Reproductive outcomes of embryo cryopreservation and transfer at the start-up phase of fertility preservation in Japan.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2024-06-19 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12581

Seido Takae, Miyuki Harada, Kentaro Nakamura, Sayako Furuyama, Masanori Ono, Yutaka Osuga, Nao Suzuki

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引用次数: 0

Abstract

Purpose: To verify the effectiveness of embryo transfer (ET) using cryopreserved embryo as fertility preservation (FP).

Methods: This study was a questionnaire survey. The total number of embryo cryopreservation (EC) was investigated between 2014 and 2020. And for patients who underwent ET among study period, details of EC, outcome of ET, number of live births, and mortality were investigated.

Results: Of the 150 facilities, 114 responded (76.0%). A total of 1420 EC were performed during the study period; and ET was performed for 417 patients. Breast cancer was the most common primary disease. A total of 199 live births (including prospective) were obtained by ET; 1.7 EC and 2.2 ET were performed per patient, and live birth rate was 21.4% per ET (28.1% on 35-37-year-old patients). The number of EC and ET increased with age. The final birth rate, including pregnancies other than FP, was 51.8%. Ovarian stimulation with aromatase inhibitors was commonly used, although with no effect on live birth rates. Random start stimulation was also common, experienced by 36.3% of breast cancer patients.

Conclusion: Reproductive outcomes of ETs following EC as FP are acceptable. This research project was registered in the University Hospital Medical Information Network (UMIN000043664).

查看原文本刊更多论文

日本生育力保存启动阶段胚胎冷冻和移植的生殖效果。

目的：验证使用冷冻胚胎作为生育力保存（FP）进行胚胎移植（ET）的有效性：本研究为问卷调查。调查了 2014 年至 2020 年间胚胎冷冻保存（EC）的总数。并对研究期间接受胚胎冷冻保存的患者的胚胎冷冻保存详情、胚胎冷冻保存结果、活产数和死亡率进行了调查：结果：在 150 家医疗机构中，有 114 家（76.0%）做出了回应。在研究期间，共进行了 1420 例产前诊断；为 417 名患者实施了产前诊断。乳腺癌是最常见的原发性疾病。通过 ET 共获得了 199 例活产（包括准活产）；每位患者接受了 1.7 次 EC 和 2.2 次 ET，每次 ET 的活产率为 21.4%（35-37 岁患者的活产率为 28.1%）。EC和ET的次数随着年龄的增长而增加。包括 FP 以外的妊娠在内，最终出生率为 51.8%。使用芳香化酶抑制剂刺激卵巢是常用的方法，但对活产率没有影响。随机开始刺激卵巢也很常见，36.3% 的乳腺癌患者使用过这种方法：结论：EC 作为 FP 后的 ET 生殖结果是可以接受的。本研究项目已在大学医院医学信息网（UMIN000043664）注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.