Restorative neurology and neuroscience最新文献

{"title":"Basilar Heart-Shaped Aneurysm: Case Illustration","authors":"José Renan Miranda Cavalcante-Filho, Bruno Gonzales Miniello, J. M. de Almeida Silva, Andre Luiz Resende, Marcus Alexandre Cavalcanti Rotta","doi":"10.33425/2692-7918.1038","DOIUrl":"https://doi.org/10.33425/2692-7918.1038","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74130373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphylitical Myelopathies: Study of 8 observations at National Hospital Ignace Deen, University of Conakry","authors":"Touré Ml, Carlos Othon G, Baldé Th, Diallo Sm, Ballo BKJB,, A. Djibo Hamani, F. Sakadi, A. Sakho, DF Kassa, FA Cissé, A. Cissé","doi":"10.33425/2692-7918.1037","DOIUrl":"https://doi.org/10.33425/2692-7918.1037","url":null,"abstract":"Introduction: Myelopathies occurring in the context of neurosyphilis have been poorly studied clinically, radiologically and in tropical settings. The diagnostic certainty of the syphilitic etiology of myelopathy is difficult to establish because of the multiplicity of causes of spinal cord damage. Patients and Methods: We carried out a retrospective study of 269 patients hospitalized for spinal cord disorders between January 2015 and December 2021, among whom 8 (eight) patients were identified for progressive syphilitic myelopathy diagnosed by the positivity of VDRL-TPHA serological reactions in the blood and cerebrospinal fluid and radiological data. Magnetic resonance imaging was performed in all patients. Results: The neurological signs were limited to the existence of a sensory-motor spinal semiology in particular, paraparesis with sphincter disorders, especially moderate urinary disorders, without an obvious infectious syndrome in a context of positive serological reactions VDRL-TPHA in the blood and cerebrovascular fluid. spinal. Lumbar puncture shows hypercellularity with lymphocyte predominance on average 65% and hyperproteinorachia varying from 0.98 to 1.36 g/l. magnetic resonance imaging performed in all patients contributed to the diagnosis by showing hypersignals in T2, expression of more or less extensive lesions on several segments.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"81 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84741684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG -guided Characterization, Monitoring, and Therapy for Neurological and Neurocognitive Sequelae of COVID‐19 and Long COVID","authors":"S. Danev, Tori R Lakey, J. Lakey, Jonathan Lakeya","doi":"10.33425/2692-7918.1034","DOIUrl":"https://doi.org/10.33425/2692-7918.1034","url":null,"abstract":"The long-term effect of the newly emerged COVID-19 (SARS-CoV-2) virus has not been fully understood. It has been reported that several patients experienced neurological and neurocognitive problems after getting infected by the COVID-19 virus. This paper will review how the COVID-19 virus has impacted the brain, will aim to detect the location of COVID-19 in the brain, and will determine if the neurological complications are a result of “direct” or “indirect” effects of the virus on brain cells. Additionally, we will focus on the neurocognitive impact of COVID‐19 and the potential of digital electroencephalography (EEG), quantitative EEG (QEEG) and standardized low resolution brain electromagnetic tomography (sLORETA) to be able to capture, assess, monitor, characterize and facilitate the treatment of both neurological and neurocognitive sequelae seen in COVID‐19 and long COVID.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"33 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86083170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in Four Children with Persistent, Recurrent, and Progressive Gangliogliomas Treated in Phase II Studies with Antineoplastons A10 and AS2-1","authors":"Burzynski Stanislaw, Burzynski Gregory, Janicki Tomasz, Beenken Samuel","doi":"10.33425/2692-7918.1036","DOIUrl":"https://doi.org/10.33425/2692-7918.1036","url":null,"abstract":"Rationale: Gangliogliomas are generally benign tumors and are classified by the World Health Organization (WHO) as grade I or II tumors. However, in 1-5% of cases, gangliogliomas can behave more aggressively (WHO grade III) and have a worse prognosis. Four children with a ganglioglioma are presented to detail and discuss the efficacy of Antineoplastons A10 (Atengenal) and AS2-1 (Astugenal) in the treatment of gangliogliomas. Objectives: The children were treated with Antineoplastons A10 and AS2-1 (ANP therapy) at the Burzynski Clinic (BC) according to the phase II Protocols, BT-10 and BT-11. ANP therapy was delivered via subclavian catheter and infusion pump. During ANP therapy, tumor response was determined by comparison of sequential magnetic resonance imaging (MRI) of the brain with a baseline brain MRI. Findings: Of the four children treated for gangliogliomas, all had prior surgery but none had radiation therapy (RT) or chemotherapy. Two had recurrent, and progressive tumors with possible high-grade transformation (thalamo-mesencephalic