Restorative neurology and neuroscience最新文献

{"title":"Anti-Oxidative Property of Pennisetum Glaucum (Poaceae) Supplement Contributes To Its Anti- Convulsant Activity In Pentylenetetrazole- Kindled Wistar Rats","authors":"HD Muhammad, F. Dawud, J. Yau, J. Abdulazeez","doi":"10.33425/2692-7918.1041","DOIUrl":"https://doi.org/10.33425/2692-7918.1041","url":null,"abstract":"Introduction: Oxidative stress is one of the prime pathogenic factors going on in both human epilepsy and experimental epileptogenic models. PTZ-Seizure has been associated with over production of superoxide anion, reduced GSH levels, increased lipid peroxidation and protein oxidation in the hippocampus. Methodology: Forty male wistar rats were divided into 5 groups (normal saline, 200 mg/kg sodium valporate, 25% PMS, 50 % PMS and 100 % PMS) with each group receiving PTZ (35 mg/kg) on every alternate day for 30 days. Thirty minutes after each PTZ injection rats were observed for seizure behavior using the Racine scale. The hippocampal tissues were isolated, homogenized and used to determine SOD, CAT, GSH and MDA level. Result: This result revealed significant increase in the mean hippocampal SOD activity of PTZ-kindled wistar rats fed with PMS [25% (18.90 ± 1.08), 50% (18.90 ± 1.08, 24.90 ± 1.37) and 100 % (11.06 ± 0.58 IU/ mg protein) when compared to normal saline group (8.84 ± 0.96 IU/ mg protein). PM Supplementation increased mean CAT activity at 25% and 50% [25% (12.68 ± 0.68), 50% (8.74 ± 0.92) and 100% (15.66 ± 1.12 µg/ mg protein)] Vs normal saline treated group (9.60 ± 0.72 µg/ mg protein). A significant increase in mean hippocampal GSH concentration was seen in all the PMS fed wistar rats [25 % (29.52 ± 0.44), 50 % (24.42 ± 1.51) and 100 % (40.32 ± 1.43 µg/ mg protein)] when compared to normal saline (10.88 ± 0.32 µg/ mg protein). PTZ-kindled wistar rats fed with PMS [25% (86.62 ± 2.81), 50% (73.86 ± 3.26) and 100% (73.56 ± 1.82 nmol/ mg protein) showed significant decrease in the mean concentration of hippocampal MDA when compared to normal saline (119.90 ± 2.34 nmol/ mg protein). Conclusion: Supplementation with PG inhibits hippocampal redox imbalance and reinforces it antioxidant system.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75445040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischemic Cerebrovascular Accidents in HIV Patients on Antiretroviral Therapy: Clinical, Paraclinical And Prognostic Aspects in The Neurology Department of The University Hospital Center of Conakry","authors":"Barry Souleymane Djigué, Doré Malé Wenceslas Sossa, Diawara Karinka, Condé Mohamed Lamine, Mohamed Lamine Touré, Bognon Victor, F. Cissé","doi":"10.33425/2692-7918.1040","DOIUrl":"https://doi.org/10.33425/2692-7918.1040","url":null,"abstract":"Introduction: Ischemic stroke (Stroke) constitute, due to the demographic and epidemiological transition, a real challenge for developing countries and HIV infection, a real public health problem in these countries. The objective of our study was to describe aspects of clinical, paraclinical and prognostic ischemic stroke in people living with HIV (PLHIV) on antiretrovirals (ARVs). Material and methods: This was a prospective study of the descriptive type lasting 6 months from January 1, 2022 to June 31, 2022, relating to ischemic cerebrovascular accidents (DALYs) in HIV patients on ARVs.Were included patients admitted or hospitalized in the service for seropositive ischemic stroke under ARV for an average duration of 35.5 months. Patients recently put on ARVs and those with an obvious cause of DALY such as (diabetes, uncontrolled hypertension, emboligenic heart disease) were excluded. Results: During our study period, 336(94%) patients were listed. Among them, 20 have ischemic stroke associated with HIV on ARVs, i.e. 6%. This study showed that the average age of onset of ischemic stroke in PLHIV on ARV was 49 ± 11.6 years with a sex ratio F/M of 1.22. The risk factors were high blood pressure 13 (65%), diabetes 05 (25%), followed by alcohol 04 (20%). HIV type 1 was represented at 100%, then 16 (80%) of our patients were at WHO stage III with a CD4 count between 200 and 300 cells/µl09 (45%). The therapeutic line of ARVs was dominated by TDF+3TC+EFV at 14 (70%) followed by AZT+3TC+LPV/r at 04 (20%) and the average duration of patients on ARV was 35.5 months. The favorable evolution was marked 13 (65%), followed by a death in (10%) or 02. The location on the cerebral scanner was dominated by the sylvian artery in 12 (60%) of cases followed by the anterior cerebral artery (ACA) 06 (30%) and the posterior cerebral artery ( PCA) 02 (10%). Conclusion: Ischemic stroke in HIV patients on ARVs requires early