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Analysis of Phenolic Compounds by LC-HRMS and Determination of Antioxidant and Enzyme Inhibitory Properties of Verbascum speciousum Schrad LC-HRMS法分析酚类化合物及石藻抗氧化和酶抑制性能的测定
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-12-13 DOI: 10.25135/rnp.370.2210.2598
I. Gülçin, Hatice Kiziltaş, Zeynebe Bi̇ngöl, A. Gören, S. Alwasel
{"title":"Analysis of Phenolic Compounds by LC-HRMS and Determination of Antioxidant and Enzyme Inhibitory Properties of Verbascum speciousum Schrad","authors":"I. Gülçin, Hatice Kiziltaş, Zeynebe Bi̇ngöl, A. Gören, S. Alwasel","doi":"10.25135/rnp.370.2210.2598","DOIUrl":"https://doi.org/10.25135/rnp.370.2210.2598","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46662372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Eupalinolide N, a Previously Undescribed Sesquiterpene Lactone with Anti-inflammatory Activity from Eupatorium lindleyanum 从紫泽兰中发现的一种具有抗炎活性的倍半萜内酯
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-12-13 DOI: 10.25135/rnp.368.2206.2499
Cheng Peng, Jie Yan, D. Guo, Jin Pei, Yun Deng, Ding Liu, Xiaofang Xie, Wenxiu Guo, Lanyu Zhou, Bin Xiao, Xue-yan Huo, Yunjie Hu
{"title":"Eupalinolide N, a Previously Undescribed Sesquiterpene Lactone with Anti-inflammatory Activity from Eupatorium lindleyanum","authors":"Cheng Peng, Jie Yan, D. Guo, Jin Pei, Yun Deng, Ding Liu, Xiaofang Xie, Wenxiu Guo, Lanyu Zhou, Bin Xiao, Xue-yan Huo, Yunjie Hu","doi":"10.25135/rnp.368.2206.2499","DOIUrl":"https://doi.org/10.25135/rnp.368.2206.2499","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41465398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diterpenoids from the Seeds of Euphorbia Lathyris and their Cytotoxic Acitivity 大戟种子中的二萜类化合物及其细胞毒活性
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-11-26 DOI: 10.25135/rnp.365.2205.2459
Na Liu, Yajie Sun, Yulin Sun, Yilin Sun, Ting Luo, Fengying Yang, Peng Wang, Di Ge
{"title":"Diterpenoids from the Seeds of Euphorbia Lathyris and their Cytotoxic Acitivity","authors":"Na Liu, Yajie Sun, Yulin Sun, Yilin Sun, Ting Luo, Fengying Yang, Peng Wang, Di Ge","doi":"10.25135/rnp.365.2205.2459","DOIUrl":"https://doi.org/10.25135/rnp.365.2205.2459","url":null,"abstract":": A total of 23 diterpenoids were isolated from the seeds of Euphorbia lathyris , and one new compound ( 1 ) and twenty-two known compounds ( 2-23 ) were characterized by using 1D- and 2D-NMR spectra and HRESIMS analysis. Cytotoxicity of the isolated compounds against BT-549 and MDA-MB-231 cancer cells lines were evaluated further. Compounds 3 , 10 , 14 , and 22 were found to exhibit considerable cytotoxic activities against BT-549 cells, with IC 50 values ranging from 4.7 to 10.1 μM. Compounds 1 , 2 , 14 and 22 were able to inhibit the MDA-MB-231 cell line growth with IC 50 values of 5.7 to 21.3 μM, while other compounds showed no obvious inhibitory effects.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47346277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essential Oil Compositions and Antimicrobial Activity of the Leaves of Alphonsea monogyma Merr. & Chun and Goniothalamus banii B. H. Quang, R. K. Choudhary & V.T. Chinh from Vietnam 山Alphonsea monogyma Merr.&来自越南的Chun和Goniothalamus banii B.H.Quang，R.K.Choudhary和V.T.Chinh
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-11-26 DOI: 10.25135/rnp.367.2208.2547
I. Ogunwande, L. Huong, L. Giang, D. Dai
