Research in veterinary science最新文献

{"title":"Beyond the usual signs: Pseudo-pericarditis as an under-appreciated outcome of tropical theileriosis","authors":"Vikrant Sudan ,&nbsp;Priyanka Syal ,&nbsp;Jasleen Kaur","doi":"10.1016/j.rvsc.2025.106029","DOIUrl":"10.1016/j.rvsc.2025.106029","url":null,"abstract":"<div><div>Pseudopericarditis is an often-overlooked clinical manifestation of tropical theileriosis, with only a few sporadic reports describing its occurrence. The present note documents clinical cases of tropical theileriosis exhibiting characteristic signs of pseudopericarditis, including jugular vein distension and brisket oedema. The proposed pathogenesis, supported by a schematic illustration, suggests that enlarged mediastinal lymph nodes exert pressure on major intrathoracic vessels, thereby impairing venous return and producing the clinical signs observed. Additionally, the roles of oncotic, osmotic, and hydrostatic pressure imbalances in the pathobiology of pseudopericarditis have been emphasised. Field veterinarians should therefore consider tropical theileriosis as a differential diagnosis in animals presenting with brisket oedema and/or jugular vein distension.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"200 ","pages":"Article 106029"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145820596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive components of Azadirachta indica (neem) leaf extract enhance immunity, health, and production parameters in broilers","authors":"Md. Shafiqul Islam,&nbsp;Md. Abu Rayhan Parvez,&nbsp;Saiful Islam,&nbsp;Md. Tanvir Hasan,&nbsp;Md. Ashraful Alam,&nbsp;Md. Najibul Hoque","doi":"10.1016/j.rvsc.2025.106040","DOIUrl":"10.1016/j.rvsc.2025.106040","url":null,"abstract":"<div><div>This study investigated the efficacy of a chemically characterized neem (<em>Azadirachta indica</em>) leaf extract as a viable alternative to antibiotics for sustainable broiler production. Comprehensive phytochemical analysis (TLC, HPLC, GC–MS, NMR) identified and quantified key bioactive compounds-azadirachtin, nimbin, nimbolide, gedunin, and salannin-with the ethanolic extract yielding a higher concentration of these limonoids. The comparative efficacy of this standardized neem preparation was evaluated against danofloxacin (antibiotic) and butaphosphan (metabolic booster) in a 28-day trial with one hundred and fifty Lohman meat chicks (10 birds/pen, 3 pens/treatment). The results demonstrated that neem supplementation significantly improved broiler performance. Birds in the neem groups, particularly the ethanolic group, achieved significantly higher final body weight and better feed conversion ratio, performing comparably to the antibiotic and booster groups. Immunologically, neem extracts significantly increased lymphocyte counts and reduced the heterophil-to-lymphocyte ratio, confirming an immunostimulatory and anti-stress effect. Serum biochemistry revealed significantly lower levels of liver enzymes (AST and ALT), indicating a hepatoprotective benefit. Histopathological examination confirmed healthier intestinal morphology, with quantifiably increased villus height and a superior villus-height-to-crypt-depth ratio in the duodenum and more caecal folds. Additionally, carcass quality and dressing percentage were significantly higher in neem-treated birds. The study concludes that the synergistic action of the identified bioactive compounds in neem leaf extract is responsible for its multifaceted benefits, making it a promising, natural, and cost-effective phytogenic alternative to in-feed antibiotics for enhancing productivity and ensuring safe broiler meat.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"200 ","pages":"Article 106040"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femorotibial joint rotation in intact joints and following partial medial collateral ligament transection, tibial plateau leveling osteotomy, and cranial cruciate ligament transection – A limb press study","authors":"M.L. Holmbjerg ,&nbsp;C.K. Tvedsborg ,&nbsp;M.B.M. Nielsen,&nbsp;J.E. Miles","doi":"10.1016/j.rvsc.2025.106026","DOIUrl":"10.1016/j.rvsc.2025.106026","url":null,"abstract":"<div><div>Despite widespread use of tibial plateau leveling osteotomy (TPLO), the influence of partial medial collateral ligament transection (pMCLX) and physiologic loading on rotational