Restorative neurology and neuroscience最新文献

{"title":"Utility and User Experience with 3-Dimensional Vibrotactile Kinesthetic Feedback for Improving Reach-to-Grasp Accuracy and Efficiency After Stroke: A Case Series.","authors":"Rachel N Mazorow, Ramsey K Rayes, Joana Flores, Gina H Guidarelli, Kimberly D Bassindale, Robert A Scheidt","doi":"10.1177/09226028261429797","DOIUrl":"10.1177/09226028261429797","url":null,"abstract":"<p><p>Recent studies have shown that supplemental sensory feedback systems have potential to mitigate functional impairment after neuromotor injury through mechanisms of sensory augmentation or replacement. In this proof-of-concept case series, we evaluated multi-session 3-dimensional kinesthetic vibrotactile feedback training as a means to enhance the accuracy and efficiency of goal-directed reaching in the absence of visual feedback in survivors of stroke. A motion capture system converted real-time position of the contralesional hand within a Cartesian frame of reference into spatiotemporal patterns of vibrotactile feedback provided to the non-moving, ipsilesional arm. Seven survivors of stroke underwent 9 hours of reach-to-grasp training under conditions that encouraged them to learn a mapping from hand position to patterns of vibrotactile feedback. We then assessed their ability to use that feedback to improve the accuracy and efficiency of reaches performed without concurrent visual feedback. Within-subject comparisons to baseline performance revealed heterogeneous learning effects on reaching both with and without supplemental vibrotactile feedback. When reaching with the supplemental feedback after training, three participants significantly improved reach accuracy, two significantly improved temporal efficiency, and three significantly improved spatial efficiency (although one significantly worsened with regard to spatial efficiency). Further, all but one of the participants who exhibited post-training performance changes during movements made with the supplemental feedback also exhibited similar post-training performance changes during movements made without the supplemental feedback. These results suggest that while a subset of stroke survivors may accrue benefits from using the form of supplemental vibrotactile kinesthetic feedback described in the paper, the effects of such training resulted primarily from ancillary benefits provided by the 9 hours of intensive reach-to-grasp training with the feedback, rather than from the ongoing use of the feedback itself. Despite the mixed kinematic results, responses to standard surveys of subjective experience suggest that training with the vibrotactile display had acceptable usability and was both motivating and satisfying to use. We conclude that while the wearable technology may provide a positive user experience, practical benefits (e.g., increased reach accuracy or efficiency) may accrue more from hours of focused reach training than from the additional sensory information provided by the vibrotactile interface. (National Clinical Trial Number: NCT03298243; clinicaltrials.gov/study/NCT03298243).</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"235-255"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13315564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft vs. Traditional AFOs: A Comparative Study on Gait Kinematics, Kinetics, and Muscle Activity.","authors":"Thomas E Augenstein, Breanna Bordine, Nyari Bhatt, Shreeya Buddaraju, Olugbenga P Adeeko, Edward P Washabaugh, Chandramouli Krishnan","doi":"10.1177/09226028251395707","DOIUrl":"10.1177/09226028251395707","url":null,"abstract":"<p><p>Reduced toe clearance during the swing phase of gait, often referred to as foot drop, is a common cause of walking disability in clinical populations like stroke, cerebral palsy, or multiple sclerosis. Individuals with foot drop often wear an ankle-foot orthosis (AFO) to prevent excessive plantarflexion, but many commercially available AFOs overly restrict ankle mobility or make the wearer feel unstable/uncomfortable. Soft AFOs-AFOs with soft attachment points and elastic assistance-are designed to retain ankle mobility and comfort. However, their effect on gait biomechanics, as compared to traditional AFOs, is not well understood. Therefore, the objective of the current study was to perform a comprehensive biomechanical and neurophysiological comparison of soft AFOs with traditional AFOs. Sagittal plane kinematics, ground reaction forces, and lower extremity muscle activation were measured in 23 neurologically intact individuals while walking on a treadmill without assistance from an AFO (No AFO) and then with unilateral assistance from four commercially available AFOs (rigid anterior, flexible posterior leaf spring, and two soft AFOs). We found that soft AFOs allowed for greater ankle dorsiflexion velocity, plantarflexion velocity, and plantarflexion angle while retaining or increasing dorsiflexion during the swing phase. We also found that the traditional AFOs reduced propulsive ground reaction forces compared to the soft AFOs, and the rigid anterior AFO reduced plantarflexor muscle activity compared to the soft AFOs. These results highlight the differences between different commercially available AFOs and present soft AFOs as an exciting alternative to traditional AFOs when ankle mobility is desired.