Reproductive Medicine and Biology最新文献_第8页

The effectiveness of controlled ovarian stimulation with tamoxifen for patients with estrogen-sensitive breast cancer: A systematic review and meta-analysis. 他莫昔芬控制性卵巢刺激治疗雌激素敏感性乳腺癌症患者的有效性：一项系统综述和荟萃分析。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-09-23 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12543

Tsukasa Yoshida, Osamu Takahashi, Yoko Suzuki, Erika Ota, Tetsuya Hirata

{"title":"The effectiveness of controlled ovarian stimulation with tamoxifen for patients with estrogen-sensitive breast cancer: A systematic review and meta-analysis.","authors":"Tsukasa Yoshida, Osamu Takahashi, Yoko Suzuki, Erika Ota, Tetsuya Hirata","doi":"10.1002/rmb2.12543","DOIUrl":"10.1002/rmb2.12543","url":null,"abstract":"Purpose: Tamoxifen is used for the suppression of estrogen-sensitive tumor recurrence in oocyte retrieval cycles. This meta-analysis aimed to evaluate the quality of controlled ovarian stimulation (COS) with co-administration of gonadotropins and tamoxifen (COS with tamoxifen).Methods: PubMed, Embase, and Cochrane Library were searched for articles on October 30, 2022. The authors included studies comparing COS with tamoxifen and COS with gonadotropins and letrozole (COS with letrozole) or gonadotropin only (COS with gonadotropin only) for fertility preservation in patients with breast cancer. The main outcome measures were the COS quality, total number of retrieved oocytes (TOR), total number of mature oocytes (TMO), and peak estradiol levels (PEL).Results: Four studies (348 patients, two randomized controlled trials, and two cohort studies) were included in our meta-analysis. There was no significant difference in TOR (95% CI, [-3.84, 2.90]) and TMO (95% CI, [-2.20, 2.64]) between COS with tamoxifen and COS with letrozole. There was also no difference in TOR (95% CI, [-6.14, 1.86]) between COS with tamoxifen and COS with gonadotropin only. Statistically significant decrease was observed in PEL during COS with letrozole compared with tamoxifen (95% CI, [1414.4, 4953.7]).Conclusions: The quality did not differ between COS with tamoxifen and COS with letrozole or gonadotropin only.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12543"},"PeriodicalIF":2.7,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis. 亚洲子宫内膜异位症和子宫腺肌症学会子宫腺肌症管理指南。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-09-10 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12535

Tasuku Harada, Fuminori Taniguchi, Sun-Wei Guo, Young Min Choi, Kutay Omer Biberoglu, Shaw-Jenq Sean Tsai, Saeed Alborzi, Moamar Al-Jefout, Amphan Chalermchokcharoenkit, Angela G Sison-Aguilar, Yoke-Fai Fong, Hemantha Senanayake, Alexander Popov, Andon Hestiantoro, Yuval Kaufman

引用次数: 0

Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis. 对患有子宫内膜异位症的绒猴施用脐带间充质干细胞的影响。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-09-08 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12540

Shunichiro Tsuji, Takeo Mukai, Hideaki Tsuchiya, Chizuru Iwatani, Akiko Nakamura, Tokiko Nagamura-Inoue, Takashi Murakami

