Reviews in Endocrine & Metabolic Disorders最新文献

Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide. 成人肥胖减肥期间保持肌肉骨骼健康的运动和饮食建议：实用指南。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-05-28 DOI: 10.1007/s11154-025-09968-3

Jakub Mesinovic, Christopher Hurst, Gloria K W Leung, Jack R Ryan, Robin M Daly, David Scott

{"title":"Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide.","authors":"Jakub Mesinovic, Christopher Hurst, Gloria K W Leung, Jack R Ryan, Robin M Daly, David Scott","doi":"10.1007/s11154-025-09968-3","DOIUrl":"https://doi.org/10.1007/s11154-025-09968-3","url":null,"abstract":"Obesity adversely impacts musculoskeletal health, contributing to functional limitations and an increased risk for falls, fractures and disability. Weight loss can mitigate these effects, but strategies that neglect to incorporate evidence-based dietary and/or exercise approaches can exacerbate musculoskeletal and functional declines. Sustainable weight loss requires a personalised approach that prioritises adequate protein intake and essential nutrients to preserve musculoskeletal health. To enhance adherence and long-term success, dietary strategies should be practical, nutritionally balanced and cost-effective. Similarly, exercise programmes should be individually tailored and progressive, with resistance training central to any program prescribed in the context of weight loss, due to its critical role in maintaining muscle and bone mass and strength. When prescribing weight loss strategies involving lifestyle behaviour changes, clinicians must consider their patient's readiness to change. We have used the transtheoretical model of change framework as an example to identify a patient's level of readiness and provided associated motivational interviewing-based strategies to enhance adherence and engagement. This review outlines evidence-based, practical diet and exercise recommendations and behavioural strategies that can facilitate effective and sustainable weight loss, which is particularly important for at-risk populations such as older adults.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity. 体重恢复过程中的适应性产热驱动追赶性脂肪：骨骼肌甲状腺功能减退的作用和肌肉减少性肥胖的风险

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-05-26 DOI: 10.1007/s11154-025-09970-9

Abdul G Dulloo

{"title":"Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity.","authors":"Abdul G Dulloo","doi":"10.1007/s11154-025-09970-9","DOIUrl":"https://doi.org/10.1007/s11154-025-09970-9","url":null,"abstract":"Across the spectrum of weight regain, ranging from cachexia rehabilitation and catch-up growth to obesity relapse, the recovery rate of body fat is often disproportionate relative to lean tissue recovery. Such preferential 'catch-up fat' is in part attributed to an increase in metabolic efficiency and embodied in the concept that 'metabolic adaptation' or 'adaptive thermogenesis' in response to large weight deficits can persist during weight regain to accelerate fat stores recovery. This paper reviews the evidence in humans for the existence of this thrifty metabolism driving catch-up fat within the framework of a feedback loop between fat stores depletion and suppressed thermogenesis. The search for its effector mechanisms suggests that whereas adaptive thermogenesis during weight loss results primarily from central suppression of sympathetic nervous system and hypothalamic-pituitary-thyroid axis, its persistence during weight regain for accelerating fat recovery is primarily mediated through peripheral tissue resistance to the actions of this systemic neurohormonal network. Emerging evidence linking it to an upregulation of skeletal muscle type 3 deiodinase (D3), the main thyroid hormone inactivating enzyme, along with slowed muscle metabolism and altered contractile properties, suggest that D3-induced muscle hypothyroidism is a key feature of such peripheral resistance. These findings underlying a role of skeletal muscle hypothyroidism in adaptive thermogenesis driving catch-up fat, but which can also concomitantly compromise muscle functionality, have been integrated into a mechanistic framework to explain how weight cycling and large weight fluctuations across the lifespan can predispose to sarcopenic obesity.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypopituitarism in non-neuroendocrine pituitary tumors: a systematic review. 非神经内分泌垂体肿瘤的垂体功能减退：系统综述。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-05-13 DOI: 10.1007/s11154-025-09969-2