{"title":"Essential Oil Compositions and Antimicrobial Activity of the Leaves of Alphonsea monogyma Merr. & Chun and Goniothalamus banii B. H. Quang, R. K. Choudhary & V.T. Chinh from Vietnam","authors":"I. Ogunwande, L. Huong, L. Giang, D. Dai","doi":"10.25135/rnp.367.2208.2547","DOIUrl":"https://doi.org/10.25135/rnp.367.2208.2547","url":null,"abstract":": Essential oils from the leaves of Alphonsea monogyma Merr. & Chun and Goniothalamus banii B. H. Quang, R. K. Choudhary & V.T. Chinh from Vietnam were obtained by hydrodisitllation and the chemical components determined by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC/MS). The antimicrobial assay was conducted by microdilution broth method. The respective yields of the essential oils were 0.18% (v/w) and 0.355% (v/w), respectively. The major components of A. monogyma were ( E )-caryophyllene (13.8%),  -cadinene (12.5%), bicyclogermacrene (12.4%), cis -β-elemene (12.1%), and germacrene D (11.4%). However, myrcene (47.1%), α-pinene (9.7%) and ( E )-caryophyllene (9.1%) were the dominant constituents of the essential oil of G. banii . The leaf essential oil of A. monogyma displayed potent antimicrobial activity towards the Gram-positive microorganisms of Enterococcus faecalis ATCC29212, Staphylococcus aureus ATCC25923 and Bacillus cereus ATCC14579 with minimum inhibitory concentration (MIC) values of 2.23 µg/mL, 10.45 µg/mL and 10.33 µg/mL, respectively. On the other hand, essential oil from G. banii exhibited the most effective antibacterial against Gram-negative Pseudomonas aeruginosa ATCC27853 (MIC 5.67 µg/mL), and anti-candidal action towards Candida albicans ATCC10231 (MIC 32.67 µg/mL). The chemical constituents and antimicrobial activity of the essential oils of A. monogyma and G. banii were being reported for the first time.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43118826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparative Analyses on Chemical Constituents and Biological Activities of Laserpitium siler L. from Serbia 塞尔维亚激光鹿的化学成分和生物活性的比较分析
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-11-25 DOI: 10.25135/rnp.364.2207.2528
Ksenija S. Mileski, A. Ćirić, U. Gašić, Lazar D. Žarković, Z. Krivošej, A. Džamić
{"title":"Comparative Analyses on Chemical Constituents and Biological Activities of Laserpitium siler L. from Serbia","authors":"Ksenija S. Mileski, A. Ćirić, U. Gašić, Lazar D. Žarković, Z. Krivošej, A. Džamić","doi":"10.25135/rnp.364.2207.2528","DOIUrl":"https://doi.org/10.25135/rnp.364.2207.2528","url":null,"abstract":": The traditional European medicinal plant Laserpitium siler L. was studied for the first time for the chemical composition and in vitro biological potential of extracts from fruits and aerial parts. Eight extracts were subjected to spectrophotometric detection and LC-MS quantification of phenolics. The bioactivity assessment comprised antioxidant, antimicrobial, anti-denaturation, acetylcholinesterase, tyrosinase, α-amylase, and α-glucosidase inhibition assays. The spectrophotometric analyses showed that the alcoholic extracts contained the most phenolic acids and coumarins. Among the twenty quantified compounds in the methanolic extracts, chlorogenic acid (29.10 mg/kg in the fruits; 47.00 mg/kg in the aerial parts) and p -coumaric acid (7.50 mg/kg in the fruits; 9.50 mg/kg in the aerial parts) were the most abundant. The DPPH/ABTS/BBT tests showed the strongest antioxidant effect of the methanolic extract of the aerial parts. The results of the microdilution assay referred to stronger antibacterial than antifungal activity, with the essential oil being as effective as the antibiotics used. The extracts expressed promising activity against P . aeruginosa PAO1 biofilm formation and pyocyanin synthesis. The prevention of BSA denaturation by the ethanolic extracts was comparable to diclofenac (91.08%-fruits, 95.08%-aerial parts, and 95.60%-diclofenac). IC 50 values showed greater enzyme inhibitory potential of aerial parts and the highest reduction of α-glucosidase activity.