{"title":"Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis.","authors":"Shunichiro Tsuji, Takeo Mukai, Hideaki Tsuchiya, Chizuru Iwatani, Akiko Nakamura, Tokiko Nagamura-Inoue, Takashi Murakami","doi":"10.1002/rmb2.12540","DOIUrl":"10.1002/rmb2.12540","url":null,"abstract":"Purpose: This study aimed to explore whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be used as a therapeutic resource for endometriosis.Methods: Of seven cynomolgus monkeys with endometriosis, five were administered UC-MSCs (intervention group) and two were administered saline (control group). First, intravenous US-MSC treatment was administered for three months. Second, weekly intravenous US-MSC administration combined with monthly intraperitoneal US-MSC administration was conducted for 3 months. Finally, weekly intraperitoneal US-MSC administration was conducted for 3 months. The dose of UC-MSCs was set to 2 × 106 cells/kg for all administration routes. Laparoscopic findings and serum cancer antigen 125 (CA125) levels were also evaluated. The Revised American Society for Reproductive Medicine classification was used for laparoscopic evaluation.Results: Laparoscopic findings showed exacerbation of endometriosis after intraperitoneal UC-MSC administration, although no changes were observed in the control group. Intravenous UC-MSC administration decreased the level of CA125 in all monkeys; however, the difference was not significant. Intraperitoneal UC-MSC administration significantly exacerbated endometriosis compared with intravenous administration (p = 0.02).Conclusions: This study revealed that intraperitoneal UC-MSC administration exacerbates endometriosis in a nonhuman primate model of the disease.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12540"},"PeriodicalIF":2.7,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10213174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging structural and pathological analyses on the erectile organ, corpus cavernous containing sinusoids. 对勃起器官、海绵体窦道的新结构和病理分析。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-09-01 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12539

Daiki Hashimoto, Kota Fujimoto, Sang Woon Kim, Yong Seung Lee, Masanori Nakata, Kentaro Suzuki, Yoshitaka Wada, Shinichi Asamura, Gen Yamada

{"title":"Emerging structural and pathological analyses on the erectile organ, corpus cavernous containing sinusoids.","authors":"Daiki Hashimoto, Kota Fujimoto, Sang Woon Kim, Yong Seung Lee, Masanori Nakata, Kentaro Suzuki, Yoshitaka Wada, Shinichi Asamura, Gen Yamada","doi":"10.1002/rmb2.12539","DOIUrl":"10.1002/rmb2.12539","url":null,"abstract":"Background: The corpus cavernosum (CC) containing sinusoids plays fundamental roles for erection. Analysis of pathological changes in the erectile system is studied by recent experimental systems. Various in vitro models utilizing genital mesenchymal-derived cells and explant culture systems are summarized.Methods: 3D reconstruction of section images of murine CC was created. Ectopic chondrogenesis in aged mouse CC was shown by a gene expression study revealing the prominent expression of Sox9. Various experimental strategies utilizing mesenchyme-derived primary cells and tissue explants are introduced.Main findings: Possible roles of Sox9 in chondrogenesis and its regulation by several signals are suggested. The unique character of genital mesenchyme is shown by various analyses of external genitalia (ExG) derived cells and explant cultures. Such strategies are also applied to the analysis of erectile contraction/relaxation responses to many signals and aging process.Conclusion: Erectile dysfunction (ED) is one of the essential topics for the modern aged society. More comprehensive studies are necessary to reveal the nature of the erectile system by combining multiple cell culture strategies.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12539"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10506565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paracrine regulation of granulosa cell development in the antral follicles in mammals. 哺乳动物中腔卵泡颗粒细胞发育的旁分泌调节。

IF 3.4 3区医学

Reproductive Medicine and Biology Pub Date : 2023-08-26 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12538

Koji Sugiura, Natsumi Maruyama, Yuki Akimoto, Kodai Matsushita, Tsutomu Endo

{"title":"Paracrine regulation of granulosa cell development in the antral follicles in mammals.","authors":"Koji Sugiura, Natsumi Maruyama, Yuki Akimoto, Kodai Matsushita, Tsutomu Endo","doi":"10.1002/rmb2.12538","DOIUrl":"10.1002/rmb2.12538","url":null,"abstract":"Background: Development of ovarian follicles is regulated by a complex interaction of intra- and extra-follicular signals. Oocyte-derived paracrine factors (ODPFs) play a central role in this process in cooperation with other signals.Methods: This review provides an overview of the recent advances in our understanding of the paracrine regulation of antral follicle development in mammals. It specifically focuses on the regulation of granulosa cell development by ODPFs, along with other intrafollicular signals.Main findings: Bi-directional communication between oocytes and surrounding cumulus cells is a fundamental mechanism that determines cumulus cell differentiation. Along with estrogen, ODPFs promote the expression of forkhead box L2, a critical transcription factor required for mural granulosa cells. Follicle-stimulating hormone (FSH) facilitates these processes by stimulating estrogen production in mural granulosa cells.Conclusion: Cooperative interactions among ODPFs, FSH, and estrogen are critical in determining the fate of cumulus and mural granulosa cells, as well as the development of oocytes.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12538"},"PeriodicalIF":3.4,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/b2/RMB2-22-e12538.PMC10457553.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10109826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of the embryo banking on the cumulative live birth rate in women with poor ovarian response according to the Bologna criteria. 根据博洛尼亚标准，胚胎银行对卵巢反应差的妇女累积活产率的影响。