Fernando Guerrero-Pérez, Natalia Vega Rojas, Pedro Iglesias

{"title":"Hypopituitarism in non-neuroendocrine pituitary tumors: a systematic review.","authors":"Fernando Guerrero-Pérez, Natalia Vega Rojas, Pedro Iglesias","doi":"10.1007/s11154-025-09969-2","DOIUrl":"https://doi.org/10.1007/s11154-025-09969-2","url":null,"abstract":"The existing evidence on pituitary function impairment in non-neuroendocrine pituitary tumors (non-PitNETs) is limited and scattered. We performed a systematic review using PubMed, Embase, Scopus, and Cochrane of all reported studies that evaluated pituitary function in craniopharyngiomas, meningiomas, germinomas, pituitary lymphomas, pituicytomas, granular cell tumors, spindle cell oncocytomas, and pituitary metastases over the past 35 years. A total of 5,614 patients from 114 studies were analyzed. The weighted mean age was 35.01 ± 2.7 years (95% CI: 34.9-35.1) and 47.5 ± 14.1% (95% CI: 47.1-47.8) were women. The overall weighted proportion of hypopituitarism was 49.1 ± 24.2% (95% CI: 48.4-49.7) and arginine vasopressin deficiency (AVD) was 18.43 ± 16.6% (95% CI: 17.9-18.9). According to tumor type, prevalence of hypopituitarism was 67.3 ± 8.1% (95% CI: 66.5-68.9) for germinomas, 61.4 ± 20.8% (95% CI: 58.8-64.1) for metastases, 58.7 ± 22.2% (95% CI: 46.2-71.3) for lymphomas, 54.4 ± 30.8% (95% CI: 45.6-63.3) for pituicytomas, 53.8 ± 12.3% (95% CI: 47.5-59.8) for oncocytomas, 49.1 ± 17.2% (95% CI: 48.6-49.6) for craniopharyngiomas, 29.7 ± 16.6% (95% CI: 22.4-36.9) for granular cell tumors, and 11.5 ± 9.1% (95% CI: 10.8-12.3) for meningiomas. When comparing the most prevalent non-PitNETs, the weighted prevalence of hypopituitarism was higher in metastases compared to craniopharyngiomas (χ2 = 696.8, df = 1), p < 0.0001. Similarly, the weighted prevalence of hypopituitarism in craniopharyngiomas was higher compared to meningiomas (χ2 = 16,278.13, df = 1), p < 0.0001. In conclusion, non-PitNETs result in hypopituitarism in approximately half of the cases and AVD in nearly one-fifth. Pituitary metastases and craniopharyngiomas demonstrate greater local aggressiveness and a higher likelihood of disrupting hypothalamic-pituitary function compared to meningiomas.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New drugs for the treatment of obesity: do we need approaches to preserve muscle mass? 治疗肥胖的新药：我们需要保持肌肉质量的方法吗？

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-05-05 DOI: 10.1007/s11154-025-09967-4

Donna H Ryan

{"title":"New drugs for the treatment of obesity: do we need approaches to preserve muscle mass?","authors":"Donna H Ryan","doi":"10.1007/s11154-025-09967-4","DOIUrl":"https://doi.org/10.1007/s11154-025-09967-4","url":null,"abstract":"The development of drugs targeting Nutrient Stimulated Hormone receptors has ushered in a dramatic change in our approach to weight management because of their ability to achieve weight losses of 10%, 20%, even 30% in significant numbers of patients. Additionally, disease modifying properties of these medications are compelling. Indications now include cardiovascular risk reduction, obstructive sleep apnea and diabetes management, and emerging evidence supports efficacy for heart failure and chronic kidney disease. These medications would need to be taken long term and the population being treated will be older than the traditional weight management patient. Emerging evidence cautions that the loss of excessive lean mass with some of the newer medications may be problematic. This is not a concern for most patients who will need the medications, but it is a concern in an older population, since loss of muscle and bone accelerates and progresses past age 60. Of weight lost with semaglutide, approximately 45% is from lean mass, while with tirzepatide, it is 25%. Going forward, combining another NuSH such as glucagon or amylin with the GLP-1 receptor agonists may lessen loss of lean mass. Another approach under study is the use of MAPi - myostatin-activin pathway inhibitors. Promising results with bimagrumab are spurring investigaton in this area. For the full potential of disease modification to be achieved, it's a given that we must demonstrate safe, long term body composition improvement when the new medications are deployed, especially in the older population. This narrative review discusses the justification for focus on lean mass preservation and reviews the status of relevant drugs in development.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothalamic control of heart rate and body temperature by thyroid hormones. 下丘脑通过甲状腺激素控制心率和体温。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-04-17 DOI: 10.1007/s11154-025-09966-5