management and regular monitoring","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88762007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Retinal Event Secondary to Ocular Ischemic Syndrome, Improved With QIAPI 1: Case Report","authors":"Arturo Solís Herrera, P. E. Solís Arias","doi":"10.33425/2692-7918.1039","DOIUrl":"https://doi.org/10.33425/2692-7918.1039","url":null,"abstract":"Ocular ischemic syndrome (OIS) is a rare condition, which is caused by ocular hypoperfusion due to stenosis or occlusion of the common or internal carotid arteries. Atherosclerosis is the major cause of changes in the carotid arteries. Since OIS is associated with atherosclerosis, patients usually have other related co-morbidities. Hypertension is found in 73% of the patients and diabetes mellitus in 56%. The first case of OIS was reported in 1963 by Hedges as a case with retinal hemorrhages and venous dilatation in a patient with complete occlusion of the internal carotid artery (ICA). The only therapy is to treat the neovascular complications. Recent studies suggest that OIS is associated with a significant risk of cerebrovascular, ocular, and systemic morbidity. OIS has a poor visual prognosis. It is imperative that the clinician be aware of the signs and symptoms of carotid disease to facilitate prompt diagnosis and appropriate referral, because OIS may be the presenting sign of serious ischemic cerebrovascular and ischemic heart disease. The 5-year mortality rate in OIS patients is as high as 40%. Most deaths are due to cardiac disease Controversy in the management of OIS arises from the fact that most patients reported in the literature are part of small retrospective series or case reports. Besides the uncertainty about the physio-pathogenic of the disease. Pan-retinal photocoagulation (PRP) is the accepted treatment for retinal ischemia predisposing to neovascularization due to retinal ischemia supposedly triggers the production of angiogenic growth factors. However, the main stimulus to abnormal angiogenesis is hypoxia more than ischemia, and opposite the best antiangiogenic factor is high levels of oxygen in tissues. Thereby, our discovery about the unexpected capacity of several organic molecules of the human body that can take the oxygen from intracellular water, like in plants, open a new way to treat these difficult cases, improving the prognosis.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77031086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basilar Heart-Shaped Aneurysm: Case Illustration","authors":"José Renan Miranda Cavalcante-Filho, Bruno Gonzales Miniello, J. M. de Almeida Silva, Andre Luiz Resende, Marcus Alexandre Cavalcanti Rotta","doi":"10.33425/2692-7918.1038","DOIUrl":"https://doi.org/10.33425/2692-7918.1038","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74130373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphylitical Myelopathies: Study of 8 observations at National Hospital Ignace Deen, University of Conakry","authors":"Touré Ml, Carlos Othon G, Baldé Th, Diallo Sm, Ballo BKJB,, A. Djibo Hamani, F. Sakadi, A. Sakho, DF Kassa, FA Cissé, A. Cissé","doi":"10.33425/2692-7918.1037","DOIUrl":"https://doi.org/10.33425/2692-7918.1037","url":null,"abstract":"Introduction: Myelopathies occurring in the context of neurosyphilis have been poorly studied clinically, radiologically and in tropical settings. The diagnostic certainty of the syphilitic etiology of myelopathy is difficult to establish because of the multiplicity of causes of spinal cord damage. Patients and Methods: We carried out a retrospective study of 269 patients hospitalized for spinal cord disorders between January 2015 and December 2021, among whom 8 (eight) patients were identified for progressive syphilitic myelopathy diagnosed by the positivity of VDRL-TPHA serological reactions in the blood and cerebrospinal fluid and radiological data. Magnetic resonance imaging was performed in all patients. Results: The neurological signs were limited to the existence of a sensory-motor spinal semiology in particular, paraparesis with sphincter disorders, especially moderate urinary disorders, without an obvious infectious syndrome in a context of positive serological reactions VDRL-TPHA in the blood and cerebrovascular fluid. spinal. Lumbar puncture shows hypercellularity with lymphocyte predominance on average 65% and hyperproteinorachia varying from 0.98 to 1.36 g/l. magnetic resonance imaging performed in all patients contributed to the diagnosis by showing hypersignals in T2, expression of more or less extensive lesions on several segments.