IF 3.4 3区医学

Reproductive Medicine and Biology Pub Date : 2023-08-26 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12533

Qiu Lin Ge, Xiao Ming Teng, Miao Xin Chen, Kun Ming Li, Ernest Hung Yu Ng, Zhi Qin Chen

{"title":"The impact of the embryo banking on the cumulative live birth rate in women with poor ovarian response according to the Bologna criteria.","authors":"Qiu Lin Ge, Xiao Ming Teng, Miao Xin Chen, Kun Ming Li, Ernest Hung Yu Ng, Zhi Qin Chen","doi":"10.1002/rmb2.12533","DOIUrl":"10.1002/rmb2.12533","url":null,"abstract":"Purpose: To evaluate the impact of embryo banking on the cumulative live birth rate (CLBR) and the time to live birth (TTLB) in poor ovarian responders (POR) according to the Bologna criteria.Methods: A total of 276 infertile women undergoing IVF with POR were included in this retrospective study. They were divided into two groups with (n = 121) or without (n = 155) embryo banking at the discretion of the attending physicians. A total of 656 and 405 stimulation cycles were started in the two groups respectively during the 24 month follow-up.Results: The biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth rate per transfer were comparable between two groups (p > 0.05). The CLBR was significantly lower in the banking group than in the non-banking group (31.4% (38/121) and 43.2% (67/151), p < 0.05). TTLB was significantly longer in the banking group (20.5 months vs. 16.0 months, p < 0.001). In the Kaplan-Meier analysis, the cumulative incidence of live birth was significantly lower in the banking group compared with the non-banking group (Log rank test, chi-square = 21.958, p < 0.001).Conclusions: Embryo banking in women undergoing IVF with POR based on the Bologna criteria reduces CLBR and lengthens TTLB when compared with no embryo banking.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12533"},"PeriodicalIF":3.4,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10109823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum leucine-rich α2-glycoprotein as a possible marker for inflammatory status in endometriosis. 血清富亮氨酸 α2-糖蛋白可能是子宫内膜异位症炎症状态的标记物。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-08-21 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12536

Mio Kobayashi, Orie Nakamura, Yoshikazu Kitahara, Naoki Inoue, Yumiko Tsukui, Yuko Hasegawa, Hikaru Hiraishi, Atsushi Yabuki, Ayako Muraoka, Satoko Osuka, Akira Iwase

{"title":"Serum leucine-rich α2-glycoprotein as a possible marker for inflammatory status in endometriosis.","authors":"Mio Kobayashi, Orie Nakamura, Yoshikazu Kitahara, Naoki Inoue, Yumiko Tsukui, Yuko Hasegawa, Hikaru Hiraishi, Atsushi Yabuki, Ayako Muraoka, Satoko Osuka, Akira Iwase","doi":"10.1002/rmb2.12536","DOIUrl":"10.1002/rmb2.12536","url":null,"abstract":"Purpose: This study aimed to investigate whether serum leucine-rich α2-glycoprotein (LRG) is a useful diagnostic biomarker for endometriosis, including the evaluation of treatment efficacy and exploration of LRG production in endometriotic lesions.Methods: Forty-three women with endometriomas were compared to 22 women with benign ovarian cysts and 30 women who underwent assisted reproduction as controls. Changes in serum LRG levels were assessed before and after surgery, and during dienogest treatment. LRG expression in endometriotic tissue samples was evaluated using immunoblotting.Results: Serum LRG levels in the endometrioma group (80.0 ± 36.3 μg/mL) were significantly higher than those in the benign ovarian cyst (65.1 ± 27.0 μg/mL, p = 0.0265) and control (57.8 ± 22.3 μg/mL, p = 0.0028) groups. Serum LRG levels after endometrioma surgery were significantly lower than preoperative levels (p = 0.0484). Serum LRG levels consistently decreased during dienogest treatment. LRG expression levels were significantly higher in endometriotic tissues than in the normal endometrium.Conclusion: Serum LRG, possibly derived from local and systemic origins, could be used as a potential biomarker for the diagnosis and treatment of endometriosis.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12536"},"PeriodicalIF":2.7,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/ee/RMB2-22-e12536.PMC10441181.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10058013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small GTP-binding protein Rap1 mediates EGF and HB-EGF signaling and modulates EGF receptor expression in HTR-8/SVneo extravillous trophoblast cells. 小 GTP 结合蛋白 Rap1 在 HTR-8/SVneo 滋养层外细胞中介导 EGF 和 HB-EGF 信号转导并调节 EGF 受体的表达。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-08-21 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12537

