Reviews in Endocrine & Metabolic Disorders最新文献_第8页

Inadequate linear catch-up growth in children born small for gestational age: Influencing factors and underlying mechanisms. 胎龄不足新生儿线性追赶生长不足：影响因素和内在机制。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1007/s11154-024-09885-x

Anran Tian, Fucheng Meng, Sujuan Li, Yichi Wu, Cai Zhang, Xiaoping Luo

引用次数: 0

Endocrine involvement in hepatic glycogen storage diseases: pathophysiology and implications for care. 肝糖原贮积症的内分泌参与：病理生理学和对护理的影响。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-08-01 Epub Date: 2024-04-01 DOI: 10.1007/s11154-024-09880-2

Alessandro Rossi, Chiara Simeoli, Rosario Pivonello, Mariacarolina Salerno, Carmen Rosano, Barbara Brunetti, Pietro Strisciuglio, Annamaria Colao, Giancarlo Parenti, Daniela Melis, Terry G J Derks

{"title":"Endocrine involvement in hepatic glycogen storage diseases: pathophysiology and implications for care.","authors":"Alessandro Rossi, Chiara Simeoli, Rosario Pivonello, Mariacarolina Salerno, Carmen Rosano, Barbara Brunetti, Pietro Strisciuglio, Annamaria Colao, Giancarlo Parenti, Daniela Melis, Terry G J Derks","doi":"10.1007/s11154-024-09880-2","DOIUrl":"10.1007/s11154-024-09880-2","url":null,"abstract":"Hepatic glycogen storage diseases constitute a group of disorders due to defects in the enzymes and transporters involved in glycogen breakdown and synthesis in the liver. Although hypoglycemia and hepatomegaly are the primary manifestations of (most of) hepatic GSDs, involvement of the endocrine system has been reported at multiple levels in individuals with hepatic GSDs. While some endocrine abnormalities (e.g., hypothalamic‑pituitary axis dysfunction in GSD I) can be direct consequence of the genetic defect itself, others (e.g., osteopenia in GSD Ib, insulin-resistance in GSD I and GSD III) may be triggered by the (dietary/medical) treatment. Being aware of the endocrine abnormalities occurring in hepatic GSDs is essential (1) to provide optimized medical care to this group of individuals and (2) to drive research aiming at understanding the disease pathophysiology. In this review, a thorough description of the endocrine manifestations in individuals with hepatic GSDs is presented, including pathophysiological and clinical implications.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"707-725"},"PeriodicalIF":6.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases). 促炎和抗炎细胞因子是改变儿童肥胖相关代谢疾病（糖尿病和非酒精性脂肪肝）的关键因素。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-08-01 Epub Date: 2024-05-06 DOI: 10.1007/s11154-024-09884-y

Amin Ullah, Rajeev K Singla, Zahra Batool, Dan Cao, Bairong Shen

{"title":"Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases).","authors":"Amin Ullah, Rajeev K Singla, Zahra Batool, Dan Cao, Bairong Shen","doi":"10.1007/s11154-024-09884-y","DOIUrl":"10.1007/s11154-024-09884-y","url":null,"abstract":"Childhood obesity is a chronic inflammatory epidemic that affects children worldwide. Obesity affects approximately 1 in 5 children worldwide. Obesity in children can worsen weight gain and raise the risk of obesity-related comorbidities like diabetes and non-alcoholic fatty liver disease (NAFLD). It can also negatively impact the quality of life for these children. Obesity disrupts immune system function, influencing cytokine (interleukins) balance and expression levels, adipokines, and innate and adaptive immune cells. The altered expression of immune system mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-17 (IL-17), interleukin-18 (IL-18), transforming growth factor (TGF), tumor necrosis factor (TNF), and others, caused inflammation, progression, and the development of pediatric obesity and linked illnesses such as diabetes and NAFLD. Furthermore, anti-inflammatory cytokines, including interleukin-2 (IL-2), have been shown to have anti-diabetes and IL-1 receptor antagonist (IL-1Ra) anti-diabetic and pro-NAFLFD properties, and interleukin-10 (IL-10) has been shown to have a dual role in managing diabetes and anti-NAFLD. In light of the substantial increase in childhood obesity-associated disorders such as diabetes and NAFLD and the absence of an effective pharmaceutical intervention to inhibit immune modulation factors, it is critical to consider the alteration of immune system components as a preventive and therapeutic approach. Thus, the current review focuses on the most recent information regarding the influence of pro- and anti-inflammatory cytokines (interleukins) and their molecular mechanisms on pediatric obesity-associated disorders (diabetes and NAFLD). Furthermore, we discussed the current therapeutic clinical trials in childhood obesity-associated diseases, diabetes, and NAFLD.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"783-803"},"PeriodicalIF":6.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Diagnostic and therapeutic use of oral micronized progesterone in endocrinology. 更正：口服微粒化黄体酮在内分泌学中的诊断和治疗用途。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-26 DOI: 10.1007/s11154-024-09887-9

