Reviews in Endocrine & Metabolic Disorders最新文献_第9页

Special features on insulin resistance, metabolic syndrome and vascular complications in hypopituitary patients. 垂体功能减退患者的胰岛素抵抗、代谢综合征和血管并发症专题。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2024-01-25 DOI: 10.1007/s11154-023-09872-8

Heraldo M Garmes

引用次数: 0

Subclinical central hypothyroidism in patients with hypothalamic-pituitary disease: does it exist? 下丘脑-垂体疾病患者的亚临床中枢性甲状腺功能减退症：存在吗？

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2024-02-07 DOI: 10.1007/s11154-024-09876-y

Julio Abucham, Manoel Martins

{"title":"Subclinical central hypothyroidism in patients with hypothalamic-pituitary disease: does it exist?","authors":"Julio Abucham, Manoel Martins","doi":"10.1007/s11154-024-09876-y","DOIUrl":"10.1007/s11154-024-09876-y","url":null,"abstract":"Central hypothyroidism (CH) is characterized by decreased thyroid hormone production due to insufficient stimulation of an otherwise normal thyroid gland by TSH. In patients with established hypothalamic-pituitary disease, a low FT4 concentration is considered highly specific, although poorly sensitive, for the diagnosis of CH. That would be comparable to diagnosing primary hypothyroidism in patients at risk only when serum FT4 concentrations are below the reference range, missing all patients with subclinical primary hypothyroidism and preventing proper therapy in patients in which thyroxine replacement is clearly beneficial. Cardiac time intervals, especially the isovolumic contraction time (ICT), have been considered the gold standard of peripheral thyroid hormone action. Using Doppler echocardiography, we have previously shown a very high proportion of prolonged ICT in patients with hypothalamic-pituitary disease and serum FT4 levels indistinguishable from controls. As ICT decreased/normalized after thyroxine-induced increases in FT4 concentrations within the normal reference range, prolonged ICT was considered a bona fide diagnostic biomarker of subclinical CH. Those findings challenge the usual interpretation that FT4 concentrations in the mid-reference range exclude hypothyroidism in patients with hypothalamic-pituitary disease. Rather, subclinical central hypothyroidism, a state analogous to subclinical primary hypothyroidism, seems to be frequent in patients with hypothalamic-pituitary disease and normal FT4 levels. They also challenge the notion that thyroid function is usually the least or the last affected in acquired hypopituitarism. The relevance of Doppler echocardiography to correctly diagnose and monitor replacement therapy in both clinical and subclinical forms of CH should improve quality of life and decrease cardiovascular risk, as already demonstrated in patients with clinical and subclinical primary hypothyroidism.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"609-618"},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognition and psychological wellbeing in hypopituitary patients. 垂体功能减退患者的认知和心理健康。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2023-12-26 DOI: 10.1007/s11154-023-09869-3

Syed Ali Imran, Michael Wilkinson

{"title":"Cognition and psychological wellbeing in hypopituitary patients.","authors":"Syed Ali Imran, Michael Wilkinson","doi":"10.1007/s11154-023-09869-3","DOIUrl":"10.1007/s11154-023-09869-3","url":null,"abstract":"Hypopituitarism (HP) frequently occurs in patients presenting with sellar masses and despite recent advances in therapeutic options, HP patients consistently suffer from impaired quality of life due to psychological distress and cognitive dysfunction. These neurocognitive complications tend to persist in spite of surgical or biochemical remission of the disease making it especially challenging to segregate the effect of HP per se from other comorbidities such as the effect of tumour, surgery, radiation therapy, or complications caused by excess hormone production. Regardless, there is ample evidence to suggest that receptors for various pituitary hormones are abundantly expressed in key areas of central nervous system that are associated with memory and behaviour function and HP is also associated with poor sleep which can further exacerbate neurocognitive dysfunction. There is also evidence that hormonal replacement in HP patients partially restores these neurocognitive functions and improves sleep disorders. However, there is a need for creating better awareness among healthcare providers interacting with HP patients to enhance an earlier recognition of these disorder and their impact on quality of life despite initial remission. Importantly, there is a need to not only develop better and more cost-effective replacement therapies that would closely mimic the physiological hormonal release patterns, but also develop coping strategies for HP patients suffering from these complications.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"505-512"},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosing and treating the elderly individual with hypopituitarism. 诊断和治疗患有垂体功能减退症的老年人。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2023-12-27 DOI: 10.1007/s11154-023-09870-w

Andrea Corsello, Rosa Maria Paragliola, Roberto Salvatori

引用次数: 0

Correction to: Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing. 更正：通过 CRISPR/Cas9 介导的基因编辑治疗骨关节炎的潜在策略。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 DOI: 10.1007/s11154-023-09867-5