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"81 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84741684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG -guided Characterization, Monitoring, and Therapy for Neurological and Neurocognitive Sequelae of COVID‐19 and Long COVID","authors":"S. Danev, Tori R Lakey, J. Lakey, Jonathan Lakeya","doi":"10.33425/2692-7918.1034","DOIUrl":"https://doi.org/10.33425/2692-7918.1034","url":null,"abstract":"The long-term effect of the newly emerged COVID-19 (SARS-CoV-2) virus has not been fully understood. It has been reported that several patients experienced neurological and neurocognitive problems after getting infected by the COVID-19 virus. This paper will review how the COVID-19 virus has impacted the brain, will aim to detect the location of COVID-19 in the brain, and will determine if the neurological complications are a result of “direct” or “indirect” effects of the virus on brain cells. Additionally, we will focus on the neurocognitive impact of COVID‐19 and the potential of digital electroencephalography (EEG), quantitative EEG (QEEG) and standardized low resolution brain electromagnetic tomography (sLORETA) to be able to capture, assess, monitor, characterize and facilitate the treatment of both neurological and neurocognitive sequelae seen in COVID‐19 and long COVID.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"33 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86083170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in Four Children with Persistent, Recurrent, and Progressive Gangliogliomas Treated in Phase II Studies with Antineoplastons A10 and AS2-1","authors":"Burzynski Stanislaw, Burzynski Gregory, Janicki Tomasz, Beenken Samuel","doi":"10.33425/2692-7918.1036","DOIUrl":"https://doi.org/10.33425/2692-7918.1036","url":null,"abstract":"Rationale: Gangliogliomas are generally benign tumors and are classified by the World Health Organization (WHO) as grade I or II tumors. However, in 1-5% of cases, gangliogliomas can behave more aggressively (WHO grade III) and have a worse prognosis. Four children with a ganglioglioma are presented to detail and discuss the efficacy of Antineoplastons A10 (Atengenal) and AS2-1 (Astugenal) in the treatment of gangliogliomas. Objectives: The children were treated with Antineoplastons A10 and AS2-1 (ANP therapy) at the Burzynski Clinic (BC) according to the phase II Protocols, BT-10 and BT-11. ANP therapy was delivered via subclavian catheter and infusion pump. During ANP therapy, tumor response was determined by comparison of sequential magnetic resonance imaging (MRI) of the brain with a baseline brain MRI. Findings: Of the four children treated for gangliogliomas, all had prior surgery but none had radiation therapy (RT) or chemotherapy. Two had recurrent, and progressive tumors with possible high-grade transformation (thalamo-mesencephalic region; temporal lobe with leptomeningeal spread) while two had tumors of the brain stem (persistent multicentric ganglioglioma; persistent and progressive ganglioglioma of the inferior medulla and superior cervical spinal cord), which are more difficult to treat and have a worse prognosis. Physical findings corresponded with the location of each child’s tumor. IV ANP therapy continued for 6.4 to 24.8 months. The two children with possible high-grade transformation achieved a partial response (PR) while the two children with brain stem tumors maintained stable disease (SD). Overall survival for these four children ranged from 10.3 to 22.4 years. Conclusions: The utilization of ANP therapy in children with gangliogliomas is presented. We conclude that ANP therapy is an attractive therapeutic option for children with gangliogliomas who are ineligible for or refuse surgical resection and/or demonstrate persistent, recurrent, or progressive disease with or without high-grade transformation following surgical resection..","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"32 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87939160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary adenomas and COVID-19 related disease in pandemic time: Clinical, pathological, immunohistochemical, and ultrastructure analysis","authors":"M. Tena Suck, Daniel Rocandio Hernández, Alma Ortiz Plata, S. Moreno-Jimenez, Jose Sandoval, M. Castillejos-López, J. Flores","doi":"10.33425/2692-7918.1033","DOIUrl":"https://doi.org/10.33425/2692-7918.1033","url":null,"abstract":"Introduction: Methods: 47 patients were emergency operated on due to pituitary apoplexy during the pandemic time. The patients were divided into two groups according to PCR COVID-19 positive vs negative test. Histopathology all cases showed varying degrees of necrosis, microthrombi formation secondary to inflammation, and endothelial cells injuries in association with TNFa, TNFk, FVIII, DPGF, HIF1a, Il6, Il10, Il17, DPGF, CD3, CD4, CD8, CD20, CD68, CD163, ACE2, and antiCOV immunoexpression. Results: 24 women and 23 men, age ranges from 21 to 76 years (mean 42.25±13.38), 14 (36%) presented positive COVID19 tests, and 30 (64%) were covid negative. 