Records of Natural Products最新文献_第10页

The Effect of Cynara cornigera L. in HepG2 Hepatocellular Carcinoma Cells 山杨对HepG2肝癌细胞的作用

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2023-01-01 DOI: 10.25135/rnp.335.2106.2092

Erdal Şanlidağ, İ. Çalış, H. Vatansever, K. Baser, E. Becer, A. Hanoğlu, Fatih Göger

{"title":"The Effect of Cynara cornigera L. in HepG2 Hepatocellular Carcinoma Cells","authors":"Erdal Şanlidağ, İ. Çalış, H. Vatansever, K. Baser, E. Becer, A. Hanoğlu, Fatih Göger","doi":"10.25135/rnp.335.2106.2092","DOIUrl":"https://doi.org/10.25135/rnp.335.2106.2092","url":null,"abstract":": Amongst all cancer types, liver cancer is the fourth leading cause of cancer mortality. It is frequently stated as hepatocellular carcinoma (HCC) and occurs in hepatocytes. Genetic alterations of hepatocytes such as Wnt/β-catenin and JAK / STAT signaling pathways play a key role for the development of the HCC. Currently, there are a few available treatments for HCC; such treatments include transplantation, surgical resections and anti-cancer drugs. Most of the anti-cancer drugs target the signaling pathways for achieving an effective treatment. However, these treatments have some undesirable side effects. Thus, there is a need for discovering alternative anti-cancer agents with no or lesser side effects. Plant constituents are promising anti-cancer agents. Cynara cornigera L. contains plenty of phenolic compounds including quercetin, apigenin, etc. This study aimed to analyze the anti-cancer property of the fractionated methanol extract of the flowers of C. cornigera . All the fractions obtained were analyzed to determine the cytotoxic activity on HepG2 cells. Two of the fractions containing polyphenolic compounds had a significant cytotoxic activity related to non-canonical Wnt11 signaling pathways on HepG2 cells.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45115909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Chemical Components and Pharmacological Activities of Gesneriaceae 苦苣苔科植物化学成分及药理活性研究进展

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-12-18 DOI: 10.25135/rnp.372.22.05.2470

Xiao-Rong Deng, Meng Li, Yingda Yang, Bowen Zhang, Weisheng Feng, Xiaoke Zheng, Jing-ke Zhang

引用次数: 0

Anti-inflammatory Benzofurans from the Heartwood of Dalbergia cochinchinensis Pierre ex Laness 南美白黄檀心材中的抗炎苯并呋喃类化合物

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-12-17 DOI: 10.25135/rnp.371.2210.2594

Qiwan Zheng, Ronghua Liu, Lanying Chen, Canyue Quyang, Xianwen Wei, Yang Liu, Jiahui Ren

引用次数: 0

Triterpenoids and Pharmacological Activities from Kadsura (Schisandraceae) were gathered from 1987 to 2022 从1987年到2022年收集了南五味子的三萜类化合物和药理活性

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-12-17 DOI: 10.25135/rnp.373.2209.2588

Xiaomei Song, Haonan Xu, Yuanyuan Liu, Chenwang Liu, Chong Deng, Yi Jiang, Yu-ze Li, Dongdong Zhang, Wei Wang

引用次数: 0

Two New Sesquiterpenoids from Kalimeris shimadae 岛马兰中两个新的倍半萜类化合物

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-12-13 DOI: 10.25135/rnp.369.2210.2604

Guo-Kai Wang, Yun-peng Sun, Yu-fei Huang, Yang Yu, Jai-Sing Yang, Jin-Song Liu

引用次数: 0

Analysis of Phenolic Compounds by LC-HRMS and Determination of Antioxidant and Enzyme Inhibitory Properties of Verbascum speciousum Schrad LC-HRMS法分析酚类化合物及石藻抗氧化和酶抑制性能的测定

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-12-13 DOI: 10.25135/rnp.370.2210.2598

I. Gülçin, Hatice Kiziltaş, Zeynebe Bi̇ngöl, A. Gören, S. Alwasel

引用次数: 5

Eupalinolide N, a Previously Undescribed Sesquiterpene Lactone with Anti-inflammatory Activity from Eupatorium lindleyanum 从紫泽兰中发现的一种具有抗炎活性的倍半萜内酯

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-12-13 DOI: 10.25135/rnp.368.2206.2499

Cheng Peng, Jie Yan, D. Guo, Jin Pei, Yun Deng, Ding Liu, Xiaofang Xie, Wenxiu Guo, Lanyu Zhou, Bin Xiao, Xue-yan Huo, Yunjie Hu

引用次数: 0

Diterpenoids from the Seeds of Euphorbia Lathyris and their Cytotoxic Acitivity 大戟种子中的二萜类化合物及其细胞毒活性

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-11-26 DOI: 10.25135/rnp.365.2205.2459

Na Liu, Yajie Sun, Yulin Sun, Yilin Sun, Ting Luo, Fengying Yang, Peng Wang, Di Ge