Jens Mittag, Beke Kolms

引用次数: 0

Weight cycling and its effects on muscle mass, sarcopenia and sarcopenic obesity. 体重循环及其对肌肉质量、肌肉减少症和肌肉减少性肥胖的影响。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-04-15 DOI: 10.1007/s11154-025-09963-8

Mauro Zamboni, Anna Giani, Francesco Fantin, Andrea P Rossi, Gloria Mazzali, Elena Zoico

{"title":"Weight cycling and its effects on muscle mass, sarcopenia and sarcopenic obesity.","authors":"Mauro Zamboni, Anna Giani, Francesco Fantin, Andrea P Rossi, Gloria Mazzali, Elena Zoico","doi":"10.1007/s11154-025-09963-8","DOIUrl":"https://doi.org/10.1007/s11154-025-09963-8","url":null,"abstract":"The prevalence of obesity is rising around the world, as the number of subjects dieting and experiencing weight loss followed by unintentional weight regain, the so-called weight cycling (WC). In this narrative review we sought to reveal the effects of WC on body composition as well as to evaluate if WC may represent a risk factor for sarcopenia and sarcopenic obesity. The relative changes in lean and fat compartments after WC have been shown to depend on several factors as the degree of energy deficit, the rate of weight loss and baseline body weight, as well as sex, age, physical activity and subject's metabolic or hormonal status. Effects of WC on body compartments may be underestimated depending on body composition measurements, interference of physical exercise, number of WC, age and population characteristics. Studies using the most precise methods to assess body composition changes, as well those with higher number of WC and/or including old subjects, show that with WC, lower fat free mass (FFM) is regained with a mismatch between muscle and fat. In addition, when WC is involuntary in old age, it drives and accelerates the age-related loss of FFM, in particular in frail populations. Finally, an association between WC and sarcopenia or sarcopenia obesity, was also observed when evaluating strength together with WC-related body composition changes. In conclusion WC may act as an accelerator of biological aging, and it could be further investigated as a potential risk factor for sarcopenia or sarcopenic obesity.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical outcomes of partial adrenalectomy for pheochromocytoma: A systematic review and meta-analysis. 肾上腺部分切除术治疗嗜铬细胞瘤的手术结果：系统回顾和荟萃分析。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-04-11 DOI: 10.1007/s11154-025-09962-9

Marta Araujo-Castro, César Mínguez Ojeda, Victoria Gómez Dos Santos, Alfonso Sanjuanbenito, Joaquín Gómez Ramírez, Enrique Mercander, Felicia Hanzu, Leire Zarain, Óscar Vidal, Alfonso Muriel García, Alberto Artiles Medina

