水稻栽培扣带球菌内酯的结构研究及抗菌性能评价

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-07-17 DOI:10.25135/rnp.340.2202.2352

Nayara F. Gomes, Manoel Leão L. Júnior, Antônio José C. Filho, Lourivaldo S. Santos, Luís Cláudio N. Silva, E. Rodrigues-Filho

{"title":"水稻栽培扣带球菌内酯的结构研究及抗菌性能评价","authors":"Nayara F. Gomes, Manoel Leão L. Júnior, Antônio José C. Filho, Lourivaldo S. Santos, Luís Cláudio N. Silva, E. Rodrigues-Filho","doi":"10.25135/rnp.340.2202.2352","DOIUrl":null,"url":null,"abstract":": Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1 H and 13 C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 ( 1 ) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 2 ) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 3 ). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereomer 3 and pestalotin-1 were inactive","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2022-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lactones from Glomerella cingulata Cultivated in Rice:Structural Studies and Antimicrobial Evaluation\",\"authors\":\"Nayara F. Gomes, Manoel Leão L. Júnior, Antônio José C. Filho, Lourivaldo S. Santos, Luís Cláudio N. Silva, E. Rodrigues-Filho\",\"doi\":\"10.25135/rnp.340.2202.2352\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1 H and 13 C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 ( 1 ) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 2 ) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 3 ). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereomer 3 and pestalotin-1 were inactive\",\"PeriodicalId\":21053,\"journal\":{\"name\":\"Records of Natural Products\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2022-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Records of Natural Products\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.25135/rnp.340.2202.2352\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Records of Natural Products","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.25135/rnp.340.2202.2352","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

摘要

：通过包括制备规模HPLC在内的色谱程序对生长在波兰水稻中的内生真菌扣带球菌的提取物进行分级。通过波谱分析，主要是1H和13C NMR和HRMS，对分离的化合物进行了结构鉴定。这些分析允许鉴定香蒜香素-1（1）和邻苯二甲酸酯（3R*，8S*）-5,7-二羟基-3-（1-羟乙基）-邻苯二甲酯（2）和（3R*、8R*）-5-7-二羟基3-（1-羟乙基。对提取物、其组分和分离物质进行了针对几种细菌的测试。内酯2对大肠杆菌和粪肠球菌的谱系显示出一定的活性，而其非对映异构体3和香蒜素-1则没有活性

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Lactones from Glomerella cingulata Cultivated in Rice:Structural Studies and Antimicrobial Evaluation

: Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1 H and 13 C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 ( 1 ) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 2 ) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 3 ). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereomer 3 and pestalotin-1 were inactive

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.