Reviews in Endocrine & Metabolic Disorders最新文献_第7页

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications. 棕色、白色和米色脂肪组织分泌功能的最新进展：走向治疗应用。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-12-05 DOI: 10.1007/s11154-023-09850-0

Zeinab Ghesmati, Mohsen Rashid, Shabnam Fayezi, Frank Gieseler, Effat Alizadeh, Masoud Darabi

{"title":"An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications.","authors":"Zeinab Ghesmati, Mohsen Rashid, Shabnam Fayezi, Frank Gieseler, Effat Alizadeh, Masoud Darabi","doi":"10.1007/s11154-023-09850-0","DOIUrl":"10.1007/s11154-023-09850-0","url":null,"abstract":"Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates energy as heat for thermoregulation. Beige adipose tissue is a hybrid form of adipose tissue that shares characteristics with WAT and BAT. Dysregulation of adipose tissue metabolism is linked to various disorders, including obesity, type 2 diabetes, cardiovascular diseases, cancer, and infertility. Both brown and beige adipocytes secrete multiple molecules, such as batokines, packaged in extracellular vesicles or as soluble signaling molecules that play autocrine, paracrine, and endocrine roles. A greater understanding of the adipocyte secretome is essential for identifying novel molecular targets in treating metabolic disorders. Additionally, microRNAs show crucial roles in regulating adipose tissue differentiation and function, highlighting their potential as biomarkers for metabolic disorders. The browning of WAT has emerged as a promising therapeutic approach in treating obesity and associated metabolic disorders. Many browning agents have been identified, and nanotechnology-based drug delivery systems have been developed to enhance their efficacy. This review scrutinizes the characteristics of and differences between white, brown, and beige adipose tissues, the molecular mechanisms involved in the development of the adipocytes, the significant roles of batokines, and regulatory microRNAs active in different adipose tissues. Finally, the potential of WAT browning in treating obesity and atherosclerosis, the relationship of BAT with cancer and fertility disorders, and the crosstalk between adipose tissue with circadian system and circadian disorders are also investigated.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"279-308"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome. 生殖中和生殖外的吻肽系统：探索子宫内膜异位症和多囊卵巢综合征之间错综复杂的途径和潜在联系。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-07-28 DOI: 10.1007/s11154-023-09826-0

Noemi Salmeri, Paola Viganò, Paolo Cavoretto, Roberto Marci, Massimo Candiani

{"title":"The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome.","authors":"Noemi Salmeri, Paola Viganò, Paolo Cavoretto, Roberto Marci, Massimo Candiani","doi":"10.1007/s11154-023-09826-0","DOIUrl":"10.1007/s11154-023-09826-0","url":null,"abstract":"Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with a significant impact on the health and quality of life of women affected. A novel hypothesis by evolutionary biologists suggested that these two diseases are inversely related to one another, representing a pair of diametrical diseases in terms of opposite alterations in reproductive physiological processes but also contrasting phenotypic traits. However, to fully explain the phenotypic features observed in women with these conditions, we need to establish a potential nexus system between the reproductive system and general biological functions. The recent discovery of kisspeptin as pivotal mediator of internal and external inputs on the hypothalamic-pituitary-gonadal axis has led to a new understanding of the neuroendocrine upstream regulation of the human reproductive system. In this review, we summarize the current knowledge on the physiological roles of kisspeptin in human reproduction, as well as its involvement in complex biological functions such as metabolism, inflammation and pain sensitivity. Importantly, these functions are known to be dysregulated in both PCOS and endometriosis. Within the evolving scientific field of \"kisspeptinology\", we critically discuss the clinical relevance of these discoveries and their potential translational applications in endometriosis and PCOS. By exploring the possibilities of manipulating this complex signaling system, we aim to pave the way for novel targeted therapies in these reproductive diseases.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"239-257"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic programming for obesity and noncommunicable disease: From womb to tomb. 肥胖和非传染性疾病的表观遗传编程:从子宫到坟墓。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-12-02 DOI: 10.1007/s11154-023-09854-w

Lucas Paulo Jacinto Saavedra, Silvano Piovan, Veridiana Mota Moreira, Gessica Dutra Gonçalves, Anna Rebeka Oliveira Ferreira, Maiara Vanusa Guedes Ribeiro, Maria Natália Chimirri Peres, Douglas Lopes Almeida, Scarlett Rodrigues Raposo, Mariane Carneiro da Silva, Letícia Ferreira Barbosa, Paulo Cezar de Freitas Mathias