Mikihiro Yoshie, Kensuke Ohishi, Gen Ishikawa, Atsuya Tsuru, Kazuya Kusama, Mana Azumi, Kazuhiro Tamura

{"title":"Small GTP-binding protein Rap1 mediates EGF and HB-EGF signaling and modulates EGF receptor expression in HTR-8/SVneo extravillous trophoblast cells.","authors":"Mikihiro Yoshie, Kensuke Ohishi, Gen Ishikawa, Atsuya Tsuru, Kazuya Kusama, Mana Azumi, Kazuhiro Tamura","doi":"10.1002/rmb2.12537","DOIUrl":"10.1002/rmb2.12537","url":null,"abstract":"Purpose: Extravillous trophoblasts (EVTs) invade the endometrium to establish a fetomaternal interaction during pregnancy. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor (HB-EGF) stimulate EVT invasion by binding to the EGF receptor (EGFR). We examined the role of the small GTP-binding protein Rap1 in EGF- and HB-EGF-stimulated EVT invasion.Methods: Expression of Rap1 in the first-trimester placenta was examined by immunohistochemistry. Effect of EGF or HB-EGF on Rap1 activation (GTP-Rap1) and Rap1 knockdown on invasion was assessed in EVT cell line (HTR-8/SVneo). In addition, effect of Rap1 knockdown and Rap1GAP (a Rap1 inactivator) overexpression on the activation of EGF signaling and EGFR expression were examined.Results: Rap1 was expressed by EVTs, villous cytotrophoblasts, and syncytiotrophoblasts in the placenta. EGF and HB-EGF activated Rap1 and promoted invasion of HTR-8/SVneo, and these effects were inhibited by Rap1 knockdown. The EGF- and HB-EGF-induced phosphorylation of AKT, ERK1/2, p38MAPK, and Src was inhibited by Rap1 knockdown. Furthermore, the knockdown of Rap1 reduced the EGFR protein level. Overexpression of Rap1GAP repressed EGF- and HB-EGF-induced Rap1 activation and reduced EGFR expression.Conclusion: Rap1 may function as a mediator of EGF and HB-EGF signaling pathways and can modulate EGFR expression in EVTs during placental development.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12537"},"PeriodicalIF":2.7,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/7e/RMB2-22-e12537.PMC10442520.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10421758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer. 研究一种通过双重刺激为癌症患者提取卵母细胞的有效方法。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-08-17 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12534

Hiroki Takeuchi, Tadashi Maezawa, Katsuyuki Hagiwara, Yuki Horage, Tetsuro Hanada, Huang Haipeng, Mito Sakamoto, Mikiko Nishioka, Erina Takayama, Kento Terada, Eiji Kondo, Yasushi Takai, Nao Suzuki, Tomoaki Ikeda

