Anti-inflammatory Continents from the Heartwood of Dalbergia melanoxylon

Abstract

: A new chalcone compound, methyl 5-cinnamoyl-2-hydroxy-4-methoxybenzoate ( 1 ), and a new cinnamylphenol compound, methyl 3-cinnamyl-5-hydroxy-4-methoxybenzoate ( 2 ) together with four known compounds ( 3 - 6 ) were isolated from the CH 2 Cl 2 fraction of Dalbergia melanoxylon . Their structures were elucidated by comprehensive spectral measurements including NMR techniques, mass spectrometry, single crystal X-ray diffraction and, together with comparison of the literature data. According to the determination results of compound 1 and 2 on RAW 264.7 cell viability, the IC 50 values of compounds were found to be 3.2 and 383.8 μM, respectively. Compared with LPS model group, compounds 1 and 2 were found to be significantly reduce the release of NO in the concentration ranges of 1.2~9.6 and 33.7 μM ( P <0.01), and significantly inhibit the secretion of LDH in the range of 4.8~9.6 and 16.8~33.7 μM . melanoxylon cinnamylphenol; activity. © 2022 ACG