{"title":"Surgical outcomes of partial adrenalectomy for pheochromocytoma: A systematic review and meta-analysis.","authors":"Marta Araujo-Castro, César Mínguez Ojeda, Victoria Gómez Dos Santos, Alfonso Sanjuanbenito, Joaquín Gómez Ramírez, Enrique Mercander, Felicia Hanzu, Leire Zarain, Óscar Vidal, Alfonso Muriel García, Alberto Artiles Medina","doi":"10.1007/s11154-025-09962-9","DOIUrl":"https://doi.org/10.1007/s11154-025-09962-9","url":null,"abstract":"The purpose of our study was to evaluate the efficacy and safety of partial adrenalectomy (PA) in the management of pheochromocytomas. A systematic review and metanalyses of all randomized controlled trials and observational studies (comparative and non-comparative studies), including case series with at least 5 cases, reporting efficacy and safety outcomes of PA in the treatment of bilateral and/or inherited pheochromocytomas was performed. A total of 33 articles were included in this systematic review, including 22 observational comparative and 11 single-arm studies. The pooled rates of biochemical and clinical cure after PA were 99.7% (95%CI: 98.7-100) and 99.8% (95%CI: 98.8-100), respectively. The pooled complication rate was 5.9% (95%CI: 0.8-10.9). Tumor recurrence and metastatic rates were 4% (95%CI: 0-1.6) and 0% (95%CI: 0.00-0.6), respectively. Steroid supplementation was required in 7.6% (95%CI: 2.8-12.5) of patients. No significant difference was detected in acute adrenal crisis (odds ratio [OR] 0.44, 95%CI: 0.16-1.22), biochemical (OR 0.42, 95%CI: 0.05-3.85) and clinical cure (OR 0.42, 95%CI: 0.05-3.85), complication (OR 1.59, 95%CI: 0.28-9.13) and metastatic rate (OR 1.56, 95%CI: 0.59-4.15) between the group of partial and total adrenalectomy. Nevertheless, recurrence rate (OR 2.55, 95%CI: 1.24-5.23) was higher with PA, while the need for supplementation rate (OR 0.01, 95%CI: 0.00-0.01) was significantly lower than in the total adrenalectomy group. The conclusion of the study is that the probability of biochemical cure and the rate of complications is similar between the group of patients who underwent total and partial adrenalectomy, but PA is associated with a lower rate of adrenal insufficiency and a higher recurrence rate than total adrenalectomy.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The science of bioelectrical impedance-derived phase angle: insights from body composition in youth. 生物电阻抗衍生相位角的科学：来自青年身体成分的见解。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-04-10 DOI: 10.1007/s11154-025-09964-7

Gil B Rosa, Henry C Lukaski, Luís B Sardinha

{"title":"The science of bioelectrical impedance-derived phase angle: insights from body composition in youth.","authors":"Gil B Rosa, Henry C Lukaski, Luís B Sardinha","doi":"10.1007/s11154-025-09964-7","DOIUrl":"https://doi.org/10.1007/s11154-025-09964-7","url":null,"abstract":"Despite bioelectrical impedance analysis (BIA)-derived phase angle (PhA) being recognized as a global marker of health, reflecting both cellular integrity and fluid distribution, its biological determinants still need to be described in youth. This narrative review provides a comprehensive framework examining to what extent dielectric properties shaping PhA are influenced by qualitative and quantitative determinants at multiple levels of body composition in healthy and clinical pediatric populations. At the atomic-molecular level, water content, glycogen, lipids, and ionic concentrations are expected to influence PhA by affecting electrical conductivity and/or capacitance. While the increase in the absolute values of intracellular (ICW) and extracellular water (ECW) enhances electric conductivity, an increase in the relative portion of ECW is expected to reflect hydration imbalances with an impact on electrical pathways. At the cellular level, body cell mass is a key determinant of PhA, mainly due to the presence of skeletal muscle cells favoring conductive and capacitive properties. At the tissue level, skeletal muscle architecture and orientation strongly influence conductivity, while increases in skeletal muscle mass positively impact PhA by enhancing electric conductivity and capacitance. Beyond the theoretical insights presented in this review, careful interpretation of dielectric data remains crucial due to the lack of methodological standardization. Future research should prioritize validated reference methods, investigate longitudinal changes, integrate localized BIA, and explore additional BIA models to refine the interpretation of PhA.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood obesity: The threatening apprentice of the adiposity empire. 儿童肥胖：肥胖帝国的威胁学徒。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-04-07 DOI: 10.1007/s11154-025-09959-4