Rexhina Vlashi, Xingen Zhang, Haibo Li, Guiqian Chen

引用次数: 0

Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis. 限时饮食对食物摄入和血糖控制的昼夜节律一致性:一项系统综述和荟萃分析。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-11-22 DOI: 10.1007/s11154-023-09853-x

Susana Rovira-Llopis, Clara Luna-Marco, Laura Perea-Galera, Celia Bañuls, Carlos Morillas, Victor M Victor

{"title":"Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis.","authors":"Susana Rovira-Llopis, Clara Luna-Marco, Laura Perea-Galera, Celia Bañuls, Carlos Morillas, Victor M Victor","doi":"10.1007/s11154-023-09853-x","DOIUrl":"10.1007/s11154-023-09853-x","url":null,"abstract":"Daily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TRE for at least 4 weeks. 20 studies were included in the qualitative systematic review, and 18 studies (n = 1169 subjects) were included in the meta-analysis. Overall, TRE had no significant effect on fasting glucose (Hedges's g = -0.08; 95% CI:-0.31,0.16; p = 0.52), but it did reduce HbA1c levels (Hedges's g = -0.27; 95% CI: -0.47, -0.06; p = 0.01). TRE significantly reduced fasting insulin (Hedges's g = -0.40; 95% CI: -0.73,-0.08; p = 0.01) and showed a tendency to decrease HOMA-IR (Hedges's g = -0.32; 95% CI:-0.66,0.02; p = 0.06). Interestingly, a cumulative analysis showed that the beneficial effects of TRE regarding glucose levels were less apparent as studies with later TRE windows (lTRE) were being included. Indeed, a subgroup analysis of the early TRE (eTRE) studies revealed that fasting glucose was significantly reduced by eTRE (Hedges's g = -0.38; 95% CI:-0.62, -0.14; p < 0.01). Our meta-analysis suggests that TRE can reduce HbA1c and insulin levels, and that timing of food intake is a crucial factor in the metabolic benefit of TRE, as only eTRE is capable of reducing fasting glucose levels in subjects with overweight or obesity.PROSPERO registration number CRD42023405946.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"325-337"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10943166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138295824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review. 减肥手术对胃肠味觉受体表达的影响：系统综述。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2024-01-11 DOI: 10.1007/s11154-023-09865-7

Rosalind Walmsley, Lynn Chong, Michael W Hii, Robyn M Brown, Priya Sumithran

{"title":"The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review.","authors":"Rosalind Walmsley, Lynn Chong, Michael W Hii, Robyn M Brown, Priya Sumithran","doi":"10.1007/s11154-023-09865-7","DOIUrl":"10.1007/s11154-023-09865-7","url":null,"abstract":"Gastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery on the expression of oral and post-oral gastrointestinal taste receptors and associations between taste receptor alterations and clinical outcomes of bariatric surgery. A systematic review was conducted to capture data from both human and animal studies on changes in the expression of taste receptors in oral or post-oral gastrointestinal tissue following any type of bariatric surgery. Databases searched included Medline, Embase, Emcare, APA PsychInfo, Cochrane Library, and CINAHL. Two human and 21 animal studies were included. Bariatric surgery alters the quantity of many sweet, umami, and fatty acid taste receptors in the gastrointestinal tract. Changes to the expression of sweet and amino acid receptors occur most often in intestinal segments surgically repositioned more proximally, such as the alimentary limb after gastric bypass. Conversely, changes to fatty acid receptors were observed more frequently in the colon than in the small intestine. Significant heterogeneity in the methodology of included studies limited conclusions regarding the direction of change in taste receptor expression induced by bariatric surgeries. Few studies have investigated associations between taste receptor expression and clinical outcomes of bariatric surgery. As such, future studies should look to investigate the relationship between bariatric surgery-induced changes to gut taste receptor expression and function and the impact of surgery on taste preferences, food palatability, and eating behaviour.Registration code in PROSPERO: CRD42022313992.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"421-446"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing. 通过 CRISPR/Cas9 介导的基因编辑治疗骨关节炎的潜在策略。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-12-06 DOI: 10.1007/s11154-023-09860-y