{"title":"Epigenetic programming for obesity and noncommunicable disease: From womb to tomb.","authors":"Lucas Paulo Jacinto Saavedra, Silvano Piovan, Veridiana Mota Moreira, Gessica Dutra Gonçalves, Anna Rebeka Oliveira Ferreira, Maiara Vanusa Guedes Ribeiro, Maria Natália Chimirri Peres, Douglas Lopes Almeida, Scarlett Rodrigues Raposo, Mariane Carneiro da Silva, Letícia Ferreira Barbosa, Paulo Cezar de Freitas Mathias","doi":"10.1007/s11154-023-09854-w","DOIUrl":"10.1007/s11154-023-09854-w","url":null,"abstract":"Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as preconception, gestation, lactation and adolescence, and the understanding of factors that influence the risk of an adult individual for developing obesity, metabolic and cardiovascular diseases, is the focus of the DOHaD (Developmental Origins of Health and Disease) research line. In this sense, advancements in molecular biology techniques have contributed significantly to the understanding of the mechanisms underlying the observed phenotypes, their morphological and physiological alterations, having as a main driving factor the epigenetic modifications and their consequent modulation of gene expression. The present narrative review aimed to characterize the different susceptible phases of development and associated epigenetic modifications, and their implication in the development of non-communicable diseases. Additionally, we provide useful insights into interventions during development to counteract or prevent long-term programming for disease susceptibility.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"309-324"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors. 根据神经内分泌肿瘤患者的性别划分体生长抑素类似物的疗效和耐受性。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-12-05 DOI: 10.1007/s11154-023-09858-6

Rosaria M Ruggeri, Irene Aini, Stefano Gay, Erika Maria Grossrubatscher, Camilla Mancini, Maria Grazia Tarsitano, Virginia Zamponi, Andrea M Isidori, Annamaria Colao, Antongiulio Faggiano

{"title":"Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors.","authors":"Rosaria M Ruggeri, Irene Aini, Stefano Gay, Erika Maria Grossrubatscher, Camilla Mancini, Maria Grazia Tarsitano, Virginia Zamponi, Andrea M Isidori, Annamaria Colao, Antongiulio Faggiano","doi":"10.1007/s11154-023-09858-6","DOIUrl":"10.1007/s11154-023-09858-6","url":null,"abstract":"As the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven management of these tumors has grown with the aim to improve survival and quality of life of these patients. Somatostatin Analogues represent the first line of systemic treatment of both functional and non-functional neuroendocrine tumors, through the expression of somatostatin receptors (SSTRs) in the tumor cells, and proved effective in controlling hormonal hypersecretion and inhibiting tumor growth, improving progression-free survival and overall survival of these patients. Aim of the present review is to investigate any differences by gender in efficacy and safety of SSTS-targeted therapies, that represent the mainstay treatment of neuroendocrine tumors, as they emerge from studies of varying design and intent. Although preclinical studies have provided evidence in favor of differences by gender in tumor expression of SSTR, as well as of the role of sex hormones and related receptors in modulating SSTRs expression and function, the clinical studies conducted so far have not shown substantial differences between males and females in either efficacy or toxicity of SSTR-targeted therapies, even if with sometimes inconsistent results. Moreover, in most studies gender was not a predictor of response to treatment. Studies specifically designed to address this issue are needed to develop gender-specific therapeutic algorithms, improving patients' prognosis and quality of life.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"383-398"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion. 蛋白质营养不良与糖尿病之间的关系:胰岛素分泌减少的分子意义。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-12-04 DOI: 10.1007/s11154-023-09856-8

Thiago Dos Reis Araujo, Bruna Lourençoni Alves, Lohanna Monali Barreto Dos Santos, Luciana Mateus Gonçalves, Everardo Magalhães Carneiro

{"title":"Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion.","authors":"Thiago Dos Reis Araujo, Bruna Lourençoni Alves, Lohanna Monali Barreto Dos Santos, Luciana Mateus Gonçalves, Everardo Magalhães Carneiro","doi":"10.1007/s11154-023-09856-8","DOIUrl":"10.1007/s11154-023-09856-8","url":null,"abstract":"Undernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with the social and economic sphere, but it can also negatively impact the health of the population. In this sense, it is believed that undernourished individuals may be more susceptible to the development of non-communicable diseases, such as diabetes mellitus, throughout life. This hypothesis was postulated and confirmed until today by several studies that demonstrate that experimental models submitted to protein undernutrition present alterations in glycemic homeostasis linked, in part, to the reduction of insulin secretion. Therefore, understanding the changes that lead to a reduction in the secretion of this hormone is essential to prevent the development of diabetes in undernourished individuals. This narrative review aims to describe the main molecular changes already characterized in pancreatic β cells that will contribute to the reduction of insulin secretion in protein undernutrition. So, it will provide new perspectives and targets for postulation and action of therapeutic strategies to improve glycemic homeostasis during this nutritional deficiency.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"259-278"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic risk assessment in patients with differentiated thyroid cancer. 分化型甲状腺癌患者的动态风险评估。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-02-01 Epub Date: 2023-11-28 DOI: 10.1007/s11154-023-09857-7

