大戟种子中的二萜类化合物及其细胞毒活性

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-11-26 DOI:10.25135/rnp.365.2205.2459

Na Liu, Yajie Sun, Yulin Sun, Yilin Sun, Ting Luo, Fengying Yang, Peng Wang, Di Ge

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引用次数: 0

摘要

从大戟种子中分离得到23个二萜类化合物，并用1D-和2D-NMR光谱和HRESIMS分析对1个新化合物（1）和22个已知化合物（2-23）进行了表征。进一步评价分离的化合物对BT-549和MDA-MB-231癌症细胞系的细胞毒性。发现化合物3、10、14和22对BT-549细胞表现出相当大的细胞毒性活性，IC50值范围为4.7至10.1μM。化合物1、2、14和22能够抑制MDA-MB-231细胞系的生长，IC50值为5.7至21.3μM，而其他化合物没有表现出明显的抑制作用。

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Diterpenoids from the Seeds of Euphorbia Lathyris and their Cytotoxic Acitivity

: A total of 23 diterpenoids were isolated from the seeds of Euphorbia lathyris , and one new compound ( 1 ) and twenty-two known compounds ( 2-23 ) were characterized by using 1D- and 2D-NMR spectra and HRESIMS analysis. Cytotoxicity of the isolated compounds against BT-549 and MDA-MB-231 cancer cells lines were evaluated further. Compounds 3 , 10 , 14 , and 22 were found to exhibit considerable cytotoxic activities against BT-549 cells, with IC 50 values ranging from 4.7 to 10.1 μM. Compounds 1 , 2 , 14 and 22 were able to inhibit the MDA-MB-231 cell line growth with IC 50 values of 5.7 to 21.3 μM, while other compounds showed no obvious inhibitory effects.

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.