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"219-234"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13315552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Ketogenic Diet as Adjunctive Therapy in Multiple Sclerosis: A Review.","authors":"Sana Rasheed, Muhammad Uzair, Muhammad Anas, Syeda Sakina Batool Naqvi, Umaima Aijaz, Ahmed Asad Raza, Abedin Samadi","doi":"10.1177/09226028251404071","DOIUrl":"10.1177/09226028251404071","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system, leading to inflammation, demyelination, and neurodegeneration. Although disease-modifying therapies (DMTs) have shown efficacy in reducing relapse rates, they offer limited benefit in addressing cognitive symptoms and overall disease burden. The ketogenic diet (KD), a high-fat, low-carbohydrate dietary approach, has emerged as a promising adjunctive strategy. Recent research suggests that KD may modulate key inflammatory pathways, enhance mitochondrial function, and reduce oxidative stress through mechanisms involving ketone bodies such as β-hydroxybutyrate. These effects have been linked to improvements in fatigue, cognition, quality of life, and markers of neuronal injury in individuals with MS. Furthermore, KD may positively influence the gut microbiome, insulin sensitivity, and myelin repair processes. Despite encouraging results, challenges such as dietary adherence, nutrient deficiencies, gastrointestinal side effects, and cardiovascular risks limit widespread adoption. Current evidence is largely based on short-term studies with limited diversity and variable dietary protocols. Future research should focus on long-term safety, standardized guidelines, and personalized strategies to better integrate KD into comprehensive MS care.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"28-36"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-stroke Fatigue and Brain Excitability: An Exploratory TMS Study.","authors":"Hui-Ting Goh, Jill C Stewart, Yu-Chen Chung, Kevin Becker, Ty Shang","doi":"10.1177/09226028251396318","DOIUrl":"10.1177/09226028251396318","url":null,"abstract":"<p><p>The purpose of this study was to explore the relationship between brain excitability indexed using different transcranial magnetic stimulation (TMS) measures and post-stroke fatigue (PSF) in individuals with mild to moderate motor impairment. We used single- and paired-pulse TMS to obtain various TMS outcomes from 24 participants with chronic stroke: resting motor threshold (RMT), motor evoked potential amplitude (MEP), Input-Output Curve (IOC) slope, short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF). IO curve slope (ρ = -0.61, p = 0.02) and SICI (ρ = -0.51, p = .03) measured from the ipsilesional hemisphere correlated with PSF. Other TMS measures were not significantly correlated with PSF measures. Findings suggest that higher levels of fatigue were associated with lower brain excitability. Together with previous studies, our findings suggest that level of motor impairment and the tool used to assess fatigue might influence the relationship between brain excitability and PSF.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"15-27"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based Functional Electrical Stimulation for Treatment of Patients with Facial Nerve Paralysis.","authors":"Maren Geitner, Jonas Ballmaier, Johannes Krauß, Gabriel Meincke, Anna-Maria Kuttenreich, Dirk Arnold, Winfried Mayr, Carsten Klingner, Valeria Mastryukova, Orlando Guntinas-Lichius, Gerd Fabian Volk","doi":"10.1177/09226028251395721","DOIUrl":"10.1177/09226028251395721","url":null,"abstract":"<p><p>Peripheral facial paralysis results in complete loss of contractibility in facial muscles, atrophy and asymmetry. Patients performed functional electrical stimulation (FES) home training twice daily over 1 year to show its effect and define stimulation parameters. A specific response was obtained in all 10 patients. Since the mean phase duration (PD) could be reduced (155.0 ± 55.0 to 51.0 ± 12.4 msec), this allowed the mean stimulation frequency to be increased (1.3 ± 0.5 to 5.0 Hz ± 1.5 Hz). The PD reduction to generate the same charge increased the voltage (16.2 ± 2.5 to 27.2 V ± 5.9). A suitable combination of PD and amplitude elicited a selective response without activation of other facial muscles using a PD of ≥ 25 ms (> 25 000 µs). FES changes the stimulation parameters for improving the training effect on denervated facial muscles. It prevents denervation atrophy and stops facial asymmetry.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"3-14"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Picture is Worth a Thousand Clinical Assessments: Use of Video-Based Pose Estimation to Augment Post-Stroke Upper Limb Assessment of Bilateral Tasks.","authors":"Rachel L Hawe, Shelby Ziccardi, Desmond Asante, Stephen J Guy","doi":"10.1177/09226028251408783","DOIUrl":"10.1177/09226028251408783","url":null,"abstract":"<p><p>Clinical assessments of the post-stroke upper limbs have several limitations in that they focus primarily on unilateral movements, rely on observer-based ordinal scales, and give limited insight into movement quality. Human pose estimation uses computer vision to extract motion data from videos, making it a clinically feasible tool to assess movement and overcome many challenges of traditional clinical assessments. Our objective of this work was to demonstrate the use of video-based pose estimation to enhance the assessment of bilateral tasks in individuals post-stroke through visualizations and quantitative metrics. Using single camera video recordings of the Chedoke Hand and Arm Activity Inventory in two individuals with chronic stroke and one neurologically intact individual, we demonstrate differences in movement patterns including increased compensatory movements of proximal joints and asymmetries. We were able to detect differences that the traditional assessment scoring could not, demonstrating the potential of computer vision to enhance clinical assessment.