Reviews in Endocrine & Metabolic Disorders最新文献

{"title":"Overcoming the barriers in the screening, diagnosis, and follow-up of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).","authors":"Roberto Vettor, Maria Letizia Petroni, Idit Dotan, Gadi Lalazar, Martin Haluzík, C Wendy Spearman, Joel A Dave, Faisal Abaalkhail, Salah Abusnana, Ali Alshehri, Radan Bruha, Mariann Harangi, Ahmad Jazzar, Michał Kukla, Shiva Kumar, Vaia Lambadiari, George Papatheodoridis, Mária Papp, Salvatore Petta, Corina Silvia Pop, Anca Pantea Stoian, Krzysztof Tomasiewicz","doi":"10.1007/s11154-026-10027-8","DOIUrl":"https://doi.org/10.1007/s11154-026-10027-8","url":null,"abstract":"<p><p>In 2024, a comprehensive framework for the screening, diagnosis, and management of metabolic dysfunction-associated steatotic liver disease (MASLD) was incorporated in the EASL-EASD-EASO clinical practice guidelines. However, physicians often face barriers applying these recommendations in routine clinical care, especially in the Southeastern Europe, Middle East, and Africa (SEEMEA) region. As a multidisciplinary group of physicians involved in MASLD and metabolic dysfunction-associated steatohepatitis (MASH) management, our objective is to provide a practice-oriented roadmap including practical and educational considerations beyond the hepatology field that could improve patient care and support implementation of clinical guidance within the SEEMEA region. This work is informed by a narrative review and expert input obtained through structured discussions, to examine the status quo and identify key gaps in the MASLD/MASH management, unravelling the patient journey from screening and diagnosis to treatment and follow-up. Furthermore, we advise on priorities on screening triggers and, considering the limited availability of vibration-controlled transient elastography (VCTE), discuss alternative approaches to achieve accurate and timely diagnosis. Finally, following the approval of resmetirom and semaglutide 2.4 mg for MASH treatment, we review the evolving pharmacotherapy landscape and propose a \"blueprint\" for a specialised MASLD clinic, suggesting mandatory and optional facilities for optimised care.</p>","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and cancer: glucose control impact on survival and tumor outcomes.","authors":"Rosaria Maddalena Ruggeri, Erika Maria Grossrubatscher, Giulia Arrivi, Eleonora Ciocca, Alessia Filice, Bianca Golisano, Rossella Mazzilli, Natalie Prinzi, Annamaria Colao, Antongiulio Faggiano","doi":"10.1007/s11154-026-10040-x","DOIUrl":"https://doi.org/10.1007/s11154-026-10040-x","url":null,"abstract":"<p><p>Diabetes mellitus (DM) and cancer are major global health challenges that increasingly coexist due to shared risk factors including aging, obesity, sedentary behavior, and chronic low-grade inflammation. Beyond being a common comorbidity, DM-particularly type 2 diabetes-has emerged as an important modifier of cancer risk, progression, treatment tolerance, and survival. Epidemiological studies consistently associate DM with a higher incidence of several malignancies, including pancreatic, liver, colorectal, breast, and endometrial cancers, as well as increased cancer-specific and overall mortality. The biological link between dysglycemia and cancer is complex and multifactorial. Chronic hyperglycemia, hyperinsulinemia, and insulin resistance promote tumor development and progression through altered cellular metabolism (Warburg effect), activation of insulin and insulin-like growth factor pathways, systemic inflammation, oxidative stress, immune dysfunction, and changes in the tumor microenvironment and gut microbiota. This review summarizes current evidence on the interplay between dysglycemia and cancer and explores how integrating continuous glucose monitoring (CGM)-based strategies into multidisciplinary oncology care may improve both metabolic and oncologic outcomes. A comprehensive search of online databases, including PubMed, ISI Web of Science, and Scopus, was conducted to identify studies assessing the impact of glycemic disturbances and glycemic control on cancer outcomes. Poor glycemic control and increased glucose variability are associated with worse oncologic outcomes, higher rates of treatment-related complications, reduced adherence to therapy, and diminished efficacy of chemotherapy, targeted agents, and immune checkpoint inhibitors. Severe hypoglycemia has also emerged as an independent predictor of poor prognosis. Although HbA1c has long been the cornerstone of glycemic assessment, it incompletely captures the dynamic glucose fluctuations commonly observed during cancer therapy. CGM provides a more comprehensive and clinically meaningful assessment of glycemic control, with the potential to reduce hypoglycemia, improve glycemic stability, and enhance tolerance and adherence to anticancer treatments. Current evidence indicates that diabetes and dysglycemia are key modifiers of cancer risk, progression, treatment tolerance, and survival. Optimizing glycemic control may therefore contribute to improved cancer outcomes. CGM represents a promising tool for personalizing diabetes management in oncology settings.