psychological and executive functions were also recorded.\u0000\u0000\u0000RESULTS\u0000Walking performance, balance and quality of life improved for both groups at post-treatment assessment which was maintained at 2-weeks follow up. A two-way ANOVA revealed a significant time effect for balance and walking performance. A significant interaction effect of time-treatment (F = 3.12, df = 2,26; p = 0.03) was found for motor aspects of quality of life assessment in patients who received real-ctDCS.\u0000\u0000\u0000CONCLUSIONS\u0000Task-oriented training improves balance and mobility in people with multiple sclerosis, but ctDCS does not boost motor training effects.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"17 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41308027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific basis and active ingredients of current therapeutic interventions for stroke rehabilitation.","authors":"R. Ranganathan, Carson Doherty, M. Gussert, Eva Kaplinski, M. Koje, C. Krishnan","doi":"10.3233/RNN-211243","DOIUrl":"https://doi.org/10.3233/RNN-211243","url":null,"abstract":"BACKGROUND\u0000Despite tremendous advances in the treatment and management of stroke, restoring motor and functional outcomes after stroke continues to be a major clinical challenge. Given the wide range of approaches used in motor rehabilitation, several commentaries have highlighted the lack of a clear scientific basis for different interventions as one critical factor that has led to suboptimal study outcomes.\u0000\u0000\u0000OBJECTIVE\u0000To understand the content of current therapeutic interventions in terms of their active ingredients.\u0000\u0000\u0000METHODS\u0000We conducted an analysis of randomized controlled trials in stroke rehabilitation over a 2-year period from 2019-2020.\u0000\u0000\u0000RESULTS\u0000There were three primary findings: (i) consistent with prior reports, most studies did not provide an explicit rationale for why the treatment would be expected to work, (ii) most therapeutic interventions mentioned multiple active ingredients and there was not a close correspondence between the active ingredients mentioned versus the active ingredients measured in the study, and (iii) multimodal approaches that involved more than one therapeutic approach tended to be combined in an ad-hoc fashion, indicating the lack of a targeted approach.\u0000\u0000\u0000CONCLUSION\u0000These results highlight the need for strengthening cross-disciplinary connections between basic science and clinical studies, and the need for structured development and testing of therapeutic approaches to find more effective treatment interventions.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43558715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex housing partially mitigates low dose radiation-induced changes in brain and behavior in rats.","authors":"Anna Kovalchuk, R. Mychasiuk, A. Muhammad, S. Hossain, Abhijit Ghose, C. Kirkby, E. Ghasroddashti, O. Kovalchuk, B. Kolb","doi":"10.3233/RNN-211216","DOIUrl":"https://doi.org/10.3233/RNN-211216","url":null,"abstract":"PURPOSE\u0000In recent years, much effort has been focused on developing new strategies for the prevention and mitigation of adverse radiation effects on healthy tissues and organs, including the brain. The brain is very sensitive to radiation effects, albeit as it is highly plastic. Hence, deleterious radiation effects may be potentially reversible. Because radiation exposure affects dendritic space, reduces the brain's ability to produce new neurons, and alters behavior, mitigation efforts should focus on restoring these parameters. To that effect, environmental enrichment through complex housing (CH) and exercise may provide a plausible avenue for exploration of protection from brain irradiation. CH is a much broader concept than exercise alone, and constitutes exposure of animals to positive physical and social stimulation that is superior to their routine housing and care conditions. We hypothesized that CHs may lessen harmful neuroanatomical and behavioural effects of low dose radiation exposure.\u0000\u0000\u0000METHODS\u0000We analyzed and compared cerebral morphology in animals exposed to low dose head, bystander (liver), and scatter irradiation on rats housed in either the environmental enrichment condos or standard housing.\u0000\u0000\u0000RESULTS\u0000Enriched condo conditions ameliorated radiation-induced neuroanatomical changes. Moreover, irradiated animals that were kept in enriched CH condos displayed fewer radiation-induced behavioural deficits than those housed in standard conditions.\u0000\u0000\u0000CONCLUSIONS\u0000Animal model-based environmental enrichment strategies, such as CH, are excellent surrogate models for occupational and exercise therapy in humans, and consequently have significant translational possibility. Our study may thus serve as a roadmap for the development of new, easy, safe and cost-effective methods to prevent and mitigate low-dose radiation effects on the brain.