黑檀心材中的抗炎成分

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-11-08 DOI:10.25135/rnp.366.2208.2560

Qing Zhu, C. Ouyang, Yang Liu, Zhangjun Xu, Ying Zhang, Ronghuai Liu, Lanying Chen

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引用次数: 1

摘要

从黄檀的ch2cl -2馏分中分离得到一个新的查尔酮化合物-5-肉桂酰-2-羟基-4-甲氧基苯甲酸甲酯(1)和一个新的肉桂基酚化合物- 3-肉桂酰-5-羟基-4-甲氧基苯甲酸甲酯(2)以及四个已知的化合物(3- 6)。通过核磁共振、质谱、单晶x射线衍射和文献资料比对等综合光谱测量方法对其结构进行了鉴定。根据化合物1和2在RAW 264.7细胞活力的测定结果，化合物的IC 50值分别为3.2和383.8 μM。与LPS模型组比较，化合物1、2在1.2~9.6、33.7 μM浓度范围内显著降低NO的释放(P <0.01)，在4.8~9.6、16.8~33.7 μM浓度范围内显著抑制LDH的分泌(P <0.01)。melanoxylon cinnamylphenol;活动。©2022 acg

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Anti-inflammatory Continents from the Heartwood of Dalbergia melanoxylon

: A new chalcone compound, methyl 5-cinnamoyl-2-hydroxy-4-methoxybenzoate ( 1 ), and a new cinnamylphenol compound, methyl 3-cinnamyl-5-hydroxy-4-methoxybenzoate ( 2 ) together with four known compounds ( 3 - 6 ) were isolated from the CH 2 Cl 2 fraction of Dalbergia melanoxylon . Their structures were elucidated by comprehensive spectral measurements including NMR techniques, mass spectrometry, single crystal X-ray diffraction and, together with comparison of the literature data. According to the determination results of compound 1 and 2 on RAW 264.7 cell viability, the IC 50 values of compounds were found to be 3.2 and 383.8 μM, respectively. Compared with LPS model group, compounds 1 and 2 were found to be significantly reduce the release of NO in the concentration ranges of 1.2~9.6 and 33.7 μM ( P <0.01), and significantly inhibit the secretion of LDH in the range of 4.8~9.6 and 16.8~33.7 μM . melanoxylon cinnamylphenol; activity. © 2022 ACG

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.