region; temporal lobe with leptomeningeal spread) while two had tumors of the brain stem (persistent multicentric ganglioglioma; persistent and progressive ganglioglioma of the inferior medulla and superior cervical spinal cord), which are more difficult to treat and have a worse prognosis. Physical findings corresponded with the location of each child’s tumor. IV ANP therapy continued for 6.4 to 24.8 months. The two children with possible high-grade transformation achieved a partial response (PR) while the two children with brain stem tumors maintained stable disease (SD). Overall survival for these four children ranged from 10.3 to 22.4 years. Conclusions: The utilization of ANP therapy in children with gangliogliomas is presented. We conclude that ANP therapy is an attractive therapeutic option for children with gangliogliomas who are ineligible for or refuse surgical resection and/or demonstrate persistent, recurrent, or progressive disease with or without high-grade transformation following surgical resection..","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"32 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87939160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary adenomas and COVID-19 related disease in pandemic time: Clinical, pathological, immunohistochemical, and ultrastructure analysis","authors":"M. Tena Suck, Daniel Rocandio Hernández, Alma Ortiz Plata, S. Moreno-Jimenez, Jose Sandoval, M. Castillejos-López, J. Flores","doi":"10.33425/2692-7918.1033","DOIUrl":"https://doi.org/10.33425/2692-7918.1033","url":null,"abstract":"Introduction: Methods: 47 patients were emergency operated on due to pituitary apoplexy during the pandemic time. The patients were divided into two groups according to PCR COVID-19 positive vs negative test. Histopathology all cases showed varying degrees of necrosis, microthrombi formation secondary to inflammation, and endothelial cells injuries in association with TNFa, TNFk, FVIII, DPGF, HIF1a, Il6, Il10, Il17, DPGF, CD3, CD4, CD8, CD20, CD68, CD163, ACE2, and antiCOV immunoexpression. Results: 24 women and 23 men, age ranges from 21 to 76 years (mean 42.25±13.38), 14 (36%) presented positive COVID19 tests, and 30 (64%) were covid negative. 15 were already recurrences, 4 recurrences in the same year, and 4 died during the pandemic time. 9 (30%) showed histological data of stroke, of which necrosis around <25% were 8 (47%), 25-50% were 2 (12%) and >50% were 8 (45%). Weak vascular changes in 4 (24%), moderate in 7 (65%) and severe in 1, moderate, and intense in 1 (6%) were observed. Conclusions: Apoplexy in a previously diagnosed macro-PAD in the setting of a recent COVID-19 infection. The patients who presented with histological features of pituitary tumor infarction alone had less severe clinical features on presentation, a longer course before presentation, and a better outcome than those presenting with hemorrhagic infarction or frank hemorrhage. Hyperactivated and dysregulated immune cells pose a substantial danger for exacerbated tissue damage. COVID-19 may increase the risk of pituitary apoplexy, and we should be vigilant for signs of this. A more insidious pathological link between COVID-19 and apoplexy may exist in addition to severe inflammatory response.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"8 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73726922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic interventions of Amyotrophic Lateral Sclerosis (ALS)","authors":"A. Chakraborty, Anil Diwan","doi":"10.33425/2692-7918.1032","DOIUrl":"https://doi.org/10.33425/2692-7918.1032","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a non-demyelinating neurodegenerative disease mostly found in adults between 40 to 60 years old. This disease is usually prevalent in males, however it’s irrespective to the different genders. ALS is progressive and within 2-5 years of diagnosis ulimately ends with death. The majority of ALS cases is sporadic (90%) and is recorded without any defined aetiology. The other 10-12% of cases is recognized from mutations in more than 20 genes. The genes reported to cause ALS are Superoxide Dismutase 1 (SOD1), TAR DNA Binding Protein (TDP), Fused in Sarcoma, (FUS), Chromosome 9 Open Reading Frame 72 (c9orf72) and Vesicle-Associated Membrane-ProteinAssociated Protein B (VAPB). Furthermore, abnormal lipid metabolism with higher LDL/HDL ratio was reported in ALS patients. The aetiology of ALS is shown in the schematic diagram below (Figure 1) Due to the multi-nature of ALS causative factors and symptoms, there is no specific therapy for ALS today. However, this paper will touch on potential therapies that are in practice or may come up in the future. The goal is to maintain and improve the function of motor neuron, the well-being and quality of life for ALS patients. Until then, we have to rely on the symptomatic treatment and rehabilitative measures to support the patient’s quality of life.