15 were already recurrences, 4 recurrences in the same year, and 4 died during the pandemic time. 9 (30%) showed histological data of stroke, of which necrosis around <25% were 8 (47%), 25-50% were 2 (12%) and >50% were 8 (45%). Weak vascular changes in 4 (24%), moderate in 7 (65%) and severe in 1, moderate, and intense in 1 (6%) were observed. Conclusions: Apoplexy in a previously diagnosed macro-PAD in the setting of a recent COVID-19 infection. The patients who presented with histological features of pituitary tumor infarction alone had less severe clinical features on presentation, a longer course before presentation, and a better outcome than those presenting with hemorrhagic infarction or frank hemorrhage. Hyperactivated and dysregulated immune cells pose a substantial danger for exacerbated tissue damage. COVID-19 may increase the risk of pituitary apoplexy, and we should be vigilant for signs of this. A more insidious pathological link between COVID-19 and apoplexy may exist in addition to severe inflammatory response.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"8 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73726922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic interventions of Amyotrophic Lateral Sclerosis (ALS)","authors":"A. Chakraborty, Anil Diwan","doi":"10.33425/2692-7918.1032","DOIUrl":"https://doi.org/10.33425/2692-7918.1032","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a non-demyelinating neurodegenerative disease mostly found in adults between 40 to 60 years old. This disease is usually prevalent in males, however it’s irrespective to the different genders. ALS is progressive and within 2-5 years of diagnosis ulimately ends with death. The majority of ALS cases is sporadic (90%) and is recorded without any defined aetiology. The other 10-12% of cases is recognized from mutations in more than 20 genes. The genes reported to cause ALS are Superoxide Dismutase 1 (SOD1), TAR DNA Binding Protein (TDP), Fused in Sarcoma, (FUS), Chromosome 9 Open Reading Frame 72 (c9orf72) and Vesicle-Associated Membrane-ProteinAssociated Protein B (VAPB). Furthermore, abnormal lipid metabolism with higher LDL/HDL ratio was reported in ALS patients. The aetiology of ALS is shown in the schematic diagram below (Figure 1) Due to the multi-nature of ALS causative factors and symptoms, there is no specific therapy for ALS today. However, this paper will touch on potential therapies that are in practice or may come up in the future. The goal is to maintain and improve the function of motor neuron, the well-being and quality of life for ALS patients. Until then, we have to rely on the symptomatic treatment and rehabilitative measures to support the patient’s quality of life.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"29 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83073766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conundrum of Cavum Septum Pellucidum in Expert Witness Testimony, Police Evidence And Neurobehavioural Consequence: Affecting Legal Practice And Criminal Justice?","authors":"S. Thompson","doi":"10.33425/2692-7918.1029","DOIUrl":"https://doi.org/10.33425/2692-7918.1029","url":null,"abstract":"Cavum septum pellucidum (CSP) is a rare condition when the septum pellucidum remains open to the inner ventricles within the brain. In many cases, CSP and the associated anatomical structure cavum vergae is thought to lead to anti-social and psychotic behaviour which poses a problem to those working in legal services. Controversy surrounds the possibility of congenital versus acquired conditions when CSP is found in those with repeated traumatic brain injuries such as professional athletes, American pro-footballers and professional and amateur boxers. Collecting police evidence and presenting expert testimony in the Courts is problematical when there is confusion over the acquisition of CSP. Treatment is compounded by differing presentations often involving psychosis which makes it a challenge to correctly place individuals within health service provision and penal institutions as well as offering appropriate treatment and criminal justice.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"57 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90496088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}