{"title":"Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer.","authors":"Hiroki Takeuchi, Tadashi Maezawa, Katsuyuki Hagiwara, Yuki Horage, Tetsuro Hanada, Huang Haipeng, Mito Sakamoto, Mikiko Nishioka, Erina Takayama, Kento Terada, Eiji Kondo, Yasushi Takai, Nao Suzuki, Tomoaki Ikeda","doi":"10.1002/rmb2.12534","DOIUrl":"10.1002/rmb2.12534","url":null,"abstract":"Purpose: To examine the optimal timing of second ovarian stimulation using the dual stimulation method for good ovarian responders with cancer undergoing oocyte retrieval for fertility preservation.Methods: A retrospective analysis was conducted using data from 69 patients with cancer who underwent oocyte retrieval for fertility preservation at four Japanese institutions during 2010-2021. Twenty-two patients underwent two oocyte retrievals for fertility preservation. We studied the relationship between the initial number of oocytes retrieved via dual stimulation and risk of ovarian enlargement as well as the appropriate waiting interval between the end of the first ovarian stimulation and beginning of the second ovarian stimulation.Results: The risk of ovarian enlargement was high when the initial number of oocytes retrieved via dual stimulation was ≥5. An 8-day waiting interval may be more effective for performing a second ovarian stimulation oocyte retrieval in these cases, although the difference was not significant.Conclusions: This study provides one policy for effectively managing ovarian enlargement and timing of second ovarian stimulation during oocyte retrieval via the dual stimulation method for patients with cancer undergoing fertility preservation. If more facilities implement this procedure, more oocytes may be obtained in a short period for fertility preservation purposes.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12534"},"PeriodicalIF":2.7,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/14/RMB2-22-e12534.PMC10433114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10046680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic efficacy and safety of a free-standing motorized ejaculation aid for patients with intravaginal ejaculatory dysfunction. 针对阴道内射精功能障碍患者的独立式电动射精辅助装置的疗效和安全性。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2023-08-17 eCollection Date: 2023-01-01 DOI: 10.1002/rmb2.12530

Shinichiro Fukuhara, Masato Shirai, Norichika Ueda, Kentaro Takezawa, Keisuke Ishikawa, Ippei Hiramatsu, Yuka Uesaka, Taiji Nozaki, Atsushi Iwasa, Kazuhiro Kobayashi, Norio Nonomura, Akira Tsujimura

{"title":"Therapeutic efficacy and safety of a free-standing motorized ejaculation aid for patients with intravaginal ejaculatory dysfunction.","authors":"Shinichiro Fukuhara, Masato Shirai, Norichika Ueda, Kentaro Takezawa, Keisuke Ishikawa, Ippei Hiramatsu, Yuka Uesaka, Taiji Nozaki, Atsushi Iwasa, Kazuhiro Kobayashi, Norio Nonomura, Akira Tsujimura","doi":"10.1002/rmb2.12530","DOIUrl":"10.1002/rmb2.12530","url":null,"abstract":"Purpose: There are no approved drugs or devices for the treatment of intravaginal ejaculation disorders, and treatment is often difficult. This study aimed to evaluate the efficacy and safety of the A10 Cyclone SA + PLUS® ejaculation aid (Rends Co., Ltd., Chiba, Japan), which allows the user to adjust the intensity of stimulation, for intravaginal ejaculation disorders.Methods: Each participant was instructed to perform practice masturbation with the A10 Cyclone SA + PLUS to simulate vaginal ejaculation. After 8 weeks of training, the participants were asked about their intravaginal ejaculation status. Sexual function was also evaluated before and after the training using several specific questionnaires, including the numerical rating scale for ejaculatory satisfaction.Results: Among the 10 participants (41.5 ± 3.21 years) who completed the training and questionnaire evaluation, four (40%) became capable of intravaginal ejaculation. The questionnaire evaluation showed predominant improvement after training in the ejaculation-capable group according to the numerical rating scale, which expresses satisfaction with ejaculation. The participants experienced no significant adverse events.Conclusion: As no effective treatment currently exists for intravaginal ejaculation disorders, we conclude that the A10 Cyclone SA + PLUS may be one treatment tool for intravaginal ejaculation disorders with good efficacy and no adverse events.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"22 1","pages":"e12530"},"PeriodicalIF":2.7,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/26/RMB2-22-e12530.PMC10433113.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10040340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0