引用次数: 0

Essential Oil Compositions and Antimicrobial Activity of the Leaves of Alphonsea monogyma Merr. & Chun and Goniothalamus banii B. H. Quang, R. K. Choudhary & V.T. Chinh from Vietnam 山Alphonsea monogyma Merr.&来自越南的Chun和Goniothalamus banii B.H.Quang，R.K.Choudhary和V.T.Chinh

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-11-26 DOI: 10.25135/rnp.367.2208.2547

I. Ogunwande, L. Huong, L. Giang, D. Dai

{"title":"Essential Oil Compositions and Antimicrobial Activity of the Leaves of Alphonsea monogyma Merr. & Chun and Goniothalamus banii B. H. Quang, R. K. Choudhary & V.T. Chinh from Vietnam","authors":"I. Ogunwande, L. Huong, L. Giang, D. Dai","doi":"10.25135/rnp.367.2208.2547","DOIUrl":"https://doi.org/10.25135/rnp.367.2208.2547","url":null,"abstract":": Essential oils from the leaves of Alphonsea monogyma Merr. & Chun and Goniothalamus banii B. H. Quang, R. K. Choudhary & V.T. Chinh from Vietnam were obtained by hydrodisitllation and the chemical components determined by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC/MS). The antimicrobial assay was conducted by microdilution broth method. The respective yields of the essential oils were 0.18% (v/w) and 0.355% (v/w), respectively. The major components of A. monogyma were ( E )-caryophyllene (13.8%),  -cadinene (12.5%), bicyclogermacrene (12.4%), cis -β-elemene (12.1%), and germacrene D (11.4%). However, myrcene (47.1%), α-pinene (9.7%) and ( E )-caryophyllene (9.1%) were the dominant constituents of the essential oil of G. banii . The leaf essential oil of A. monogyma displayed potent antimicrobial activity towards the Gram-positive microorganisms of Enterococcus faecalis ATCC29212, Staphylococcus aureus ATCC25923 and Bacillus cereus ATCC14579 with minimum inhibitory concentration (MIC) values of 2.23 µg/mL, 10.45 µg/mL and 10.33 µg/mL, respectively. On the other hand, essential oil from G. banii exhibited the most effective antibacterial against Gram-negative Pseudomonas aeruginosa ATCC27853 (MIC 5.67 µg/mL), and anti-candidal action towards Candida albicans ATCC10231 (MIC 32.67 µg/mL). The chemical constituents and antimicrobial activity of the essential oils of A. monogyma and G. banii were being reported for the first time.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43118826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative Analyses on Chemical Constituents and Biological Activities of Laserpitium siler L. from Serbia 塞尔维亚激光鹿的化学成分和生物活性的比较分析

IF 1.9 4区生物学

Records of Natural Products Pub Date : 2022-11-25 DOI: 10.25135/rnp.364.2207.2528

Ksenija S. Mileski, A. Ćirić, U. Gašić, Lazar D. Žarković, Z. Krivošej, A. Džamić

{"title":"Comparative Analyses on Chemical Constituents and Biological Activities of Laserpitium siler L. from Serbia","authors":"Ksenija S. Mileski, A. Ćirić, U. Gašić, Lazar D. Žarković, Z. Krivošej, A. Džamić","doi":"10.25135/rnp.364.2207.2528","DOIUrl":"https://doi.org/10.25135/rnp.364.2207.2528","url":null,"abstract":": The traditional European medicinal plant Laserpitium siler L. was studied for the first time for the chemical composition and in vitro biological potential of extracts from fruits and aerial parts. Eight extracts were subjected to spectrophotometric detection and LC-MS quantification of phenolics. The bioactivity assessment comprised antioxidant, antimicrobial, anti-denaturation, acetylcholinesterase, tyrosinase, α-amylase, and α-glucosidase inhibition assays. The spectrophotometric analyses showed that the alcoholic extracts contained the most phenolic acids and coumarins. Among the twenty quantified compounds in the methanolic extracts, chlorogenic acid (29.10 mg/kg in the fruits; 47.00 mg/kg in the aerial parts) and p -coumaric acid (7.50 mg/kg in the fruits; 9.50 mg/kg in the aerial parts) were the most abundant. The DPPH/ABTS/BBT tests showed the strongest antioxidant effect of the methanolic extract of the aerial parts. The results of the microdilution assay referred to stronger antibacterial than antifungal activity, with the essential oil being as effective as the antibiotics used. The extracts expressed promising activity against P . aeruginosa PAO1 biofilm formation and pyocyanin synthesis. The prevention of BSA denaturation by the ethanolic extracts was comparable to diclofenac (91.08%-fruits, 95.08%-aerial parts, and 95.60%-diclofenac). IC 50 values showed greater enzyme inhibitory potential of aerial parts and the highest reduction of α-glucosidase activity.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45884088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1