stability remains unclear. This cadaveric study quantified internal and external tibial rotation in canine stifles under simulated weightbearing conditions. Ten unpaired pelvic limbs were mounted in a custom limb press applying axial loads equivalent to 30 % body weight with the stifle fixed at 135°. Quadriceps tension was simulated using a load cell and turnbuckle, and controlled internal and external torques (0.007 Nm/kg) were applied twice per condition. Joints were tested sequentially: intact, after pMCLX at the level of the planned TPLO osteotomy, following TPLO (target tibial plateau angle 5°), and after cranial cruciate ligament transection (CCLX). Internal rotation changed minimally after pMCLX (<em>P</em> = 1.0) but increased significantly following TPLO (<em>P</em> = 0.001) and CCLX (<em>P</em> = 0.002), with limited changes following CCLX (<em>P</em> = 1.0). External rotation increased significantly only between TPLO and CCLX (<em>P</em> = 0.02). These findings indicate that pMCLX does not contribute to significant rotational laxity, while TPLO increases internal rotation independently of CCL integrity. The stabilizing effects of quadriceps tension and axial loading highlight the importance of physiologic constructs in ex vivo models. Overall, these results challenge concerns about iatrogenic instability from pMCLX and support current TPLO positioning strategies.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"200 ","pages":"Article 106026"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical evaluation of a cemented femoral stem for canine total hip replacement across two breeds","authors":"K.S. Kamalesh Kumar ,&nbsp;Rohit Kumar ,&nbsp;T. Sai Kumar ,&nbsp;Aman Kumar Tiwari ,&nbsp;Abhishek C. Saxena ,&nbsp;O.R. Vinodh Kumar ,&nbsp;Bhanu Pratap Singh ,&nbsp;Abhijit Pawde ,&nbsp;Amarpal","doi":"10.1016/j.rvsc.2026.106057","DOIUrl":"10.1016/j.rvsc.2026.106057","url":null,"abstract":"<div><div>Cemented total hip replacement (THR) remains an established procedure for restoring hip joint function in dogs with degenerative or traumatic coxofemoral disease; however, limited evidence exists regarding the mechanical integrity and load-transfer characteristics of cemented femoral stem constructs within native canine femora. This study critically evaluated the biomechanical performance of a novel modular cemented femoral stem using cadaveric femora from German Shepherd Dogs (GSDs) and Labrador Retrievers (LABs), emphasizing axial, bending, and torsional behaviors in correlation with radiographic and morphometric parameters. Eighteen pairs of adult canine femora were harvested postmortem, with one side implanted following standardized second-generation cementation protocols and the contralateral side retained intact. Following radiographic and CT-based templating, specimens underwent displacement-controlled axial compression, three-point bending, and torsion tests. Cemented implantation significantly reduced ultimate compressive, bending, and torsional strengths compared to intact femora (<em>p</em> &lt; 0.05), though stiffness remained unaffected, suggesting preservation of elastic response despite altered failure thresholds. GSD femora consistently exhibited greater load-bearing capacity, yield strength, and energy absorption than LABs, reflecting breed-specific variations in cortical geometry and canal morphology. Radiographs confirmed precise stem alignment, uniform cement mantles averaging 5 mm, and consistent canal fill exceeding 60 %, indicative of optimized cementation. Failure patterns transitioned from brittle cortical fractures in intact specimens to ductile interfacial shear at the bone-cement interface in implanted constructs, demonstrating efficient load redistribution through the composite system. Collectively, these findings highlight the mechanical reliability and breed-dependent adaptability of the cemented THR system, supporting its translational potential for achieving durable fixation and functional load transfer in canine clinical applications while offering valuable insights relevant to comparative orthopedic biomechanics.