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46725661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of gunshot wounds to the spine at Parakou University Teaching Hospital In Benin Republics","authors":"Quenum Kisito, Coulibaly Oumar, Yakhya Cisse, Padonou Christian, Quenum Hountondji Bernice, F. O. Holden","doi":"10.33425/2692-7918.1024","DOIUrl":"https://doi.org/10.33425/2692-7918.1024","url":null,"abstract":"Objective: Describe the clinical features and bullet removal in gunshot wound (GSW) to the spine. Patients and methods: From 2015 to 2021 we present Case series of consecutive five cases of GSW with spinal cord injury treated at a single center of parakou university neurosurgery department. Results: Patient ages ranged from 16 to 40 yr (mean: 27.4 yr). All the patients were male. Three had complete thoracic spinal cord injury (ASIA A), two had lumbar level injury with cauda equina syndrome in one case. Surgical and rehabilitation management, as well as the outcome, of a patient who with sustained spinal cord injury from a high velocity gunshot wound to the thoracic spine. Decompression and bullet removal were performed using an open surgery. The patient with thoracic spinal cord lesion associated with extended injuries related to bullet fragmentation have a poor prognosis. The patients with incomplete injuries had a good follow-up and neurologic recovery. There were no postoperative wound infections, cerebrospinal fluid (CSF) fistulas, or other complications related to the procedure. Conclusion: Surgical decompression and bullet removal is a safe technique that may help reduce the risk of postoperative infections and CSF fistulas in patients with GSW to the thoracic and lumbar spine.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"22 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84684828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Social Support on Mental Wellbeing among Internet Users In Nigeria During Covid-19 Pandemic","authors":"Emmanuel Sochukwuma Ezaka,, M. F. Asiegbu, O. P. Chibuike, Okpara Titus Chukwubuzo, Chime Peter Ekpunobi, Ozougwu Augustine Obumneme, Ofojebe Chukwuma Philip, Okoli Alexander Chinwike","doi":"10.33425/2692-7918.1023","DOIUrl":"https://doi.org/10.33425/2692-7918.1023","url":null,"abstract":"This study investigated the role of social support on mental wellbeing during COVID-19 Pandemic among internet users in Nigeria. A total of one hundred and six (106) participants (55 (51.9%) females, and 51 (48.9%) males participated in the study. The participant ages ranged from 19-29 years with a mean age of 28.68 and standard deviation of 8.14. Participants were drawn using convenience sampling technique and data were collated using the online Google form method. The link to the survey was shared across different platforms such: as Facebook, Whatsapp, and email list. The participants gave their consent and willingness to participate by checking a box in the online survey. Two instruments were used in data collection namely; a 15-item COVID-19 social support questionnaire (COVID-19- SSQ) and Warwick-Edinburgh Mental Well-being Scale (AWEMWBS). Two hypotheses were tested. The study adopted cross sectional design, while regression was employed for data analysis. The findings indicate that the presence of social support has significant influence on existence of mental wellbeing. It is recommended that social support factor should be sustained because of its buffer effect on mental wellbeing during COVID-19 Pandemic among internet users in Nigeria.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88914452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Donation to Sharing, Experimental Study in Kanak Society : Methodology","authors":"Prou Jean-Pierre","doi":"10.33425/2692-7918.1025","DOIUrl":"https://doi.org/10.33425/2692-7918.1025","url":null,"abstract":"Since Kanak social norms have a major influence on this endowment effect cognitive bias , I launched a second line of research to examine the extent to which Kanak children and adults exhibit an altruistic (qualified as such in the Western world) pro-social behavior. I switched from gift-giving to sharing, and I examined whether these two were correlated","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90267709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of undulatory rhythmic lingual myoclonus in a patient with intracranial hemorrhage and diffuse pontine lesion","authors":"C. Zachariadi, Ioanna Alexandratou, V. Katsaros, S. Gatzonis","doi":"10.33425/2692-7918.1026","DOIUrl":"https://doi.org/10.33425/2692-7918.1026","url":null,"abstract":"We describe a 35-year-old man, who suffered a severe intraventricular hemorrhage and was admitted to the intensive care unit of our tertiary clinic. Two weeks after the incident, while in ICU, a neurological examination revealed persistent, undulating, rhythmic, myoclonic tongue movements. The diagnostic evaluation via CT scan, MRI and EEGs elicited a diffuse brainstem lesion as well as multiple corpus callosum lesions as a considerable underlying etiology. This case presentation attempts to update the current investigation of the rare phenomenon of lingual myoclonus.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"23 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83994627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice regarding several articles published in Restorative Neurology and Neuroscience.","authors":"","doi":"10.3233/RNN-239001","DOIUrl":"10.3233/RNN-239001","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 4-6","pages":"289-290"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restorative Neurology and Neuroscience: Celebrating the 40th volume of an academic journal.","authors":"Bernhard A Sabel","doi":"10.3233/RNN-239003","DOIUrl":"https://doi.org/10.3233/RNN-239003","url":null,"abstract":"<p><p>Since the first issue of the academic journal Restorative Neurology and Neuroscience (RNN) was published in 1989, 40 volumes with a total of 1,550 SCI publications have helped advance basic and clinical sciences in the fields of central and peripheral nervous system rescue, regeneration, restoration and plasticity in experimental and clinical disorders. In this way RNN helped advance the development of a range of neuropsychiatric intervention across a broad spectrum of approaches such as drugs, training (rehabilitation), psychotherapy or neuromodulation with current stimulation. Today, RNN remains a focused, innovative and viable source of scientific information in the neurosciences with high visibility in an ever changing world of academic publishing.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"40 4-6","pages":"209-215"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}