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"37-48"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13044263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: Appointment of New Editor-in-Chief Henriette van Praag, MD, PhD as Co-Editor-in-Chief of Restorative Neurology and Neuroscience.","authors":"","doi":"10.1177/09226028251396770","DOIUrl":"https://doi.org/10.1177/09226028251396770","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"43 3-4","pages":"79"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Balance Coordination Program on Postural Stability in Children with Dyslexia: An Observational Clinical Study.","authors":"Rekib Sacaklidir, Evrim Karadag Saygi, Kardelen Gencer Atalay, Nurullah Eren, Ayse Burcu Erdogdu Yıldırım","doi":"10.1177/09226028251347430","DOIUrl":"10.1177/09226028251347430","url":null,"abstract":"<p><p>BackgroundThe aim of study was to determine changes in the balance parameters after balance-coordination program in children with dyslexia.MethodsProspectively sixteen children with dyslexia were included. Balance parameters of dyslexic children were compared with healthy children. Dyslexic children were given balance coordination exercises three times a week for six weeks. The static and dynamic balance were tested with the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) and Limits of Stability (LOS) tests and Pediatric Quality of Life Inventory Scale (PedsQL) was used to assess quality of life.ResultsPostural sway velocities on the firm and foam surfaces with eyes opened and closed conditions of mCTSIB were found to be decreased and movement velocity, endpoint excursion, and maximum excursion in anterior and posterior directions of LOS, social, school and total scores of PedsQL increased in the dyslexia group after the treatment (p < 0,01).ConclusionThe children with dyslexia have distinct alterations on balance compared to their peers. These alterations, along with their quality of life, have shown to be greatly improved after a exercise program.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"80-88"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics in Acute Stroke and Transient Ischemic Attack Measured with Accelerometers.","authors":"Ilona Ruotsalainen, Carolynn Patten, Timo Niemirepo, Juha Pajula, Heidi Similä, Milla Immonen","doi":"10.1177/09226028251395715","DOIUrl":"10.1177/09226028251395715","url":null,"abstract":"<p><p>Gait impairments are a well-documented consequence of stroke, yet the impact of transient ischemic attack (TIA) on gait remains underexplored. This study aimed to characterize acute changes in gait patterns within three days of stroke or TIA onset using an accelerometer, and to examine the relationship between gait patterns and questionnaire-based measures of balance confidence. We found that patients with TIA showed significantly lower variability in swing time, stance time, and step time than patients with stroke. Comparisons between patients with TIA and controls indicated that controls had higher mean step velocity and lower step time asymmetry. Additionally, compared with controls, patients with stroke demonstrated a slower and less temporally consistent pace, indicated by shorter step length, lower step velocity, and higher standard deviation (SD) for swing time, stance time, and step time. They also showed greater variability, reflected by higher step length SD, and more pronounced gait asymmetry, with greater asymmetry in swing time, step time, and stance time. The balance confidence was associated with gait parameters in patients with stroke and in controls, but not in patients with TIA. In both groups, higher confidence related to longer step length and faster step velocity; in stroke it was also linked to lower swing time variability and longer step and stance times, and in controls to lower step time variability. These findings demonstrate that TIA involves detectable neurological changes affecting motor control, highlighting the value of detailed accelerometer-based gait analysis for early detection of functional deficits.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"112-121"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13328929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: Appointment of New Editor-in-Chief Henriette van Praag, MD, PhD as Co-Editor-in-Chief of Restorative Neurology and Neuroscience.","authors":"","doi":"10.1177/09226028251396770","DOIUrl":"10.1177/09226028251396770","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"79"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}