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"201 ","pages":"Article 106057"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Escherichia coli strains from wild birds in Türkiye: Antibiotic resistance, virulence factors and phylogroups","authors":"Doğancan Yarım,&nbsp;Emre Karakaya,&nbsp;Fuat Aydın,&nbsp;Seçil Abay","doi":"10.1016/j.rvsc.2025.106045","DOIUrl":"10.1016/j.rvsc.2025.106045","url":null,"abstract":"<div><div>This study aimed to isolate and identify <em>Escherichia coli</em> (<em>E. coli</em>) from the feces of wild bird species and to determine antibiotic susceptibilities, phylogroups, and virulence genes in the isolates obtained.</div><div>For this purpose, a total of 575 fecal samples from 100 Eurasian Tree Sparrow, 250 Eurasian Jackdaw, 156 Eurasian Magpie, 4 Short-toed Snake-Eagle, 60 Rock dove, and 5 Long-legged Buzzard were used. <em>E. coli</em> isolation was performed using direct inoculation on MacConkey agar. The isolates were identified through phenotypic tests, Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF-MS), and Polymerase Chain Reaction (PCR). The susceptibility of the isolates to nine antibiotics was determined by the disk diffusion method. Phylogroups and the presence of virulence genes were determined by Clermont typing and the multiplex PCR (mPCR) methods, respectively. Among 575 feces samples, <em>E. coli</em> was isolated from 37 (6.43 %). The highest antibiotic resistance was found in ampicillin, azithromycin, and trimethoprim-sulfamethoxazole at 35.1 %. Moreover, 43.2 % of the <em>E. coli</em> isolates were detected as Multidrug-Resistant (MDR), and these isolates exhibited 13 different MDR patterns by demonstrating resistance to three to eight various antibiotic classes. While the most common phylogroup detected among isolates was A (18.9 %), none belonged to phylogroups C and F. 72.9 % had at least one virulence gene. The most frequently detected virulence gene was <em>stx1</em> + <em>stx2</em> (32.4 %), and all isolates were negative for <em>bfpA</em> and <em>lt</em> genes.</div><div>In conclusion, considering the role of birds of prey in the ecological balance, the data obtained in this study suggest that wild birds may contribute to the spread of pathogenic and antibiotic-resistant <em>E. coli</em> strains globally.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"200 ","pages":"Article 106045"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145864882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of endoparasite infections in the European hedgehog (Erinaceus europaeus) and association with rehabilitation outcome in wildlife centres in Northwest France","authors":"Paula Yagüez I. López-Jurado ,&nbsp;Katie Beckmann ,&nbsp;Rob Kelly","doi":"10.1016/j.rvsc.2025.106034","DOIUrl":"10.1016/j.rvsc.2025.106034","url":null,"abstract":"<div><div>The European hedgehog (<em>Erinaceus europaeus</em>) is prevalent across Western Europe, with many individuals admitted to wildlife rehabilitation centres. Parasitic infections, particularly helminth parasites, may threaten rehabilitation success. This study investigated respiratory and gastrointestinal endoparasite prevalence, risk factors, and associations with survival in 300 hedgehogs admitted to four rehabilitation centres in northwestern France (May 2023–May 2024). Faecal samples were analysed using either the modified McMaster technique (Oise) or direct smear (Seine-Maritime, Loir-et-Cher, Essonne). Overall, 58.3 % of hedgehogs carried at least one endoparasite. The most common were <em>Capillaria</em> species group (43.6 %) and <em>Crenosoma striatum</em> (25.7 %), followed by <em>Brachylaemus erinacei</em> (11 %) and <em>Cycloisospora</em> species group (7.3 %). Co-infection was common; 35 % of infected individuals harboured both <em>Capillaria</em> spp. and <em>C. striatum</em>. Younger hedgehogs showed lower prevalence but higher parasite burdens, suggesting reduced resistance. <em>Capillaria</em> spp. prevalence peaked in winter across all age groups. Multivariable analysis identified age, weight, season, and admission reason as significant risk factors for parasitism. Importantly, detection of <em>C. striatum</em> significantly increased mortality risk during rehabilitation (OR = 3.44, <em>p</em> = 0.0002). These findings highlight the need for targeted parasite screening and treatment protocols for specific risk groups, for example for juveniles and individuals with clinical signs. Coprological analysis offers a practical, non-invasive tool for parasite detection in resource-limited rehabilitation settings. This is the first study to report endoparasite prevalence in live hedgehogs in France using coprological methods and to demonstrate a statistical association between <em>C. striatum</em> infection and mortality in rehabilitation.