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45884088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anti-inflammatory Continents from the Heartwood of Dalbergia melanoxylon 黑檀心材中的抗炎成分
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-11-08 DOI: 10.25135/rnp.366.2208.2560
Qing Zhu, C. Ouyang, Yang Liu, Zhangjun Xu, Ying Zhang, Ronghuai Liu, Lanying Chen
{"title":"Anti-inflammatory Continents from the Heartwood of Dalbergia melanoxylon","authors":"Qing Zhu, C. Ouyang, Yang Liu, Zhangjun Xu, Ying Zhang, Ronghuai Liu, Lanying Chen","doi":"10.25135/rnp.366.2208.2560","DOIUrl":"https://doi.org/10.25135/rnp.366.2208.2560","url":null,"abstract":": A new chalcone compound, methyl 5-cinnamoyl-2-hydroxy-4-methoxybenzoate ( 1 ), and a new cinnamylphenol compound, methyl 3-cinnamyl-5-hydroxy-4-methoxybenzoate ( 2 ) together with four known compounds ( 3 - 6 ) were isolated from the CH 2 Cl 2 fraction of Dalbergia melanoxylon . Their structures were elucidated by comprehensive spectral measurements including NMR techniques, mass spectrometry, single crystal X-ray diffraction and, together with comparison of the literature data. According to the determination results of compound 1 and 2 on RAW 264.7 cell viability, the IC 50 values of compounds were found to be 3.2 and 383.8 μM, respectively. Compared with LPS model group, compounds 1 and 2 were found to be significantly reduce the release of NO in the concentration ranges of 1.2~9.6 and 33.7 μM ( P <0.01), and significantly inhibit the secretion of LDH in the range of 4.8~9.6 and 16.8~33.7 μM . melanoxylon cinnamylphenol; activity. © 2022 ACG","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47938929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Editorial 社论
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-10-29 DOI: 10.25135/rnp.389.2210.2400
M. Öztürk, Ahmet C. Gören
{"title":"Editorial","authors":"M. Öztürk, Ahmet C. Gören","doi":"10.25135/rnp.389.2210.2400","DOIUrl":"https://doi.org/10.25135/rnp.389.2210.2400","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44476165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyketides and Alkaloids from the Fungus Penicillium sp. 真菌青霉菌的聚酮和生物碱。
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-10-29 DOI: 10.25135/rnp.363.2210.2593
Q. Chen, Yifang Chen, Ying Lu, Jian-Qiang Zhao
{"title":"Polyketides and Alkaloids from the Fungus Penicillium sp.","authors":"Q. Chen, Yifang Chen, Ying Lu, Jian-Qiang Zhao","doi":"10.25135/rnp.363.2210.2593","DOIUrl":"https://doi.org/10.25135/rnp.363.2210.2593","url":null,"abstract":": The marine-derived fungus SCZ-1 was cultured on rice solid medium. The fermented materials was extracted using ethyl acetate to afford an extract, which was separated by repeated column chromatography to afford three polyketides and five alkaloids, including 2 new polyketides ( 1 and 2 ). The known compounds were identified to be penipyrol A ( 3 ), cyclopenin ( 4 ), cyclopenol ( 5 ), terretrione D ( 6 ), viridicatol ( 7 ), and viridicatin ( 8 ). The structures of 1 and 2 were determined by extensive analyses of spectroscopic data (1D and 2D NMR, and HRESIMS). The absolute configuration of 2 was assigned by comparison of the experimental ECD spectrum with calculated ECD spectrum. Compound 1 , bearing a two-carbon side chain at C-2, is seldom found among natural isocoumarins. All metabolites were screened for their inhibitory effects toward  -glucosidase, only compound 8 showed weak activity with an IC 50 value of 548  M.