Erika Abelleira, Fernando Jerkovich

引用次数: 0

Management of radioiodine refractory differentiated thyroid cancer: the Latin American perspective. 放射性碘难治性分化型甲状腺癌的治疗：拉丁美洲视角。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-02-01 Epub Date: 2023-06-29 DOI: 10.1007/s11154-023-09818-0

Fabian Pitoia, Rafael Selbach Scheffel, Ines Califano, Alicia Gauna, Hernán Tala, Fernanda Vaisman, Alejandro Roman Gonzalez, Ana Oliveira Hoff, Ana Luiza Maia

{"title":"Management of radioiodine refractory differentiated thyroid cancer: the Latin American perspective.","authors":"Fabian Pitoia, Rafael Selbach Scheffel, Ines Califano, Alicia Gauna, Hernán Tala, Fernanda Vaisman, Alejandro Roman Gonzalez, Ana Oliveira Hoff, Ana Luiza Maia","doi":"10.1007/s11154-023-09818-0","DOIUrl":"10.1007/s11154-023-09818-0","url":null,"abstract":"Radioiodine (RAI) refractory differentiated thyroid cancer is an uncommon and challenging situation that requires a multidisciplinary approach to therapeutic strategies. The definition of RAI-refractoriness is usually a clear situation in specialized centers. However, the right moment for initiation of multikinase inhibitors (MKI), the time and availability for genomic testing, and the possibility of prescribing MKI and selective kinase inhibitors differ worldwide.Latin America (LA) refers to the territories of the world that stretch across two regions: North America (including Central America and the Caribbean) and South America, containing 8.5% of the world's population. In this manuscript, we critically review the current standard approach recommended for patients with RAI refractory differentiated thyroid cancer, emphasizing the challenges faced in LA. To achieve this objective, the Latin American Thyroid Society (LATS) convened a panel of experts from Brazil, Argentina, Chile, and Colombia. Access to MKI compounds continues to be a challenge in all LA countries. This is true not only for MKI but also for the new selective tyrosine kinase inhibitor, which will also require genomic testing, that is not widely available. Thus, as precision medicine advances, significant disparities will be made more evident, and despite efforts to improve coverage and reimbursement, molecular-based precision medicine remains inaccessible to most of the LA population. Efforts should be undertaken to alleviate the discrepancies between the current state-of-the-art care for RAI-refractory differentiated thyroid cancer and the present situation in Latin America.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"109-121"},"PeriodicalIF":6.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10070991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does it work in childhood and adolescence? The predictive role of postoperative/preablative stimulated thyroglobulin levels in paediatric thyroid cancer. A systematic review of the literature. 它在儿童和青少年时期有效吗？术后/术前刺激甲状腺球蛋白水平对儿童甲状腺癌症的预测作用。对文献的系统综述。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-02-01 Epub Date: 2023-09-25 DOI: 10.1007/s11154-023-09835-z

Arnoldo Piccardo, Francesco Fiz, Gianluca Bottoni, Luca Foppiani, Domenico Albano, Francesco Bertagna, Ugo Catrambone, Federica Mariani, Beatrice Sambucco, Michela Massollo, Giorgio Treglia, Pierpaolo Trimboli