Eleni Memi, Polina Pavli, Maria Papagianni, Nikolaos Vrachnis, George Mastorakos

引用次数: 0

Androgen deficiency in hypopituitary women: its consequences and management. 垂体功能减退妇女的雄激素缺乏症：其后果和处理方法。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2024-01-19 DOI: 10.1007/s11154-024-09873-1

Daniela Esposito, Åsa Tivesten, Catharina Olivius, Oskar Ragnarsson, Gudmundur Johannsson

{"title":"Androgen deficiency in hypopituitary women: its consequences and management.","authors":"Daniela Esposito, Åsa Tivesten, Catharina Olivius, Oskar Ragnarsson, Gudmundur Johannsson","doi":"10.1007/s11154-024-09873-1","DOIUrl":"10.1007/s11154-024-09873-1","url":null,"abstract":"Women with hypopituitarism have various degrees of androgen deficiency, which is marked among those with combined hypogonadotrophic hypogonadism and secondary adrenal insufficiency. The consequences of androgen deficiency and the effects of androgen replacement therapy have not been fully elucidated. While an impact of androgen deficiency on outcomes such as bone mineral density, quality of life, and sexual function is plausible, the available evidence is limited. There is currently no consensus on the definition of androgen deficiency in women and it is still controversial whether androgen substitution should be used in women with hypopituitarism and coexisting androgen deficiency. Some studies suggest beneficial clinical effects of androgen replacement but data on long-term benefits and risk are not available. Transdermal testosterone replacement therapy in hypopituitary women has shown some positive effects on bone metabolism and body composition. Studies of treatment with oral dehydroepiandrosterone have yielded mixed results, with some studies suggesting improvements in quality of life and sexual function. Further research is required to elucidate the impact of androgen deficiency and its replacement treatment on long-term outcomes in women with hypopituitarism. The lack of transdermal androgens for replacement in this patient population and limited outcome data limit its use. A cautious and personalized treatment approach in the clinical management of androgen deficiency in women with hypopituitarism is recommended while awaiting more efficacy and safety data.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"479-488"},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New findings on brain actions of growth hormone and potential clinical implications. 生长激素脑作用的新发现及其潜在临床意义。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2023-12-07 DOI: 10.1007/s11154-023-09861-x

Jose Donato, John J Kopchick

{"title":"New findings on brain actions of growth hormone and potential clinical implications.","authors":"Jose Donato, John J Kopchick","doi":"10.1007/s11154-023-09861-x","DOIUrl":"10.1007/s11154-023-09861-x","url":null,"abstract":"Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth, lipolysis, and insulin resistance. The GH receptor (GHR) is expressed in numerous brain regions. Notably, a growing body of evidence indicates that GH-induced GHR signaling in specific neuronal populations regulates multiple physiological functions, including energy balance, glucose homeostasis, stress response, behavior, and several neurological/cognitive aspects. The importance of central GHR signaling is particularly evident when the organism is under metabolic stress, such as pregnancy, chronic food deprivation, hypoglycemia, and prolonged exercise. These particular situations are associated with elevated GH secretion. Thus, central GH action represents an internal signal that coordinates metabolic, neurological, neuroendocrine, and behavioral adaptations that are evolutionarily advantageous to increase the chances of survival. This review summarizes and discusses recent findings indicating that the brain is an important target of GH, and GHR signaling in different neuronal populations regulates essential physiological functions.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"541-553"},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress, challenges and perspectives in the management of hypopituitarism. 垂体功能减退症治疗的进展、挑战和前景。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2024-05-27 DOI: 10.1007/s11154-024-09889-7