</p>","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing food cue evoked neuroimaging towards treatment optimisation for obesity and binge eating disorder.","authors":"Kayla Flanagan, Luiza Bonfim Pacheco, Mengxia Gao, Antonio Verdejo-Garcia","doi":"10.1007/s11154-026-10045-6","DOIUrl":"https://doi.org/10.1007/s11154-026-10045-6","url":null,"abstract":"<p><p>Obesity and binge eating disorder (BED) are global health concerns that share overlapping neural mechanisms. These include alterations in the brain's reward and control systems leading to heightened sensitivity to food cues and impaired self-regulation, which underpin overeating. Identifying neuroimaging-based biomarkers that index these mechanisms could advance individualised treatments. This scoping review examined evidence on fMRI food cue reactivity as a potential approach for developing predictive and response biomarkers relevant to the treatment of obesity and BED. A systematic search of MEDLINE, Scopus, PsycINFO, and Embase (to July 2025) identified 57 eligible studies incorporating fMRI cue reactivity measures in the context of pharmacological, surgical, psychological, and lifestyle interventions. Of these, 7 reported predictive outcomes only (6 for adults with obesity and 1 for children and adolescents with obesity), 41 reported response outcomes only (36 for adults with obesity, 3 for children and adolescents with obesity and 2 for adults with binge eating), and 9 reported both predictive and response outcomes (8 for adults with obesity and 1 for adults with binge eating). Across paradigms and intervention modalities, there was consistent involvement of reward (striatum, insula, orbitofrontal and ventromedial prefrontal cortex) and cognitive control regions (dorsolateral and dorsomedial prefrontal cortex) as response outcomes from successful treatment. Reductions in reward-system reactivity following interventions were consistently associated with improved clinical outcomes, supporting the potential of fMRI food cue reactivity as a candidate biomarker of treatment response. However, this finding is highly skewed towards obesity, given the limited number of studies that report results for BED (3 studies). Furthermore, consistent evidence for reliable predictive biomarkers was also limited, likely due to methodological variability and small sample sizes. Overall, this review supports the potential of response outcomes from fMRI food cue reactivity as an indicator of treatment efficacy in obesity and highlights the limited evidence in BED. We also emphasise the need for further standardisation of paradigms and biomarker validation efforts.</p>","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Brain factors in eating disorders and obesity: a systematic review of functional near-infrared spectroscopy (fNIRS) studies.","authors":"Enrico Collantoni, Sofia Gentili, Valentina Meregalli, Serena Giovannini, Gaia Risso, Marco Romanelli, Angela Favaro","doi":"10.1007/s11154-026-10043-8","DOIUrl":"https://doi.org/10.1007/s11154-026-10043-8","url":null,"abstract":"<p><p>Eating disorders (EDs) and obesity have traditionally been conceptualized as distinct entities, yet accumulating evidence points to overlapping vulnerabilities spanning genetic, neurobiological, behavioral and psychological domains. Shared risk factors suggest convergent mechanisms, particularly in impulse control, reward processing, emotion regulation and body-image representation. In this scenario, functional near-infrared spectroscopy (fNIRS) offers a clinically accessible tool to examine cortical activity, although findings remain dispersed across heterogeneous studies. A systematic search of PubMed, Scopus and Ovid Embase identified peer-reviewed fNIRS studies in individuals with anorexia nervosa, bulimia nervosa, binge eating disorder and obesity. Eligible studies included at least one clinical group, reported original data and applied fNIRS to assess cortical responses. From 990 records, 26 studies met inclusion criteria. Eighteen studies incorporated healthy controls, while eight investigated clinical samples only. Across case-control comparisons, consistent alteration emerged in the prefrontal cortex (PFC). Obesity and binge eating disorders were associated with attenuated PFC activation during inhibitory control, decision-making and food-related paradigms, whereas bulimia nervosa showed condition-dependent alterations linked to loss-of-control symptoms. Findings in anorexia nervosa were mixed, with reduced activation during executive tasks but heightened responses to socially or emotionally salient stimuli. Broader ED samples showed blunted frontal and temporal activation during verbal fluency. Evidence highlights the PFC as a transdiagnostic hub of altered activity in EDs and obesity, consistent with overlapping vulnerabilities. Disorder-specific profiles underscore context-dependent modulation. Standardized, large-scale studies are needed to clarify the utility of fNIRS in delineating common and distinct neural substrates across the ED-obesity spectrum.