Rexhina Vlashi, Xingen Zhang, Haibo Li, Guiqian Chen

{"title":"Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing.","authors":"Rexhina Vlashi, Xingen Zhang, Haibo Li, Guiqian Chen","doi":"10.1007/s11154-023-09860-y","DOIUrl":"10.1007/s11154-023-09860-y","url":null,"abstract":"Osteoarthritis (OA) is an incapacitating and one of the most common physically degenerative conditions with an assorted etiology and a highly complicated molecular mechanism that to date lacks an efficient treatment. The capacity to design biological networks and accurately modify existing genomic sites holds an apt potential for applications across medical and biotechnological sciences. One of these highly specific genomes editing technologies is the CRISPR/Cas9 mechanism, referred to as the clustered regularly interspaced short palindromic repeats, which is a defense mechanism constituted by CRISPR associated protein 9 (Cas9) directed by small non-coding RNAs (sncRNA) that bind to target DNA through Watson-Crick base pairing rules where subsequent repair of the target DNA is initiated. Up-to-date research has established the effectiveness of the CRISPR/Cas9 mechanism in targeting the genetic and epigenetic alterations in OA by suppressing or deleting gene expressions and eventually distributing distinctive anti-arthritic properties in both in vitro and in vivo osteoarthritic models. This review aims to epitomize the role of this high-throughput and multiplexed gene editing method as an analogous therapeutic strategy that could greatly facilitate the clinical development of OA-related treatments since it's reportedly an easy, minimally invasive technique, and a comparatively less painful method for osteoarthritic patients.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"339-367"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications. 棕色、白色和米色脂肪组织分泌功能的最新进展：走向治疗应用。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-12-05 DOI: 10.1007/s11154-023-09850-0

Zeinab Ghesmati, Mohsen Rashid, Shabnam Fayezi, Frank Gieseler, Effat Alizadeh, Masoud Darabi

{"title":"An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications.","authors":"Zeinab Ghesmati, Mohsen Rashid, Shabnam Fayezi, Frank Gieseler, Effat Alizadeh, Masoud Darabi","doi":"10.1007/s11154-023-09850-0","DOIUrl":"10.1007/s11154-023-09850-0","url":null,"abstract":"Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates energy as heat for thermoregulation. Beige adipose tissue is a hybrid form of adipose tissue that shares characteristics with WAT and BAT. Dysregulation of adipose tissue metabolism is linked to various disorders, including obesity, type 2 diabetes, cardiovascular diseases, cancer, and infertility. Both brown and beige adipocytes secrete multiple molecules, such as batokines, packaged in extracellular vesicles or as soluble signaling molecules that play autocrine, paracrine, and endocrine roles. A greater understanding of the adipocyte secretome is essential for identifying novel molecular targets in treating metabolic disorders. Additionally, microRNAs show crucial roles in regulating adipose tissue differentiation and function, highlighting their potential as biomarkers for metabolic disorders. The browning of WAT has emerged as a promising therapeutic approach in treating obesity and associated metabolic disorders. Many browning agents have been identified, and nanotechnology-based drug delivery systems have been developed to enhance their efficacy. This review scrutinizes the characteristics of and differences between white, brown, and beige adipose tissues, the molecular mechanisms involved in the development of the adipocytes, the significant roles of batokines, and regulatory microRNAs active in different adipose tissues. Finally, the potential of WAT browning in treating obesity and atherosclerosis, the relationship of BAT with cancer and fertility disorders, and the crosstalk between adipose tissue with circadian system and circadian disorders are also investigated.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"279-308"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome. 生殖中和生殖外的吻肽系统：探索子宫内膜异位症和多囊卵巢综合征之间错综复杂的途径和潜在联系。

IF 6.9 2区医学

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2023-07-28 DOI: 10.1007/s11154-023-09826-0

Noemi Salmeri, Paola Viganò, Paolo Cavoretto, Roberto Marci, Massimo Candiani

{"title":"The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome.","authors":"Noemi Salmeri, Paola Viganò, Paolo Cavoretto, Roberto Marci, Massimo Candiani","doi":"10.1007/s11154-023-09826-0","DOIUrl":"10.1007/s11154-023-09826-0","url":null,"abstract":"Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with a significant impact on the health and quality of life of women affected. A novel hypothesis by evolutionary biologists suggested that these two diseases are inversely related to one another, representing a pair of diametrical diseases in terms of opposite alterations in reproductive physiological processes but also contrasting phenotypic traits. However, to fully explain the phenotypic features observed in women with these conditions, we need to establish a potential nexus system between the reproductive system and general biological functions. The recent discovery of kisspeptin as pivotal mediator of internal and external inputs on the hypothalamic-pituitary-gonadal axis has led to a new understanding of the neuroendocrine upstream regulation of the human reproductive system. In this review, we summarize the current knowledge on the physiological roles of kisspeptin in human reproduction, as well as its involvement in complex biological functions such as metabolism, inflammation and pain sensitivity. Importantly, these functions are known to be dysregulated in both PCOS and endometriosis. Within the evolving scientific field of \"kisspeptinology\", we critically discuss the clinical relevance of these discoveries and their potential translational applications in endometriosis and PCOS. By exploring the possibilities of manipulating this complex signaling system, we aim to pave the way for novel targeted therapies in these reproductive diseases.","PeriodicalId":21106,"journal":{"name":"Reviews in Endocrine & Metabolic Disorders","volume":" ","pages":"239-257"},"PeriodicalIF":6.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0