Cesar Luiz Boguszewski, Sebastian Neggers

引用次数: 0

Fertility issues in hypopituitarism. 垂体功能减退症的生育问题。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2023-12-14 DOI: 10.1007/s11154-023-09863-9

Julie Chen, Julia J Chang, Esther H Chung, Ruth B Lathi, Lusine Aghajanova, Laurence Katznelson

引用次数: 0

Diagnosis and management of secondary adrenal crisis. 继发性肾上腺危象的诊断和处理。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2024-02-27 DOI: 10.1007/s11154-024-09877-x

Luciana Martel-Duguech, Jonathan Poirier, Isabelle Bourdeau, André Lacroix

{"title":"Diagnosis and management of secondary adrenal crisis.","authors":"Luciana Martel-Duguech, Jonathan Poirier, Isabelle Bourdeau, André Lacroix","doi":"10.1007/s11154-024-09877-x","DOIUrl":"10.1007/s11154-024-09877-x","url":null,"abstract":"Adrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventive strategies, its prevalence is increasing in patients with SAI, TAI and IAI due to more frequent exogenous steroid administration, pituitary immune-related effects of immune checkpoint inhibitors and opioid use in pain management. The delayed diagnosis of acute AI which remains infrequently suspected increases the risk of AC. Its main precipitating factors are infections, emotional distress, surgery, cessation or reduction in GC doses, pituitary infarction or surgical cure of endogenous Cushing's syndrome. In patients not known previously to have SAI/TAI/IAI, recognition of its symptoms, signs, and biochemical abnormalities can be challenging and cause delay in proper diagnosis and therapy. Effective therapy of AC is rapid intravenous administration of hydrocortisone (initial bolus of 100 mg followed by 200 mg/24 h as continuous infusion or bolus of 50 mg every 6 h) and 0.9% saline. In diagnosed patients, preventive education in sick-day rules adjustment of glucocorticoid replacement and hydrocortisone parenteral self-administration must be performed repeatedly by trained health care providers. Strategies to improve the adequate preventive education in patients at risk for secondary AI should be promoted in collaboration with various medical specialist societies and patients support associations.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"619-637"},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management. 垂体功能减退症住院病人的发病率和死亡率：发病率、原因和管理。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2024-05-27 DOI: 10.1007/s11154-024-09888-8

Fahim Ebrahimi, Lukas Andereggen, Emanuel R Christ

{"title":"Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management.","authors":"Fahim Ebrahimi, Lukas Andereggen, Emanuel R Christ","doi":"10.1007/s11154-024-09888-8","DOIUrl":"10.1007/s11154-024-09888-8","url":null,"abstract":"Hypopituitarism is a highly heterogeneous multisystem disorder that can have a major impact on long-term morbidity and mortality, but even more so during acute medical conditions requiring hospitalization. Recent studies suggest a significant in-hospital burden with prolonged length of stay, increased rate of intensive care unit (ICU) admission, and initiation of mechanical ventilation - all of which may lead to an increased risk of in-hospital mortality. On the one hand, patients with hypopituitarism are often burdened by metabolic complications, including obesity, hypertension, dyslipidemia, and hyperglycemia, which alone, or in combination, are known to significantly alter relevant physiological mechanisms, including metabolism, innate and adaptive immune responses, coagulation, and wound healing, thereby contributing to adverse in-hospital outcomes. On the other hand, depending on the extent and the number of pituitary hormone deficiencies, early recognition of hormone deficiencies and appropriate management and replacement strategy within a well-organized multidisciplinary team are even stronger determinants of short-term outcomes during acute hospitalization in this vulnerable patient population. This review aims to provide an up-to-date summary of recent advances in pathophysiologic understanding, clinical implications, and recommendations for optimized multidisciplinary management of hospitalized patients with hypopituitarism.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"599-608"},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0