</p>","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond weight loss: Integrating GLP-1 RA therapies into psychological and behavioral care for obesity and binge eating disorder.","authors":"Isa Mack, Stephanie Kullmann, Charlotte Le Morvan de Sequeira, Bea Klos, Stephan Zipfel, Andreas Birkenfeld, Rebecca Erschens","doi":"10.1007/s11154-026-10047-4","DOIUrl":"https://doi.org/10.1007/s11154-026-10047-4","url":null,"abstract":"<p><p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) represent a major advancement in obesity treatment, offering robust efficacy in weight loss and metabolic regulation. Beyond these effects, emerging evidence indicates that GLP-1 RAs also modulate appetite, reward sensitivity, and self-regulation, domains that intersect with behavioral and psychological functioning. This review adopts a biopsychosocial perspective to examine how GLP-1 RAs interact with eating behavior, mood, identity, and self-regulation, particularly in individuals with binge eating disorder (BED) or other psychiatric comorbidities. A clinical framework is proposed to integrate pharmacotherapy with lifestyle and psychological interventions. The temporary reduction in appetite and food reward may create a \"low-drive window\" in which behavioral strategies such as self-monitoring or stimulus control become more effective. However, high emotional eating, mood symptoms, or identity conflicts may moderate treatment response. Given the high prevalence of psychiatric comorbidities, structured screening using tools like the Patient Health Questionnaire-9 (PHQ-9) or Binge Eating Scale (BES) is recommended. A stepped-care approach from brief digital interventions to formal psychotherapy may help address varying support needs. Crucially, weight regain after discontinuation is common. The review discusses behavioral, psychological, and social mechanisms of relapse and highlights strategies for long-term stabilization. These include emotion regulation, body image work, and maintenance-focused behavioral interventions. GLP-1 RAs should therefore be seen not as standalone treatments but as facilitators of self-directed, sustainable change within integrated care models. Future research should define composite outcomes, explore digital tools for relapse prevention, and develop adaptive pathways tailored to individual psychological profiles.</p>","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can breastfeeding practices explain sociodemographic disparities in childhood obesity and healthy eating? Results from NHANES 2005-2018.","authors":"Frauke Klicker, Georg Halbeisen, Georgios Paslakis","doi":"10.1007/s11154-026-10049-2","DOIUrl":"https://doi.org/10.1007/s11154-026-10049-2","url":null,"abstract":"","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distractor effect of food stimuli among patients with binge eating behaviour - a narrative review and pilot data.","authors":"Sebastian M Max, Katrin E Giel, Christian Plewnia, Kathrin Schag","doi":"10.1007/s11154-026-10048-3","DOIUrl":"https://doi.org/10.1007/s11154-026-10048-3","url":null,"abstract":"<p><p>The distractor effect refers to performance impairments caused by task-irrelevant stimuli capturing attention and disrupt goal-directed behaviour, amplified by food-related cues due to their motivational salience. Individuals with binge eating behaviour (BE) show altered attentional and inhibitory control in response to food stimuli which may contribute to the development and maintenance of eating disorders. This work combines a narrative review with pilot data from a novel virtual reality (VR) paradigm. The review synthesized behavioural, neurobiological, and clinical findings on distractibility by food-related distractibility across different experimental paradigms and study samples (clinical, sub-clinical, healthy). The pilot study compared matched individuals with Binge Eating Disorder (BED) and healthy controls (N = 32) in a VR task assessing recognition, movement initiation and motor execution under food-related distraction in a two-choice-forced paradigm. The narrative review may point at food cues disrupting inhibitory control across populations, with BED associated with reduced prefrontal regulation and heightened responsivity to motivational stimuli, though findings remain mixed. Pilot data showed that individuals with BED displayed enhanced distractibility by food cues compared to healthy controls during both early recognition/movement initiation and later execution of goal-directed actions. No significant clinical associations were found in the BED group. The distractor effect emerges as a transdiagnostic phenomenon, with BED showing particular vulnerabilities extending from attentional capture to motor execution. VR paradigms provide ecological validity compared to classical button-press paradigms. Future research should employ multimodal and longitudinal approaches, and develop stage-specific interventions to strengthen control over food-related distractibility and reduce consecutively BE.</p>","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothalamic regulation of energy homeostasis: Quo vadis.","authors":"Miguel López, Jeffrey M Friedman","doi":"10.1007/s11154-026-10042-9","DOIUrl":"https://doi.org/10.1007/s11154-026-10042-9","url":null,"abstract":"","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.","authors":"Tatiana Korotkova","doi":"10.1007/s11154-026-10036-7","DOIUrl":"https://doi.org/10.1007/s11154-026-10036-7","url":null,"abstract":"","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Early-life programming of hypothalamic circuits by maternal obesity: implications for neuroendocrine disorders.","authors":"Óscar Freire-Agulleiro, Thomas H Lee, Carmelo Quarta","doi":"10.1007/s11154-026-10035-8","DOIUrl":"https://doi.org/10.1007/s11154-026-10035-8","url":null,"abstract":"","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}