{"title":"Does it work in childhood and adolescence? The predictive role of postoperative/preablative stimulated thyroglobulin levels in paediatric thyroid cancer. A systematic review of the literature.","authors":"Arnoldo Piccardo, Francesco Fiz, Gianluca Bottoni, Luca Foppiani, Domenico Albano, Francesco Bertagna, Ugo Catrambone, Federica Mariani, Beatrice Sambucco, Michela Massollo, Giorgio Treglia, Pierpaolo Trimboli","doi":"10.1007/s11154-023-09835-z","DOIUrl":"10.1007/s11154-023-09835-z","url":null,"abstract":"Background: Thyroglobulin is a well-established disease marker during follow-up in paediatric differentiated thyroid cancer. However, no conclusive data on the role of endogenously stimulated thyroglobulin after thyroidectomy (ptTg) in predicting disease-specific outcomes are available. This review aims to establish the prognostic value of ptTg in children with DTC.Methods: Online medical databases were searched for studies evaluating the association between ptTg and disease-specific outcomes in DTC-affected children. Documents not in English, preclinical studies, other review articles, case reports, and small case series were excluded. The risk of bias was assessed with the QUADAS-2 tool.Results: Twelve studies, analysing 1043 children in total, were included in the review. They all had a retrospective design and were published between 2016 and 2022. Of all patients, 1008 (97%) and 849 (81%) had undergone thyroidectomy and RAI, respectively. Eight studies (756 children) evaluated the correlation between ptTg and disease persistence/relapse: six reported a significant association between these parameters; a specific ptTg cut-off (10-14 ng/ml) was identified at the multivariate analysis in three studies. The remaining four studies assessed the link between ptTg levels and disease extension, with three reporting a correlation between ptTg and lung/nodal metastases.Discussion: ptTg is a readily available and inexpensive parameter, bearing a strong prognostic power in identifying disease persistence, relapse, and the presence of metastases in children affected by DTC.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"53-63"},"PeriodicalIF":6.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of radiomics and machine learning to thyroid diseases in nuclear medicine: a systematic review. 放射组学和机器学习在核医学中对甲状腺疾病的应用：系统综述。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-02-01 Epub Date: 2023-07-12 DOI: 10.1007/s11154-023-09822-4

Francesco Dondi, Roberto Gatta, Giorgio Treglia, Arnoldo Piccardo, Domenico Albano, Luca Camoni, Elisa Gatta, Maria Cavadini, Carlo Cappelli, Francesco Bertagna

{"title":"Application of radiomics and machine learning to thyroid diseases in nuclear medicine: a systematic review.","authors":"Francesco Dondi, Roberto Gatta, Giorgio Treglia, Arnoldo Piccardo, Domenico Albano, Luca Camoni, Elisa Gatta, Maria Cavadini, Carlo Cappelli, Francesco Bertagna","doi":"10.1007/s11154-023-09822-4","DOIUrl":"10.1007/s11154-023-09822-4","url":null,"abstract":"Background: In the last years growing evidences on the role of radiomics and machine learning (ML) applied to different nuclear medicine imaging modalities for the assessment of thyroid diseases are starting to emerge. The aim of this systematic review was therefore to analyze the diagnostic performances of these technologies in this setting.Methods: A wide literature search of the PubMed/MEDLINE, Scopus and Web of Science databases was made in order to find relevant published articles about the role of radiomics or ML on nuclear medicine imaging for the evaluation of different thyroid diseases.Results: Seventeen studies were included in the systematic review. Radiomics and ML were applied for assessment of thyroid incidentalomas at 18 F-FDG PET, evaluation of cytologically indeterminate thyroid nodules, assessment of thyroid cancer and classification of thyroid diseases using nuclear medicine techniques.Conclusion: Despite some intrinsic limitations of radiomics and ML may have affect the results of this review, these technologies seem to have a promising role in the assessment of thyroid diseases. Validation of preliminary findings in multicentric studies is needed to translate radiomics and ML approaches in the clinical setting.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"175-186"},"PeriodicalIF":6.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9760997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular testing for thyroid nodules: Where are we now? 甲状腺结节的分子检测：我们现在在哪里？

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-02-01 Epub Date: 2023-10-30 DOI: 10.1007/s11154-023-09842-0

Carolina Ferraz

{"title":"Molecular testing for thyroid nodules: Where are we now?","authors":"Carolina Ferraz","doi":"10.1007/s11154-023-09842-0","DOIUrl":"10.1007/s11154-023-09842-0","url":null,"abstract":"Approximately 25% of the fine needle aspiration samples (FNAB) of thyroid nodules are classified as \"indeterminate samples\", that means, Bethesda III and IV categories. Until the last decade, most of these cases underwent diagnostic surgery, although only a minority (13-34%) confirmed malignancy postoperatively. In view of this, with the objective of improving the preoperative diagnosis in these cases, the molecular tests emerged, which are validated from the diagnostic point of view, presenting good performance, with good diagnostic accuracy, being able to avoid diagnostic surgeries. With the advancement of knowledge of the role of each of the mutations and gene rearrangements in thyroid oncogenesis, molecular markers have left to play only a diagnostic role and have been gaining more and more space both in defining the prognostic role of the tumor, as well as in the indication of target therapy. Thus, the objective of this review is to show how to use the tool of molecular tests, now commercially available in the world, in the management of indeterminate cytological nodules, assessing the pre-test malignancy risk of the nodule, through clinical, ultrasonographic and cytological characteristics, and decide on the benefit of molecular testing for each patient. In addition, to discuss its new and promising prognostic and therapeutic role in thyroid cancer.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"149-159"},"PeriodicalIF":6.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71413754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0