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"200 ","pages":"Article 106034"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of a novel porcine reproductive and respiratory syndrome virus strain inducing biphasic temperature fluctuations in Tianjin, northern China","authors":"Jia Wang ,&nbsp;Yi-Han Lu ,&nbsp;Bo-Han ,&nbsp;Hai-Tao Yang ,&nbsp;Xin-lei Li ,&nbsp;Wen Sun ,&nbsp;Shi-Qin Zhang ,&nbsp;Zhuo-Ran Miao ,&nbsp;Xue-Jiao Cheng ,&nbsp;Chun-Xue You ,&nbsp;Ying-Feng Sun","doi":"10.1016/j.rvsc.2025.106037","DOIUrl":"10.1016/j.rvsc.2025.106037","url":null,"abstract":"<div><div>Porcine reproductive and respiratory syndrome virus (PRRSV) has imposed significant economic burdens on the global swine industry. The majority of PRRSV strains can induce high fever at various stages of pig development. However, the PRRSV strain that triggers the biphasic temperature phenomenon remains relatively rare. In this study, a novel PRRSV variant, designated SJ0107, was isolated from local pig farms in Tianjin, Northern China, in 2024. Recombination analysis reveals that SJ0107 is a recombinant PRRSV strain resulting from the interaction between lineage 1.8 and lineage 8.3, with four potential recombination breakpoints located in Nsp2 (nt 766/1997), Nsp4 (nt 5413), and Nsp9 (nt 7750). Animal challenge experiments conducted on four-week-old piglets demonstrated that SJ0107 can induce rare initial hypothermia symptoms within 5 days post-inoculation (dpi). Subsequently, the body temperature returned to normal, and high-grade fever symptoms emerged at 11 dpi, lasting for one week before normalizing again. Meanwhile, severe histopathological lung lesions were also detected in the pathological sections. In conclusion, the findings reveal that the SJ0107 strain undergoes a dual-phase temperature alteration, which not only complicates traditional diagnostic criteria reliant on persistent fever but also heightens the risk of misdiagnosis in the initial phases of infection. These insights underscore the necessity of revising surveillance protocols for emerging PRRSV variants that exhibit atypical pathogenic characteristics.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"200 ","pages":"Article 106037"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145820587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A field observational study evaluating antemortem inspection as a predictive tool for postmortem lesion findings at a Portuguese pig abattoir","authors":"Márcia Santos Nunes ,&nbsp;Abbey Olsen ,&nbsp;Rui Pedro Cordeiro ,&nbsp;Madalena Vieira-Pinto","doi":"10.1016/j.rvsc.2025.106043","DOIUrl":"10.1016/j.rvsc.2025.106043","url":null,"abstract":"<div><div>Risk-based inspection of pigs at the abattoir depends on accurately identifying high-risk animals before slaughter. Food Chain Information (FCI) provides data on farm management, animal health, and treatments that can support this process; however, its limited completeness and reliability highlight the need for complementary approaches. Antemortem (AM) conditions may serve as practical predictors of postmortem (PM) lesions, supporting the development of risk-based inspection systems. This study investigated the potential of AM inspection in detecting PM lesions in finisher pigs, slaughtered at a commercial abattoir in Portugal. Data were collected from 62 batches (<em>n</em> = 9542 pigs) for a cross-sectional study, and 245 pigs for a case control study. Detection of coughing, skin lesions, and growth retardation was significantly higher when pigs were inspected from inside the pens, compared with unloading or outside the pens observations. At batch-level coughing at AM inspection was associated with a higher number of PM lesions, particularly pneumonia (OR = 1.08) and pleurisy (OR = 1.03). At animal-level, AM conditions showed consistent associations with PM lesions, including coughing with pneumonia (OR = 6.7), and lung lesion (OR = 6.2), lameness with arthritis (OR = 14.9) and growth retardation with several PM lesions. These findings are consistent with those reported in other countries and confirm that specific AM conditions can reliably predict certain PM lesions, contributing to the refinement of risk-based inspection approaches in Portugal.