J Karina Zapata, Javier Gómez-Ambrosi, Gema Frühbeck

{"title":"Childhood obesity: The threatening apprentice of the adiposity empire.","authors":"J Karina Zapata, Javier Gómez-Ambrosi, Gema Frühbeck","doi":"10.1007/s11154-025-09959-4","DOIUrl":"https://doi.org/10.1007/s11154-025-09959-4","url":null,"abstract":"Childhood obesity is a global health problem, with its prevalence having tripled since 1975. The increase in its prevalence has been predominantly in developing countries, but also in those with high economic status. Nowadays, there are multiple obesity definitions, however, one of the most accurate is the one which defines obesity as the accumulation of excessive body adiposity and not as an body weight excess. Nevertheless, the body mass index (BMI) is the most frequently used tool for its classification, according to the cut-off points established by the Center for Disease Control and World Health Organization tables. In children and adolescents an adiposity excess is related to the appearance of cardiovascular disease in adulthood and with many comorbidities such as metabolic syndrome, insulin resistance, type 2 diabetes, hypertension and metabolic dysfunction-associated steatotic liver disease, among others. Currently, there is still controversy about which is the ideal indicator for measuring overweight and obesity. BMI is still used as a standardized measure but may miss cases in which body composition is pathological despite a BMI within the normal-weight category. An adequate knowledge of the impact on health of dysfunctional adiposity as well as its accurate diagnosis will allow health professionals to address this condition in a more precise and comprehensive manner, and substantially improve the associated cardiometabolic risk and prognosis.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incretins and SGLT-2 inhibitors in diabetic patients with neuroendocrine tumors: current updates and future directions. 肠促胰岛素和SGLT-2抑制剂在糖尿病神经内分泌肿瘤患者中的应用：最新进展和未来方向

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-04-02 DOI: 10.1007/s11154-025-09958-5

Rosaria M Ruggeri, Erika Maria Grossrubatscher, Eleonora Ciocca, Iderina Hasballa, Simona Jaafar, Monica Oldani, Manila Rubino, Flaminia Russo, Andrea M Isidori, Annamaria Colao, Antongiulio Faggiano

{"title":"Incretins and SGLT-2 inhibitors in diabetic patients with neuroendocrine tumors: current updates and future directions.","authors":"Rosaria M Ruggeri, Erika Maria Grossrubatscher, Eleonora Ciocca, Iderina Hasballa, Simona Jaafar, Monica Oldani, Manila Rubino, Flaminia Russo, Andrea M Isidori, Annamaria Colao, Antongiulio Faggiano","doi":"10.1007/s11154-025-09958-5","DOIUrl":"https://doi.org/10.1007/s11154-025-09958-5","url":null,"abstract":"Neuroendocrine tumors (NET) are frequently associated with glycemic disorders, such as prediabetes or diabetes, which may result from either surgical or medical treatments or hormonal hypersecretion by the tumor itself. Moreover, pre-existing diabetes is a known risk factor for NET development, with metabolic control and antidiabetic therapies potentially influencing tumor progression. The complex interplay between diabetes and NET, which share several molecular pathways, has spurred interest in the anti-cancer effects of antidiabetic medications. This is particularly relevant as new antidiabetic drugs continue to emerge, including sodium-glucose cotransporter-2 (SGLT2) inhibitors and incretin-based therapies, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 receptor (GLP-1R) agonists and dual GIP/GLP- 1 R agonists. This review explores the impact of these novel pharmacological options on NET development and progression through a comprehensive analysis of pre-clinical and clinical studies, with the purpose to evaluate safety and feasibility of introducing these drugs in the treatment of NETs patients. We conducted a comprehensive search of online databases, including PubMed, ISI Web of Science, and Scopus, for studies assessing the therapeutic effects and potential mechanisms of action of incretins and SGLT2 inhibitors in patients with NET. These novel antidiabetic drugs exhibit promising anticancer properties, potentially inhibiting tumor cell proliferation and inducing apoptosis, though concerns about certain cancer risks remain. Based on current evidence, the benefits of incretin-based therapies outweigh any potential cancer risks, leading to the proposal of tailored management algorithms for diabetes in NET patients, factoring in the diabetes aetiology, comorbidities, and life expectancy.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0