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44531358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Metabolites from Marine-Derived Fungus Aspergillus carneus GXIMD00519 海洋来源真菌鹿角曲霉GXIMD00519的次生代谢物
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-10-29 DOI: 10.25135/rnp.355.2207.2518
Xinya Xu, Chun-Ju Lu, Zhenzhou Tang, Y. Liu, Cheng-Hai Gao, Haiyan Li, Ge Zhang, Zhi-wei Su
{"title":"Secondary Metabolites from Marine-Derived Fungus Aspergillus carneus GXIMD00519","authors":"Xinya Xu, Chun-Ju Lu, Zhenzhou Tang, Y. Liu, Cheng-Hai Gao, Haiyan Li, Ge Zhang, Zhi-wei Su","doi":"10.25135/rnp.355.2207.2518","DOIUrl":"https://doi.org/10.25135/rnp.355.2207.2518","url":null,"abstract":": Two new compounds, carneusins A-B ( 1-2 ), as well as fifteen known compounds ( 3-17 ), were isolated from the marine-derived fungus Aspergillus carneus GXIMD00519. Their structures were elucidated by the analysis of detailed spectroscopic data and quantum chemistry calculations. All the compounds were evaluated for their antibacterial, antibiofilm and cytotoxic effects. Compound 1 showed a moderate inhibitory effect against MRSA with the MIC value of 32 µg/mL. Compound 2 exhibited an anti-microfouling effect against biofouling bacterial Vibrio rotiferianus and Alteromonas macleodii with MIC value of 64 µg/mL. Compound 5 displayed antibiofilm activity against A. macleodii with the EC 50 value of 10.42 ± 0.58 µg/mL. Compounds 1 , 3 , 4 , 8 and 15 showed cytotoxicity against human pancreatic cancer cell lines SW1990, colorectal adenocarcinoma cell line DLD1, human pancreatic cancer cell line PANC1, and human hepatocellular carcinoma cell line Bel7402 with IC 50 values ranging of 2.75-17.77 µM.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":"1 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69542884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Monoterpene Rhamnoside from Cercis glabra Legumes 一种新的单萜类鼠李糖苷
IF 1.9 4区 生物学
Records of Natural Products Pub Date : 2022-10-27 DOI: 10.25135/rnp.362.2209.2593
Penghua Shu, Tingxiao Xu, Yueyue Lou, Yabing Ge, Xiaoqing Lu, Pengpai Zhang
{"title":"A New Monoterpene Rhamnoside from Cercis glabra Legumes","authors":"Penghua Shu, Tingxiao Xu, Yueyue Lou, Yabing Ge, Xiaoqing Lu, Pengpai Zhang","doi":"10.25135/rnp.362.2209.2593","DOIUrl":"https://doi.org/10.25135/rnp.362.2209.2593","url":null,"abstract":": A new monoterpene rhamnoside, (+)-( R )- α -terpineol α -L-rhamnoside ( 1 ), along with ten known compounds ( 2 – 11 ) were obtained after purification of the ethanol extract of Cercis glabra legumes. Their structures were elucidated by spectroscopic evidence including NMR, optical rotatory dispersion (ORD), HR-ESI-MS and chemical hydrolysis. In the acetylcholinesterase inhibitory assay, compounds 3 and 8 showed high percentages of inhibition which were comparable to the activity of donepezil (a commercial drug, the positive control), and exhibited IC 50 values of 0.488, 0.391 mg/mL. These bioactive components could be promising acetylcholinesterase inhibitors.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48266366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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