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"29 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83073766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conundrum of Cavum Septum Pellucidum in Expert Witness Testimony, Police Evidence And Neurobehavioural Consequence: Affecting Legal Practice And Criminal Justice?","authors":"S. Thompson","doi":"10.33425/2692-7918.1029","DOIUrl":"https://doi.org/10.33425/2692-7918.1029","url":null,"abstract":"Cavum septum pellucidum (CSP) is a rare condition when the septum pellucidum remains open to the inner ventricles within the brain. In many cases, CSP and the associated anatomical structure cavum vergae is thought to lead to anti-social and psychotic behaviour which poses a problem to those working in legal services. Controversy surrounds the possibility of congenital versus acquired conditions when CSP is found in those with repeated traumatic brain injuries such as professional athletes, American pro-footballers and professional and amateur boxers. Collecting police evidence and presenting expert testimony in the Courts is problematical when there is confusion over the acquisition of CSP. Treatment is compounded by differing presentations often involving psychosis which makes it a challenge to correctly place individuals within health service provision and penal institutions as well as offering appropriate treatment and criminal justice.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"57 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90496088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip Fracture As A Potential Contributor To Cognitive Decline And Dementia","authors":"S. Thompson","doi":"10.33425/2692-7918.1030","DOIUrl":"https://doi.org/10.33425/2692-7918.1030","url":null,"abstract":"This paper reviews the possible link between hip fracture and cognitive decline and dementia. There is a growing body of clinical research literature that indicates that cognitive decline is associated with the presence of delirium and that delirium is a predictor of dementia. Hip fracture is thought to be an independent factor that may lead to cognitive decline and dementia. It is suggested that cost implications should not become an obstacle to determining the best course of rehabilitation when delirium signals the need for preventive measures to protect the welfare of patients with hip fracture.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"110 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87714902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The patient-centered care for patients with acute myocardial infarction: what can be improved the disease management","authors":"Cláudia Amaro dos Santos, Telmo Pequito, A. Fonseca","doi":"10.33425/2692-7918.1028","DOIUrl":"https://doi.org/10.33425/2692-7918.1028","url":null,"abstract":"Introduction: Cardiovascular diseases are presented as a set of diseases that affect the cardiovascular system because of inappropriate lifestyles or unhealthy, they are consistent in risk might be modifiable through a proper disease management factor. Aim: Assess the perceptions of patients with acute myocardial infarction about this heart disease and risk factors associated. Also, identify the risk factors that can be improved to manage the disease. Design: Observational and prospective study. Methods: The survey was conducted in a Cardiac Intensive Care Unit of a Central Hospital, with inclusion of all patients admitted on a period of two months. Nineteen patients were studied with a clinical diagnosis of Acute Myocardial Infarction. Results: The analysis of the questionnaires showed that, approach the subject has a justified and reasoned relevance. The high prevalence of risk factors that can be modified highlighted the need for intervention in patients with non-modifiable risk factors. Conclusion: Patients with acute myocardial infarction do not have a correct perception of the disease and associated factors. Many of the risk factors present in patients with acute myocardial infarction are likely to be modified by an appropriate disease management, with a patient-centred care.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"51 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72489076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon monoxide poisoning: Recommendations for neuropsychological assessment","authors":"S. Thompson","doi":"10.33425/2692-7918.1031","DOIUrl":"https://doi.org/10.33425/2692-7918.1031","url":null,"abstract":"Carbon monoxide poisoning is potentially significant in terms of mortality rates, and survivors can have serious deleterious neurological consequences. Diagnosis may be hampered because of symptoms that are similar to other benign conditions. Neuropsychological assessment is complicated due to the need to assess potentially global brain dysfunction. Assessment recommendations are presented and discussed together with an overview of treatment options.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"36 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80038501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}