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"201 ","pages":"Article 106043"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145895943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of detection method of chicken infectious anemia virus based on CRISPR/Cas12a system","authors":"Chenchen Sheng ,&nbsp;Jingfang Wang ,&nbsp;Mengyuan Tan ,&nbsp;jingwen Zhang ,&nbsp;Mengran Sun ,&nbsp;Jiumeng Sun ,&nbsp;Ying Shao ,&nbsp;Jian Tu ,&nbsp;Liangqiang Zhu ,&nbsp;Xiangjun Song","doi":"10.1016/j.rvsc.2025.106046","DOIUrl":"10.1016/j.rvsc.2025.106046","url":null,"abstract":"<div><div>Chicken Infectious Anemia Virus (CIAV) causes chicken infectious anemia, characterized by anemia and immune dysfunction. The rapid dissemination of this virus is generating substantial economic consequences for poultry producers.</div><div>The CRISPR/Cas12a system is widely used for virus detection through crRNA-guided target recognition and the paracrine activity of Cas12a. To enable rapid and highly sensitive detection of Chicken Infectious Anemia Virus (CIAV), a CRISPR-Cas12a-based fluorescence assay was refined. Through optimization of the CRISPR/Cas12a system and integration of enzymatic recombinase amplification (ERA), the assay achieved a detection limit of 1 copy/μL, demonstrating its significant utility for CIAV diagnostics. In addition, a CRISPR/Cas12a lateral flow assay was developed and optimized, achieving a sensitivity of 10^3 copies/μL for the rapid and visual detection of target analytes. This technique exhibits high specificity for CIAV, showing no cross-reactivity with other chicken viruses. Overall, the system enables rapid CIAV detection with cost-effective equipment, making it suitable for virus monitoring.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"201 ","pages":"Article 106046"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remedial effects of extracellular polymeric substances (EPS) from Arthrospira platensis against Di-n-butyl phthalate (DBP) toxicity on gilthead seabream (Sparus aurata)","authors":"Amira Bemri ,&nbsp;Fethi Jebali ,&nbsp;Jihene Ammar ,&nbsp;Tahar Gharred ,&nbsp;Jamel Jebali ,&nbsp;Hamadi Guerbej ,&nbsp;Hatem Ben Ouada ,&nbsp;Zied Bouraoui","doi":"10.1016/j.rvsc.2025.106041","DOIUrl":"10.1016/j.rvsc.2025.106041","url":null,"abstract":"<div><div>Di-n-butyl phthalate (DBP) is an organic compound of phthalate, commonly used in the production of various plastic materials and its detrimental effects on marine ecosystems and human health have a great concern. Bioactive compounds derived from microalgae have numerous biological and pharmacological activities and their remedial role in alleviating the adverse effects of toxicity induced by environmental and other agents has also been reported. Thus, in this work, we carried out studies to ascertain if exopolysaccharides (EPS) extracted from <em>Arthrospira platensis</em> (Cyanobacteria) would ameliorate DBP-induced toxicity in gilthead seabream (<em>Sparus aurata</em>), used as model organism, focusing on growth performance, oxidative stress, neurotoxicity, histopathological changes in liver and intestine, and muscle nutritional quality. Firstly, fish in triplicate were fed separately a supplemented diet with 0 % (control group) and 6 % of EPS (EPS group) for 21 days. Consequently, each group were intraperitoneally exposed to DBP at a concentration of 85 μg /kg body weight. The results showed that DBP impaired growth, induced antioxidant-oxidative stress imbalance and caused genotoxicity and liver and intestine damage. Also, DBP disrupted muscle proximate composition and fatty acid profiles. Interestingly, feeding the DBP-exposed fish with EPS partially restored, histopathological damage in liver and intestine, antioxidant markers, lipid balance, notably improving the ω3/ω6 ratio, likely through EPS's antioxidant and metabolic regulatory effects.</div><div>Overall, this study offered further insights on the antioxidative and chemopreventive properties of exopolysaccharides (EPS) extracted from <em>Arthrospira platensis</em> to modulate fish health and to enhance growth and protect against DBP-induced toxicity.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"200 ","pages":"Article 106041"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}